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Psychiatric disturbances in patients with progressive supranuclear palsy: a case-control study.

Abstract：

OBJECTIVES:To investigate the frequency and the different types of psychiatric disturbances in PSP patients using validated psychiatric instruments. METHODS:We conducted a case-control study using the Structured Clinical Interview (SCID-I) for DSM-IV to investigate psychiatric disorders in 28 PSP patients and 28 age and gender matched healthy controls. PSP severity was scored using the PSP rating scale; cognitive functions were assessed using the Montreal Cognitive Assessment scale and the Frontal Assessment Battery scale. RESULTS:SCID-I disclosed that psychiatric disturbances were more frequent in PSP patients (53%) than in healthy controls (17.8%) (p = 0.005). Psychiatric disorders in PSP patients were characterized by mood disorders. Depression due to PSP was the most frequent diagnosis and was found in 8 of the 15 patients with depressive disorders. None of the PSP patients had a diagnosis of other SCID-I disorders. No clinical or demographic differences were found when comparing PSP patients with and without psychiatric disturbances. CONCLUSIONS:Psychiatric disturbances, namely depressive disorders, were more frequent in PSP patients than in controls. A thorough evaluation of psychiatric disorders is important to insure appropriate treatment of PSP patients..

journal_name

Parkinsonism Relat Disord

journal_title

Parkinsonism & related disorders

authors

Bloise MC,Berardelli I,Roselli V,Pasquini M,Stirpe P,Colosimo C,Berardelli A,Fabbrini G

doi

10.1016/j.parkreldis.2014.05.015

subject

Has Abstract

pub_date

2014-09-01 00:00:00

pages

965-8

issue

9

eissn

1353-8020

issn

1873-5126

pii

S1353-8020(14)00218-1

journal_volume

20

pub_type

临床试验,杂志文章

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