The hung-up knee jerk in Huntington's Disease.

abstract：:Parkinson disease (PD) reduces health-related quality of life (HRQoL), but exercise may improve HRQoL. This pilot study compared the effects of Tango, Waltz/Foxtrot, Tai Chi and No Intervention on HRQoL in individuals with PD. Seventy-five persons with PD (Hoehn and Yahr I-III) were assigned to 20 lessons of Tango, Wa...

journal_title：Parkinsonism & related disorders

authors： Hackney ME,Earhart GM

更新日期：2009-11-01 00:00:00

abstract：INTRODUCTION:Increasing evidence demonstrates the relevant association between Parkinson's disease (PD) and vascular diseases/risk factors, as well as a worse clinico-pathological progression in those patients with vascular comorbidity. The mechanisms underlying this relationship have not been clarified yet, although t...

journal_title：Parkinsonism & related disorders

authors： Imbriani P,D'Angelo V,Platania P,Di Lazzaro G,Scalise S,Salimei C,El Atiallah I,Colona VL,Mercuri NB,Bonsi P,Pisani A,Schirinzi T,Martella G

更新日期：2020-05-01 00:00:00

abstract：BACKGROUND:Non-motor symptom (NMS) differences between male Parkinson's disease (PD) and female PD, and between early-onset PD (EOPD) and late-onset PD (LOPD) in Chinese populations remain largely unknown. METHODS:A total of 522 PD patients from Southwest China were included. Patients were assessed using the Non-Motor...

journal_title：Parkinsonism & related disorders

authors： Guo X,Song W,Chen K,Chen X,Zheng Z,Cao B,Huang R,Zhao B,Wu Y,Shang HF

更新日期：2013-11-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Disturbance of the autonomic nervous system (ANS) is frequently encountered in Parkinson's disease (PD). In this study, we examined changes in systemic and cerebral hemodynamics during the cold pressor test (CPT) to determine whether cerebrovascular reactivity, controlled by the sympathetic nervo...

journal_title：Parkinsonism & related disorders

authors： Tsai SJ,Chen SC,Leu TM,Chen CM,Chou HH,Peng HY,Liao JM,Lin TB

更新日期：2009-02-01 00:00:00

abstract：INTRODUCTION:There is an unmet need to better control motor complications in Parkinson's disease (PD). Naftazone, which exhibits glutamate release inhibition properties, has shown antiparkinsonian and antidyskinetic activity in preclinical models of PD and in a clinical proof of concept study. METHODS:We conducted a d...

journal_title：Parkinsonism & related disorders

authors： Corvol JC,Durif F,Meissner WG,Azulay JP,Haddad R,Guimarães-Costa R,Mariani LL,Cormier-Dequaire F,Thalamas C,Galitzky M,Boraud T,Debilly B,Eusebio A,Houot M,Dellapina E,Chaigneau V,Salis A,Lacomblez L,Benel L,Rascol

更新日期：2019-03-01 00:00:00

abstract：INTRODUCTION:Alzheimer's disease neuropathologies (amyloid-β and tau) frequently co-exist to varying degrees in Lewy body dementias (LBD), which include dementia with Lewy bodies (DLB) and Parkinson's disease dementia (PDD). OBJECTIVES:To investigate the prevalence of tau in DLB and PDD, and its associations with clin...

journal_title：Parkinsonism & related disorders

authors： Chin KS,Yassi N,Churilov L,Masters CL,Watson R

更新日期：2020-11-01 00:00:00

abstract：:The clinical phenotype of frontotemporal dementia with parkinsonism linked to chromosome 17 (FTDP-17) varies. This variability is seen not only between kindreds with different mutations but also in families sharing the same mutation. Inheritance of tau haplotype (H1) and genotype (H1/H1) has been established as a risk...

journal_title：Parkinsonism & related disorders

authors： Baba Y,Tsuboi Y,Baker MC,Uitti RJ,Hutton ML,Dickson DW,Farrer M,Putzke JD,Woodruff BK,Ghetti B,Murrell JR,Boeve BF,Petersen RC,Verpillat P,Brice A,Delisle MB,Rascol O,Arima K,Dysken MW,Yasuda M,Kobayashi T,Sunoh

