当前位置： SCI文献检索 > PARKINSONISM & RELATED DISORDERS期刊下所有文献 > Eye movement deficits in X-linked dystonia-parkinsonism are related to striatal degeneration.

Eye movement deficits in X-linked dystonia-parkinsonism are related to striatal degeneration.

Abstract：

BACKGROUND:X-linked dystonia-parkinsonism (XDP) is characterized by the unique transition of dystonia to parkinsonism and striatal degeneration. Slowing of saccades on clinical examination has been taken as suggestive of a progressive supranuclear palsy (PSP) phenotype. OBJECTIVES:To elucidate whether eye movement abnormalities in XDP patients reflect striatonigral impairment or deficits in the brainstem saccade generator as present in PSP. METHODS:Eye movements of 18 male XDP patients from the Philippines and 16 ethnically and age-matched, healthy control participants were analyzed and the results related to morphometric frontostriatal changes. RESULTS:There was moderate saccade hypometria in XDP but velocity of visually guided saccades was normal. XDP patients showed an increased antisaccade error rate which correlated with the reduction of (i) the volume of the pallidum and putamen as well as (ii) the volume and cortical thickness in dorsolateral prefrontal cortex. Amplitude of memory-guided saccades was smaller and latency prolonged. Horizontal smooth pursuit eye movements were impaired. CONCLUSIONS:Oculomotor abnormalities in XDP resemble those of patients with the Parkinsonian type of multiple system atrophy and - to a lesser degree - Parkinson's disease, but are not compatible with PSP. They indicate striatal impairment and may represent preclinical signs of the parkinsonian stage of XDP. The increasing failure of response inhibition in the antisaccade task with increasing striatal atrophy may indicate an endophenotype for striatal degeneration. Dorsolateral prefrontal degeneration can be inferred from the failure in initiating antisaccades, prolonged latency of memory-guided saccades and the reduction of dorsolateral prefrontal volume and cortical thickness.

journal_name

Parkinsonism Relat Disord

journal_title

Parkinsonism & related disorders

authors

Sprenger A,Hanssen H,Hagedorn I,Prasuhn J,Rosales RL,Jamora RDG,Diesta CC,Domingo A,Klein C,Brüggemann N,Helmchen C

doi

10.1016/j.parkreldis.2018.10.016

subject

Has Abstract

pub_date

2019-04-01 00:00:00

pages

170-178

eissn

1353-8020

issn

1873-5126

pii

S1353-8020(18)30450-4

journal_volume

61

pub_type

杂志文章

相关文献

PARKINSONISM & RELATED DISORDERS文献大全
  • Diagnostic accuracy of ¹²³I-FP-CIT (DaTSCAN) in dementia with Lewy bodies: a meta-analysis of published studies.

    abstract：PURPOSE:A systematic meta-analysis of published studies on the diagnostic accuracy of presynaptic dopaminergic imaging with ¹²³I-FP-CIT (DaTSCAN) in dementia with Lewy bodies (DLB). METHODS:We included (a) studies in which DaTSCAN was performed in cases of diagnostic uncertainty to differentiate between DLB and non-DL...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章,meta分析,评审

    doi：10.1016/j.parkreldis.2011.09.015

    authors： Papathanasiou ND,Boutsiadis A,Dickson J,Bomanji JB

    更新日期：2012-03-01 00:00:00

  • A pathophysiological model of freezing of gait in Parkinson's disease.

    abstract：:Freezing of gait (FOG) is a common phenomenon in Parkinson's disease (PD) affecting over half of those in the advanced stages of the disease and often does not respond to standard drug therapies. This article proposes a possible mechanism by which this disorder of movement comes about. Co-ordinated neural activities a...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/j.parkreldis.2008.08.006

    authors： Lewis SJ,Barker RA

    更新日期：2009-06-01 00:00:00

  • Medical decision-making in progressive supranuclear palsy: A comparison to other neurodegenerative disorders.

    abstract：INTRODUCTION:Cognitive dysfunction is common in progressive supranuclear palsy (PSP) but its effect on medical decision-making has not been well studied. To address this gap in the research literature, we compared the medical decision-making capacity of patients with PSP to groups of patients with other neurodegenerati...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/j.parkreldis.2018.11.022

    authors： Gerstenecker A,Grimsley L,Otruba B,Cowden L,Marson DC,Gerstenecker KT,Martin RC,Roberson ED

