Abstract:
:Henoch-Schonlein purpura is a clinical syndrome characterized by the association of skin, joint, and gastrointestinal symptoms. Henoch-Schonlein purpura is characterized by wide-spread vasculitis. Although the clinical symptoms of this disease are characteristic, the diagnosis is not always easy to establish because other forms of systemic vasculitis - mainly the microscopic form of periarteritis nodosa - may mimic the disease. In addition, in contrast to systemic lupus erythematosus, there are no biological tests that can identify Henoch-Schonlein purpura with certainty. Immunofluorescence microscopic techniques have made an important contribution to both the diagnosis and the study of the pathogenesis of the disease, particularly since they have demonstrated the presence of IgA deposits in the glomeruli and in the vessel walls. These findings not only confirmed the immunologic nature of the pathologic lesions but also drew attention to the remarkable similarity between Henoch-Schonlein purpura nephritis and IgA nephropathy.
journal_name
J Nephroljournal_title
Journal of nephrologyauthors
Ferrario F,Rastaldi MPsubject
Has Abstractpub_date
2005-11-01 00:00:00pages
637-41issue
6eissn
1121-8428issn
1724-6059journal_volume
18pub_type
杂志文章abstract:BACKGROUND:Patients (pts) with primary Membranous nephropathy (MN) have an autoimmune disease caused by autoantibodies against podocyte antigens and 60-80% of them have antibodies directed against the M-type phospholipase A2 receptor (PLA2R). Immunosuppressive treatment is recommended in high-medium risk pts. Recently ...
journal_title:Journal of nephrology
pub_type: 杂志文章
doi:10.1007/s40620-020-00781-6
更新日期:2020-06-27 00:00:00
abstract::Kidney stone disease is a common condition with a high recurrence rate and elevated costs. Despite the well-known positive effects of high fluid intake, there are little data about the roles of water composition and timing of ingestion during the day. This study examines the effect of two different waters [calcium-bic...
journal_title:Journal of nephrology
pub_type: 杂志文章
doi:10.1007/s40620-020-00769-2
更新日期:2020-06-08 00:00:00
abstract::The metabolic syndrome is a cluster of cardiometabolic alterations at least partly dependent on reduced insulin sensitivity and hyperinsulinemia that can have several renal implications. A systematic review and meta-analysis of studies available in the international literature in English language demonstrates that the...
journal_title:Journal of nephrology
pub_type: 杂志文章,meta分析,评审
doi:10.1007/s40620-014-0085-9
更新日期:2014-08-01 00:00:00
abstract:BACKGROUND:Recently, some studies have emphasized the role of plasma 25-(OH)vitamin D (25OHD) levels in mineral metabolism dysregulation in chronic kidney diseases (CKDs). However, to date little attention has been paid to 25OHD metabolism abnormalities after renal transplantation (Tx). This cross-sectional study aimed...
journal_title:Journal of nephrology
pub_type: 杂志文章
doi:
更新日期:2005-01-01 00:00:00
abstract:BACKGROUND:The recent multicenter, randomized, open-label INDEPENDENT study demonstrated that sevelamer improves survival in new to hemodialysis (HD) patients compared with calcium carbonate. The objective of this study was to determine the cost-effectiveness of sevelamer versus calcium carbonate for patients new to HD...
journal_title:Journal of nephrology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1007/s40620-014-0122-8
更新日期:2015-10-01 00:00:00
abstract:BACKGROUND:A sensitive, feasible and reproducible marker for renal function is necessary to evaluate the clinical efficacy of enzyme replacement therapy (ERT) in Fabry nephropathy. Serum creatinine has some limitations and cystatin C has been proposed, in other nephropathies, as a useful marker of renal function. The u...
journal_title:Journal of nephrology
pub_type: 临床试验,杂志文章
doi:
更新日期:2007-07-01 00:00:00
abstract::Epicardial adipose tissue (EAT) is localized between the myocardial surface and visceral layer of the pericardium. It is a metabolically active organ that secretes several cytokines which modulate cardiovascular morphology and function. EAT may interact locally with coronary arteries through paracrine secretion mechan...
