当前位置： SCI文献检索 > PARKINSONISM & RELATED DISORDERS期刊下所有文献 > Altered body composition, sarcopenia, frailty, and their clinico-biological correlates, in Parkinson's disease.

Altered body composition, sarcopenia, frailty, and their clinico-biological correlates, in Parkinson's disease.

Abstract：

INTRODUCTION:Low body weight in Parkinson's disease (PD) is poorly understood despite the associated risks of malnutrition, fractures, and death. Sarcopenia (loss of muscle bulk and strength) and frailty are geriatric syndromes that are likewise associated with adverse health outcomes, yet have received scant attention in PD. We studied body composition, sarcopenia, frailty, and their clinico-biological correlates in PD. METHODS:93 patients and 78 spousal/sibling controls underwent comprehensive assessment of diet, clinical status, muscle strength/performance, frailty, body composition (using dual-energy X-ray absorptiometry), and serum levels of neurogastrointestinal hormones and inflammatory markers. RESULTS:PD patients were older than controls (66.0 ± 8.5 vs. 62.4 ± 8.4years, P = 0.003). Mean body mass index (24.0 ± 0.4 vs. 25.6 ± 0.5kg/m2, Padjusted = 0.016), fat mass index (7.4 ± 0.3 vs. 9.0 ± 0.3kg/m2, Padjusted<0.001), and whole-body fat percentage (30.7 ± 0.8 vs. 35.7 ± 0.9%, Padjusted<0.001) were lower in patients, even after controlling for age and gender. There were no between-group differences in skeletal muscle mass index and whole-body bone mineral density. Body composition parameters did not correlate with disease duration or motor severity. Reduced whole-body fat percentage was associated with higher risk of motor response complications as well as higher levels of insulin-growth factor-1 and inflammatory markers. PD patients had a higher prevalence of sarcopenia (17.2% vs. 10.3%, Padjusted = 0.340) and frailty (69.4% vs. 24.2%, Padjusted = 0.010). Older age and worse PD motor severity were predictors of frailty in PD. CONCLUSIONS:We found reduced body fat with relatively preserved skeletal muscle mass, and a high prevalence of frailty, in PD. Further studies are needed to understand the patho-mechanisms underlying these alterations.

journal_name

Parkinsonism Relat Disord

journal_title

Parkinsonism & related disorders

authors

Tan AH,Hew YC,Lim SY,Ramli NM,Kamaruzzaman SB,Tan MP,Grossmann M,Ang BH,Tan JY,Manap MAAA,Tay TK,Tan SL,New RP,Fadzli F,Yee EJ,Moy FM,Mahadeva S,Lang AE

doi

10.1016/j.parkreldis.2018.06.020

subject

Has Abstract

pub_date

2018-11-01 00:00:00

pages

58-64

eissn

1353-8020

issn

1873-5126

pii

S1353-8020(18)30279-7

journal_volume

56

pub_type

杂志文章

相关文献

PARKINSONISM & RELATED DISORDERS文献大全
  • Variants in the SNCA gene associate with motor progression while variants in the MAPT gene associate with the severity of Parkinson's disease.

    abstract：INTRODUCTION:It is well known that α-synuclein (SNCA) and microtubule associated protein (MAPT) genes predispose individuals to develop Parkinson's disease (PD). However, whether these genes contribute to differences in the variable progression observed in PD is obscure. This study aims to evaluate the association of c...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/j.parkreldis.2015.12.018

    authors： Wang G,Huang Y,Chen W,Chen S,Wang Y,Xiao Q,Liu J,Fung VS,Halliday G,Chen S

    更新日期：2016-03-01 00:00:00

  • Deep brain stimulation in neurologic disorders.

    abstract：:Deep brain stimulation (DBS) is an effective surgical therapy for well-selected patients with medically intractable Parkinson's disease (PD) and essential tremor (ET). The purpose of this review is to describe the success of DBS in these two disorders and its promising application in dystonia, Tourette Syndrome (TS) a...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章,评审

    doi：10.1016/j.parkreldis.2006.03.001

    authors： Halpern C,Hurtig H,Jaggi J,Grossman M,Won M,Baltuch G

    更新日期：2007-02-01 00:00:00

  • Impaired eye blink classical conditioning distinguishes dystonic patients with and without tremor.