    更新日期：2019-04-01 00:00:00

  • Women pioneers in basal ganglia surgery.

    abstract：BACKGROUND:Stereotactic functional neurosurgery on basal ganglia has a long history and the pioneers are mostly men. We aimed at finding out if there were women who have contributed pioneering work in this field. METHODS:The literature was searched to identify women who have been first to publish innovative papers rel...

    journal_title：Parkinsonism & related disorders

    pub_type： 传,历史文章,杂志文章,评审

    doi：10.1016/j.parkreldis.2013.11.002

    authors： Hariz GM,Rehncrona S,Blomstedt P,Limousin P,Hamberg K,Hariz M

    更新日期：2014-02-01 00:00:00

  • Is there a pathogenic role for mitochondria in Parkinson's disease?

    abstract：:Parkinson's disease (PD) is a common neurodegenerative disorder of unknown cause. For decades, a deficit in mitochondrial respiration was thought to be a key factor in PD neurodegeneration. However, excluding a few exceptions where a clinical picture of parkinsonism is associated with a mitochondrial DNA mutation, pre...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/S1353-8020(09)70823-5

    authors： Vives-Bauza C,de Vries RL,Tocilescu MA,Przedborski S

    更新日期：2009-12-01 00:00:00

  • Randomized, controlled pilot trial of solifenacin succinate for overactive bladder in Parkinson's disease.

    abstract：OBJECTIVE:To evaluate the efficacy of solifenacin succinate in Parkinson's disease (PD) patients suffering from overactive bladder (OAB). BACKGROUND:Urinary dysfunction is a commonly encountered non-motor feature in PD that significantly impacts patient quality of life. DESIGN/METHODS:This was a double-blind, randomi...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1016/j.parkreldis.2015.02.025

    authors： Zesiewicz TA,Evatt M,Vaughan CP,Jahan I,Singer C,Ordorica R,Salemi JL,Shaw JD,Sullivan KL,Non-Motor Working Group of the Parkinson Study Group (PSG).

    更新日期：2015-05-01 00:00:00

  • Familial Behr syndrome-like phenotype with autosomal dominant inheritance.

    abstract：:Behr syndrome is an autosomal recessive disease characterized by early-onset ataxia, optic atrophy and other signs such as pyramidal tract dysfunction. Autosomal dominant inheritance has also been described. In this case report we present a family pedigree of patients with an inherited autosomal dominant Behr syndrome...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/j.parkreldis.2007.08.008

    authors： Felicio AC,Godeiro-Junior C,Alberto LG,Pinto AP,Sallum JM,Teive HG,Barsottini OG

    更新日期：2008-01-01 00:00:00

  • High-dose treatment with pergolide in Parkinson's disease patients with motor fluctuations and dyskinesias.

    abstract：:Motor complications arising after long-term treatment with levodopa remain one of the main challenges in the treatment of patients with Parkinson's disease (PD). Monotherapy with dopamine agonists may delay the onset of motor complications or reduce their severity when added to levodopa treatment. Here, we retrospecti...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/j.parkreldis.2005.03.005

    authors： Storch A,Trenkwalder C,Oehlwein C,Winkelmann J,Polzer U,Hundemer HP,Schwarz J

    更新日期：2005-09-01 00:00:00

  • Impaired decision-making in Parkinson's disease.

    abstract：:The present study demonstrated that individuals with Parkinson's disease display impairments in making profitable decisions, as evidenced by poorer performance on the Iowa Gambling Task relative to matched controls. The ability to make beneficial judgments solely correlates with ability to appropriately attribute inte...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/j.parkreldis.2005.12.003

    authors： Mimura M,Oeda R,Kawamura M

    更新日期：2006-04-01 00:00:00

  • The stiff-man syndrome and related disorders.

    abstract：:The stiff-man syndrome (SMS) is characterised by rigidity and spasm of predominantly axial and proximal limb muscles. The cause of the condition is unknown but the finding of antibodies to glutamic acid decarboxylase (GAD) in approximately 60% of patients has suggested an autoimmune basis. Pathological findings are li...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章,评审

    doi：10.1016/s1353-8020(01)00029-3

    authors： Thompson PD

    更新日期：2001-10-01 00:00:00

  • Orthostatic myoclonus after brain tumor radiation: Insights from two lesional cases.

