The SCA17 phenotype can include features of MSA-C, PSP and cognitive impairment.

abstract：INTRODUCTION:There is a dearth of studies of spinocerebellar ataxias (SCAs) and diffusion tensor magnetic resonance imaging (DTI). OBJECTIVE:To analyze changes observed in DTI parameters and correlate these to clinical findings in SCA3 and SCA10 patients. METHODS:SCA3 (n = 19) and SCA10 (n = 18) patients were compare...

journal_title：Parkinsonism & related disorders

authors： Meira AT,Arruda WO,Ono SE,Franklin GL,de Carvalho Neto A,Raskin S,Ashizawa T,Camargo CHF,Teive HAG

更新日期：2020-09-01 00:00:00

abstract：BACKGROUND:Parkinson's disease (PD) patients are hospitalized more frequently than their peers as a result of falls, psychosis, infections and other medical complications. However, patient-specific risk factors for hospitalization are unclear. OBJECTIVE:To identify rates and risk factors for hospital encounters (Emerg...

journal_title：Parkinsonism & related disorders

authors： Hassan A,Wu SS,Schmidt P,Dai Y,Simuni T,Giladi N,Bloem BR,Malaty IA,Okun MS,NPF-QII Investigators.

更新日期：2013-11-01 00:00:00

abstract：:This preliminary study aimed to analyse the roll-off of the foot during gait before and after implantation of a unilateral pallidal electrode in severely affected patients with Parkinson's disease (PD). Five subjects were tested in a gait laboratory during the "on" phase of the medication cycle. Spatiotemporal variabl...

journal_title：Parkinsonism & related disorders

authors： Nieuwboer A,De Weerdt W,Dom R,Nuttin B,Peeraer L,Pattyn A

更新日期：1998-12-01 00:00:00

abstract：:Impulsive personalities are considered to have a general impairment in cognitive flexibility and cortical inhibition. To examine this hypothesis we used a trial by trial Stroop task in impulsive and non impulsive patients with Parkinson's disease (PD) and recorded errors and reaction times (RT). We tested 28 impulsive...

journal_title：Parkinsonism & related disorders

authors： Djamshidian A,O'Sullivan SS,Lees A,Averbeck BB

更新日期：2011-03-01 00:00:00

abstract：INTRODUCTION:The aim of this study was to examine the association between mild parkinsonian signs (MPS), cerebral small-vessel disease (SVD), and total SVD burden in patients with vascular risk factors. METHODS:We performed a cross-sectional study among 268 patients with vascular risk factors but without parkinsonism ...

journal_title：Parkinsonism & related disorders

authors： Hatate J,Miwa K,Matsumoto M,Sasaki T,Yagita Y,Sakaguchi M,Kitagawa K,Mochizuki H

更新日期：2016-05-01 00:00:00

abstract：BACKGROUND:Deep brain stimulation (DBS) is an effective and approved therapy for advanced Parkinson's disease (PD), and a recent study suggests efficacy in mid-stage disease. This manuscript reports the results of a pilot trial investigating preliminary safety and tolerability of DBS in early PD. METHODS:Thirty subjec...

journal_title：Parkinsonism & related disorders

authors： Charles D,Konrad PE,Neimat JS,Molinari AL,Tramontana MG,Finder SG,Gill CE,Bliton MJ,Kao C,Phibbs FT,Hedera P,Salomon RM,Cannard KR,Wang L,Song Y,Davis TL

更新日期：2014-07-01 00:00:00

abstract：BACKGROUND:In late stage Parkinson patients there is an unmet need for new treatments to adequately control motor complications, especially dyskinesias. In several preliminary studies, it has been suggested that applying unilateral low-frequency repetitive transcranial magnetic stimulation (LF rTMS), delivered at the p...

journal_title：Parkinsonism & related disorders

authors： Flamez A,Cordenier A,De Raedt S,Michiels V,Smetcoren S,Van Merhaegen-Wieleman A,Parys E,De Keyser J,Baeken C

