abstract：BACKGROUND AND AIMS:Arterial stiffness is a risk factor for chronic kidney disease progression (CKD). Pulse pressure is a surrogate marker of arterial stiffness. It is unclear if pulse pressure predicts CKD progression in type 2 diabetes mellitus. METHODS:This was prospective study involving 1494 patients with estimat...

journal_title：Journal of nephrology

authors： Low S,Moh A,Ang SF,Lim CL,Liu YL,Wang J,Ang K,Tang WE,Kwan PY,Lim Z,Subramaniam T,Sum CF,Lim SC

更新日期：2021-01-25 00:00:00

abstract：BACKGROUND:Atypical haemolytic uremic syndrome (aHUS) is at high risk of relapse at any time, therefore patients require lifelong monitoring. The most appropriate way to monitor patients is not yet clear. Patients could be monitored for relapse by urine dipstick testing for haemoglobinuria based on the hypothesis that ...

journal_title：Journal of nephrology

authors： Brambilla M,Ardissino G,Paglialonga F,Testa S,Capone V,Montini G

更新日期：2021-01-18 00:00:00

abstract：BACKGROUND:Neurocognitive impairment is commonly reported in patients with chronic kidney disease (CKD). The precise nature of this impairment is unclear, due to the lack of objective and quantitative assessment tools used. The feasibility of using robotic technology to precisely quantify neurocognitive impairment in p...

journal_title：Journal of nephrology

authors： Vanderlinden JA,Holden RM,Scott SH,Boyd JG

更新日期：2021-01-05 00:00:00

abstract：:Acute kidney injury (AKI) is an increasing health burden with high morbidity and mortality rates worldwide. AKI is a risk factor for chronic kidney disease (CKD) development and progression to end stage renal disease (ESRD). Rapid action is required to find treatment options for AKI, plus to anticipate the development...

journal_title：Journal of nephrology

authors： Kurzhagen JT,Dellepiane S,Cantaluppi V,Rabb H

更新日期：2020-12-01 00:00:00

abstract：:Patients with type 2 diabetes run a high risk for progressive renal function loss. Many interventions have been tested to reduce the risk, but we are nowadays still confronted with a high unmet need. To improve on this unmet need, we will have to change the current strategies in drug discovery, clinical trials and cli...

journal_title：Journal of nephrology

authors： de Zeeuw D

更新日期：2020-12-01 00:00:00

abstract：BACKGROUND:Improved responsiveness to erythropoiesis stimulating agents (ESAs) in patients on on-line post-dilution hemodiafiltration (Post-HDF) compared with conventional hemodialysis (HD) was reported by some authors but challenged by others. This prospective, cross-over randomized study tested the hypothesis that an...

journal_title：Journal of nephrology

authors： Pedrini LA,Comelli M,Ruggiero P,Feliciani A,Manfrini V,Cozzi G,Castellano A,Pezzotta M,Gatti G,Arazzi M,Auriemma L,di Benedetto A,Stuard S

更新日期：2020-10-01 00:00:00

abstract：:The clinical manifestations of diabetic nephropathy are similar in type 1 and type 2 diabetes, while the renal lesions may differ. Indeed, diabetic glomerulopathy is the predominant renal lesion in type 1 diabetes, although also tubular, interstitial and arteriolar lesions are present in the advanced stages of renal d...

journal_title：Journal of nephrology

authors： Di Vincenzo A,Bettini S,Russo L,Mazzocut S,Mauer M,Fioretto P

更新日期：2020-10-01 00:00:00

abstract：:Diabetic kidney disease (DKD) affects approximately one-third of patients with diabetes and taking into consideration the high cardiovascular risk burden associated to this condition a multifactorial therapeutic approach is traditionally recommended, in which glucose and blood pressure control play a central role. The...

journal_title：Journal of nephrology

authors： Leoncini G,Viazzi F,De Cosmo S,Russo G,Fioretto P,Pontremoli R

更新日期：2020-10-01 00:00:00

abstract：BACKGROUND:Gut-derived uremic toxins have been associated with adverse outcomes in chronic kidney disease (CKD). Alterations in bowel habits, including constipation, seem to play an additional role in uremic toxicity. The aim of this study is to investigate the association of bowel habits with gut-derived uremic toxins...

