Prescribing medications in Parkinson's disease (PD) patients during acute admissions to a District General Hospital.

abstract：OBJECTIVE:The primary objective was to evaluate the efficacy and safety of droxidopa as add-on therapy in improving stiffness, tremors and other motor functions and activities of daily living for moderate-to-severe Parkinson's disease (PD). METHODS:PD patients, above Hoehn-Yahr III (including Hoehn-Yahr III), were ran...

journal_title：Parkinsonism & related disorders

authors： Zhao S,Cheng R,Zheng J,Li Q,Wang J,Fan W,Zhang L,Zhang Y,Li H,Liu S

更新日期：2015-10-01 00:00:00

abstract：INTRODUCTION:It is well known that α-synuclein (SNCA) and microtubule associated protein (MAPT) genes predispose individuals to develop Parkinson's disease (PD). However, whether these genes contribute to differences in the variable progression observed in PD is obscure. This study aims to evaluate the association of c...

journal_title：Parkinsonism & related disorders

authors： Wang G,Huang Y,Chen W,Chen S,Wang Y,Xiao Q,Liu J,Fung VS,Halliday G,Chen S

更新日期：2016-03-01 00:00:00

abstract：:The 'hung-up' knee jerk (HUKJ) is a specific, although rarely appreciated, clinical sign of Huntington's Disease. A HUKJ was present in 11 of 31 consecutive patients with Huntington's Disease seen in our practice. The clinical characteristics of these patients are described and an EMG recording of the HUKJ is presente...

journal_title：Parkinsonism & related disorders

authors： Brannan T

更新日期：2003-06-01 00:00:00

abstract：:We report 27 cases of delayed-onset dystonia in patients with antecendents of perinatal asphyxia after excluding other possible causes of dystonia. The patients were 16 males and 11 females (mean +/- SD age at onset of dystonia = 13.0 +/- 9.4 yr). Adverse obstetric and/or perinatal events were presented by 20 patients...

journal_title：Parkinsonism & related disorders

authors： Jiménez-Jiménez FJ,Burguera J,Catalán MJ,Vázquez A,Vaamonde J,Vela-Desojo L,Martínez-Martín P,Balseiro J,Pondal-Sordo M,Domingo J,García-Ruiz PJ,Muñoz-Vázquez A,Molina J,Ceballos-Hernánsont MA,Arcaya J,Duarte J

更新日期：1997-01-01 00:00:00

abstract：BACKGROUND:No effective treatment for tardive dystonia (TD) has been well established. Deep brain stimulation (DBS) can ameliorate motor manifestations in primary dystonia, and may also be an effective approach for TD. OBJECTIVES:This study aimed to illuminate the long-term efficacy and safety of subthalamic nucleus (...

journal_title：Parkinsonism & related disorders

authors： Deng ZD,Li DY,Zhang CC,Pan YX,Zhang J,Jin H,Zeljec K,Zhan SK,Sun BM

更新日期：2017-08-01 00:00:00

abstract：:Parkinson's disease (PD) studies often measure daily motor function with paper diaries resulting in issues of compliance and reliability. The feasibility and compliance of PD patients using electronic diaries were examined. Twelve patients completed diaries for 7 consecutive days. Diaries recorded motor function, time...

journal_title：Parkinsonism & related disorders

authors： Lyons KE,Pahwa R

更新日期：2007-07-01 00:00:00

abstract：INTRODUCTION:Psychosis is one of the common non-motor symptoms of PD, which substantially worsens the quality of life. Hence, it is important to identify factors that are associated with early onset of psychosis in PD. In order to identify those factors, the current study aims to compare various demographic and clinica...

journal_title：Parkinsonism & related disorders

authors： Lenka A,George L,Arumugham SS,Hegde S,Reddy V,Kamble N,Yadav R,Pal PK

更新日期：2017-11-01 00:00:00

abstract：OBJECTIVES:Longitudinal assessment of a Parkinson's disease (PD) cohort, to investigate the evolution or REM sleep behavior symptoms (RBD) over time and to test the relation between RBD at onset and motor dysfunction progression. METHODS:An early stage PD cohort (n = 61) was assessed at two time points, separated by a...