更新日期：2016-01-01 00:00:00

abstract：:The inhibition of uptake of radioactive dopamine into PC-12 cells by analogues of MPTP with systematic variations of structure was studied in order to assess the steric constraints of the transmembrane dopamine transporter. Of 15 analogues tested, 11 were found to inhibit dopamine uptake, all being competitive inhibit...

journal_title：Parkinsonism & related disorders

authors： Athwal NS,Ramsden DB,Simpson M,Williams AC

更新日期：1996-01-01 00:00:00

abstract：:The clinical phenotype of frontotemporal dementia with parkinsonism linked to chromosome 17 (FTDP-17) varies. This variability is seen not only between kindreds with different mutations but also in families sharing the same mutation. Inheritance of tau haplotype (H1) and genotype (H1/H1) has been established as a risk...

journal_title：Parkinsonism & related disorders

authors： Baba Y,Tsuboi Y,Baker MC,Uitti RJ,Hutton ML,Dickson DW,Farrer M,Putzke JD,Woodruff BK,Ghetti B,Murrell JR,Boeve BF,Petersen RC,Verpillat P,Brice A,Delisle MB,Rascol O,Arima K,Dysken MW,Yasuda M,Kobayashi T,Sunoh

更新日期：2005-06-01 00:00:00

abstract：OBJECTIVE:To estimate the frequency and correlates of involuntary emotional expression disorder (IEED) in Parkinson's disease (PD) using the Center for Neurologic Study-Lability Scale (CNS-LS) and recently-proposed diagnostic criteria for IEED. BACKGROUND:IEED is characterized by uncontrollable emotional episodes, typ...

journal_title：Parkinsonism & related disorders

authors： Phuong L,Garg S,Duda JE,Stern MB,Weintraub D

更新日期：2009-08-01 00:00:00

abstract：:We report 27 cases of delayed-onset dystonia in patients with antecendents of perinatal asphyxia after excluding other possible causes of dystonia. The patients were 16 males and 11 females (mean +/- SD age at onset of dystonia = 13.0 +/- 9.4 yr). Adverse obstetric and/or perinatal events were presented by 20 patients...

journal_title：Parkinsonism & related disorders

authors： Jiménez-Jiménez FJ,Burguera J,Catalán MJ,Vázquez A,Vaamonde J,Vela-Desojo L,Martínez-Martín P,Balseiro J,Pondal-Sordo M,Domingo J,García-Ruiz PJ,Muñoz-Vázquez A,Molina J,Ceballos-Hernánsont MA,Arcaya J,Duarte J

更新日期：1997-01-01 00:00:00

abstract：OBJECTIVE:We report a prospective, open label study of 24 h levodopa-carbidopa intestinal gel (LCIG) as treatment for levodopa "unresponsive" freezing of gait (FOG) associated with Parkinson's disease. METHOD:5 patients with disabling FOG, documented as being levodopa "unresponsive", were commenced on continuous 24 h ...

journal_title：Parkinsonism & related disorders

authors： Chang FC,Tsui DS,Mahant N,Wolfe N,Kim SD,Ha AD,Drury M,Griffith JM,Fung VS

更新日期：2015-03-01 00:00:00

abstract：OBJECTIVE:To assess the association between diabetes preceding Parkinson's disease (PD) and PD. METHODS:PD individuals were matched to PD free individuals randomly selected from people in the same municipality as the cases. Occurrence of diabetes preceding PD onset among cases and controls was assessed through a struc...

journal_title：Parkinsonism & related disorders

authors： D'Amelio M,Ragonese P,Callari G,Di Benedetto N,Palmeri B,Terruso V,Salemi G,Famoso G,Aridon P,Savettieri G

更新日期：2009-11-01 00:00:00

abstract：BACKGROUND:Apathy is a common neuropsychiatric syndrome in Parkinson's Disease (PD) that affects quality of life. Research into apathy has been hampered by a lack of broadly accepted diagnostic criteria. Recently, diagnostic criteria for apathy in neuropsychiatric disorders have been proposed, which to date have not be...