journal_title：Journal of nephrology

authors： Pereira NBF,Ramos CI,de Andrade LS,Teixeira RR,Nakao LS,Rodrigues SD,de Lima JD,Dalboni MA,Cuppari L

更新日期：2020-10-01 00:00:00

abstract：:The term sarcopenia was first introduced in 1988 by Irwin Rosenberg to define a condition of muscle loss that occurs in the elderly. Since then, a broader definition comprising not only loss of muscle mass, but also loss of muscle strength and low physical performance due to ageing or other conditions, was developed a...

journal_title：Journal of nephrology

authors： Sabatino A,Cuppari L,Stenvinkel P,Lindholm B,Avesani CM

更新日期：2020-09-02 00:00:00

abstract：BACKGROUND:Malnutrition is common and associated with poor outcomes in patients with chronic kidney disease (CKD) and end-stage renal disease (ESRD). Recently, the geriatric nutritional risk index (GNRI) was reported as a novel tool for evaluating nutritional status. However, the association between GNRI and renal outc...

journal_title：Journal of nephrology

authors： Xiong J,Wang M,Wang J,Yang K,Shi Y,Zhang J,Zhang B,Zhang L,Zhao J,Chinese Cohort Study of Chronic Kidney Disease (C-STRIDE).

更新日期：2020-08-01 00:00:00

abstract：:The presence of circulating permeability factors (cPFs) has been hypothesized to be associated with recurrence of focal segmental glomerulosclerosis (rFSGS) in renal allografts. The available methods to detect cPFs are complex, not easily repeatable and inappropriate to represent the anatomical characteristics of the ...

journal_title：Journal of nephrology

authors： Li M,Alfieri CM,Morello W,Cellesi F,Armelloni S,Mattinzoli D,Montini G,Messa P

更新日期：2020-08-01 00:00:00

abstract：BACKGROUND:Patients (pts) with primary Membranous nephropathy (MN) have an autoimmune disease caused by autoantibodies against podocyte antigens and 60-80% of them have antibodies directed against the M-type phospholipase A2 receptor (PLA2R). Immunosuppressive treatment is recommended in high-medium risk pts. Recently ...

journal_title：Journal of nephrology

authors： Fenoglio R,Baldovino S,Sciascia S,De Simone E,Del Vecchio G,Ferro M,Quattrocchio G,Naretto C,Roccatello D

更新日期：2020-06-27 00:00:00

abstract：:Kidney stone disease is a common condition with a high recurrence rate and elevated costs. Despite the well-known positive effects of high fluid intake, there are little data about the roles of water composition and timing of ingestion during the day. This study examines the effect of two different waters [calcium-bic...

journal_title：Journal of nephrology

authors： Ferraro PM,Baccaro R,Baroni S,D'Alessandri L,Carpenito C,Di Daniele N,Urbani A,Gambaro G

更新日期：2020-06-08 00:00:00

abstract：:Patients with chronic kidney disease (CKD) have a greatly enhanced risk of cardiovascular morbidity and mortality. Over the past decade it has come clear that a disturbed calcium-phosphate metabolism, with Fibroblast Growth Factor-23 as a key hormone, is partly accountable for this enhanced risk. Numerous studies have...

journal_title：Journal of nephrology

authors： Bouma-de Krijger A,Vervloet MG

更新日期：2020-06-01 00:00:00

abstract：:The most common cause of liver disease worldwide is now non-alcoholic fatty liver disease (NAFLD). NAFLD refers to a spectrum of disease ranging from steatosis to non-alcoholic steatohepatitis, causing cirrhosis, and ultimately hepatocellular carcinoma. However, the impact of NAFLD is not limited to the liver. NAFLD h...

journal_title：Journal of nephrology

authors： Kanbay M,Bulbul MC,Copur S,Afsar B,Sag AA,Siriopol D,Kuwabara M,Badarau S,Covic A,Ortiz A

更新日期：2020-05-21 00:00:00

abstract：:Urine samples can be readily obtained from patients in everyday clinical practice. Therefore, the availability of urine allows physicians to obtain relevant clinical information in a timely manner. Since the measurement of urinary protein levels is essential in diagnosing and treating a host of diseases, the potential...

