当前位置： SCI文献检索 > PARKINSONISM & RELATED DISORDERS期刊下所有文献 > Staged pathology in Parkinson's disease.

Staged pathology in Parkinson's disease.

Abstract：

:There has been a tremendous development since a regional progression of pathology in subjects with Lewy bodies (LB) was initially proposed 30 years ago. The entity of dementia with Lewy bodies has been acknowledged, the main protein constituent of LBs--aggregated α-synuclein (αS)--has been identified and a stepwise progression of the pathology has been reported. Implementation of the staging strategies published provides a common ground for handling a case with a suspected α-synucleinopathy. It is always important to state the staging strategy implemented while assessing a case, as the strategy applied might influence both the reported stage of LB pathology and, ultimately, the final diagnosis of the patient.

journal_name

Parkinsonism Relat Disord

journal_title

Parkinsonism & related disorders

authors

Alafuzoff I,Parkkinen L

doi

10.1016/S1353-8020(13)70016-6

subject

Has Abstract

pub_date

2014-01-01 00:00:00

pages

S57-61

eissn

1353-8020

issn

1873-5126

pii

S1353-8020(13)70016-6

journal_volume

20 Suppl 1

pub_type

杂志文章,评审

相关文献

PARKINSONISM & RELATED DISORDERS文献大全
  • Serotonergic action on dorsal striatal function.

    abstract：:Serotonin (5-HT) is a monoamine neurotransmitter released throughout the brain. The serotonergic system is implicated in a host of neuropsychiatric disorders including, but not limited to, Parkinson's disease and L-DOPA-induced dyskinesia. These are pathological and drug-induced states that center on dysfunction of th...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章,评审

    doi：10.1016/S1353-8020(11)70040-2

    authors： Mathur BN,Lovinger DM

    更新日期：2012-01-01 00:00:00

  • Inhibition of dopamine uptake into PC-12 cells by analogues of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP).

    abstract：:The inhibition of uptake of radioactive dopamine into PC-12 cells by analogues of MPTP with systematic variations of structure was studied in order to assess the steric constraints of the transmembrane dopamine transporter. Of 15 analogues tested, 11 were found to inhibit dopamine uptake, all being competitive inhibit...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/1353-8020(95)00020-8

    authors： Athwal NS,Ramsden DB,Simpson M,Williams AC

    更新日期：1996-01-01 00:00:00

  • CSF biomarker profiles do not differentiate between the cerebellar and parkinsonian phenotypes of multiple system atrophy.

    abstract：BACKGROUND:Multiple system atrophy (MSA) can clinically be divided into the cerebellar (MSA-C) and the parkinsonian (MSA-P) variants. It is unknown whether the variation in clinical expression is also reflected by a different underlying neurochemical profile. METHODS:We analyzed brain specific proteins and neurotransm...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/j.parkreldis.2007.02.002

    authors： Abdo WF,van de Warrenburg BP,Kremer HP,Bloem BR,Verbeek MM

    更新日期：2007-12-01 00:00:00

  • From sweet to sweat: Hedonic olfactory range is impaired in Parkinson's disease.

    abstract：INTRODUCTION:Olfactory dysfunction and neuropsychological symptoms like depression and anhedonia are common non-motor symptoms in Parkinson's disease (PD). The assessment of both functional domains includes clinical examination, olfactory testing, and standardized questionnaires. While olfaction is readily assessed by ...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/j.parkreldis.2015.09.035

    authors： Mrochen A,Marxreiter F,Kohl Z,Schlachetzki J,Renner B,Schenk T,Winkler J,Klucken J

    更新日期：2016-01-01 00:00:00

  • Adenosine, adenosine A 2A antagonists, and Parkinson's disease.