    abstract：INTRODUCTION:Tremor is frequently associated with dystonia, but its pathophysiology is still unclear. Dysfunctions of cerebellar circuits are known to play a role in the pathophysiology of action-induced tremors, and cerebellar impairment has frequently been associated to dystonia. However, a link between dystonic trem...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/j.parkreldis.2016.06.011

    authors： Antelmi E,Di Stasio F,Rocchi L,Erro R,Liguori R,Ganos C,Brugger F,Teo J,Berardelli A,Rothwell J,Bhatia KP

    更新日期：2016-10-01 00:00:00

  • Quantifying physical activity in early Parkinson disease using a commercial activity monitor.

    abstract：INTRODUCTION:Physical inactivity in Parkinson disease (PD) has an impact on motor and non-motor symptoms of the disease. It is unclear whether this decline in physical activity occurs early in the disease, in addition to any decline due to aging, and whether commercial activity monitors can be used to self-monitor phys...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/j.parkreldis.2019.08.001

    authors： Pradhan S,Kelly VE

    更新日期：2019-09-01 00:00:00

  • Metformin-inclusive sulfonylurea therapy reduces the risk of Parkinson's disease occurring with Type 2 diabetes in a Taiwanese population cohort.

    abstract：OBJECTIVES:Type 2 diabetes (T2DM) may increase the risk of Parkinson's disease (PD). We evaluated the role of oral anti-hyperglycemic agents (OAA) in any diabetes-PD linkage. METHODS:From the Taiwan National Health Insurance database on 01-01-2000, a representative cohort of 800,000 was obtained between 1996-01-01 and...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/j.parkreldis.2012.03.010

    authors： Wahlqvist ML,Lee MS,Hsu CC,Chuang SY,Lee JT,Tsai HN

    更新日期：2012-07-01 00:00:00

  • Stroke of the substance nigra and parkinsonism as first manifestation of systemic lupus erythematosus.

    abstract：:The authors report one case of parkinsonism associated with systemic lupus erythematosus (SLE): a 45-year-old woman, who presented with a strategic infarct of the right substance nigra secondary to vasculitis, and contralateral symptoms. Other causes of parkinsonism were excluded. She had a partial response to therapy...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/j.parkreldis.2007.08.001

    authors： Orta Daniel SJ,Ulises RO

    更新日期：2008-01-01 00:00:00

  • Dihydroergotoxine mesylate for the treatment of sialorrhea in Parkinson's disease.

    abstract：BACKGROUND:Many patients with Parkinson's disease (PD) suffer from sialorrhea. Sialorrhea is often treated with anticholinergics and botulinum toxin, but some adverse effects have limited the use of these treatments. Dihydroergotoxine mesylate is an α-adrenergic blocking agents as well as some affinities to the dopamin...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.parkreldis.2018.08.022

    authors： Cheng YQ,Ge NN,Zhu HH,Sha ZT,Jiang T,Zhang YD,Tian YY

    更新日期：2019-01-01 00:00:00

  • Adenosine, adenosine A 2A antagonists, and Parkinson's disease.

    abstract：:Adenosine derived from the degradation of ATP/AMP functions as a signalling molecule in the nervous system through the occupation of A1, A2, and A3 adenosine receptors. Adenosine A(2A) receptors have a selective localization to the basal ganglia and specifically to the indirect output pathway, and as a consequence off...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章,评审

    doi：10.1016/j.parkreldis.2008.12.006

    authors： Jenner P,Mori A,Hauser R,Morelli M,Fredholm BB,Chen JF

    更新日期：2009-07-01 00:00:00

  • Levodopa and neuropathy risk in patients with Parkinson disease: Effect of COMT inhibition.

    abstract：OBJECTIVE:Our purpose was to determine whether the use of catechol-O-methyltransferase-inhibitors (ICOMT) can reduce the risk of developing levodopa (LD)-induced neuropathy in Parkinson's disease (PD) patients. METHODS:A multicentre study of 197 PD patients was performed. 144 were exposed to LD for more than three yea...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.parkreldis.2016.04.016

    authors： Cossu G,Ceravolo R,Zibetti M,Arca R,Ricchi V,Paribello A,Murgia D,Merola A,Romagnolo A,Nicoletti V,Palermo G,Mereu A,Lopiano L,Melis M,Abbruzzese G,Bonuccelli U

    更新日期：2016-06-01 00:00:00

  • Adult-onset primary focal foot dystonia.