    abstract：INTRODUCTION:Orthostatic myoclonus (OM) is a recognized syndrome of gait unsteadiness accompanied by lower limb myoclonus provoked by the assumption of an upright posture. OM typically affects the elderly and is often associated with neurodegenerative disease. We sought to review the clinical and electrophysiologic cha...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/j.parkreldis.2017.04.015

    authors： Cutsforth-Gregory JK,Hammack JE,Matsumoto JY

    更新日期：2017-08-01 00:00:00

  • Functional correlates of cognitive slowing in Parkinson's disease.

    abstract：:Although attentional impairments (particularly cognitive slowing) are frequent in Parkinson's disease (PD), the mechanisms underlying these phenomena have not been fully characterized. The MRI-compatible version of the Symbol Digit Modalities Test (SDMT) has been applied to healthy individuals but not previously to pa...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/j.parkreldis.2020.05.006

    authors： Grolez G,Viard R,Lopes R,Kuchcinski G,Defebvre L,Devos D,Dujardin K,Moreau C

    更新日期：2020-07-01 00:00:00

  • CSF biomarker profiles do not differentiate between the cerebellar and parkinsonian phenotypes of multiple system atrophy.

    abstract：BACKGROUND:Multiple system atrophy (MSA) can clinically be divided into the cerebellar (MSA-C) and the parkinsonian (MSA-P) variants. It is unknown whether the variation in clinical expression is also reflected by a different underlying neurochemical profile. METHODS:We analyzed brain specific proteins and neurotransm...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/j.parkreldis.2007.02.002

    authors： Abdo WF,van de Warrenburg BP,Kremer HP,Bloem BR,Verbeek MM

    更新日期：2007-12-01 00:00:00

  • The pattern of FP-CIT PET in pure white matter hyperintensities-related vascular parkinsonism.

    abstract：OBJECTIVES:To determine whether vascular parkinsonism (VaP) patients with visually normal dopamine transporter (DAT) scans have presynaptic dopaminergic depletion. METHODS:We enrolled 23 VaP patients who had parkinsonism, relevant diffuse subcortical white matter hyperintensities (WMH), and visually normal DAT scans, ...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/j.parkreldis.2020.11.002

    authors： Lee YH,Lee S,Chung SJ,Yoo HS,Jung JH,Baik K,Ye BS,Sohn YH,Yun M,Lee PH

    更新日期：2021-01-01 00:00:00

  • Comparison of IPX066 with carbidopa-levodopa plus entacapone in advanced PD patients.

    abstract：BACKGROUND:IPX066, an investigational extended-release carbidopa-levodopa (CD-LD) preparation, has demonstrated a rapid attainment and prolonged maintenance of therapeutic LD plasma concentrations in advanced Parkinson's disease (PD). This phase-3 crossover study assessed its efficacy and safety vs. CD-LD plus entacapo...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.parkreldis.2014.08.004

    authors： Stocchi F,Hsu A,Khanna S,Ellenbogen A,Mahler A,Liang G,Dillmann U,Rubens R,Kell S,Gupta S

    更新日期：2014-12-01 00:00:00

  • Memory perception and strategy use in Parkinson's disease.

    abstract：:Although there is growing support for the existence of memory deficits within Parkinson's disease (PD), little has been done to evaluate the extent to which PD patients demonstrate differences in their use of metacognitive strategies. In the present study, 79 PD patients (46 men and 33 women) and 49 age-matched health...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/j.parkreldis.2004.06.005

    authors： Johnson AM,Pollard CC,Vernon PA,Tomes JL,Jog MS

    更新日期：2005-03-01 00:00:00

  • Naftazone in advanced Parkinson's disease: An acute L-DOPA challenge randomized controlled trial.

    abstract：INTRODUCTION:There is an unmet need to better control motor complications in Parkinson's disease (PD). Naftazone, which exhibits glutamate release inhibition properties, has shown antiparkinsonian and antidyskinetic activity in preclinical models of PD and in a clinical proof of concept study. METHODS:We conducted a d...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1016/j.parkreldis.2018.10.005

    authors： Corvol JC,Durif F,Meissner WG,Azulay JP,Haddad R,Guimarães-Costa R,Mariani LL,Cormier-Dequaire F,Thalamas C,Galitzky M,Boraud T,Debilly B,Eusebio A,Houot M,Dellapina E,Chaigneau V,Salis A,Lacomblez L,Benel L,Rascol

