Motor impairment in normal aging, clinically possible Parkinson's disease, and clinically probable Parkinson's disease: longitudinal evaluation of a cohort of prospective brain donors.

abstract：OBJECTIVE:To investigate whether dopamine transporter (DAT) binding, as measured with single photon emission computed tomography (SPECT), can be used to predict mortality in patients with Parkinson's disease (PD). METHODS:A total of 162 patients with PD and abnormal [I-123]FP-CIT SPECT were clinically followed for a m...

journal_title：Parkinsonism & related disorders

authors： Mäkinen E,Joutsa J,Vahlberg T,Kaasinen V

更新日期：2017-09-01 00:00:00

abstract：:Pathogenic mutations in the EIF4G1 gene were recently reported as a cause of autosomal dominant parkinsonism. To assess the frequency of EIF4G1 mutations in the Japanese population we sequenced the entire gene coding region (31 exons) in 95 patients with an apparent autosomal dominant inherited form of Parkinson's dis...

journal_title：Parkinsonism & related disorders

authors： Nishioka K,Funayama M,Vilariño-Güell C,Ogaki K,Li Y,Sasaki R,Kokubo Y,Kuzuhara S,Kachergus JM,Cobb SA,Takahashi H,Mizuno Y,Farrer MJ,Ross OA,Hattori N

更新日期：2014-06-01 00:00:00

abstract：:Parkinson's disease (PD) is a common neurodegenerative disorder that produces progressive disability despite symptomatic treatment. Several strategies, including stereotaxic brain lesions, deep brain stimulation, transplants of dopamine cells and administration of neurotrophic factors, have been proposed to improve ef...

journal_title：Parkinsonism & related disorders

authors： Fontan A,Rojo A,Sanchez Pernaute R,Hernández I,López I,Castilla C,Sanchez Albisua J,Perez Higueras A,Al-Rashid I,Rabano A,Gonzalo I,Angeles Mena M,Cools A,Eshuis S,Maguire P,Pruim J,Leenders K,Garcia de Yebenes J

更新日期：2002-06-01 00:00:00

abstract：:Autosomal recessive juvenile parkinsonism (ARJP/PARK2) is a distinct clinical and genetic entity characterized by early-onset levodopa-responsive parkinsonism, foot dystonia, sleep benefit, and hyperactive tendon reflexes. We report a patient with genetically confirmed ARJP, who showed mild sensory disturbance and dim...

journal_title：Parkinsonism & related disorders

authors： Okuma Y,Hattori N,Mizuno Y

更新日期：2003-06-01 00:00:00

abstract：BACKGROUND:In addition to classic midbrain pathology, Parkinson's disease (PD) is accompanied by changes in pontine and medullary brainstem structures. These additional abnormalities may underlie non-motor features as well as play a role in motor disability. METHODS:Using novel magnetic resonance imaging (MRI) methods...

journal_title：Parkinsonism & related disorders

authors： Tuite PJ,Mangia S,Tyan AE,Lee MK,Garwood M,Michaeli S

更新日期：2012-06-01 00:00:00

abstract：:Behr syndrome is an autosomal recessive disease characterized by early-onset ataxia, optic atrophy and other signs such as pyramidal tract dysfunction. Autosomal dominant inheritance has also been described. In this case report we present a family pedigree of patients with an inherited autosomal dominant Behr syndrome...

journal_title：Parkinsonism & related disorders

authors： Felicio AC,Godeiro-Junior C,Alberto LG,Pinto AP,Sallum JM,Teive HG,Barsottini OG

更新日期：2008-01-01 00:00:00

abstract：:Six healthy controls and eighteen patients with Parkinson's disease in different disability stages were studied with SPECT using [(123)I]beta-CIT to label the striatal dopamine transporter. The mean uptake of [(123)I]beta-CIT in the putamen was reduced to 54% of the control mean and to 65% of the average control value...

journal_title：Parkinsonism & related disorders

authors： Rinne JO,Kuikka JT,Bergström KA,Rinne UK

更新日期：1995-07-01 00:00:00

abstract：:Anterograde tract-tracing and immunohistochemical methods were used to study projections from the pedunculopontine tegmental nucleus (PPN) to midbrain dopaminergic neurons in the squirrel monkey (Saimiri sciureus). The PPN harbored numerous cholinergic and glutamatergic neurons, as well as neurons that displayed both ...

journal_title：Parkinsonism & related disorders

authors： Parent A,Parent M,Charara A

更新日期：1999-12-01 00:00:00

abstract：INTRODUCTION:Inconsistent results regarding the association between the components of metabolic syndrome and Parkinson's disease (PD) have been reported. We investigated whether the metabolic syndrome or its components, or serum total cholesterol, predict PD incidence in a prospective cohort study design. METHODS:The ...

journal_title：Parkinsonism & related disorders

authors： Sääksjärvi K,Knekt P,Männistö S,Lyytinen J,Heliövaara M

更新日期：2015-10-01 00:00:00

abstract：:The stiff-man syndrome (SMS) is characterised by rigidity and spasm of predominantly axial and proximal limb muscles. The cause of the condition is unknown but the finding of antibodies to glutamic acid decarboxylase (GAD) in approximately 60% of patients has suggested an autoimmune basis. Pathological findings are li...