    abstract：:Adenosine derived from the degradation of ATP/AMP functions as a signalling molecule in the nervous system through the occupation of A1, A2, and A3 adenosine receptors. Adenosine A(2A) receptors have a selective localization to the basal ganglia and specifically to the indirect output pathway, and as a consequence off...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章,评审

    doi：10.1016/j.parkreldis.2008.12.006

    authors： Jenner P,Mori A,Hauser R,Morelli M,Fredholm BB,Chen JF

    更新日期：2009-07-01 00:00:00

  • The medical treatment of patients with Parkinson's disease receiving subthalamic neurostimulation.

    abstract：INTRODUCTION:Deep brain stimulation of subthalamic nucleus (STN-DBS) for Parkinson's disease allows for a reduction in medication dosage. Changes in total levodopa equivalent daily dose (LEDD) have been frequently reported, there is little information about changes within the drug classes. METHODS:We retrospectively a...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/j.parkreldis.2015.03.003

    authors： Alexoudi A,Shalash A,Knudsen K,Witt K,Mehdorn M,Volkmann J,Deuschl G

    更新日期：2015-06-01 00:00:00

  • Wheeled and standard walkers in Parkinson's disease patients with gait freezing.

    abstract：OBJECTIVES:Compare the efficacy of two walking assistance devices (wheeled walker and standard walker) to unassisted walking for patients with PD and gait freezing. BACKGROUND:Although numerous walking devices are used clinically, their relative effects on freezing and walking speed have never been systematically test...

    journal_title：Parkinsonism & related disorders

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/s1353-8020(03)00060-9

    authors： Cubo E,Moore CG,Leurgans S,Goetz CG

    更新日期：2003-10-01 00:00:00

  • Lrrk2 G2385R is an ancestral risk factor for Parkinson's disease in Asia.

    abstract：:The goal of genetic association studies is to identify common (>5%) risk factors in complex disease traits. Herein we describe the first replicable 'functional' risk allele for Parkinson's disease. The leucine-rich repeat kinase 2 (Lrrk2) G2385R substitution is associated with familial parkinsonism, late-, and early-o...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/j.parkreldis.2006.12.001

    authors： Farrer MJ,Stone JT,Lin CH,Dächsel JC,Hulihan MM,Haugarvoll K,Ross OA,Wu RM

    更新日期：2007-03-01 00:00:00

  • Variants in the SNCA gene associate with motor progression while variants in the MAPT gene associate with the severity of Parkinson's disease.

    abstract：INTRODUCTION:It is well known that α-synuclein (SNCA) and microtubule associated protein (MAPT) genes predispose individuals to develop Parkinson's disease (PD). However, whether these genes contribute to differences in the variable progression observed in PD is obscure. This study aims to evaluate the association of c...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/j.parkreldis.2015.12.018

    authors： Wang G,Huang Y,Chen W,Chen S,Wang Y,Xiao Q,Liu J,Fung VS,Halliday G,Chen S

    更新日期：2016-03-01 00:00:00

  • Diabetes preceding Parkinson's disease onset. A case-control study.

    abstract：OBJECTIVE:To assess the association between diabetes preceding Parkinson's disease (PD) and PD. METHODS:PD individuals were matched to PD free individuals randomly selected from people in the same municipality as the cases. Occurrence of diabetes preceding PD onset among cases and controls was assessed through a struc...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/j.parkreldis.2009.02.013

    authors： D'Amelio M,Ragonese P,Callari G,Di Benedetto N,Palmeri B,Terruso V,Salemi G,Famoso G,Aridon P,Savettieri G

    更新日期：2009-11-01 00:00:00

  • Altered body composition, sarcopenia, frailty, and their clinico-biological correlates, in Parkinson's disease.