更新日期：2005-06-01 00:00:00

abstract：:Positron emission tomography (PET) scan is considered to be the most useful tool with which to assess the integrity of nigrostriatal function in the living brain. Recently, different genetic defects have been associated with a variety of familial parkinsonian syndromes, the clinical phenotypes of which have varying de...

journal_title：Parkinsonism & related disorders

authors： Pal PK,Wszolek ZK,Uitti R,Markopoulou K,Calne SM,Stoessl AJ,Calne DB

更新日期：2001-09-01 00:00:00

abstract：:Several factors involved in the etiology of Parkinson's disease (PD) have been proposed, including genetic and environmental factors or even a combination of both. Thus, multiple cellular hits are likely to contribute to neurodegeneration in PD. If such a mechanism happens to occur, our therapeutic intervention may pe...

journal_title：Parkinsonism & related disorders

authors： Hirsch EC

更新日期：2007-01-01 00:00:00

abstract：INTRODUCTION:Cognitive decline is common in Parkinson's disease (PD), and identifying patients at highest risk for it is essential. We aimed to examine the effect of possible REM sleep behavior disorder (pRBD) on rate of cognitive decline in early PD, for both global cognition and in specific cognitive domains. METHOD...

journal_title：Parkinsonism & related disorders

authors： Chahine LM,Xie SX,Simuni T,Tran B,Postuma R,Amara A,Oertel WH,Iranzo A,Scordia C,Fullard M,Linder C,Purri R,Darin A,Rennert L,Videnovic A,Del Riva P,Weintraub D

更新日期：2016-06-01 00:00:00

abstract：INTRODUCTION:Physical inactivity in Parkinson disease (PD) has an impact on motor and non-motor symptoms of the disease. It is unclear whether this decline in physical activity occurs early in the disease, in addition to any decline due to aging, and whether commercial activity monitors can be used to self-monitor phys...

journal_title：Parkinsonism & related disorders

authors： Pradhan S,Kelly VE

更新日期：2019-09-01 00:00:00

abstract：:Approximately 10% of patients with a presumed diagnosis of Parkinson's disease (PD) remain misdiagnosed despite recent advances in neuroimaging. The current study addresses the use of transcranial sonography and single-photon emission computed tomography (SPECT) using (99m)Tc-TRODAT-1 to evaluate the echogenicity of t...

journal_title：Parkinsonism & related disorders

authors： Bor-Seng-Shu E,Pedroso JL,Felicio AC,de Andrade DC,Teixeira MJ,Braga-Neto P,Batista IR,Barsottini OG,Borges V,Ferraz HB,Shih MC,Bressan RA,de Andrade LA,Walter U

更新日期：2014-05-01 00:00:00

abstract：INTRODUCTION:Executive dysfunction is a common and early cognitive symptom in Parkinson's disease (PD) with a detrimental effect on quality of life of patients and their care givers. Thus, a number of neuroimaging studies investigated the underlying neural correlates of such an impairment. Results of individual studies...

journal_title：Parkinsonism & related disorders

authors： Giehl K,Tahmasian M,Eickhoff SB,van Eimeren T

更新日期：2019-06-01 00:00:00

abstract：OBJECTIVE:To explore the microstructural integrity of the optic nerve and its role as a cognitive predictor in patients with de novo Parkinson's disease (PD) using diffusion tensor image-based magnetic resonance scans. METHODS:We enrolled 82 patients with de novo PD, 36 patients with drug-induced parkinsonism (DIP), a...

journal_title：Parkinsonism & related disorders

authors： Lee JJ,Shin NY,Lee Y,Lee SK,Sohn YH,Lee PH

更新日期：2016-10-01 00:00:00

abstract：:Non motor symptoms (NMS) represent a significant burden in Parkinson's disease (PD) with numerous studies highlighting the importance of NMS both in "pre-motor" phase of PD as well as throughout the course of disease. In part this has led the international Parkinson and Movement Disorder Society (IPMDS) task force to ...

