Abstract:
BACKGROUND:Parkinson's disease is characterized by pathological α-synuclein accumulation and cell death, which has been hypothesized to originate in peripheral nerve terminals and subsequently spread via autonomic nerves. Supporting this, most Parkinson's disease patients experience autonomic non-motor symptoms such as constipation, often years prior to diagnosis. OBJECTIVE:We aimed to study gastrointestinal transit time, colonic volume, and peristaltic movements in idiopathic REM Sleep Behavior Disorder patients, a prodromal marker of Parkinson's disease or Dementia with Lewy bodies. METHODS:Twenty-two patients were included and compared to previously published data from Parkinson's disease patients and controls. Gastrointestinal transit time, computed tomography-based volume estimation, and colonic motility were performed as markers of gastrointestinal function and autonomic involvement. Subjective constipation symptoms were evaluated with two different questionnaires. RESULTS:Gastrointestinal transit time was increased in 33% (p = 0.039) and colonic volume in 48% (p = 0.0049) of patients. Colonic transit time measured by the 3D-Transit system was increased in 70% (p = 0.0326) and the number of fast peristaltic colonic movements was reduced (p = 0.015). Mean small intestinal transit time was comparable to Parkinson's disease patients, although not significantly different compared to controls (p = 0.18). Subjective constipation symptoms were present in 18 or 41%, depending on type of questionnaire. CONCLUSIONS:Total gastrointestinal transit time, colonic volume, and 3D-Transit colonic transit time were significantly increased compared to controls, although not to the extent seen in medicated Parkinson's patients. Limited correlation was seen between subjective constipation and objective markers. The findings support that marked GI dysfunction is present in the early prodromal PD phase.
journal_name
Parkinsonism Relat Disordjournal_title
Parkinsonism & related disordersauthors
Knudsen K,Fedorova TD,Hansen AK,Sommerauer M,Haase AM,Svendsen KB,Otto M,Østergaard K,Krogh K,Borghammer Pdoi
10.1016/j.parkreldis.2018.08.011subject
Has Abstractpub_date
2019-01-01 00:00:00pages
28-34eissn
1353-8020issn
1873-5126pii
S1353-8020(18)30362-6journal_volume
58pub_type
杂志文章abstract:INTRODUCTION:The Montreal Cognitive Assessment (MoCA) is a frequently utilized cognitive screening tool that has attractive clinical attributes when utilized in individuals with Parkinson's disease. However, the construct validity of this instrument has not been well-characterized in Parkinson's samples. The purpose of...
journal_title:Parkinsonism & related disorders
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abstract::Although the subspeciality of movement disorders was established in neurology more than 20 years ago, it is relatively new in Thailand, and while most physicians are generally aware of Parkinson's disease, they often are not familiar with dystonia. As one of the common movement disorders seen in general practice, a nu...
journal_title:Parkinsonism & related disorders
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journal_title:Parkinsonism & related disorders
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journal_title:Parkinsonism & related disorders
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abstract:OBJECTIVE:The primary objective was to evaluate the efficacy and safety of droxidopa as add-on therapy in improving stiffness, tremors and other motor functions and activities of daily living for moderate-to-severe Parkinson's disease (PD). METHODS:PD patients, above Hoehn-Yahr III (including Hoehn-Yahr III), were ran...
journal_title:Parkinsonism & related disorders
pub_type: 杂志文章,多中心研究,随机对照试验
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journal_title:Parkinsonism & related disorders
pub_type: 传,历史文章,杂志文章,评审
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journal_title:Parkinsonism & related disorders
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doi:10.1016/j.parkreldis.2020.10.024
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journal_title:Parkinsonism & related disorders
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journal_title:Parkinsonism & related disorders
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journal_title:Parkinsonism & related disorders
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doi:10.1016/j.parkreldis.2016.02.011
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journal_title:Parkinsonism & related disorders
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journal_title:Parkinsonism & related disorders
pub_type: 杂志文章,随机对照试验
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abstract:BACKGROUND:Non-motor complications of Parkinson's disease (PD), specifically cognitive impairment, sleep disturbances, and fatigue, are recognized as important contributors to poor patient outcomes and quality of life. How sleep problems and fatigue interrelate and impact cognitive function, however, has not systematic...
