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Prevalence of orthostatic hypotension in Parkinson's disease: a systematic review and meta-analysis.

Abstract：

BACKGROUND:Although orthostatic hypotension (OH) is recognized as one of the main non-motor symptoms of Parkinson's disease (PD), there is inconsistent evidence about the prevalence of OH in PD. To estimate the prevalence of OH in PD more precisely we conducted a systematic review of the literature. METHODS:From PubMed and Embase searches with predefined inclusion criteria, we identified studies published up till December 2009. Prevalence numbers from studies were pooled using a non-linear random-effects meta-analysis. RESULTS:We found 25 studies from which the prevalence of OH could be calculated. The pooled estimate of the point prevalence of OH in PD was 30.1% (95% CI: 22.9% to 38.4%). We found a large statistical heterogeneity between studies which could not be reduced by several subgroup analyses. CONCLUSIONS:The estimated prevalence of OH in PD is 30%. However, due to the large heterogeneity between studies this pooled estimate should be interpreted with caution. More data from unselected population-based cohorts are needed.

journal_name

Parkinsonism Relat Disord

journal_title

Parkinsonism & related disorders

authors

Velseboer DC,de Haan RJ,Wieling W,Goldstein DS,de Bie RM

doi

10.1016/j.parkreldis.2011.04.016

subject

Has Abstract

pub_date

2011-12-01 00:00:00

pages

724-9

issue

10

eissn

1353-8020

issn

1873-5126

pii

S1353-8020(11)00110-6

journal_volume

17

pub_type

杂志文章,meta分析,评审

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