Washout of chronic therapeutic deep brain stimulation increases cortical phase-amplitude coupling.

abstract：:Dystonia is an incurable movement disorder which can cause not only physical but also mental problems, leading to impaired health-related quality of life (HRQoL). For patients with dystonia refractory to medical treatment, deep brain stimulation (DBS) is a well-established surgical treatment. The objective of this sys...

journal_title：Parkinsonism & related disorders

authors： Tsuboi T,Wong JK,Okun MS,Ramirez-Zamora A

更新日期：2020-01-01 00:00:00

abstract：INTRODUCTION:Pimavanserin is a selective 5-HT2A inverse agonist/antagonist approved for treating hallucinations and delusions associated with Parkinson's disease psychosis (PDP). Results from short-term, placebo-controlled studies demonstrated a positive benefit/risk profile. This multi-year, open-label study assessed ...

journal_title：Parkinsonism & related disorders

authors： Ballard CG,Kreitzman DL,Isaacson S,Liu IY,Norton JC,Demos G,Fernandez HH,Ilic TV,Azulay JP,Ferreira JJ,Abler V,Stankovic S,015 Study Group.

更新日期：2020-08-01 00:00:00

abstract：BACKGROUND:Essential tremor is the most common movement disorder in adults, but its exact etiology and pathophysiology are still not fully understood. There is some consensus, however, about the involvement of the cerebellum and accumulating evidence points towards a dysfunction of the gabaergic system. We hypothesize ...

journal_title：Parkinsonism & related disorders

authors： Gironell A,Figueiras FP,Pagonabarraga J,Herance JR,Pascual-Sedano B,Trampal C,Gispert JD

更新日期：2012-08-01 00:00:00

abstract：:Several factors involved in the etiology of Parkinson's disease (PD) have been proposed, including genetic and environmental factors or even a combination of both. Thus, multiple cellular hits are likely to contribute to neurodegeneration in PD. If such a mechanism happens to occur, our therapeutic intervention may pe...

journal_title：Parkinsonism & related disorders

authors： Hirsch EC

更新日期：2007-01-01 00:00:00

abstract：:Forty patients with Parkinson's disease (PD) were studied to explore the relationship between aspects of psychological functioning (depression, problems in motoric, cognitive and psychological areas) and physical illness (stage and duration of illness, functional disability, global cognitive status). Depression, motor...

journal_title：Parkinsonism & related disorders

authors： Gupta A,Bhatia S

更新日期：2000-07-01 00:00:00

abstract：UNLABELLED:Transcranial magnetic resonance imaging-guided focused ultrasound (tcMRgFUS) is a novel technique to supplement the spectrum of established neurosurgical interventions. In contrast to traditional ablative procedures, tcMRgFUS is noninvasive and entirely imaging-guided with continuous temperature measurements...

journal_title：Parkinsonism & related disorders

authors： Bauer R,Martin E,Haegele-Link S,Kaegi G,von Specht M,Werner B

更新日期：2014-01-01 00:00:00

abstract：INTRODUCTION:The diagnosis of progressive supranuclear palsy is often challenging early in the course of the disease, when clinical signs of the condition may be less apparent and patients do not clearly meet diagnostic criteria. In this study, we examine a potential radiographic marker in progressive supranuclear pals...

journal_title：Parkinsonism & related disorders

authors： Owens E,Krecke K,Ahlskog JE,Fealey R,Hassan A,Josephs KA,Klassen B,Matsumoto J,Bower J

更新日期：2016-07-01 00:00:00

abstract：OBJECTIVE:To investigate the association between Apolipoprotein E (APOE) genotype and freezing of gait (FOG) in Parkinson's disease (PD). METHODS:This cohort study included 339 early PD patients who were divided into APOE ε4-positive (n = 88) and ε4-negative (n = 251) groups. They were followed-up for up to 6 years to...

journal_title：Parkinsonism & related disorders

authors： Kim R,Shin JH,Park S,Kim HJ,Jeon B

更新日期：2020-12-01 00:00:00

abstract：:Patients with advanced Parkinson's Disease (PD) may be eligible for Deep Brain Stimulation (DBS) in case of medication-related motor fluctuations or tremor refractory to oral medication. However, several PD symptoms are unresponsive to DBS and constitute relative contra-indications for DBS. Patients referred for DBS u...

journal_title：Parkinsonism & related disorders

authors： Geraedts VJ,Kuijf ML,van Hilten JJ,Marinus J,Oosterloo M,Contarino MF

更新日期：2019-09-01 00:00:00

abstract：OBJECTIVE:To examine the tolerability and effectiveness of propranolol in treating tardive dyskinesia (TD). BACKGROUND:TD is a disabling, often irreversible, movement disorder that results from chronic therapy with dopamine receptor blocking drugs. There are no treatments currently approved for this disorder. Proprano...

journal_title：Parkinsonism & related disorders

authors： Hatcher-Martin JM,Armstrong KA,Scorr LM,Factor SA

更新日期：2016-11-01 00:00:00

abstract：:Recently, several genes for parkinsonism have been identified. Among them, familial Parkinson's disease (PD) could be assigned for PARK disorders. PARK disorders consist of three different inherited modes such as autosomal recessive, autosomal dominant modes and susceptible genes. Some of them manifest not only typica...