    abstract：INTRODUCTION:Low body weight in Parkinson's disease (PD) is poorly understood despite the associated risks of malnutrition, fractures, and death. Sarcopenia (loss of muscle bulk and strength) and frailty are geriatric syndromes that are likewise associated with adverse health outcomes, yet have received scant attention...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/j.parkreldis.2018.06.020

    authors： Tan AH,Hew YC,Lim SY,Ramli NM,Kamaruzzaman SB,Tan MP,Grossmann M,Ang BH,Tan JY,Manap MAAA,Tay TK,Tan SL,New RP,Fadzli F,Yee EJ,Moy FM,Mahadeva S,Lang AE

    更新日期：2018-11-01 00:00:00

  • Defining delirium in idiopathic Parkinson's disease: A systematic review.

    abstract：BACKGROUND:Parkinson's disease patients may be at increased risk of delirium and developing adverse outcomes, such as cognitive decline and increased mortality. Delirium is an acute state of confusion that has overlapping symptoms with Parkinson's dementia, making it difficult to identify. This study aimed to determine...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/j.parkreldis.2018.09.025

    authors： Lawson RA,McDonald C,Burn DJ

    更新日期：2019-07-01 00:00:00

  • Rhythmic finger tapping reveals cerebellar dysfunction in essential tremor.

    abstract：INTRODUCTION:Cerebellar circuits are hypothesized to play a central role in the pathogenesis of essential tremor. Rhythmic finger tapping is known to strongly engage the cerebellar motor circuitry. We characterize cerebellar and, more specifically, dentate nucleus function, and neural correlates of cerebellar output in...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.parkreldis.2015.02.003

    authors： Buijink AW,Broersma M,van der Stouwe AM,van Wingen GA,Groot PF,Speelman JD,Maurits NM,van Rootselaar AF

    更新日期：2015-04-01 00:00:00

  • Adults with a history of illicit amphetamine use exhibit abnormal substantia nigra morphology and parkinsonism.

    abstract：INTRODUCTION:The sonographic appearance of the substantia nigra is abnormally bright and enlarged (hyperechogenic) in young adults with a history of illicit stimulant use. The abnormality is a risk factor for Parkinson's disease. The aim of the current study was to identify the type of illicit stimulant drug associated...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/j.parkreldis.2016.02.019

    authors： Todd G,Pearson-Dennett V,Wilcox RA,Chau MT,Thoirs K,Thewlis D,Vogel AP,White JM

    更新日期：2016-04-01 00:00:00

  • Cognitive associations with comprehensive gait and static balance measures in Parkinson's disease.

    abstract：INTRODUCTION:Gait and balance impairments are cardinal features of Parkinson's disease (PD) that require cognitive input. However, the extent to which specific gait and balance characteristics relate to cognition in PD is unclear. In addition, independent models of gait and balance have not been developed from the same...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/j.parkreldis.2019.06.014

    authors： Morris R,Martini DN,Smulders K,Kelly VE,Zabetian CP,Poston K,Hiller A,Chung KA,Yang L,Hu SC,Edwards KL,Cholerton B,Grabowski TJ,Montine TJ,Quinn JF,Horak F

    更新日期：2019-12-01 00:00:00

  • Hypothesis: a role for EBV-induced molecular mimicry in Parkinson's disease.

    abstract：:Current concepts regarding the pathogenesis of Parkinson's disease support a model whereby environmental factors conspire with a permissive genetic background to initiate the disease. The identity of the responsible environmental trigger has remained elusive. There is incontrovertible evidence that aggregation of the ...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章,评审

    doi：10.1016/j.parkreldis.2014.02.031

    authors： Woulfe JM,Gray MT,Gray DA,Munoz DG,Middeldorp JM

    更新日期：2014-07-01 00:00:00

  • Movement disorders in Latin America.

    abstract：:The authors review some particularities of movement disorders (MDs) in the ethnically diverse population of Latin America. Although idiopathic diseases are evenly prevalent, access to treatment encounters difficulties that are worth discussing. Infectious-parasitic diseases observed throughout the continent occasional...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章,评审

    doi：10.1016/j.parkreldis.2005.08.009

    authors： Troiano AR,Micheli FE,Alarcón F,Teive HA

    更新日期：2006-04-01 00:00:00

  • Mechanical failure of the electrode wire in deep brain stimulation.