    abstract：:Although primary focal hand dystonia has been well characterized, primary focal foot dystonia in adults has rarely been reported. Our objective was to describe the clinical phenotype and treatment outcomes in patients with primary, adult-onset focal foot dystonia. To this end we conducted a retrospective study of four...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/j.parkreldis.2005.07.004

    authors： Singer C,Papapetropoulos S

    更新日期：2006-01-01 00:00:00

  • Long-term evaluation of open-label pimavanserin safety and tolerability in Parkinson's disease psychosis.

    abstract：INTRODUCTION:Pimavanserin is a selective 5-HT2A inverse agonist/antagonist approved for treating hallucinations and delusions associated with Parkinson's disease psychosis (PDP). Results from short-term, placebo-controlled studies demonstrated a positive benefit/risk profile. This multi-year, open-label study assessed ...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/j.parkreldis.2020.06.026

    authors： Ballard CG,Kreitzman DL,Isaacson S,Liu IY,Norton JC,Demos G,Fernandez HH,Ilic TV,Azulay JP,Ferreira JJ,Abler V,Stankovic S,015 Study Group.

    更新日期：2020-08-01 00:00:00

  • Prevalence survey of movement disorders, epilepsy, hypertension and smoking habit in Vejer de la Frontera, Southern Spain-I. Methodology.

    abstract：:A prevalence survey of movement disorders, epilepsy, hypertension and smoking was undertaken in Vejer de la Frontera, Southern Spain in 1988. A validated screening instrument designed for door-to-door tracing of specific disorders was used. Neurological diagnoses were based on: (1) direct anamnesis and examination by ...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/s1353-8020(96)00021-1

    authors： Acosta-Varo J,De Pedro-Cuesta J

    更新日期：1996-10-01 00:00:00

  • Reduced orexin immunoreactivity in Perry syndrome and multiple system atrophy.

    abstract：INTRODUCTION:Orexin is a neuropeptide that plays a key role in maintaining a state of arousal, and possibly associates with sleep apnea syndrome (SAS). Reduced orexin immunoreactivity has been reported in various neurologic conditions such as narcolepsy, Alzheimer's disease, Lewy body disease and multiple system atroph...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/j.parkreldis.2017.06.003

    authors： Mishima T,Kasanuki K,Koga S,Castanedes-Casey M,Wszolek ZK,Tsuboi Y,Dickson DW

    更新日期：2017-09-01 00:00:00

  • Longitudinal changes in cognition in early Parkinson's disease patients with REM sleep behavior disorder.

    abstract：INTRODUCTION:Cognitive decline is common in Parkinson's disease (PD), and identifying patients at highest risk for it is essential. We aimed to examine the effect of possible REM sleep behavior disorder (pRBD) on rate of cognitive decline in early PD, for both global cognition and in specific cognitive domains. METHOD...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.parkreldis.2016.03.006

    authors： Chahine LM,Xie SX,Simuni T,Tran B,Postuma R,Amara A,Oertel WH,Iranzo A,Scordia C,Fullard M,Linder C,Purri R,Darin A,Rennert L,Videnovic A,Del Riva P,Weintraub D

    更新日期：2016-06-01 00:00:00

  • Hypertrophic olivary degeneration: A clinico-radiologic study.

    abstract：INTRODUCTION:The frequency and causes of hypertrophic olivary degeneration (HOD) are unknown. We compared the clinical and radiological characteristics of unilateral HOD and bilateral HOD. METHODS:We performed a search of a radiologic report database for patients who were radiologically diagnosed as having HOD. This d...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/j.parkreldis.2016.04.008

    authors： Konno T,Broderick DF,Tacik P,Caviness JN,Wszolek ZK

    更新日期：2016-07-01 00:00:00

  • Oropharyngeal freezing and its relation to dysphagia - An analogy to freezing of gait.

    abstract：INTRODUCTION:The pathophysiology of dysphagia in Parkinson's disease (PD) is heterogeneous and poorly understood at present. This study investigated the phenotypes, prevalence and pathophysiology of oropharyngeal freezing (OPF) in PD and its relation to dysphagia. METHODS:In a prospective study, 50 PD patients were sy...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/j.parkreldis.2020.05.002

    authors： Labeit B,Claus I,Muhle P,Lapa S,Suntrup-Krueger S,Dziewas R,Osada N,Warnecke T

    更新日期：2020-06-01 00:00:00

  • Health-related quality of life and alternative forms of exercise in Parkinson disease.