journal_title：Parkinsonism & related disorders

authors： Drijgers RL,Dujardin K,Reijnders JS,Defebvre L,Leentjens AF

更新日期：2010-12-01 00:00:00

abstract：:Some procedures, such as deep inspiration, increase sweat output (SSwR; sympathetic sweat response) and reduce cutaneous blood flow (SVR; skin vasomotor reflex) on the palm. We investigated SSwR, SVR, and cardiovascular function in 12 patients with progressive supranuclear palsy (PSP), 13 patients with Parkinson's dis...

journal_title：Parkinsonism & related disorders

authors： Kikkawa Y,Asahina M,Suzuki A,Hattori T

更新日期：2003-12-01 00:00:00

abstract：:Over the last decade, several autosomal dominant and recessive genes causative of Parkinson's disease (PD) have been identified. The functional studies on their protein products and the pathogenetic effect related to their mutations have greatly contributed to understand the many cellular pathways leading to neurodege...

journal_title：Parkinsonism & related disorders

authors： Valente EM,Arena G,Torosantucci L,Gelmetti V

更新日期：2012-01-01 00:00:00

abstract：INTRODUCTION:The aim of the study was to identify abnormalities of whole-brain network functional organization and their relation to clinical measures in a well-characterized, multi-site cohort of very early-stage, drug-naïve Parkinson's Disease (PD) patients. METHODS:Functional-MRI data for 16 healthy controls and 20...

journal_title：Parkinsonism & related disorders

authors： Sreenivasan K,Mishra V,Bird C,Zhuang X,Yang Z,Cordes D,Walsh RR

更新日期：2019-05-01 00:00:00

abstract：:Levodopa is one of the most effective symptomatic treatment options for Parkinsonism with a favorable safety and tolerability profile. In some patients, particularly those suffering from orthostatic intolerance, the hypotensive effect of levodopa limits its therapeutic use. We used continuous noninvasive cardiovascula...

journal_title：Parkinsonism & related disorders

authors： Noack C,Schroeder C,Heusser K,Lipp A

更新日期：2014-08-01 00:00:00

abstract：:The interactive effects of neonatal iron and adult MPTP treatment groups of C57 Bl/6 mice were studied through adminustration of iron (Fe(2+)) 7.5mg/kg b.w., p.o. or vehicle (saline) on days 10-12 post partum, followed at 3months of age by administration of either MPTP (2x20 or 2x40mg/kg, s.c.) or saline. Neonatal iro...

journal_title：Parkinsonism & related disorders

authors： Fredriksson A,Schröder N,Eriksson P,Izquierdo I,Archer T

更新日期：2001-04-01 00:00:00

abstract：:Deep brain stimulation (DBS) is an effective surgical therapy for well-selected patients with medically intractable Parkinson's disease (PD) and essential tremor (ET). The purpose of this review is to describe the success of DBS in these two disorders and its promising application in dystonia, Tourette Syndrome (TS) a...

journal_title：Parkinsonism & related disorders

authors： Halpern C,Hurtig H,Jaggi J,Grossman M,Won M,Baltuch G

更新日期：2007-02-01 00:00:00

abstract：:Duplications and triplications of the alpha-synuclein (SNCA) gene have been reported in Parkinson's disease patients belonging to the Southern Swedish "Lister family". Further genealogical research has now shown that these individuals are descended from a large kindred characterized by Herman Lundborg in 1901-1913. In...

journal_title：Parkinsonism & related disorders

authors： Puschmann A,Wszolek ZK,Farrer M,Gustafson L,Widner H,Nilsson C

更新日期：2009-06-01 00:00:00

abstract：:Recently, several genes for parkinsonism have been identified. Among them, familial Parkinson's disease (PD) could be assigned for PARK disorders. PARK disorders consist of three different inherited modes such as autosomal recessive, autosomal dominant modes and susceptible genes. Some of them manifest not only typica...