    abstract：:The feasibility and efficacy of deep brain stimulation (DBS) has offered new possibilities for treatment of movement disorders. Mechanical failure of the DBS system is a potential complication. Here we report five patients who presented with mechanical failure of the DBS system. Radiographs of the skull and cervical s...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/j.parkreldis.2003.11.001

    authors： Alex Mohit A,Samii A,Slimp JC,Grady MS,Goodkin R

    更新日期：2004-03-01 00:00:00

  • Low doses of sarizotan reduce dyskinesias and maintain antiparkinsonian efficacy of L-Dopa in parkinsonian monkeys.

    abstract：:Dyskinesia is an important complication of treatment in Parkinson's disease (PD). Sarizotan, a 5-HT(1A) agonist with high affinity for D3 and D4 receptors was investigated on L-Dopa-induced dyskinesia (LID) in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) animal model of PD. Five MPTP female cynomolgus monke...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/j.parkreldis.2008.11.001

    authors： Grégoire L,Samadi P,Graham J,Bédard PJ,Bartoszyk GD,Di Paolo T

    更新日期：2009-07-01 00:00:00

  • Increases in institutionalization, healthcare resource utilization, and mortality risk associated with Parkinson disease psychosis: Retrospective cohort study.

    abstract：INTRODUCTION:Patients with Parkinson disease (PD) often develop psychosis (P). The association of PDP with death and long-term custodial care (CC) has not been well studied. METHODS:Medicare Parts A, B, and D data, 2007-2015, were used to define cohorts of PD and PDP patients. PD was defined by ≥ 2 ICD-9-CM codes (332...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/j.parkreldis.2019.10.018

    authors： Wetmore JB,Li S,Yan H,Irfan M,Rashid N,Peng Y,Gilbertson DT,Shim A

    更新日期：2019-11-01 00:00:00

  • Historical perspective: The pros and cons of conventional outcome measures in Parkinson's disease.

    abstract：BACKGROUND:Conventional outcome measures (COMs) in Parkinson's disease (PD) refer to rating scales, questionnaires, patient diaries and clinically-based tests that do not require specialized equipment. METHODS:It is timely at this juncture - as clinicians and researchers begin to grapple with the "invasion" of digital...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章,评审

    doi：10.1016/j.parkreldis.2017.07.029

    authors： Lim SY,Tan AH

    更新日期：2018-01-01 00:00:00

  • Factor structure of the Montreal Cognitive Assessment items in a sample with early Parkinson's disease.

    abstract：INTRODUCTION:The Montreal Cognitive Assessment (MoCA) is a frequently utilized cognitive screening tool that has attractive clinical attributes when utilized in individuals with Parkinson's disease. However, the construct validity of this instrument has not been well-characterized in Parkinson's samples. The purpose of...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/j.parkreldis.2017.05.023

    authors： Benge JF,Balsis S,Madeka T,Uhlman C,Lantrip C,Soileau MJ

    更新日期：2017-08-01 00:00:00

  • Striatal plasticity and extrapyramidal motor dysfunction.

    abstract：:Knowledge of molecular events contributing to motor dysfunction in Parkinson's disease has advanced rapidly during the past decade. Studies in animal models as well as in patients afflicted by this disorder suggest that the nonphysiologic stimulation of striatal dopamine receptors, first as a result of dopaminergic de...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章,评审

    doi：10.1016/j.parkreldis.2004.02.012

    authors： Chase TN

    更新日期：2004-07-01 00:00:00

  • Memory perception and strategy use in Parkinson's disease.