journal_title：Parkinsonism & related disorders

authors： Thompson PD

更新日期：2001-10-01 00:00:00

abstract：:Parkinson's disease (PD) is the most common neurodegenerative movement disorder. Currently, no curative treatments or treatments that interdict disease progression are available. Over the past decade, immunization strategies were developed in our laboratories to combat disease progression. These strategies were develo...

journal_title：Parkinsonism & related disorders

authors： Ha D,Stone DK,Mosley RL,Gendelman HE

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:Non-motor symptom (NMS) differences between male Parkinson's disease (PD) and female PD, and between early-onset PD (EOPD) and late-onset PD (LOPD) in Chinese populations remain largely unknown. METHODS:A total of 522 PD patients from Southwest China were included. Patients were assessed using the Non-Motor...

journal_title：Parkinsonism & related disorders

authors： Guo X,Song W,Chen K,Chen X,Zheng Z,Cao B,Huang R,Zhao B,Wu Y,Shang HF

更新日期：2013-11-01 00:00:00

abstract：BACKGROUND:Mutations in GNAL have recently been identified as responsible for primary dystonia, however, GNAL mutations in Chinese patients with primary dystonia are not well characterized. PATIENTS AND METHODS:Fifty-nine unrelated patients with cervical onset or cervical involved primary dystonia and 120 neurological...

journal_title：Parkinsonism & related disorders

authors： Miao J,Wan XH,Sun Y,Feng JC,Cheng FB

更新日期：2013-10-01 00:00:00

abstract：INTRODUCTION:Physical inactivity in Parkinson disease (PD) has an impact on motor and non-motor symptoms of the disease. It is unclear whether this decline in physical activity occurs early in the disease, in addition to any decline due to aging, and whether commercial activity monitors can be used to self-monitor phys...

journal_title：Parkinsonism & related disorders

authors： Pradhan S,Kelly VE

更新日期：2019-09-01 00:00:00

abstract：OBJECTIVE:To investigate the association between Apolipoprotein E (APOE) genotype and freezing of gait (FOG) in Parkinson's disease (PD). METHODS:This cohort study included 339 early PD patients who were divided into APOE ε4-positive (n = 88) and ε4-negative (n = 251) groups. They were followed-up for up to 6 years to...

journal_title：Parkinsonism & related disorders

authors： Kim R,Shin JH,Park S,Kim HJ,Jeon B

更新日期：2020-12-01 00:00:00

abstract：INTRODUCTION:Recent work suggests that wearables can augment conventional measures of Parkinson's disease (PD). We evaluated the relationship between conventional measures of disease and motor severity (e.g., MDS-UPDRS part III), laboratory-based measures of gait and balance, and daily-living physical activity measures...

journal_title：Parkinsonism & related disorders

authors： Galperin I,Hillel I,Del Din S,Bekkers EMJ,Nieuwboer A,Abbruzzese G,Avanzino L,Nieuwhof F,Bloem BR,Rochester L,Della Croce U,Cereatti A,Giladi N,Mirelman A,Hausdorff JM

更新日期：2019-05-01 00:00:00

abstract：:Levodopa serves as the gold standard of anti-parkinsonian therapy and nearly every patient with Parkinson's disease eventually receives this drug. To improve upon levodopa therapy, several forms of treatment have been devised to augment its actions, and new delivery systems are under development. This new research off...

journal_title：Parkinsonism & related disorders

authors： LeWitt PA

更新日期：2009-01-01 00:00:00

abstract：:Positron emission tomography (PET) scan is considered to be the most useful tool with which to assess the integrity of nigrostriatal function in the living brain. Recently, different genetic defects have been associated with a variety of familial parkinsonian syndromes, the clinical phenotypes of which have varying de...

journal_title：Parkinsonism & related disorders

authors： Pal PK,Wszolek ZK,Uitti R,Markopoulou K,Calne SM,Stoessl AJ,Calne DB

更新日期：2001-09-01 00:00:00

abstract：:Tardive dyskinesia (TD) is a common, iatrogenic movement disorder affecting many individuals treated with dopamine-receptor blocking agents (DRBAs). Studying treatment of TD can be complex, as the symptoms can be affected by changes in either dosage or type of DRBA, as well as by the variable natural course of the dis...

journal_title：Parkinsonism & related disorders

authors： Margolius A,Fernandez HH

更新日期：2019-02-01 00:00:00

abstract：OBJECTIVE:To demonstrate that degeneration of substantia nigra neurons may occur at later stages of disease in some patients with corticobasal syndrome (CBS) who evidenced preserved nigrostriatal pathway at a baseline FP-CIT SPECT study. BACKGROUND:Current pathological criteria for the definite diagnosis of corticobas...

journal_title：Parkinsonism & related disorders

authors： Ceravolo R,Rossi C,Cilia R,Tognoni G,Antonini A,Volterrani D,Bonuccelli U