journal_title：Parkinsonism & related disorders

authors： Hattori N

更新日期：2012-01-01 00:00:00

abstract：OBJECTIVE:To investigate whether dopamine transporter (DAT) binding, as measured with single photon emission computed tomography (SPECT), can be used to predict mortality in patients with Parkinson's disease (PD). METHODS:A total of 162 patients with PD and abnormal [I-123]FP-CIT SPECT were clinically followed for a m...

journal_title：Parkinsonism & related disorders

authors： Mäkinen E,Joutsa J,Vahlberg T,Kaasinen V

更新日期：2017-09-01 00:00:00

abstract：OBJECTIVE:To evaluate the efficacy of solifenacin succinate in Parkinson's disease (PD) patients suffering from overactive bladder (OAB). BACKGROUND:Urinary dysfunction is a commonly encountered non-motor feature in PD that significantly impacts patient quality of life. DESIGN/METHODS:This was a double-blind, randomi...

journal_title：Parkinsonism & related disorders

authors： Zesiewicz TA,Evatt M,Vaughan CP,Jahan I,Singer C,Ordorica R,Salemi JL,Shaw JD,Sullivan KL,Non-Motor Working Group of the Parkinson Study Group (PSG).

更新日期：2015-05-01 00:00:00

abstract：INTRODUCTION:Alzheimer's disease neuropathologies (amyloid-β and tau) frequently co-exist to varying degrees in Lewy body dementias (LBD), which include dementia with Lewy bodies (DLB) and Parkinson's disease dementia (PDD). OBJECTIVES:To investigate the prevalence of tau in DLB and PDD, and its associations with clin...

journal_title：Parkinsonism & related disorders

authors： Chin KS,Yassi N,Churilov L,Masters CL,Watson R

更新日期：2020-11-01 00:00:00

abstract：:The recently discovered trace amine associated receptors (TAARs) represent attractive potential mediators of certain aspects of movement control. The TAAR that is best characterized, TAAR1, is particularly interesting because it can be activated by a variety of monoaminergic compounds including trace amines, amphetami...

journal_title：Parkinsonism & related disorders

authors： Sotnikova TD,Zorina OI,Ghisi V,Caron MG,Gainetdinov RR

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:Non-motor complications of Parkinson's disease (PD), specifically cognitive impairment, sleep disturbances, and fatigue, are recognized as important contributors to poor patient outcomes and quality of life. How sleep problems and fatigue interrelate and impact cognitive function, however, has not systematic...

journal_title：Parkinsonism & related disorders

authors： Goldman JG,Stebbins GT,Leung V,Tilley BC,Goetz CG

更新日期：2014-11-01 00:00:00

abstract：INTRODUCTION:123I-MIBG is the most commonly used radiopharmaceutical to depict cardiac sympathetic innervation. The purpose of this study was to validate the feasibility of 131I-MIBG as an alternative myocardial sympathetic imaging probe in differential diagnosis of Parkinsonism. METHODS:We recruited 17 patients with ...

journal_title：Parkinsonism & related disorders

authors： Xu D,Zhu W,Huo L,Zhu S,Li F,Wang H

更新日期：2018-05-01 00:00:00

abstract：:Involuntary movements are not a known feature of vitamin B12 (vB12) deficiency in adults, though they are a characteristic feature of vB12 deficiency in infants. This case report presents an adult patient with vB12 deficiency in whom, myoclonus-like muscular contractions appeared soon after the initiation of vB12 and ...

journal_title：Parkinsonism & related disorders

authors： Celik M,Barkut IK,Oncel C,Forta H

更新日期：2003-10-01 00:00:00

abstract：BACKGROUND:Hyposmia is a common non-motor symptom in Parkinson's disease (PD). However, patients with PD are sometimes unaware of their olfactory dysfunction, resulting in an under-diagnosis of this symptom. To determine whether the loss of awareness of hyposmia results from cognitive impairment in patients with PD, we...

journal_title：Parkinsonism & related disorders

authors： Kawasaki I,Baba T,Takeda A,Mori E

更新日期：2016-01-01 00:00:00