journal_title：Parkinsonism & related disorders

authors： Bugalho P,Viana-Baptista M

更新日期：2013-12-01 00:00:00

abstract：:Involuntary movements are not a known feature of vitamin B12 (vB12) deficiency in adults, though they are a characteristic feature of vB12 deficiency in infants. This case report presents an adult patient with vB12 deficiency in whom, myoclonus-like muscular contractions appeared soon after the initiation of vB12 and ...

journal_title：Parkinsonism & related disorders

authors： Celik M,Barkut IK,Oncel C,Forta H

更新日期：2003-10-01 00:00:00

abstract：INTRODUCTION:Neurotrophic factors (NTFs) have been evaluated for neuroprotective effects in Parkinson's disease (PD). However, clinical trials examining the efficacy of intracerebral administration of NTFs on motor symptoms in PD have produced mixed results, and are thus inconclusive. The objective of this systematic r...

journal_title：Parkinsonism & related disorders

authors： Hegarty SV,Lee DJ,O'Keeffe GW,Sullivan AM

更新日期：2017-05-01 00:00:00

abstract：OBJECTIVES:Type 2 diabetes (T2DM) may increase the risk of Parkinson's disease (PD). We evaluated the role of oral anti-hyperglycemic agents (OAA) in any diabetes-PD linkage. METHODS:From the Taiwan National Health Insurance database on 01-01-2000, a representative cohort of 800,000 was obtained between 1996-01-01 and...

journal_title：Parkinsonism & related disorders

authors： Wahlqvist ML,Lee MS,Hsu CC,Chuang SY,Lee JT,Tsai HN

更新日期：2012-07-01 00:00:00

abstract：OBJECTIVE:To determine the nationwide prevalence of primary dystonia, ataxia and hereditary spastic paraplegia (HSP) in Sweden. METHODS:We extracted data on all patients who were registered in The National Patient Register (NPR) in Sweden (population 9.64 million) at least twice during five consecutive years with a di...

journal_title：Parkinsonism & related disorders

authors： Hellberg C,Alinder E,Jaraj D,Puschmann A

更新日期：2019-12-01 00:00:00

abstract：BACKGROUND:Mutations in GNAL have recently been identified as responsible for primary dystonia, however, GNAL mutations in Chinese patients with primary dystonia are not well characterized. PATIENTS AND METHODS:Fifty-nine unrelated patients with cervical onset or cervical involved primary dystonia and 120 neurological...

journal_title：Parkinsonism & related disorders

authors： Miao J,Wan XH,Sun Y,Feng JC,Cheng FB

更新日期：2013-10-01 00:00:00

abstract：BACKGROUND:Conventional outcome measures (COMs) in Parkinson's disease (PD) refer to rating scales, questionnaires, patient diaries and clinically-based tests that do not require specialized equipment. METHODS:It is timely at this juncture - as clinicians and researchers begin to grapple with the "invasion" of digital...

journal_title：Parkinsonism & related disorders

authors： Lim SY,Tan AH

更新日期：2018-01-01 00:00:00

abstract：INTRODUCTION:In addition to neurogenic orthostatic hypotension (nOH), patients with synucleinopathies frequently have hypertension when supine. The long-term consequences of both abnormalities are difficult to disentangle. We aimed to determine if supine hypertension is associated with target organ damage and worse sur...

journal_title：Parkinsonism & related disorders

authors： Palma JA,Redel-Traub G,Porciuncula A,Samaniego-Toro D,Millar Vernetti P,Lui YW,Norcliffe-Kaufmann L,Kaufmann H

更新日期：2020-06-01 00:00:00

abstract：:Approximately 10% of patients with a presumed diagnosis of Parkinson's disease (PD) remain misdiagnosed despite recent advances in neuroimaging. The current study addresses the use of transcranial sonography and single-photon emission computed tomography (SPECT) using (99m)Tc-TRODAT-1 to evaluate the echogenicity of t...

