Serotonergic action on dorsal striatal function.

abstract：BACKGROUND:Deep brain stimulation of the internal pallidum (GPi-DBS) is effective for various types of drug-refractory primary dystonias. Rare clinical forms as dystonic camptocormia may profit but available data are scarce. METHODS:We here report on a retrospective clinical assessment of three patients with primary d...

journal_title：Parkinsonism & related disorders

authors： Reese R,Knudsen K,Falk D,Mehdorn HM,Deuschl G,Volkmann J

更新日期：2014-02-01 00:00:00

abstract：BACKGROUND:Deep brain stimulation surgery (DBS) for movement disorders has become commonplace and patients are beginning to present to specialized centers for second opinions. We aimed to uncover reasons for referral by analyzing a large single center cohort of DBS patients referred for management. METHODS:Data were c...

journal_title：Parkinsonism & related disorders

authors： Kluger BM,Foote KD,Jacobson CE,Okun MS

更新日期：2011-05-01 00:00:00

abstract：:The present study demonstrated that individuals with Parkinson's disease display impairments in making profitable decisions, as evidenced by poorer performance on the Iowa Gambling Task relative to matched controls. The ability to make beneficial judgments solely correlates with ability to appropriately attribute inte...

journal_title：Parkinsonism & related disorders

authors： Mimura M,Oeda R,Kawamura M

更新日期：2006-04-01 00:00:00

abstract：BACKGROUND:In addition to classic midbrain pathology, Parkinson's disease (PD) is accompanied by changes in pontine and medullary brainstem structures. These additional abnormalities may underlie non-motor features as well as play a role in motor disability. METHODS:Using novel magnetic resonance imaging (MRI) methods...

journal_title：Parkinsonism & related disorders

authors： Tuite PJ,Mangia S,Tyan AE,Lee MK,Garwood M,Michaeli S

更新日期：2012-06-01 00:00:00

abstract：:There is evidence that astrocytes and microglia can release agents which might have a protective effect on damaged neurons. However the associations of glia with dopaminergic neurons in Parkinson's disease are not defined. Our studies showed that in post mortem parkinsonian nigra healthy neuronal somata were enveloped...

journal_title：Parkinsonism & related disorders

authors： Knott C,Wilkin GP,Stern G

更新日期：1999-09-01 00:00:00

abstract：:Abnormally aggregated tau protein is central to the pathophysiology of Alzheimer's disease, frontotemporal dementia variants, progressive supranuclear palsy, corticobasal degeneration and chronic traumatic encephalopathy. The post-mortem cortical density of hyperphosphorylated tau tangles correlates with pre-morbid co...

journal_title：Parkinsonism & related disorders

authors： Dani M,Edison P,Brooks DJ

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:Microstructural white matter integrity captured by diffusion-tensor imaging (DTI) is significantly more affected in progressive supranuclear palsy-Richardson's syndrome (PSP-RS) compared to PSP-parkinsonism (PSP-P). OBJECTIVES:To characterize the microstructural integrity of large fascicular bundles using s...

journal_title：Parkinsonism & related disorders

authors： Potrusil T,Krismer F,Beliveau V,Seppi K,Müller C,Troger F,Göbel G,Steiger R,Gizewski ER,Poewe W,Scherfler C

更新日期：2020-03-01 00:00:00

abstract：:Cerebrotendinous xanthomatosis (CTX) is an inborn error of cholesterol and bile acid metabolism, leading to neuropsychiatric and systemic manifestations. Movement disorders have rarely been reported in CTX, while a detailed appreciation of the full phenotypic spectrum is required in order to prevent underdiagnosis of ...

journal_title：Parkinsonism & related disorders

authors： Stelten BML,van de Warrenburg BPC,Wevers RA,Verrips A

更新日期：2019-01-01 00:00:00

abstract：:Corticobasal degeneration (CBD) presents with symptoms that often overlap with other neurological conditions. In many cases, diagnosis, prognosis and consequent clinical management remain uncertain. Structural and functional asymmetric brain changes represent the most consistent imaging findings that may assist in CBD...

journal_title：Parkinsonism & related disorders

authors： Bozzali M,Cercignani M,Baglio F,Scotti G,Farina E,Pugnetti L,Ashburner J,Nemni R,Falini A

更新日期：2008-01-01 00:00:00

abstract：:We describe a patient with Parkinson's Disease who underwent bilateral subthalamic nucleus deep brain stimulation and later presented with episodes of aggressive behavior disorder with disturbed impulse control and an inability to control anger likely related to the deep brain stimulation "switch-on stimulation". We h...

journal_title：Parkinsonism & related disorders

authors： Sensi M,Eleopra R,Cavallo MA,Sette E,Milani P,Quatrale R,Capone JG,Tugnoli V,Tola MR,Granieri E,Data PG

更新日期：2004-06-01 00:00:00

abstract：:A confluence of variables in Parkinson's disease results in Parkinson's informal caregivers facing tremendous challenges. Factors include: motor and non-motor symptoms, staging, rate of progression and increased life expectancy of people with Parkinson's (PwP) due to effective drug therapy and surgery. Informal caregi...