journal_title：Journal of nephrology

authors： Résimont G,Piéroni L,Bigot-Corbel E,Cavalier E,Delanaye P

更新日期：2020-04-23 00:00:00

abstract：AIMS:This joint document of the Italian Diabetes Society and the Italian Society of Nephrology reviews the natural history of diabetic kidney disease (DKD) in the light of the recent epidemiological literature and provides updated recommendations on anti-hyperglycemic treatment with non-insulin agents. DATA SYNTHESIS:...

journal_title：Journal of nephrology

authors： Pugliese G,Penno G,Natali A,Barutta F,Di Paolo S,Reboldi G,Gesualdo L,De Nicola L,Italian Diabetes Society and the Italian Society of Nephrology.

更新日期：2020-02-01 00:00:00

abstract：:Synthetic immunosuppressive drugs are largely used in immune-related renal diseases and in kidney transplantation. Most of these drugs have a low therapeutic index (the ratio that compares the blood concentration at which a drug becomes toxic and the concentration at which the drug is effective), which means that the ...

journal_title：Journal of nephrology

authors： Ponticelli C,Glassock RJ

更新日期：2019-12-01 00:00:00

abstract：BACKGROUND:Cardiac surgery-associated acute kidney injury (CSA-AKI) is associated with high risk for complications and mortality. Whether renin-angiotensin system (RAS) inhibitor should be continued or withdrawn in patients with long-term use before cardiac surgery has been lack of consensus. METHODS:We performed this...

journal_title：Journal of nephrology

authors： Chou YH,Huang TM,Wu VC,Chen WS,Wang CH,Chou NK,Chiang WC,Chu TS,Lin SL,National Taiwan University Study Group on Acute Renal Failure (NSARF).

更新日期：2019-12-01 00:00:00

abstract：BACKGROUND:Incremental dialysis may preserve residual renal function and improve survival in comparison with full-dose dialysis; however, available evidence is limited. We therefore compared all-cause mortality and residual kidney function (RKF) loss in incremental and full-dose dialysis and time to full-dose dialysis ...

journal_title：Journal of nephrology

authors： Garofalo C,Borrelli S,De Stefano T,Provenzano M,Andreucci M,Cabiddu G,La Milia V,Vizzardi V,Sandrini M,Cancarini G,Cupisti A,Bellizzi V,Russo R,Chiodini P,Minutolo R,Conte G,De Nicola L

更新日期：2019-10-01 00:00:00

abstract：:A symposium on kidney stones and mineral metabolism held on December 2017 in Brussels, Belgium was the first international multidisciplinary conference of the International Collaborative Network on Kidney Stones and Mineral Metabolism. This meeting addressed epidemiology, underlying pathophysiological mechanisms, gene...

journal_title：Journal of nephrology

authors： Pozdzik A,Maalouf N,Letavernier E,Brocheriou I,Body JJ,Vervaet B,Van Haute C,Noels J,Gadisseur R,Castiglione V,Cotton F,Gambaro G,Daudon M,Sakhaee K

更新日期：2019-10-01 00:00:00

abstract：:Clinically apparent venous thromboembolism (VTE) occurs in approximately 7% of patients with membranous nephropathy. Hypoalbuminemia at diagnosis is an independent risk factor for VTE, and risk increases significantly as albumin falls. Optimal prophylactic and treatment anticoagulation regimens in the nephrotic syndro...

journal_title：Journal of nephrology

authors： Reynolds ML,Nachman PH,Mooberry MJ,Crona DJ,Derebail VK

更新日期：2019-08-01 00:00:00

abstract：OBJECTIVE:Intradialytic exercise (IDE) is not yet a routine practice for hemodialysis patients, the lack of guidelines supporting it being a major reason. This systematic review and meta-analysis of aerobic IDE interventions examined the efficacy of IDE regarding quality of life (QOL), serum phosphorus, dialysis effici...