journal_title：Parkinsonism & related disorders

authors： Hattori N

更新日期：2012-01-01 00:00:00

abstract：:Spinocerebellar ataxia (SCA) 17 is a dominant, progressive, neurodegenerative disorder. The disease is caused by a triplet repeat expansion mutation within TATA-binding protein (TBP). Ataxia, dementia, parkinsonism and dystonia are common features. We have previously shown in several pedigrees that SCA-2 and SCA-3 can...

journal_title：Parkinsonism & related disorders

authors： Hernandez D,Hanson M,Singleton A,Gwinn-Hardy K,Freeman J,Ravina B,Doheny D,Gallardo M,Weiser R,Hardy J,Singleton A

更新日期：2003-08-01 00:00:00

abstract：:Clinical symptoms in Parkinson's disease (PD) comprise both motor and non-motor symptoms. In this disease, synucleinopathic-induced, nigral dopamine deficiency-related dysfunction of the basal ganglia is held responsible for the characteristic levodopa-responsive motor signs and symptoms (bradykinesia, hypokinesia, ri...

journal_title：Parkinsonism & related disorders

authors： Wolters ECh

更新日期：2009-12-01 00:00:00

abstract：BACKGROUND:Significant efforts have been focused on investigating the contribution of common variants to Parkinson disease (PD) risk. Several independent GWAS and metanalysis studies have shown a genome-wide significant association of single nucleotide polymorphisms (SNPs) in the α-synuclein (SNCA) and microtubule-asso...

journal_title：Parkinsonism & related disorders

authors： Trotta L,Guella I,Soldà G,Sironi F,Tesei S,Canesi M,Pezzoli G,Goldwurm S,Duga S,Asselta R

更新日期：2012-03-01 00:00:00

abstract：:We report here on a Japanese family in which five members in three generations developed non-progressive adult onset cortical tremor and epilepsy. Other than tremulous movements resembling essential tremor, the neurologic findings were unremarkable. Electrophysiologic studies revealed giant somatosensory evoked potent...

journal_title：Parkinsonism & related disorders

authors： Okuma Y,Shimo Y,Hatori K,Hattori T,Tanaka S,Mizuno Y

更新日期：1997-04-01 00:00:00

abstract：:Primary monogenic forms of dystonia manifest solely or mainly with dystonia; they have been linked to a number of genes and loci and assigned "DYT" numbers. The pure dystonia syndrome early-onset primary dystonia (DYT1) manifests with dominantly-inherited generalized dystonia, often with focal onset in a limb. DYT1 is...

journal_title：Parkinsonism & related disorders

authors： Spatola M,Wider C

更新日期：2012-01-01 00:00:00

abstract：:Duplications and triplications of the alpha-synuclein (SNCA) gene have been reported in Parkinson's disease patients belonging to the Southern Swedish "Lister family". Further genealogical research has now shown that these individuals are descended from a large kindred characterized by Herman Lundborg in 1901-1913. In...

journal_title：Parkinsonism & related disorders

authors： Puschmann A,Wszolek ZK,Farrer M,Gustafson L,Widner H,Nilsson C

更新日期：2009-06-01 00:00:00

abstract：BACKGROUND:The freezing phenomenon is among the most disabling symptoms of Parkinson's disease (PD) manifesting most commonly as Freezing of Gait with a paroxysmal cessation of effective stepping. Recent studies have suggested that freezing is related to both impairments in conflict resolution as well as the processing...

journal_title：Parkinsonism & related disorders

authors： Matar E,Shine JM,Naismith SL,Lewis SJ

更新日期：2013-11-01 00:00:00

abstract：INTRODUCTION:The deep brain stimulation (DBS) withdrawal syndrome (DBS-WDS) is a rare, life-threatening complication in Parkinson's disease (PD) patients with long disease duration and stimulation when stimulation is terminated for extended periods mostly due to infection of the DBS-hardware. METHODS, RESULTS:In five ...

journal_title：Parkinsonism & related disorders

authors： Reuter S,Deuschl G,Berg D,Helmers A,Falk D,Witt K

更新日期：2018-11-01 00:00:00

abstract：BACKGROUND:In patients with GTP-cyclohydrolase deficient dopa-responsive dystonia (DRD) the occurrence of associated non-motor symptoms (NMS) is to be expected. Earlier studies report conflicting results with regard to the nature and severity of NMS. The aim of our study was to investigate the prevalence of psychiatric...

journal_title：Parkinsonism & related disorders

authors： Timmers ER,Kuiper A,Smit M,Bartels AL,Kamphuis DJ,Wolf NI,Poll-The BT,Wassenberg T,Peeters EAJ,de Koning TJ,Tijssen MAJ

更新日期：2017-12-01 00:00:00

abstract：BACKGROUND:Subthalamic nucleus (STN) deep brain stimulation (DBS) has recently been shown to be an effective treatment for Meige syndrome but efficacy of symptomatic improvement and its relationship to factors in DBS remains to be explored. OBJECTIVES:This study explored the relationship of electrode contact location ...