journal_title:Journal of nephrology
pub_type: 杂志文章,评审
doi:10.1007/s40620-018-0491-5
更新日期:2018-12-01 00:00:00
abstract:BACKGROUND:Hypertension and left ventricular hypertrophy (LVH) are independent predictors of morbidity and mortality in maintenance hemodialysis (MHD) patients. The level of serum asymmetric dimethylarginine (ADMA) is increased in MHD patients, which is a kind of uremic toxin. It can competitively inhibit nitric oxide ...
journal_title:Journal of nephrology
pub_type: 杂志文章,随机对照试验
doi:10.5301/jn.2011.6252
更新日期:2011-03-01 00:00:00
abstract::Emphysematous pyelonephritis is a rare life-threatening infection of the renal parenchyma. It usually affects unilateral kidney and occurs mostly in diabetic patients. It is characterized by the presence of gas within the renal parenchyma and requires prompt diagnosis and early aggressive therapy. Bilateral emphysemat...
journal_title:Journal of nephrology
pub_type: 杂志文章
doi:
更新日期:2000-03-01 00:00:00
abstract:BACKGROUND:Previous in vitro experiments of human polycystic kidney disease (PKD) cells reported that caffeine is a risk factor for the promotion of cyst enlargement in patients with autosomal dominant PKD (ADPKD). The relentless progression of ADPKD inclines the majority of physicians to advocate minimization of caffe...
journal_title:Journal of nephrology
pub_type: 杂志文章
doi:10.1007/s40620-017-0396-8
更新日期:2018-02-01 00:00:00
abstract::Lupus is now regarded as a syndrome which results from several related auto-immune processes, although the exact mechanisms of how the disease arises in susceptible individuals remain obscure. When the San Carlo meetings began in 1968, much less was known about the pathogenesis of autoimmunity, but the presence of aut...
journal_title:Journal of nephrology
pub_type: 杂志文章,评审
doi:
更新日期:1999-07-01 00:00:00
abstract:BACKGROUND:Peripheral artery disease (PAD) represents a major complication in chronic kidney disease (CKD) patients, but its early diagnosis is still problematic. Traditionally, ankle-arm blood pressure index (API) determined by means of a simple hand-held unidimensional Doppler device has been used for noninvasive dia...
journal_title:Journal of nephrology
pub_type: 杂志文章
doi:
更新日期:2009-07-01 00:00:00
abstract::Colchicine is an effective antiinflammatory medication. It should be used with great caution, however, in patients requiring dialysis. Coadministration of colchicine and macrolides may impair colchicine elimination, resulting in excess drug exposure and toxicity. We report 2 renal failure cases of colchicine intoxicat...
journal_title:Journal of nephrology
pub_type: 杂志文章
doi:
更新日期:2006-07-01 00:00:00
abstract:BACKGROUND:The G-1082A polymorphism of the interleukin-10 (IL-10) gene has been associated with modified gene expression and the progression of primary IgA nephropathy (IgAN). In the present study, we evaluated its influence on recurrent IgAN after renal transplantation. METHODS:We studied 103 patients who suffered fr...
journal_title:Journal of nephrology
pub_type: 杂志文章
doi:
更新日期:2008-11-01 00:00:00
abstract::Cyclosporine A has been empirically used for more than 12 years in the treatment of idiopathic nephrotic syndrome, in both children and adults. There is consistent evidence, from both experimental and human studies, that the highly lipophilic cyclosporine molecule diminishes or abolishes proteinuria by two differing m...
journal_title:Journal of nephrology
pub_type: 杂志文章,评审
doi:
更新日期:1997-01-01 00:00:00
abstract:BACKGROUND:Dialysate calcium (Ca) concentration should be viewed as part of the integrated therapeutic regimen to control renal osteodystrophy and maintain normal mineral metabolism. Thus, a correct ionized calcium mass balance (Ca++MB) during hemodialysis (HD) is crucial in the treatment of renal osteodystrophy. The G...