    更新日期：2019-03-01 00:00:00

  • Levodopa and neuropathy risk in patients with Parkinson disease: Effect of COMT inhibition.

    abstract：OBJECTIVE:Our purpose was to determine whether the use of catechol-O-methyltransferase-inhibitors (ICOMT) can reduce the risk of developing levodopa (LD)-induced neuropathy in Parkinson's disease (PD) patients. METHODS:A multicentre study of 197 PD patients was performed. 144 were exposed to LD for more than three yea...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.parkreldis.2016.04.016

    authors： Cossu G,Ceravolo R,Zibetti M,Arca R,Ricchi V,Paribello A,Murgia D,Merola A,Romagnolo A,Nicoletti V,Palermo G,Mereu A,Lopiano L,Melis M,Abbruzzese G,Bonuccelli U

    更新日期：2016-06-01 00:00:00

  • Urinary 8-hydroxydeoxyguanosine correlate with hallucinations rather than motor symptoms in Parkinson's disease.

    abstract：BACKGROUND:Oxidative stress is causally associated with the pathogenesis of Parkinson's disease (PD). Oxygen generates a large amount of reactive oxygen species (ROS). ROS including hydroxyl radicals and H(2)O(2) react with guanine residues in DNA and produce 8-hydroxydeoxyguanosine (8-OHdG). 8-OHdG serves as a biomark...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/j.parkreldis.2010.11.004

    authors： Hirayama M,Nakamura T,Watanabe H,Uchida K,Hama T,Hara T,Niimi Y,Ito M,Ohno K,Sobue G

    更新日期：2011-01-01 00:00:00

  • Proton magnetic resonance spectroscopy of the striatum in Parkinson's disease patients with motor response fluctuations.

    abstract：:We have performed proton magnetic resonance spectroscopy centred on the putamen contralateral to the worst affected side in 10 patients with idiopathic Parkinson's disease (PD) and motor response fluctuations and seven age matched healthy controls. In PD, there was striking reduction in the N-acetylaspartate (NAA) and...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/1353-8020(96)00007-7

    authors： Chaudhuri KR,Lemmens GM,Williams SC,Ellis C,Lloyd CM,Dawson J,Simmons A,Leigh PN

    更新日期：1996-04-01 00:00:00

  • Cognitive correlates of visual hallucinations in non-demented Parkinson's disease patients.

    abstract：BACKGROUND:Visual hallucinations (VH) in Parkinson's disease (PD) are associated with PD dementia and have been related to cognitive impairments in non-demented PD patients. Reports on the specific cognitive domains affected are conflicting. The aim of the present study was to investigate the presence of specific cogni...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/j.parkreldis.2013.04.026

    authors： Hepp DH,da Hora CC,Koene T,Uitdehaag BM,van den Heuvel OA,Klein M,van de Berg WD,Berendse HW,Foncke EM

    更新日期：2013-09-01 00:00:00

  • Astrocytes and microglia in the substantia nigra and caudate-putamen in Parkinson's disease.

    abstract：:There is evidence that astrocytes and microglia can release agents which might have a protective effect on damaged neurons. However the associations of glia with dopaminergic neurons in Parkinson's disease are not defined. Our studies showed that in post mortem parkinsonian nigra healthy neuronal somata were enveloped...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/s1353-8020(99)00022-x

    authors： Knott C,Wilkin GP,Stern G

    更新日期：1999-09-01 00:00:00

  • Long-term evaluation of open-label pimavanserin safety and tolerability in Parkinson's disease psychosis.

    abstract：INTRODUCTION:Pimavanserin is a selective 5-HT2A inverse agonist/antagonist approved for treating hallucinations and delusions associated with Parkinson's disease psychosis (PDP). Results from short-term, placebo-controlled studies demonstrated a positive benefit/risk profile. This multi-year, open-label study assessed ...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/j.parkreldis.2020.06.026

    authors： Ballard CG,Kreitzman DL,Isaacson S,Liu IY,Norton JC,Demos G,Fernandez HH,Ilic TV,Azulay JP,Ferreira JJ,Abler V,Stankovic S,015 Study Group.

