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Proton magnetic resonance spectroscopy of the striatum in Parkinson's disease patients with motor response fluctuations.

Abstract：

:We have performed proton magnetic resonance spectroscopy centred on the putamen contralateral to the worst affected side in 10 patients with idiopathic Parkinson's disease (PD) and motor response fluctuations and seven age matched healthy controls. In PD, there was striking reduction in the N-acetylaspartate (NAA) and creatine and NAA/choline ratios compared to controls. This pilot study provides in vivo evidence of striatal neuronal dysfunction in PD and further studies are in progress to establish if the observed changes are due to the disease process itself or due to chronic levodopa therapy.

journal_name

Parkinsonism Relat Disord

journal_title

Parkinsonism & related disorders

authors

Chaudhuri KR,Lemmens GM,Williams SC,Ellis C,Lloyd CM,Dawson J,Simmons A,Leigh PN

doi

10.1016/1353-8020(96)00007-7

subject

Has Abstract

pub_date

1996-04-01 00:00:00

pages

63-7

issue

2

eissn

1353-8020

issn

1873-5126

pii

1353-8020(96)00007-7

journal_volume

2

pub_type

杂志文章

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