journal_title：Parkinsonism & related disorders

authors： Sauerbier A,Jenner P,Todorova A,Chaudhuri KR

更新日期：2016-01-01 00:00:00

abstract：OBJECTIVE:To estimate the frequency and correlates of involuntary emotional expression disorder (IEED) in Parkinson's disease (PD) using the Center for Neurologic Study-Lability Scale (CNS-LS) and recently-proposed diagnostic criteria for IEED. BACKGROUND:IEED is characterized by uncontrollable emotional episodes, typ...

journal_title：Parkinsonism & related disorders

authors： Phuong L,Garg S,Duda JE,Stern MB,Weintraub D

更新日期：2009-08-01 00:00:00

abstract：INTRODUCTION:Low body weight in Parkinson's disease (PD) is poorly understood despite the associated risks of malnutrition, fractures, and death. Sarcopenia (loss of muscle bulk and strength) and frailty are geriatric syndromes that are likewise associated with adverse health outcomes, yet have received scant attention...

journal_title：Parkinsonism & related disorders

authors： Tan AH,Hew YC,Lim SY,Ramli NM,Kamaruzzaman SB,Tan MP,Grossmann M,Ang BH,Tan JY,Manap MAAA,Tay TK,Tan SL,New RP,Fadzli F,Yee EJ,Moy FM,Mahadeva S,Lang AE

更新日期：2018-11-01 00:00:00

abstract：BACKGROUND:Parkinson's disease (PD) patients are hospitalized more frequently than their peers as a result of falls, psychosis, infections and other medical complications. However, patient-specific risk factors for hospitalization are unclear. OBJECTIVE:To identify rates and risk factors for hospital encounters (Emerg...

journal_title：Parkinsonism & related disorders

authors： Hassan A,Wu SS,Schmidt P,Dai Y,Simuni T,Giladi N,Bloem BR,Malaty IA,Okun MS,NPF-QII Investigators.

更新日期：2013-11-01 00:00:00

abstract：:Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder. An association with sleep breathing disorder has not previously been established in the literature. We report the case of a 45-year-old woman with HD, presenting with snoring and observed apnea. Polysomnography showed obstructive sleep apne...

journal_title：Parkinsonism & related disorders

authors： Banno K,Hobson DE,Kryger MH

更新日期：2005-06-01 00:00:00

abstract：OBJECTIVES:Dissatisfaction with subthalamic deep brain stimulation (STN-DBS) despite motor improvements has been observed in Parkinson's disease (PD). Hence, we compared patient's subjective perceived outcome 12 months after surgery (12mFU) with clinical measures to identify risk factors of dissatisfaction. METHODS:Pa...

journal_title：Parkinsonism & related disorders

authors： Maier F,Lewis CJ,Horstkoetter N,Eggers C,Dembek TA,Visser-Vandewalle V,Kuhn J,Zurowski M,Moro E,Woopen C,Timmermann L

更新日期：2016-03-01 00:00:00

abstract：BACKGROUND:Sleep disorders occur commonly in Parkinson's disease and are often under-recognized and under treated in clinical practice. OBJECTIVES:To determine the quality of sleep in patients with Young onset Parkinson's disease (YOPD) and to note whether there is any difference in quality of sleep from those patient...

journal_title：Parkinsonism & related disorders

authors： Mahale R,Yadav R,Pal PK

更新日期：2015-05-01 00:00:00

abstract：:There has been a tremendous development since a regional progression of pathology in subjects with Lewy bodies (LB) was initially proposed 30 years ago. The entity of dementia with Lewy bodies has been acknowledged, the main protein constituent of LBs--aggregated α-synuclein (αS)--has been identified and a stepwise pr...

journal_title：Parkinsonism & related disorders

authors： Alafuzoff I,Parkkinen L

更新日期：2014-01-01 00:00:00

abstract：INTRODUCTION:Freezing of gait (FoG) is one of the most disabling gait disorders in Parkinson's disease (PD), reflecting motor and cognitive impairments, mainly related to dopamine deficiency. Recent studies investigating kinematic and kinetic factors affecting gait in these patients showed a postural instability charac...

