The renoprotective effect of antihypertensive drugs.

Abstract:

:Some antihypertensive drugs may have a renoprotective effect, that is partially independent of their ability to reduce blood pressure. ACE-inhibitors are safe and effective agents that are capable of reducing proteinuria and preventing CRF progression. The results of the AIPRI extension study suggest that they may also have a long-term renoprotective effect. ACE gene polymorphism may partially influence the response to these agents. Angiotensin II receptor 1 antagonists (AT1RA) are effective in reducing proteinuria, but their clinical impact is still a matter of study. It has been shown that non-dihydropyridine and some dihydropyridine calcium channel blockers (CCBs) reduce proteinuria and are also renoprotective, but there is a lack of large-scale prospective randomised trials. Given that the use of various drugs is usually needed to achieve good blood pressure control in patients with CRF, the possibility that a combination of ACE-inhibitors with CCBs or ATIRAs may have an additive renoprotective effect is intriguing.

journal_name

J Nephrol

journal_title

Journal of nephrology

authors

Locatelli F,Del Vecchio L,Marai P,Colzani S

subject

Has Abstract

pub_date

1998-11-01 00:00:00

pages

330-6

issue

6

eissn

1121-8428

issn

1724-6059

journal_volume

11

pub_type

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