journal_title：Parkinsonism & related disorders

authors： Dyck C

更新日期：2009-12-01 00:00:00

abstract：INTRODUCTION:Freezing of gait (FoG) is one of the most disabling gait disorders in Parkinson's disease (PD), reflecting motor and cognitive impairments, mainly related to dopamine deficiency. Recent studies investigating kinematic and kinetic factors affecting gait in these patients showed a postural instability charac...

journal_title：Parkinsonism & related disorders

authors： Mezzarobba S,Grassi M,Pellegrini L,Catalan M,Krüger B,Stragapede L,Manganotti P,Bernardis P

更新日期：2020-11-01 00:00:00

abstract：OBJECTIVES:Limited data currently exists within the UK addressing the level of Parkinson's disease (PD) healthcare provision. We investigated whether care for PD patients in a UK community met national guidelines, and the determinants of sub-optimal care for this patient group. METHODS:340 PD patients were identified ...

journal_title：Parkinsonism & related disorders

authors： Hu MT,Butterworth R,Kumar V,Cooper J,Jones E,Catterall L,Ben-Shlomo Y

更新日期：2011-03-01 00:00:00

abstract：:The mild cognitive impairment (MCI) concept was developed to identify the earliest stages of cognitive impairment. MCI and, more specifically, amnestic MCI were initially proposed as transitional states that ultimately progress to full blown Alzheimer's disease (AD). However, MCI subjects do not uniformly progress to ...

journal_title：Parkinsonism & related disorders

authors： Korczyn AD

更新日期：2016-01-01 00:00:00

abstract：INTRODUCTION:The aim of the study was to identify abnormalities of whole-brain network functional organization and their relation to clinical measures in a well-characterized, multi-site cohort of very early-stage, drug-naïve Parkinson's Disease (PD) patients. METHODS:Functional-MRI data for 16 healthy controls and 20...

journal_title：Parkinsonism & related disorders

authors： Sreenivasan K,Mishra V,Bird C,Zhuang X,Yang Z,Cordes D,Walsh RR

更新日期：2019-05-01 00:00:00

abstract：INTRODUCTION:This study of thalamic deep brain stimulation (DBS) investigated whether a novel constant-current device improves tremor and activities of daily living (ADL) in patients with essential tremor (ET). METHODS:A prospective, controlled, multicenter study was conducted at 12 academic centers. We investigated t...

journal_title：Parkinsonism & related disorders

authors： Wharen RE Jr,Okun MS,Guthrie BL,Uitti RJ,Larson P,Foote K,Walker H,Marshall FJ,Schwalb J,Ford B,Jankovic J,Simpson R,Dashtipour K,Phibbs F,Neimat JS,Stewart RM,Peichel D,Pahwa R,Ostrem JL,SJM DBS ET Study Group.

更新日期：2017-07-01 00:00:00

abstract：:The interactive effects of neonatal iron and adult MPTP treatment groups of C57 Bl/6 mice were studied through adminustration of iron (Fe(2+)) 7.5mg/kg b.w., p.o. or vehicle (saline) on days 10-12 post partum, followed at 3months of age by administration of either MPTP (2x20 or 2x40mg/kg, s.c.) or saline. Neonatal iro...

journal_title：Parkinsonism & related disorders

authors： Fredriksson A,Schröder N,Eriksson P,Izquierdo I,Archer T

更新日期：2001-04-01 00:00:00

abstract：:We examined the autopsied brains of two parkinsonian patients who had malignant syndrome (MS). Neopterin and biopterin contents, and GTP cyclohydrolase I activity were measured in various region of the brain. We found relatively higher GTP cyclohydrolase I activities in the hypothalamus compared with other regions of ...

journal_title：Parkinsonism & related disorders

authors： Ichinose H,Ohye T,Shinotoh H,Arai K,Yamazaki S,Mizuta E,Kuno S,Nagatsu T

更新日期：2003-04-01 00:00:00

abstract：INTRODUCTION:Orthostatic myoclonus (OM) is a recognized syndrome of gait unsteadiness accompanied by lower limb myoclonus provoked by the assumption of an upright posture. OM typically affects the elderly and is often associated with neurodegenerative disease. We sought to review the clinical and electrophysiologic cha...

journal_title：Parkinsonism & related disorders

authors： Cutsforth-Gregory JK,Hammack JE,Matsumoto JY

更新日期：2017-08-01 00:00:00

abstract：OBJECTIVE:Our purpose was to determine whether the use of catechol-O-methyltransferase-inhibitors (ICOMT) can reduce the risk of developing levodopa (LD)-induced neuropathy in Parkinson's disease (PD) patients. METHODS:A multicentre study of 197 PD patients was performed. 144 were exposed to LD for more than three yea...