journal_title：Parkinsonism & related disorders

authors： Mezzarobba S,Grassi M,Pellegrini L,Catalan M,Krüger B,Stragapede L,Manganotti P,Bernardis P

更新日期：2020-11-01 00:00:00

abstract：INTRODUCTION:Two phase3 studies (SP512; SP513) involving mostly Caucasian patients showed that rotigotine (≤8 mg/24 h) was efficacious and welltolerated in early-stage Parkinson's disease (PD). We report results from a phase 3 study (SP0914/NCT01646268) investigating rotigotine in Chinese patients with early-stage PD. ...

journal_title：Parkinsonism & related disorders

authors： Zhang ZX,Shang HF,Hu X,Chen S,Zhao Z,Du X,Surmann E,Bauer L,Asgharnejad M

更新日期：2016-07-01 00:00:00

abstract：INTRODUCTION:Spinocerebellar ataxia 48 has recently been described as an adult onset ataxia associated with a cerebellar cognitive affective syndrome, caused by a heterozygous mutation in the STUB1 gene. METHODS:We characterized the clinical and neuroimaging phenotype of eight patients from two autosomal dominant atax...

journal_title：Parkinsonism & related disorders

authors： De Michele G,Lieto M,Galatolo D,Salvatore E,Cocozza S,Barghigiani M,Tessa A,Baldacci J,Pappatà S,Filla A,De Michele G,Santorelli FM

更新日期：2019-08-01 00:00:00

abstract：:Freezing of gait (FOG) is a common phenomenon in Parkinson's disease (PD) affecting over half of those in the advanced stages of the disease and often does not respond to standard drug therapies. This article proposes a possible mechanism by which this disorder of movement comes about. Co-ordinated neural activities a...

journal_title：Parkinsonism & related disorders

authors： Lewis SJ,Barker RA

更新日期：2009-06-01 00:00:00

abstract：:This is a short report illustrating the problems of the prescribing of anti-Parkinson's disease (PD) medication in patients with PD who are admitted acutely to hospital for any reason. There were a large number of complications as a result of inappropriate or lack of anti-PD drug administration and poor understanding ...

journal_title：Parkinsonism & related disorders

authors： Magdalinou KN,Martin A,Kessel B

更新日期：2007-12-01 00:00:00

abstract：:The authors report one case of parkinsonism associated with systemic lupus erythematosus (SLE): a 45-year-old woman, who presented with a strategic infarct of the right substance nigra secondary to vasculitis, and contralateral symptoms. Other causes of parkinsonism were excluded. She had a partial response to therapy...

journal_title：Parkinsonism & related disorders

authors： Orta Daniel SJ,Ulises RO

更新日期：2008-01-01 00:00:00

abstract：:Autosomal recessive juvenile parkinsonism (ARJP/PARK2) is a distinct clinical and genetic entity characterized by early-onset levodopa-responsive parkinsonism, foot dystonia, sleep benefit, and hyperactive tendon reflexes. We report a patient with genetically confirmed ARJP, who showed mild sensory disturbance and dim...

journal_title：Parkinsonism & related disorders

authors： Okuma Y,Hattori N,Mizuno Y

更新日期：2003-06-01 00:00:00

abstract：:The alpha-synuclein gene (SNCA) multiplication causes autosomal dominant Parkinson Disease (PD): triplication is associated with early-onset rapidly progressing parkinsonism with a strong likelihood of developing dementia, while duplication is associated with a less severe phenotype similar to idiopathic PD. We tested...

journal_title：Parkinsonism & related disorders

authors： Sironi F,Trotta L,Antonini A,Zini M,Ciccone R,Della Mina E,Meucci N,Sacilotto G,Primignani P,Brambilla T,Coviello DA,Pezzoli G,Goldwurm S

更新日期：2010-03-01 00:00:00