journal_title：Parkinsonism & related disorders

authors： Bor-Seng-Shu E,Pedroso JL,Felicio AC,de Andrade DC,Teixeira MJ,Braga-Neto P,Batista IR,Barsottini OG,Borges V,Ferraz HB,Shih MC,Bressan RA,de Andrade LA,Walter U

更新日期：2014-05-01 00:00:00

abstract：:Spinocerebellar ataxia (SCA) 17 is a dominant, progressive, neurodegenerative disorder. The disease is caused by a triplet repeat expansion mutation within TATA-binding protein (TBP). Ataxia, dementia, parkinsonism and dystonia are common features. We have previously shown in several pedigrees that SCA-2 and SCA-3 can...

journal_title：Parkinsonism & related disorders

authors： Hernandez D,Hanson M,Singleton A,Gwinn-Hardy K,Freeman J,Ravina B,Doheny D,Gallardo M,Weiser R,Hardy J,Singleton A

更新日期：2003-08-01 00:00:00

abstract：:Invasive human brain recordings have shown that acute therapeutic deep brain stimulation (DBS) reduces cortical synchronization, measured by coupling of beta phase to gamma amplitude. Here we show by noninvasive scalp electroencephalography that withdrawal of chronic DBS elevates phase-amplitude coupling, in proportio...

journal_title：Parkinsonism & related disorders

authors： Rajagopalan SS,Miller AM,de Hemptinne C,San Luciano M,Ostrem JL,Starr PA

更新日期：2019-09-01 00:00:00

abstract：:The recently discovered trace amine associated receptors (TAARs) represent attractive potential mediators of certain aspects of movement control. The TAAR that is best characterized, TAAR1, is particularly interesting because it can be activated by a variety of monoaminergic compounds including trace amines, amphetami...

journal_title：Parkinsonism & related disorders

authors： Sotnikova TD,Zorina OI,Ghisi V,Caron MG,Gainetdinov RR

更新日期：2008-01-01 00:00:00

abstract：:This study presents data on the antemortem evaluations of a cohort of individuals registered in a brain donation program. Clinical evaluation determined that many individuals were unaware they had clinical signs of Parkinson's disease (PD) (rest tremor, bradykinesia, rigidity). Quantitative motor testing (timed tappin...

journal_title：Parkinsonism & related disorders

authors： Adler CH,Hentz JG,Joyce JN,Beach T,Caviness JN

更新日期：2002-12-01 00:00:00

abstract：:We evaluated the diagnostic accuracy of SPECT imaging using [(99m)Tc]TRODAT-1 (TRODAT), a relatively inexpensive technetium-labeled dopamine transporter ligand, in distinguishing 29 patients with early PD from 38 healthy volunteers. Mean TRODAT uptake values were significantly decreased in the caudate (p=0.0097) and a...

journal_title：Parkinsonism & related disorders

authors： Chou KL,Hurtig HI,Stern MB,Colcher A,Ravina B,Newberg A,Mozley PD,Siderowf A

更新日期：2004-08-01 00:00:00

abstract：INTRODUCTION:The aim of this study was to examine the association between mild parkinsonian signs (MPS), cerebral small-vessel disease (SVD), and total SVD burden in patients with vascular risk factors. METHODS:We performed a cross-sectional study among 268 patients with vascular risk factors but without parkinsonism ...

journal_title：Parkinsonism & related disorders

authors： Hatate J,Miwa K,Matsumoto M,Sasaki T,Yagita Y,Sakaguchi M,Kitagawa K,Mochizuki H

更新日期：2016-05-01 00:00:00

abstract：OBJECTIVES:To determine whether vascular parkinsonism (VaP) patients with visually normal dopamine transporter (DAT) scans have presynaptic dopaminergic depletion. METHODS:We enrolled 23 VaP patients who had parkinsonism, relevant diffuse subcortical white matter hyperintensities (WMH), and visually normal DAT scans, ...