    更新日期：2020-08-01 00:00:00

  • Could Mucuna pruriens be the answer to Parkinson's disease management in sub-Saharan Africa and other low-income countries worldwide?

    abstract：:Parkinson's disease (PD) is a progressive, disabling, neurodegenerative disease that requires long term care and pharmaceutical treatment. Levodopa remains the gold standard treatment for PD globally, although it is largely unavailable and unaffordable for the majority of patients in many sub-Saharan African and other...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/j.parkreldis.2020.03.002

    authors： Fothergill-Misbah N,Maroo H,Cham M,Pezzoli G,Walker R,Cilia R

    更新日期：2020-04-01 00:00:00

  • Analysis of LRRK2, SNCA, Parkin, PINK1, and DJ-1 in Zambian patients with Parkinson's disease.

    abstract：:Recent studies delineate substantial genetic components in Parkinson's disease (PD). However, very few studies were performed in Sub-Saharan African populations. Here, we explore the contribution of known PD-causing genes in patients of indigenous Zambian ancestry. We studied thirty-nine Zambian patients, thirty-eight...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/j.parkreldis.2012.02.018

    authors： Yonova-Doing E,Atadzhanov M,Quadri M,Kelly P,Shawa N,Musonda ST,Simons EJ,Breedveld GJ,Oostra BA,Bonifati V

    更新日期：2012-06-01 00:00:00

  • Consecutive analyses of cerebrospinal fluid axonal and glial markers in Parkinson's disease and atypical Parkinsonian disorders.

    abstract：:Cerebrospinal fluid (CSF) levels of neurofilament light protein (NFL), a marker of neuronal damage, are normal in Parkinson's disease (PD) but elevated in multiple system atrophy (MSA) and progressive supranuclear palsy (PSP). Therefore, CSF NFL can help differentiate between PD on one hand and MSA/PSP on the other. I...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/j.parkreldis.2009.07.007

    authors： Constantinescu R,Rosengren L,Johnels B,Zetterberg H,Holmberg B

    更新日期：2010-02-01 00:00:00

  • Involuntary movements associated with vitamin B12 deficiency.

    abstract：:Involuntary movements are not a known feature of vitamin B12 (vB12) deficiency in adults, though they are a characteristic feature of vB12 deficiency in infants. This case report presents an adult patient with vB12 deficiency in whom, myoclonus-like muscular contractions appeared soon after the initiation of vB12 and ...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/s1353-8020(03)00065-8

    authors： Celik M,Barkut IK,Oncel C,Forta H

    更新日期：2003-10-01 00:00:00

  • A randomized, double-blind, controlled trial of add-on therapy in moderate-to-severe Parkinson's disease.

    abstract：OBJECTIVE:The primary objective was to evaluate the efficacy and safety of droxidopa as add-on therapy in improving stiffness, tremors and other motor functions and activities of daily living for moderate-to-severe Parkinson's disease (PD). METHODS:PD patients, above Hoehn-Yahr III (including Hoehn-Yahr III), were ran...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1016/j.parkreldis.2015.08.023

    authors： Zhao S,Cheng R,Zheng J,Li Q,Wang J,Fan W,Zhang L,Zhang Y,Li H,Liu S

    更新日期：2015-10-01 00:00:00

  • Positron emission tomography of dopamine pathways in familial Parkinsonian syndromes.

    abstract：:Positron emission tomography (PET) scan is considered to be the most useful tool with which to assess the integrity of nigrostriatal function in the living brain. Recently, different genetic defects have been associated with a variety of familial parkinsonian syndromes, the clinical phenotypes of which have varying de...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章,评审

    doi：10.1016/s1353-8020(01)00008-6

    authors： Pal PK,Wszolek ZK,Uitti R,Markopoulou K,Calne SM,Stoessl AJ,Calne DB

    更新日期：2001-09-01 00:00:00

  • Biochemical mechanisms of pallidal deep brain stimulation in X-linked dystonia parkinsonism.

    abstract：OBJECTIVE:Invasive techniques such as in-vivo microdialysis provide the opportunity to directly assess neurotransmitter levels in subcortical brain areas. METHODS:Five male Filipino patients (mean age 42.4, range 34-52 years) with severe X-linked dystonia-parkinsonism underwent bilateral implantation of deep brain lea...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/j.parkreldis.2015.06.010

    authors： Tronnier VM,Domingo A,Moll CK,Rasche D,Mohr C,Rosales R,Capetian P,Jamora RD,Lee LV,Münchau A,Diesta CC,Tadic V,Klein C,Brüggemann N,Moser A

    更新日期：2015-08-01 00:00:00