journal_title：Journal of nephrology

authors： Salhab N,Karavetian M,Kooman J,Fiaccadori E,El Khoury CF

更新日期：2019-08-01 00:00:00

abstract：BACKGROUND:The clinical benefits of on-line hemodiafiltration (HDF) versus high-flux membranes hemodialysis (hf-HD) are still debated. In fact, although a superiority of one treatment over the other, especially in terms of mortality, did not emerge from the analysis of clinical trials, improved intradialytic vascular s...

journal_title：Journal of nephrology

authors： La Milia V,Ravasi C,Carfagna F,Alberghini E,Baragetti I,Buzzi L,Ferrario F,Furiani S,Barbone GS,Pontoriero G

更新日期：2019-06-01 00:00:00

abstract：OBJECTIVE:Chronic kidney disease (CKD) pregnancies are at high risk of developing adverse outcomes. In non-pregnant subjects with CKD, higher urinary IgM levels are associated with poor renal survival and higher rates of cardiovascular deaths. In this study, we assessed whether urinary IgM levels are associated with an...

journal_title：Journal of nephrology

authors： Leaños-Miranda A,Campos-Galicia I,Ramírez-Valenzuela KL,Berumen-Lechuga MG,Isordia-Salas I,Molina-Pérez CJ

更新日期：2019-04-01 00:00:00

abstract：:The abnormal metabolism of uric acid results in many disease such as chronic kidney disease, hyperuricemia, nephrolithiasis, gout, hypertension, vascular disease and so on. Serum uric acid levels are maintained by the balance between production and elimination. There are many factors that maintain the balance of serum...

journal_title：Journal of nephrology

authors： Wang Z,Cui T,Ci X,Zhao F,Sun Y,Li Y,Liu R,Wu W,Yi X,Liu C

更新日期：2019-04-01 00:00:00

abstract：:Late-presenting end-stage renal disease is a significant problem worldwide. Up to 70% of patients start dialysis in an unplanned manner without a definitive dialysis access in place. Haemodialysis via a central venous catheter is the default modality for the majority of such patients, and peritoneal dialysis is usuall...

journal_title：Journal of nephrology

authors： Javaid MM,Khan BA,Subramanian S

更新日期：2019-02-01 00:00:00

abstract：BACKGROUND:The prominent features of autosomal dominant polycystic kidney disease (ADPKD) are early development of hypertension, chronic kidney disease and cardiovascular problems. Thus, we aimed to investigate the role of endothelin, a vascular biomarker, in the clinical course of ADPKD, including renal and cardiovasc...

journal_title：Journal of nephrology

authors： Kocyigit I,Eroglu E,Kaynar AS,Kocer D,Kargi S,Zararsiz G,Bayramov R,Imamoglu H,Sipahioglu MH,Tokgoz B,Dundar M,Oymak O

更新日期：2019-02-01 00:00:00

abstract：:Epicardial adipose tissue (EAT) is localized between the myocardial surface and visceral layer of the pericardium. It is a metabolically active organ that secretes several cytokines which modulate cardiovascular morphology and function. EAT may interact locally with coronary arteries through paracrine secretion mechan...

journal_title：Journal of nephrology

authors： Russo R,Di Iorio B,Di Lullo L,Russo D

更新日期：2018-12-01 00:00:00

abstract：OBJECTIVE:To investigate the pregnancy outcomes for patients with stage 3-4 chronic kidney disease (CKD) and the effects of pregnancy on kidney function. METHODS:Clinical data of pregnant women with CKD in the Peking University First Hospital between January 1st 2005 and October 1st 2016 were retrospectively analysed....

journal_title：Journal of nephrology

authors： He Y,Liu J,Cai Q,Lv J,Yu F,Chen Q,Zhao M

更新日期：2018-12-01 00:00:00

abstract：BACKGROUND:In older patients with chronic kidney disease (CKD), the risk of progression to end stage renal disease and cardiovascular death both differ compared to younger patients. This likely reflects differences in case mix and co-morbid burdens. We sought to establish the extent to which age itself is an independen...

journal_title：Journal of nephrology

authors： Raman M,Green D,Middleton RJ,Kalra PA

更新日期：2018-12-01 00:00:00

abstract：:IgM secreting myelomas or lymphomas, including Waldenström macroglobulinemia, are associated with a varied spectrum of renal pathology, including intracapillary hyaline deposits, cryoglobulin, membranoproliferative glomerulonephritis, amyloid, monoclonal immunoglobulin deposition disease, cast nephropathy, and lymphom...

