Abstract:
BACKGROUND:Neurocognitive impairment is commonly reported in patients with chronic kidney disease (CKD). The precise nature of this impairment is unclear, due to the lack of objective and quantitative assessment tools used. The feasibility of using robotic technology to precisely quantify neurocognitive impairment in patients with CKD is unknown. METHODS:Patients with stage 4 and 5 CKD with no previous history of stroke or neurodegenerative disease were eligible for study enrollment. Feasibility was defined as successful study enrollment, high data capture rates (> 90%), and assessment tolerability. Our assessment included a traditional assessment: The Repeatable Battery for the Assessment of Neuropsychological Status (RBANS), and a robot-based assessment: Kinarm. RESULTS:Our enrollment rate was 1.6 patients/month. All patients completed the RBANS portion of the assessment, with a 97.8% (range 92-100%) completion rate on Kinarm. Missing data on Kinarm were mainly due to time constraints. Data from 49 CKD patients were analyzed. Kinarm defined more individuals as impaired, compared to RBANS, particularly in the domains of perceptual-motor function (17-49% impairment), complex attention (22-49% impairment), and executive function (29-37.5% impairment). Demographic features (sex and education) predicted performance on some, but not all neurocognitive tasks. CONCLUSIONS:It is feasible to quantify neurocognitive impairments in patients with CKD using robotic technology. Kinarm characterized more patients with CKD as impaired, and importantly identified novel perceptual-motor impairments in these patients, when compared to traditional assessments.
journal_name
J Nephroljournal_title
Journal of nephrologyauthors
Vanderlinden JA,Holden RM,Scott SH,Boyd JGdoi
10.1007/s40620-020-00912-zsubject
Has Abstractpub_date
2021-01-05 00:00:00eissn
1121-8428issn
1724-6059pii
10.1007/s40620-020-00912-zpub_type
杂志文章abstract::Wilson's disease is an autosomal recessive disorder of hepatobiliary copper metabolism. Glomerular diseases can ensue during the course of Wilson's disease and membranous nephropathy is the eventual pathology in the majority of these cases. Membranoproliferative glomerulonephritis (MPGN) has rarely been reported in pa...
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pub_type: 杂志文章,多中心研究
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pub_type: 杂志文章,评审
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pub_type: 杂志文章,评审
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journal_title:Journal of nephrology
pub_type: 杂志文章,评审
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pub_type: 杂志文章
doi:
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pub_type: 临床试验,杂志文章
doi:
更新日期:2008-07-01 00:00:00
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pub_type: 杂志文章,评审
doi:
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pub_type: 杂志文章,评审
doi:
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pub_type: 杂志文章
doi:
更新日期:2003-11-01 00:00:00
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pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:2003-05-01 00:00:00
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journal_title:Journal of nephrology
pub_type: 杂志文章,评审
doi:
更新日期:2004-11-01 00:00:00
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pub_type: 杂志文章,评审
doi:
更新日期:2004-11-01 00:00:00
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pub_type: 杂志文章
doi:
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pub_type: 杂志文章
doi:
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pub_type: 杂志文章,多中心研究,随机对照试验
doi:
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pub_type: 杂志文章,评审
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journal_title:Journal of nephrology
pub_type: 杂志文章,评审
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pub_type: 杂志文章
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pub_type: 杂志文章,评审
doi:
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pub_type: 杂志文章
doi:
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pub_type: 杂志文章,meta分析,评审
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pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
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