journal_title:Parkinsonism & related disorders
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doi:10.1016/j.parkreldis.2014.08.001
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journal_title:Parkinsonism & related disorders
pub_type: 杂志文章
doi:10.1016/j.parkreldis.2007.04.002
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journal_title:Parkinsonism & related disorders
pub_type: 临床试验,杂志文章
doi:10.1016/j.parkreldis.2005.05.009
更新日期:2005-09-01 00:00:00
abstract:INTRODUCTION:It is well known that α-synuclein (SNCA) and microtubule associated protein (MAPT) genes predispose individuals to develop Parkinson's disease (PD). However, whether these genes contribute to differences in the variable progression observed in PD is obscure. This study aims to evaluate the association of c...
journal_title:Parkinsonism & related disorders
pub_type: 杂志文章
doi:10.1016/j.parkreldis.2015.12.018
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journal_title:Parkinsonism & related disorders
pub_type: 杂志文章
doi:10.1016/j.parkreldis.2016.06.020
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abstract:INTRODUCTION:Alpha-synuclein (α-syn) aggregation is the pathological hallmark of Parkinson's Disease (PD). In this study, we measured α-syn total (α-syntotal), oligomeric α-syn (α-synolig) and α-synolig/α-syntotal ratio in the saliva of patients affected by PD and in age and sex-matched healthy subjects. We also compar...
journal_title:Parkinsonism & related disorders
pub_type: 杂志文章
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journal_title:Parkinsonism & related disorders
pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:Parkinsonism & related disorders
pub_type: 杂志文章
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journal_title:Parkinsonism & related disorders
pub_type: 杂志文章
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journal_title:Parkinsonism & related disorders
pub_type: 杂志文章,随机对照试验
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journal_title:Parkinsonism & related disorders
pub_type: 杂志文章
doi:10.1016/j.parkreldis.2010.05.003
更新日期:2011-05-01 00:00:00
abstract:INTRODUCTION:This study of thalamic deep brain stimulation (DBS) investigated whether a novel constant-current device improves tremor and activities of daily living (ADL) in patients with essential tremor (ET). METHODS:A prospective, controlled, multicenter study was conducted at 12 academic centers. We investigated t...
journal_title:Parkinsonism & related disorders
pub_type: 杂志文章,多中心研究
doi:10.1016/j.parkreldis.2017.03.017
更新日期:2017-07-01 00:00:00
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journal_title:Parkinsonism & related disorders
pub_type: 杂志文章
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journal_title:Parkinsonism & related disorders
pub_type: 杂志文章,meta分析,评审
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journal_title:Parkinsonism & related disorders
pub_type: 杂志文章
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abstract::Pathogenic mutations in the EIF4G1 gene were recently reported as a cause of autosomal dominant parkinsonism. To assess the frequency of EIF4G1 mutations in the Japanese population we sequenced the entire gene coding region (31 exons) in 95 patients with an apparent autosomal dominant inherited form of Parkinson's dis...
journal_title:Parkinsonism & related disorders
pub_type: 杂志文章
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journal_title:Parkinsonism & related disorders
pub_type: 杂志文章
doi:10.1016/j.parkreldis.2015.10.017
更新日期:2015-12-01 00:00:00
abstract::Knowledge of molecular events contributing to motor dysfunction in Parkinson's disease has advanced rapidly during the past decade. Studies in animal models as well as in patients afflicted by this disorder suggest that the nonphysiologic stimulation of striatal dopamine receptors, first as a result of dopaminergic de...
journal_title:Parkinsonism & related disorders
pub_type: 杂志文章,评审
doi:10.1016/j.parkreldis.2004.02.012
更新日期:2004-07-01 00:00:00