journal_title：Parkinsonism & related disorders

authors： Lee YH,Lee S,Chung SJ,Yoo HS,Jung JH,Baik K,Ye BS,Sohn YH,Yun M,Lee PH

更新日期：2021-01-01 00:00:00

abstract：BACKGROUND:The Vanderbilt pilot trial of deep brain stimulation (DBS) in early Parkinson's disease (PD) enrolled patients on medications six months to four years without motor fluctuations or dyskinesias. We conducted a patient-centered analysis based on clinically important worsening of motor symptoms and complication...

journal_title：Parkinsonism & related disorders

authors： Hacker ML,Tonascia J,Turchan M,Currie A,Heusinkveld L,Konrad PE,Davis TL,Neimat JS,Phibbs FT,Hedera P,Wang L,Shi Y,Shade DM,Sternberg AL,Drye LT,Charles D

更新日期：2015-10-01 00:00:00

abstract：:Current concepts regarding the pathogenesis of Parkinson's disease support a model whereby environmental factors conspire with a permissive genetic background to initiate the disease. The identity of the responsible environmental trigger has remained elusive. There is incontrovertible evidence that aggregation of the ...

journal_title：Parkinsonism & related disorders

authors： Woulfe JM,Gray MT,Gray DA,Munoz DG,Middeldorp JM

更新日期：2014-07-01 00:00:00

abstract：INTRODUCTION:Leucine-rich repeat kinase 2 (LRRK2) mutations are the most common genetic cause of Parkinson's disease (PD). However, only few cases carrying LRRK2 mutations have been reported in Taiwanese PD patients. METHODS:We used targeted next generation sequencing (NGS), covering 24 candidate genes involved in neu...

journal_title：Parkinsonism & related disorders

authors： Fan TS,Wu RM,Chen PL,Chen TF,Li HY,Lin YH,Chen CY,Chen ML,Tai CH,Lin HI,Lin CH

更新日期：2016-12-01 00:00:00

abstract：:Pathogenic mutations in the EIF4G1 gene were recently reported as a cause of autosomal dominant parkinsonism. To assess the frequency of EIF4G1 mutations in the Japanese population we sequenced the entire gene coding region (31 exons) in 95 patients with an apparent autosomal dominant inherited form of Parkinson's dis...

journal_title：Parkinsonism & related disorders

authors： Nishioka K,Funayama M,Vilariño-Güell C,Ogaki K,Li Y,Sasaki R,Kokubo Y,Kuzuhara S,Kachergus JM,Cobb SA,Takahashi H,Mizuno Y,Farrer MJ,Ross OA,Hattori N

更新日期：2014-06-01 00:00:00

abstract：:There has been a tremendous development since a regional progression of pathology in subjects with Lewy bodies (LB) was initially proposed 30 years ago. The entity of dementia with Lewy bodies has been acknowledged, the main protein constituent of LBs--aggregated α-synuclein (αS)--has been identified and a stepwise pr...

journal_title：Parkinsonism & related disorders

authors： Alafuzoff I,Parkkinen L

更新日期：2014-01-01 00:00:00

abstract：:Positron emission tomography (PET) scan is considered to be the most useful tool with which to assess the integrity of nigrostriatal function in the living brain. Recently, different genetic defects have been associated with a variety of familial parkinsonian syndromes, the clinical phenotypes of which have varying de...

journal_title：Parkinsonism & related disorders

authors： Pal PK,Wszolek ZK,Uitti R,Markopoulou K,Calne SM,Stoessl AJ,Calne DB

更新日期：2001-09-01 00:00:00

abstract：OBJECTIVE:Mutations in the GBA gene are associated with Parkinson's disease (PD). A definite description of the clinical characteristics of PD patients who are compound heterozygotes or homozygotes for mutations in the GBA gene (GD-PD) requires further elucidation. METHODS:We assessed motor, cognitive, olfactory and a...

journal_title：Parkinsonism & related disorders

authors： Thaler A,Gurevich T,Bar Shira A,Gana Weisz M,Ash E,Shiner T,Orr-Urtreger A,Giladi N,Mirelman A

更新日期：2017-03-01 00:00:00