    abstract：:Although there is growing support for the existence of memory deficits within Parkinson's disease (PD), little has been done to evaluate the extent to which PD patients demonstrate differences in their use of metacognitive strategies. In the present study, 79 PD patients (46 men and 33 women) and 49 age-matched health...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/j.parkreldis.2004.06.005

    authors： Johnson AM,Pollard CC,Vernon PA,Tomes JL,Jog MS

    更新日期：2005-03-01 00:00:00

  • Post-vaccinic opsoclonus-myoclonus syndrome: a case report.

    abstract：:The opsoclonus-myoclonus syndrome is a pathological condition characterized mainly by involuntary myoclonic movements involving ocular, trunk and limb muscles associated with ataxia and other neurological signs.We describe the case of a 30-year-old woman who developed this syndrome 15days after anti-Rubella vaccinatio...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/s1353-8020(00)00020-1

    authors： Lapenna F,Lochi L,de Mari M,Iliceto G,Lamberti P

    更新日期：2000-10-01 00:00:00

  • Impairment of complex upper limb motor function in de novo Parkinson's disease.

    abstract：:The aim of the present study was to evaluate complex upper limb motor function in newly diagnosed, untreated Parkinson's disease (PD) patients. Four different unimanual upper limb motor tasks were applied to 13 newly diagnosed, untreated PD patients and 13 age- and sex-matched controls. In a handwriting task, PD patie...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/j.parkreldis.2007.07.019

    authors： Ponsen MM,Daffertshofer A,Wolters ECh,Beek PJ,Berendse HW

    更新日期：2008-01-01 00:00:00

  • Systematic review of apomorphine infusion, levodopa infusion and deep brain stimulation in advanced Parkinson's disease.

    abstract：:The effectiveness of oral levodopa in complex Parkinson's disease (PD) is limited by its short half-life, and the resulting pulsatile dopaminergic stimulation leads to complex motor fluctuations and dyskinesia. Several treatments provide more continuous/less pulsatile dopaminergic stimulation by modifying the pharmaco...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章,评审

    doi：10.1016/j.parkreldis.2009.09.005

    authors： Clarke CE,Worth P,Grosset D,Stewart D

    更新日期：2009-12-01 00:00:00

  • Diagnostic potential of automated tractography in progressive supranuclear palsy variants.

    abstract：BACKGROUND:Microstructural white matter integrity captured by diffusion-tensor imaging (DTI) is significantly more affected in progressive supranuclear palsy-Richardson's syndrome (PSP-RS) compared to PSP-parkinsonism (PSP-P). OBJECTIVES:To characterize the microstructural integrity of large fascicular bundles using s...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/j.parkreldis.2020.02.007

    authors： Potrusil T,Krismer F,Beliveau V,Seppi K,Müller C,Troger F,Göbel G,Steiger R,Gizewski ER,Poewe W,Scherfler C

    更新日期：2020-03-01 00:00:00

  • Wilson's disease with myoclonus and white matter lesions.

    abstract：:White matter lesions (WML) and epilepsy have been occasionally seen in Wilson's disease. No cases of generalized myoclonus have been reported so far. We present a patient with psychiatric symptoms starting at age 16, followed by tremor, generalized dystonia and severe generalized myoclonus. In addition to classical fi...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/j.parkreldis.2006.03.012

    authors： Barbosa ER,Silveira-Moriyama L,Machado AC,Bacheschi LA,Rosemberg S,Scaff M

    更新日期：2007-04-01 00:00:00

  • Young onset Hemifacial Spasm in patients with Chiari type I malformation.

    abstract：:Hemifacial spasm (HFS) resulting from Chiari type I malformation (CIM) is rare. We retrospectively evaluated five patients with CIM and HFS among a series of 103 subjects. The frequency of HFS associated to CIM was of 4.85%. The clinical profile did not differ from the classical primary cases except for young-onset de...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/j.parkreldis.2007.04.002

    authors： Felício AC,de Godeiro C Jr,Borges V,de Azevedo Silva SM,Ferraz HB

    更新日期：2008-01-01 00:00:00