Abstract：
BACKGROUND:Incremental dialysis may preserve residual renal function and improve survival in comparison with full-dose dialysis; however, available evidence is limited. We therefore compared all-cause mortality and residual kidney function (RKF) loss in incremental and full-dose dialysis and time to full-dose dialysis in incremental hemodialysis (IHD) and incremental peritoneal dialysis (IPD). METHODS:We performed a systematic review and meta-analysis of cohort studies of adults with ESRD starting IHD and IPD. We identified in PubMed and Web of Science database all cohort studies evaluating incremental dialysis evaluating three outcomes: all-cause mortality, RKF loss, time to full dialysis. IPD was defined as < 3 daily dwells in Continuous Ambulatory Peritoneal Dialysis and < 5 sessions per week in Automated Peritoneal Dialysis, while IHD was defined as < 3 HD sessions per week. RESULTS:22 studies (75,292 participants), 15 in HD and 7 in PD, were analyzed. Mean age at dialysis start was 62 and 57 years in IHD and IPD subjects, respectively. When compared to full dose, incremental dialysis (IHD or IPD) had an overall mortality risk of 1.14 [95% CI 0.85-1.52] with high heterogeneity among studies (I2 86%, P < 0.001), and lower mean RKF loss (- 0.58 ml/min/months, 95% CI 0.16-1.01, P = 0.007). Overall, time to full-dose dialysis was 12.1 months (95% CI 9.8-14.3) with no difference between IHD and IPD (P = 0.217). CONCLUSIONS:Incremental dialysis allows longer preservation of RKF thus deferring full-dose dialysis, by about 1 year in HD and PD, with no increase in mortality risk. Large and adequate studies are needed to confirm these findings.
journal_name
J Nephroljournal_title
Journal of nephrologyauthors
Garofalo C,Borrelli S,De Stefano T,Provenzano M,Andreucci M,Cabiddu G,La Milia V,Vizzardi V,Sandrini M,Cancarini G,Cupisti A,Bellizzi V,Russo R,Chiodini P,Minutolo R,Conte G,De Nicola Ldoi
10.1007/s40620-018-00577-9subject
Has Abstractpub_date
2019-10-01 00:00:00pages
823-836issue
5eissn
1121-8428issn
1724-6059pii
10.1007/s40620-018-00577-9journal_volume
32pub_type
杂志文章,meta分析abstract：:Hemolytic uremic syndrome (HUS) is a rare disease characterized by microangiopathic hemolytic anemia, thrombocytopenia and acute renal failure. It is usually secondary to infections by strains of Escherichia coli (STEC) that produce Shiga-like toxin. In about 10% of patients, no STEC infections are reported. In these ...
journal_title：Journal of nephrology
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abstract：:Recent molecular cloning experiments have identified the existence of four NBC isoforms (NBC1, 2, 3 and 4) and two NBC-related proteins AE4 and NCBE (Anion Exchanger 4 and Sodium-dependent Chloride-Bicarbonate Exchanger). Except for AE4 which does not transport Na, all are presumed to mediate the cotransport of Na+ an...
journal_title：Journal of nephrology
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journal_title：Journal of nephrology
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journal_title：Journal of nephrology
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journal_title：Journal of nephrology
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doi：
更新日期：2006-05-01 00:00:00
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journal_title：Journal of nephrology
pub_type： 杂志文章,评审
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journal_title：Journal of nephrology
pub_type： 杂志文章,评审
doi：10.1007/s40620-014-0068-x
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journal_title：Journal of nephrology
pub_type： 杂志文章
doi：10.5301/jn.5000074
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journal_title：Journal of nephrology
pub_type： 杂志文章,多中心研究
doi：10.1007/s40620-015-0186-0
更新日期：2016-02-01 00:00:00
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journal_title：Journal of nephrology
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doi：10.1007/s40620-019-00683-2
更新日期：2020-08-01 00:00:00
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doi：10.1007/s40620-020-00954-3
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journal_title：Journal of nephrology
pub_type： 杂志文章,评审
doi：
更新日期：1998-05-01 00:00:00
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journal_title：Journal of nephrology
pub_type： 杂志文章,评审
doi：
更新日期：2002-07-01 00:00:00
abstract：:The term thin glomerular basement membrane disease (TBMD) refers to a condition characterised by thinning of the GBM at electron microscopy examination and, clinically, by isolated hematuria, frequently occurring in other family members, with no extra-renal manifestations. Progression towards chronic renal failure (CR...
journal_title：Journal of nephrology
pub_type： 杂志文章,评审
doi：
更新日期：2000-01-01 00:00:00
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journal_title：Journal of nephrology
pub_type： 杂志文章,多中心研究
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journal_title：Journal of nephrology
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journal_title：Journal of nephrology
pub_type： 杂志文章,多中心研究,随机对照试验
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pub_type： 杂志文章,评审
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pub_type： 传,历史文章,杂志文章
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更新日期：2006-05-01 00:00:00
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journal_title：Journal of nephrology
pub_type： 杂志文章
doi：
更新日期：2004-05-01 00:00:00
abstract：BACKGROUND:Numerous data support the possible role of myeloblastin/proteinase 3 (PR3) in growth and differentiation of neutrophil granulocytes and certain monocyte subtypes. However, whether PR3 is expressed in non-myeloid cells remains a matter of debate even though recent studies clearly demonstrated its expression i...
journal_title：Journal of nephrology
pub_type： 杂志文章
doi：
更新日期：2003-11-01 00:00:00
abstract：:Cardiovascular disease is the leading cause of the poor long-term survival of patients with chronic kidney disease (CKD). Anemia, which is a frequent and early complication of CKD, not only impairs patients' quality of life, but also is an independent risk factor for adverse cardiovascular outcomes. This may be due to...
journal_title：Journal of nephrology
pub_type： 杂志文章,评审
doi：
更新日期：2007-11-01 00:00:00
abstract：INTRODUCTION:Medullary cystic kidney disease type 1 (MCKD1; OMIM #174000) is a familial progressive tubule-interstitial nephropathy belonging to the recently defined group of autosomal dominant tubulointerstitial kidney diseases (ADTKD). CASE REPORT:A specific type of cytosine insertion in the extracellular variable n...
journal_title：Journal of nephrology
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doi：10.1007/s40620-016-0282-9
更新日期：2016-06-01 00:00:00
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journal_title：Journal of nephrology
pub_type： 杂志文章,评审
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更新日期：2011-11-01 00:00:00
abstract：BACKGROUND:Uremic pruritus as a symptom that affects hemodialysis (HD) patients can decrease the quality of life and increase morbidity in these patients. The aim of this study was to evaluate the effects of turmeric on uremic pruritus in HD patients. SUBJECTS AND METHODS:This was a double-blind placebo-controlled tri...
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