Abstract：
:Kidney stone disease is a common condition with a high recurrence rate and elevated costs. Despite the well-known positive effects of high fluid intake, there are little data about the roles of water composition and timing of ingestion during the day. This study examines the effect of two different waters [calcium-bicarbonate water (CBW) and oligomineral water (OW)] consumed at different times during the day on urine composition in a group of healthy volunteers. In a cross-over randomized trial, 12 healthy volunteers were assigned to a different sequence of four combined interventions (1 L of water consumed during fasting and 1 L of water consumed with meals): CBW/OW; OW/CBW; CBW/CBW; OW/OW. Participants were instructed to follow the same diet and to avoid smoking, caffeine and other beverages during the day of intervention, and to collect their urine every 2 h during the day, followed by a single overnight collection. The relative supersaturation for calcium oxalate was higher for CBW/CBW compared with all other interventions, while relative supersaturation for calcium phosphate was lower for the combination OW/CBW with meals. Urinary excretion of oxalate was lower in all interventions including CBW, while no significant differences were found for urinary calcium. Water composition and timing of ingestion have complex and interacting effects on lithogenic risk. Depending on individual characteristics, a strategy involving either OW or a mix of CBW during meals and OW outside of meals could be effective in modulating the lithogenic profile.Trial registered at clinicaltrial.gov: Protocol ID NCT03447847.
journal_name
J Nephroljournal_title
Journal of nephrologyauthors
Ferraro PM,Baccaro R,Baroni S,D'Alessandri L,Carpenito C,Di Daniele N,Urbani A,Gambaro Gdoi
10.1007/s40620-020-00769-2subject
Has Abstractpub_date
2020-06-08 00:00:00eissn
1121-8428issn
1724-6059pii
10.1007/s40620-020-00769-2pub_type
杂志文章abstract：:Icodextrin, a glucose polymer, is widely used as an alternative to glucose as the osmotic agent in peritoneal dialysis (PD). We describe a case of a continuous ambulatory peritoneal dialysis patient who developed severe cutaneous hypersensitivity after initiation of icodextrin PD solution. Erythematous skin lesions gr...
journal_title：Journal of nephrology
pub_type： 杂志文章
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更新日期：2006-09-01 00:00:00
abstract：BACKGROUND AND METHODS:Smoking is associated with hyperparathyroidism in the elderly general population and nicotine, the main component of tobacco smoke, stimulates PTH release in experimental models. Although smoking is a persisting problem in patients with end-stage renal disease (ESRD), the association between smok...
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abstract：BACKGROUND:Cardiac surgery-associated acute kidney injury (CSA-AKI) is associated with high risk for complications and mortality. Whether renin-angiotensin system (RAS) inhibitor should be continued or withdrawn in patients with long-term use before cardiac surgery has been lack of consensus. METHODS:We performed this...
journal_title：Journal of nephrology
pub_type： 杂志文章,多中心研究
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abstract：BACKGROUND:Until now, the survival of iliac vein tunneled cuffed catheters (TCCs) used in elderly patients has not been fully investigated. Accordingly, we evaluated their use in elderly hemodialysis patients with no other venous access options. METHODS:A total of 70 elderly patients with iliac vein TCCs undergoing ch...
journal_title：Journal of nephrology
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更新日期：2016-02-01 00:00:00
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journal_title：Journal of nephrology
pub_type： 杂志文章
doi：10.1007/s40620-015-0188-y
更新日期：2015-12-01 00:00:00
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journal_title：Journal of nephrology
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更新日期：2007-11-01 00:00:00
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journal_title：Journal of nephrology
pub_type： 杂志文章
doi：10.1007/s40620-014-0091-y
更新日期：2014-08-01 00:00:00
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journal_title：Journal of nephrology
pub_type： 杂志文章,评审
doi：10.1007/s40620-017-0423-9
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journal_title：Journal of nephrology
pub_type： 杂志文章
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更新日期：2001-01-01 00:00:00
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journal_title：Journal of nephrology
pub_type： 杂志文章,评审
doi：
更新日期：2002-01-01 00:00:00
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journal_title：Journal of nephrology
pub_type： 临床试验,杂志文章
doi：
更新日期：2000-09-01 00:00:00
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journal_title：Journal of nephrology
pub_type： 杂志文章,随机对照试验
doi：
更新日期：2008-07-01 00:00:00
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journal_title：Journal of nephrology
pub_type： 临床试验,杂志文章
doi：
更新日期：2008-07-01 00:00:00
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journal_title：Journal of nephrology
pub_type： 杂志文章
doi：10.1007/s40620-018-0552-9
更新日期：2019-08-01 00:00:00
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journal_title：Journal of nephrology
pub_type： 杂志文章
doi：10.1007/s40620-016-0282-9
更新日期：2016-06-01 00:00:00
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journal_title：Journal of nephrology
pub_type： 杂志文章
doi：
更新日期：2006-01-01 00:00:00
abstract：BACKGROUND:Hypertension and left ventricular hypertrophy (LVH) are independent predictors of morbidity and mortality in maintenance hemodialysis (MHD) patients. The level of serum asymmetric dimethylarginine (ADMA) is increased in MHD patients, which is a kind of uremic toxin. It can competitively inhibit nitric oxide ...
journal_title：Journal of nephrology
pub_type： 杂志文章,随机对照试验
doi：10.5301/jn.2011.6252
更新日期：2011-03-01 00:00:00
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journal_title：Journal of nephrology
pub_type： 杂志文章
doi：
更新日期：2003-01-01 00:00:00
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pub_type： 杂志文章
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更新日期：2010-05-01 00:00:00
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更新日期：2005-11-01 00:00:00
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journal_title：Journal of nephrology
pub_type： 传,历史文章,杂志文章
doi：
更新日期：2006-05-01 00:00:00
abstract：:Some antihypertensive drugs may have a renoprotective effect, that is partially independent of their ability to reduce blood pressure. ACE-inhibitors are safe and effective agents that are capable of reducing proteinuria and preventing CRF progression. The results of the AIPRI extension study suggest that they may als...
journal_title：Journal of nephrology
pub_type： 杂志文章,评审
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更新日期：1998-11-01 00:00:00
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journal_title：Journal of nephrology
pub_type： 杂志文章,评审
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journal_title：Journal of nephrology
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更新日期：2016-12-01 00:00:00
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journal_title：Journal of nephrology
pub_type： 杂志文章
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更新日期：2019-02-01 00:00:00
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journal_title：Journal of nephrology
pub_type： 杂志文章
doi：10.1007/s40620-016-0324-3
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journal_title：Journal of nephrology
pub_type： 杂志文章
doi：
更新日期：2010-01-01 00:00:00
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journal_title：Journal of nephrology
pub_type： 杂志文章
doi：10.1007/s40620-016-0321-6
更新日期：2016-12-01 00:00:00