journal_title：Journal of nephrology

authors： Tan SYS,Sibley RK,Belani S,Iwasaki S,Yankulin L,Jonelis T,Higgins JPT,Kambham N,Troxell ML

更新日期：2018-12-01 00:00:00

abstract：:Hepatitis C virus (HCV) infection is now considered a systemic disease due to the occurrence of extra-hepatic manifestations. Among these, the renal involvement is frequent. HCV infection, in fact, is strongly associated with proteinuria and chronic kidney disease (CKD) and negatively affects the prognosis of renal pa...

journal_title：Journal of nephrology

authors： Minutolo R,Aghemo A,Chirianni A,Fabrizi F,Gesualdo L,Giannini EG,Maggi P,Montinaro V,Paoletti E,Persico M,Perticone F,Petta S,Puoti M,Raimondo G,Rendina M,Zignego AL,Italian Society of Nephrology (SIN).,Italian Associat

更新日期：2018-10-01 00:00:00

abstract：BACKGROUND:Acute kidney injury (AKI) following acute ST elevation myocardial infarction (STEMI) is associated with adverse outcomes. The recently proposed KDIGO criteria suggested modifications to the consensus classification system for AKI, namely lowering the threshold of increase in absolute serum creatinine and ext...

journal_title：Journal of nephrology

authors： Margolis G,Gal-Oz A,Letourneau-Shesaf S,Khoury S,Keren G,Shacham Y

更新日期：2018-06-01 00:00:00

abstract：:Aim of the study was the definition of a predictive model for the initial diagnosis of thrombotic microangiopathies (TMA). We retrospectively collected data on all adult patients admitted to the Gemelli Hospital from 2010 to 2014. ICD-9 codes from primary diagnoses were used for TMA diagnosis. Demographic and laborato...

journal_title：Journal of nephrology

authors： Ferraro PM,Lombardi G,Naticchia A,Sturniolo A,Zuppi C,De Stefano V,Bonelli P,Buonocore R,Cervellin G,Lippi G,Gambaro G

更新日期：2018-06-01 00:00:00

abstract：:Influenza is a commonly encountered and serious pathogen. Patients with end-stage renal disease are more susceptible to serious morbidity and mortality associated with influenza infection. Proper management of patients includes: vaccination, monitoring for symptoms and isolation of potentially infected patients as wel...

journal_title：Journal of nephrology

authors： Bowman BT,Rosner MH

更新日期：2018-04-01 00:00:00

abstract：:Hyperuricosuric calcium urolithiasis is a condition of mixed calcium oxalate stones characterized by hyperuricosuria either in isolation or in conjunction with other risk factors for calcium oxalate stones such as hypercalciuria, hyperoxaluria, and hypocitraturia. There are three proposed physicochemical models of pat...

journal_title：Journal of nephrology

authors： Moe OW,Xu LHR

更新日期：2018-04-01 00:00:00

abstract：BACKGROUND:Rural-dwelling hemodialysis patients have less frequent contact with nephrologists than urban-dwelling patients, and are known to have higher mortality. We hypothesized that rural-dwelling hemodialysis patients would have more evidence of poorly controlled extracellular fluid volume (ECVF) than otherwise sim...

journal_title：Journal of nephrology

authors： Tonelli M,Lloyd A,Pannu N,Klarenbach S,Ravani P,Jindal K,MacRae J,Unsworth L,Manns B,Hemmelgarn B

更新日期：2018-02-01 00:00:00

abstract：BACKGROUND AND AIMS:Encapsulating peritoneal sclerosis (EPS) is an uncommon but severe complication of peritoneal dialysis (PD). A reliable screening tool to identify patients at risk of developing or not EPS is currently not available. We aimed to evaluate whether the reduction in dialysate sodium concentration (sodiu...

journal_title：Journal of nephrology

authors： La Milia V,Longhi S,Sironi E,Pontoriero G

更新日期：2018-02-01 00:00:00