journal_title：Parkinsonism & related disorders

authors： Cossu G,Ceravolo R,Zibetti M,Arca R,Ricchi V,Paribello A,Murgia D,Merola A,Romagnolo A,Nicoletti V,Palermo G,Mereu A,Lopiano L,Melis M,Abbruzzese G,Bonuccelli U

更新日期：2016-06-01 00:00:00

abstract：BACKGROUND:Lower levels of physical activity are associated with lower Health-Related Quality of Life (HRQoL) in Parkinson's disease (PD). We evaluated the influence of quantitative physical activity parameters among other (disease-related) features representing other domains of the WHO International model for classifi...

journal_title：Parkinsonism & related disorders

authors： van Uem JMT,Cerff B,Kampmeyer M,Prinzen J,Zuidema M,Hobert MA,Gräber S,Berg D,Maetzler W,Liepelt-Scarfone I

更新日期：2018-03-01 00:00:00

abstract：BACKGROUND:The Vanderbilt pilot trial of deep brain stimulation (DBS) in early Parkinson's disease (PD) enrolled patients on medications six months to four years without motor fluctuations or dyskinesias. We conducted a patient-centered analysis based on clinically important worsening of motor symptoms and complication...

journal_title：Parkinsonism & related disorders

authors： Hacker ML,Tonascia J,Turchan M,Currie A,Heusinkveld L,Konrad PE,Davis TL,Neimat JS,Phibbs FT,Hedera P,Wang L,Shi Y,Shade DM,Sternberg AL,Drye LT,Charles D

更新日期：2015-10-01 00:00:00

abstract：:Primary monogenic forms of dystonia manifest solely or mainly with dystonia; they have been linked to a number of genes and loci and assigned "DYT" numbers. The pure dystonia syndrome early-onset primary dystonia (DYT1) manifests with dominantly-inherited generalized dystonia, often with focal onset in a limb. DYT1 is...

journal_title：Parkinsonism & related disorders

authors： Spatola M,Wider C

更新日期：2012-01-01 00:00:00

abstract：INTRODUCTION:To overcome travel distance and lack of local expertise, telemedicine programs have been implemented and are still pilot programs in many jurisdictions. Patient perspectives remain poorly understood. In the largest study to date, we examined user satisfaction and predictors of patient choice to use telemed...

journal_title：Parkinsonism & related disorders

authors： Qiang JK,Marras C

更新日期：2015-05-01 00:00:00

abstract：:Several factors involved in the etiology of Parkinson's disease (PD) have been proposed, including genetic and environmental factors or even a combination of both. Thus, multiple cellular hits are likely to contribute to neurodegeneration in PD. If such a mechanism happens to occur, our therapeutic intervention may pe...

journal_title：Parkinsonism & related disorders

authors： Hirsch EC

更新日期：2007-01-01 00:00:00

abstract：:Head drop is characterized by marked anterior flexion of the cervical spine, caused by weakness of the neck extensors or by increased tone of the flexor muscles. We report a woman with Parkinson's disease and head drop not due to cervical dystonia (a common cause of antecollis in parkinsonisms). Clinical, radiological...

journal_title：Parkinsonism & related disorders

authors： Fasano A,Evoli A,Piano C,Tonali PA,Bentivoglio AR

更新日期：2008-01-01 00:00:00

abstract：:The aim of this study was to assess the middle latency auditory evoked potential (MLAEP) findings in idiopathic Parkinson's disease (IPD) and in patients who are regarded as having atypical parkinsonian disorders (AP) and to determine whether MLAEPs could contribute to the differential diagnosis of IPD and AP.MLAEPs w...

journal_title：Parkinsonism & related disorders

authors： Çelik M,Seleker FK,Sucu H,Forta H

更新日期：2000-04-01 00:00:00

abstract：:Positron emission tomography (PET) scan is considered to be the most useful tool with which to assess the integrity of nigrostriatal function in the living brain. Recently, different genetic defects have been associated with a variety of familial parkinsonian syndromes, the clinical phenotypes of which have varying de...

journal_title：Parkinsonism & related disorders

authors： Pal PK,Wszolek ZK,Uitti R,Markopoulou K,Calne SM,Stoessl AJ,Calne DB

更新日期：2001-09-01 00:00:00

abstract：:Understanding of the pathophysiology of Parkinson disease (PD) has advanced rapidly over the last two decades through basic and clinical studies using modern neuroanatomical, clinical assessment, neuropathological and functional brain imaging methods. Two interacting processes determine the development of functional i...

journal_title：Parkinsonism & related disorders

authors： Moore RY

更新日期：2003-08-01 00:00:00

abstract：:Anterograde tract-tracing and immunohistochemical methods were used to study projections from the pedunculopontine tegmental nucleus (PPN) to midbrain dopaminergic neurons in the squirrel monkey (Saimiri sciureus). The PPN harbored numerous cholinergic and glutamatergic neurons, as well as neurons that displayed both ...

journal_title：Parkinsonism & related disorders

authors： Parent A,Parent M,Charara A

更新日期：1999-12-01 00:00:00