    abstract：:Parkinson disease (PD) reduces health-related quality of life (HRQoL), but exercise may improve HRQoL. This pilot study compared the effects of Tango, Waltz/Foxtrot, Tai Chi and No Intervention on HRQoL in individuals with PD. Seventy-five persons with PD (Hoehn and Yahr I-III) were assigned to 20 lessons of Tango, Wa...

    journal_title：Parkinsonism & related disorders

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.parkreldis.2009.03.003

    authors： Hackney ME,Earhart GM

    更新日期：2009-11-01 00:00:00

  • Orthostatic myoclonus after brain tumor radiation: Insights from two lesional cases.

    abstract：INTRODUCTION:Orthostatic myoclonus (OM) is a recognized syndrome of gait unsteadiness accompanied by lower limb myoclonus provoked by the assumption of an upright posture. OM typically affects the elderly and is often associated with neurodegenerative disease. We sought to review the clinical and electrophysiologic cha...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/j.parkreldis.2017.04.015

    authors： Cutsforth-Gregory JK,Hammack JE,Matsumoto JY

    更新日期：2017-08-01 00:00:00

  • Salivary alpha-synuclein in the diagnosis of Parkinson's disease and Progressive Supranuclear Palsy.

    abstract：INTRODUCTION:Alpha-synuclein (α-syn) aggregation is the pathological hallmark of Parkinson's Disease (PD). In this study, we measured α-syn total (α-syntotal), oligomeric α-syn (α-synolig) and α-synolig/α-syntotal ratio in the saliva of patients affected by PD and in age and sex-matched healthy subjects. We also compar...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/j.parkreldis.2019.02.014

    authors： Vivacqua G,Suppa A,Mancinelli R,Belvisi D,Fabbrini A,Costanzo M,Formica A,Onori P,Fabbrini G,Berardelli A

    更新日期：2019-06-01 00:00:00

  • Daytime sleep in Parkinson's disease measured by episodes of immobility.

    abstract：:Excessive daytime sleepiness (EDS) is common in Parkinson's Disease (PD). Actigraphy uses periods of immobility as surrogate markers of nighttime sleep but there are no examples of its use in assessing EDS of PD. A commercial wrist worn system for measuring bradykinesia and dyskinesia also detects 2 min periods of imm...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/j.parkreldis.2014.02.011

    authors： Kotschet K,Johnson W,McGregor S,Kettlewell J,Kyoong A,O'Driscoll DM,Turton AR,Griffiths RI,Horne MK

    更新日期：2014-06-01 00:00:00

  • A randomized, double-blind, controlled trial of add-on therapy in moderate-to-severe Parkinson's disease.

    abstract：OBJECTIVE:The primary objective was to evaluate the efficacy and safety of droxidopa as add-on therapy in improving stiffness, tremors and other motor functions and activities of daily living for moderate-to-severe Parkinson's disease (PD). METHODS:PD patients, above Hoehn-Yahr III (including Hoehn-Yahr III), were ran...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1016/j.parkreldis.2015.08.023

    authors： Zhao S,Cheng R,Zheng J,Li Q,Wang J,Fan W,Zhang L,Zhang Y,Li H,Liu S

    更新日期：2015-10-01 00:00:00

  • Objective intestinal function in patients with idiopathic REM sleep behavior disorder.

    abstract：BACKGROUND:Parkinson's disease is characterized by pathological α-synuclein accumulation and cell death, which has been hypothesized to originate in peripheral nerve terminals and subsequently spread via autonomic nerves. Supporting this, most Parkinson's disease patients experience autonomic non-motor symptoms such as...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/j.parkreldis.2018.08.011

    authors： Knudsen K,Fedorova TD,Hansen AK,Sommerauer M,Haase AM,Svendsen KB,Otto M,Østergaard K,Krogh K,Borghammer P

    更新日期：2019-01-01 00:00:00

  • Barriers to reporting non-motor symptoms to health-care providers in people with Parkinson's.

    abstract：BACKGROUND:Non-motor symptoms (NMS) are common in Parkinson's disease (PD) and cause significant distress. A high rate of non-declaration of NMS by patients to healthcare providers (HCP) means that many NMS remain untreated. Current understanding of the factors preventing disclosure of NMS to HCPs is limited. The prese...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/j.parkreldis.2019.04.014

    authors： Hurt CS,Rixon L,Chaudhuri KR,Moss-Morris R,Samuel M,Brown RG

    更新日期：2019-07-01 00:00:00

  • The pimple sign of progressive supranuclear palsy syndrome.