journal_title：Parkinsonism & related disorders

authors： Yao C,Horn A,Li N,Lu Y,Fu Z,Wang N,Aziz TZ,Wang L,Zhang S

更新日期：2019-01-01 00:00:00

abstract：:Parkinson's disease (PD) studies often measure daily motor function with paper diaries resulting in issues of compliance and reliability. The feasibility and compliance of PD patients using electronic diaries were examined. Twelve patients completed diaries for 7 consecutive days. Diaries recorded motor function, time...

journal_title：Parkinsonism & related disorders

authors： Lyons KE,Pahwa R

更新日期：2007-07-01 00:00:00

abstract：:We report 27 cases of delayed-onset dystonia in patients with antecendents of perinatal asphyxia after excluding other possible causes of dystonia. The patients were 16 males and 11 females (mean +/- SD age at onset of dystonia = 13.0 +/- 9.4 yr). Adverse obstetric and/or perinatal events were presented by 20 patients...

journal_title：Parkinsonism & related disorders

authors： Jiménez-Jiménez FJ,Burguera J,Catalán MJ,Vázquez A,Vaamonde J,Vela-Desojo L,Martínez-Martín P,Balseiro J,Pondal-Sordo M,Domingo J,García-Ruiz PJ,Muñoz-Vázquez A,Molina J,Ceballos-Hernánsont MA,Arcaya J,Duarte J

更新日期：1997-01-01 00:00:00

abstract：INTRODUCTION:Psychosis is one of the common non-motor symptoms of PD, which substantially worsens the quality of life. Hence, it is important to identify factors that are associated with early onset of psychosis in PD. In order to identify those factors, the current study aims to compare various demographic and clinica...

journal_title：Parkinsonism & related disorders

authors： Lenka A,George L,Arumugham SS,Hegde S,Reddy V,Kamble N,Yadav R,Pal PK

更新日期：2017-11-01 00:00:00

abstract：BACKGROUND:Clinical differentiation between parkinsonian syndromes (PS) remains a challenge despite well-established clinical diagnostic criteria. Specific diagnostic biomarkers have yet to be identified, though in recent years, studies have been published on the aid of certain brain related proteins (BRP) in the diagn...

journal_title：Parkinsonism & related disorders

authors： Bech S,Hjermind LE,Salvesen L,Nielsen JE,Heegaard NH,Jørgensen HL,Rosengren L,Blennow K,Zetterberg H,Winge K

更新日期：2012-01-01 00:00:00

abstract：INTRODUCTION:Cognitive dysfunction is common in progressive supranuclear palsy (PSP) but its effect on medical decision-making has not been well studied. To address this gap in the research literature, we compared the medical decision-making capacity of patients with PSP to groups of patients with other neurodegenerati...

journal_title：Parkinsonism & related disorders

authors： Gerstenecker A,Grimsley L,Otruba B,Cowden L,Marson DC,Gerstenecker KT,Martin RC,Roberson ED

更新日期：2019-04-01 00:00:00

abstract：INTRODUCTION:Cognitive deficits and neuropsychiatric symptoms occur in parkinsonian and cerebellar subtypes of Multiple System Atrophy (MSA-P and MSA-C). These symptoms have been investigated mainly in cross-sectional studies. The present 1-year follow-up study aimed at evaluating the evolution of cognitive and neurops...

journal_title：Parkinsonism & related disorders

authors： Santangelo G,Cuoco S,Picillo M,Erro R,Squillante M,Volpe G,Cozzolino A,Cicarelli G,Barone P,Pellecchia MT

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:Although orthostatic hypotension (OH) is recognized as one of the main non-motor symptoms of Parkinson's disease (PD), there is inconsistent evidence about the prevalence of OH in PD. To estimate the prevalence of OH in PD more precisely we conducted a systematic review of the literature. METHODS:From PubMe...

journal_title：Parkinsonism & related disorders

authors： Velseboer DC,de Haan RJ,Wieling W,Goldstein DS,de Bie RM

更新日期：2011-12-01 00:00:00

abstract：:An abnormal accumulation and distribution of brain iron are common to different neurodegenerative disorders, including Parkinson's disease (PD), and alteration of genes involved in iron metabolism cause neurodegeneration with brain iron accumulation. HFE participates in the regulation of iron metabolism, its mutations...

journal_title：Parkinsonism & related disorders

authors： Biasiotto G,Goldwurm S,Finazzi D,Tunesi S,Zecchinelli A,Sironi F,Pezzoli G,Arosio P

更新日期：2008-01-01 00:00:00

abstract：:Today, the basal ganglia (BG) network can be viewed as a three-layer neural network in which the striatum and the subthalamic nucleus (STN) are the two BG input structures and together innervate BG downstream structures using GABA and glutamate, respectively. The striatum is larger than the STN and is the main site of...

journal_title：Parkinsonism & related disorders

authors： Deffains M,Bergman H

更新日期：2019-02-01 00:00:00