更新日期：2013-05-01 00:00:00

abstract：BACKGROUND:Japan and the United States (US) have different cultures of caregiving including differences in family structure and social programs that may influence caregiver strain. Differences in caregiver strain between regions in Japan and in the US have not been investigated in patient-spouse dyads in PD. OBJECTIVE...

journal_title：Parkinsonism & related disorders

authors： Tanji H,Koyama S,Wada M,Kawanami T,Kurita K,Tamiya G,Saito N,Suzuki K,Kato T,Anderson KE,Gruber-Baldini AL,Fishman PS,Reich SG,Weiner WJ,Shulman LM

更新日期：2013-06-01 00:00:00

abstract：OBJECTIVES:Longitudinal assessment of a Parkinson's disease (PD) cohort, to investigate the evolution or REM sleep behavior symptoms (RBD) over time and to test the relation between RBD at onset and motor dysfunction progression. METHODS:An early stage PD cohort (n = 61) was assessed at two time points, separated by a...

journal_title：Parkinsonism & related disorders

authors： Bugalho P,Viana-Baptista M

更新日期：2013-12-01 00:00:00

abstract：:We describe the outcome of deep brain stimulation of the internal pallidum in a 57-year old patient with multiple system atrophy. Although the prominent dystonic features of this patient were markedly attenuated post-operatively, the outcome was to be considered unfavourable. There was a severe increase in akinesia re...

journal_title：Parkinsonism & related disorders

authors： Santens P,Vonck K,De Letter M,Van Driessche K,Sieben A,De Reuck J,Van Roost D,Boon P

更新日期：2006-04-01 00:00:00

abstract：INTRODUCTION:Continuous infusion of levodopa/carbidopa intestinal gel (LCIG) is an effective treatment for patients with advanced Parkinson Disease (PD) that cannot be further improved by oral therapy. METHODS:We conducted an observational, prospective, and multicenter study to collect, in a large sample of PD treated...

journal_title：Parkinsonism & related disorders

authors： Buongiorno M,Antonelli F,Cámara A,Puente V,de Fabregues-Nebot O,Hernandez-Vara J,Calopa M,Pascual-Sedano B,Campolongo A,Valldeoriola F,Tolosa E,Kulisevsky J,Martí MJ

更新日期：2015-08-01 00:00:00

abstract：OBJECTIVES:Compare the efficacy of two walking assistance devices (wheeled walker and standard walker) to unassisted walking for patients with PD and gait freezing. BACKGROUND:Although numerous walking devices are used clinically, their relative effects on freezing and walking speed have never been systematically test...

journal_title：Parkinsonism & related disorders

authors： Cubo E,Moore CG,Leurgans S,Goetz CG

更新日期：2003-10-01 00:00:00

abstract：BACKGROUND:Deep brain stimulation of the subthalamic nucleus (STN-DBS) reduces motor fluctuations in Parkinson's disease (PD) but its effect on non-motor fluctuations (NMF) is not well known. In this study we assess the efficacy of STN-DBS on NMF two years after surgery. METHODS:Autonomic, cognitive, psychiatric and s...

journal_title：Parkinsonism & related disorders

authors： Ortega-Cubero S,Clavero P,Irurzun C,Gonzalez-Redondo R,Guridi J,Obeso JA,Rodriguez-Oroz MC

更新日期：2013-05-01 00:00:00

abstract：:The mild cognitive impairment (MCI) concept was developed to identify the earliest stages of cognitive impairment. MCI and, more specifically, amnestic MCI were initially proposed as transitional states that ultimately progress to full blown Alzheimer's disease (AD). However, MCI subjects do not uniformly progress to ...

journal_title：Parkinsonism & related disorders

authors： Korczyn AD

更新日期：2016-01-01 00:00:00

abstract：:Knowledge of molecular events contributing to motor dysfunction in Parkinson's disease has advanced rapidly during the past decade. Studies in animal models as well as in patients afflicted by this disorder suggest that the nonphysiologic stimulation of striatal dopamine receptors, first as a result of dopaminergic de...

journal_title：Parkinsonism & related disorders

authors： Chase TN

更新日期：2004-07-01 00:00:00

abstract：:We studied daytime sleepiness in 160 patients with Parkinson's disease and 40 normal subjects. We compared the prevalence of daytime sleepiness in patients who were taking levodopa alone, levodopa with bromocriptine, levodopa with ropinirole, and levodopa with pramipexole. We found that (1) all these anti-Parkinson dr...

journal_title：Parkinsonism & related disorders

authors： Sanjiv CC,Schulzer M,Mak E,Fleming J,Martin WR,Brown T,Calne SM,Tsui J,Stoessl AJ,Lee CS,Calne DB

更新日期：2001-10-01 00:00:00

abstract：:Parkinson's disease (PD) is a common neurodegenerative disorder of unknown cause. For decades, a deficit in mitochondrial respiration was thought to be a key factor in PD neurodegeneration. However, excluding a few exceptions where a clinical picture of parkinsonism is associated with a mitochondrial DNA mutation, pre...

journal_title：Parkinsonism & related disorders

authors： Vives-Bauza C,de Vries RL,Tocilescu MA,Przedborski S

更新日期：2009-12-01 00:00:00