    abstract：BACKGROUND:Some patients with progressive supranuclear palsy syndrome (PSPS) demonstrate a focal area of midbrain hypometabolism on FDG-PET scans which we call the 'pimple sign'. We assessed its association with midbrain atrophy, its reliability and its ability to differentiate PSPS from corticobasal syndrome (CBS) and...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/j.parkreldis.2013.10.023

    authors： Botha H,Whitwell JL,Madhaven A,Senjem ML,Lowe V,Josephs KA

    更新日期：2014-02-01 00:00:00

  • Phenotype of non-c.907_909delGAG mutations in TOR1A: DYT1 dystonia revisited.

    abstract：BACKGROUND:In addition to the most frequent TOR1A/DYT1 mutation (c.907_909delGAG), a growing number of TOR1A sequence variants are found in dystonia patients. For most, functional characterization has demonstrated pathogenicity at different levels, implying that TOR1A genetic testing should not be limited to screening ...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/j.parkreldis.2015.08.001

    authors： Dobričić V,Kresojević N,Žarković M,Tomić A,Marjanović A,Westenberger A,Cvetković D,Svetel M,Novaković I,Kostić VS

    更新日期：2015-10-01 00:00:00

  • Highly specific radiographic marker predates clinical diagnosis in progressive supranuclear palsy.

    abstract：INTRODUCTION:The diagnosis of progressive supranuclear palsy is often challenging early in the course of the disease, when clinical signs of the condition may be less apparent and patients do not clearly meet diagnostic criteria. In this study, we examine a potential radiographic marker in progressive supranuclear pals...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/j.parkreldis.2016.05.006

    authors： Owens E,Krecke K,Ahlskog JE,Fealey R,Hassan A,Josephs KA,Klassen B,Matsumoto J,Bower J

    更新日期：2016-07-01 00:00:00

  • The medical treatment of patients with Parkinson's disease receiving subthalamic neurostimulation.

    abstract：INTRODUCTION:Deep brain stimulation of subthalamic nucleus (STN-DBS) for Parkinson's disease allows for a reduction in medication dosage. Changes in total levodopa equivalent daily dose (LEDD) have been frequently reported, there is little information about changes within the drug classes. METHODS:We retrospectively a...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/j.parkreldis.2015.03.003

    authors： Alexoudi A,Shalash A,Knudsen K,Witt K,Mehdorn M,Volkmann J,Deuschl G

    更新日期：2015-06-01 00:00:00

  • Changes in quality of life, burden and mood among spouses of Parkinson's disease patients receiving neurostimulation.

    abstract：BACKGROUND:Deep brain stimulation improves motor function and quality of life in patients with Parkinson's disease. The impact of these changes on patients' spouses is largely unknown. METHODS:Twenty-six spouses of patients undergoing surgery were evaluated before and 12 months after surgery, using the 36-Item Short F...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/j.parkreldis.2011.11.008

    authors： Soulas T,Sultan S,Gurruchaga JM,Palfi S,Fénelon G

    更新日期：2012-06-01 00:00:00

  • Validation of diagnostic criteria for apathy in Parkinson's disease.

    abstract：BACKGROUND:Apathy is a common neuropsychiatric syndrome in Parkinson's Disease (PD) that affects quality of life. Research into apathy has been hampered by a lack of broadly accepted diagnostic criteria. Recently, diagnostic criteria for apathy in neuropsychiatric disorders have been proposed, which to date have not be...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/j.parkreldis.2010.08.015

    authors： Drijgers RL,Dujardin K,Reijnders JS,Defebvre L,Leentjens AF

    更新日期：2010-12-01 00:00:00

  • Exercise hemodynamics in Parkinson's disease and autonomic dysfunction.

    abstract：AIM:To clarify the characteristics of hemodynamic responses to exercise and orthostasis in Parkinson's disease patients, especially those with autonomic failure. METHODS:Clinical audit of supine cycling exercise test data (with active standing tests pre- and post-exercise) of Parkinson's patients with autonomic dysfun...

    journal_title：Parkinsonism & related disorders

    pub_type： 杂志文章

    doi：10.1016/j.parkreldis.2014.02.006

    authors： Low DA,Vichayanrat E,Iodice V,Mathias CJ

    更新日期：2014-05-01 00:00:00