journal_title:Journal of nephrology
pub_type: 杂志文章,随机对照试验
doi:10.5301/JN.2011.6385
更新日期:2011-11-01 00:00:00
abstract:BACKGROUND:To report clinical symptoms and outcome of systemic paraphenylene diamine (PPD) intoxication. METHODS:Our study was retrospective. It was conducted over 6 yrs (1994-2000) in the medical intensive care unit (ICU) of a university hospital and it concerned 19 patients hospitalized for systemic PPD intoxication...
journal_title:Journal of nephrology
pub_type: 杂志文章
doi:
更新日期:2005-05-01 00:00:00
abstract::In 1998, the Italian Ministry of Health urged the Italian Society of Nephrology (SIN) to draft recommendations for uniform decision-making procedures in the field of dialysis. In accordance with the Ministry's specifications, at the time the Society approved diagnostic protocols regarding clinical questions, but witho...
journal_title:Journal of nephrology
pub_type: 指南,杂志文章,实务指引
doi:
更新日期:2001-03-01 00:00:00
abstract::Clinical immunology laboratories play an essential role in diagnosis and monitoring of systemic lupus erythematosus (SLE). To obtain the best results in terms of diagnostic performance and clinical usefulness, the following recommendations should be fulfilled: Indirect immunofluorescence on Hep-2 cells remains the met...
journal_title:Journal of nephrology
pub_type: 杂志文章,评审
doi:
更新日期:2002-11-01 00:00:00
abstract:BACKGROUND:With improvements in technology, renal biopsies have become safer and could potentially be effectively carried out in the outpatient setting. The purpose of our study is to compare the safety and cost of performing outpatient versus inpatient renal biopsies at a single Northern California pediatric hospital....
journal_title:Journal of nephrology
pub_type: 杂志文章
doi:
更新日期:2009-01-01 00:00:00
abstract::The analysis of the urinary proteome is a potential source of information regarding the kidney's physiopathology. A clear knowledge of the protein composition of normal urine is an essential prerequisite to looking at its pathology. Technological evolution in the field of proteomics (2-dimensional [2D] electrophoresis...
journal_title:Journal of nephrology
pub_type: 杂志文章,评审
doi:10.5301/jn.5000233
更新日期:2013-07-01 00:00:00
abstract::Gonadal dysfunction is a frequent finding in men with chronic kidney disease and with end-stage renal disease. Testosterone deficiency, usually accompanied by elevation of serum gonadotropin concentrations, is present in 26-66% of men with different degrees of renal failure. Uremia-associated hypogonadism is multifact...
journal_title:Journal of nephrology
pub_type: 杂志文章,评审
doi:10.5301/JN.2011.8481
更新日期:2012-01-01 00:00:00
abstract:BACKGROUND:Causes of hypertension and cardiac hypertrophy in hemodialysis (HD) patients are multiple, but the role of fluid overload appears to be crucial. Short daily HD (sDHD = 2 hr x 6/week) seems to allow reductions in left ventricular mass (LVM) through the reduction of extracellular water (ECW). Better cardiovasc...
journal_title:Journal of nephrology
pub_type: 杂志文章
doi:
更新日期:2006-01-01 00:00:00
abstract::Glomerulonephritis rarely appears associated with Hodgkin's disease or non-Hodgkin's lymphoma (NHL). We present a patient with a relapse of a non-Hodgkin's lymphoma which first presented as nephrotic syndrome due to focal segmental glomerulosclerosis (FSGS). This case report discusses the unusual association of non-Ho...
journal_title:Journal of nephrology
pub_type: 杂志文章
doi:
更新日期:2007-09-01 00:00:00
abstract:BACKGROUND:Oxidative stress plays a crucial role in chronic complications of diabetes such as diabetic nephropathy (DN), the main cause of renal failure. In diabetes, whether peroxynitrite (ONOO(-)), generated from inducible nitric oxide synthase (iNOS) induced by tumor necrosis factor alpha (TNF-alpha), plays a primar...
journal_title:Journal of nephrology
pub_type: 杂志文章
doi:
更新日期:2009-11-01 00:00:00
abstract:BACKGROUND:Numerous data support the possible role of myeloblastin/proteinase 3 (PR3) in growth and differentiation of neutrophil granulocytes and certain monocyte subtypes. However, whether PR3 is expressed in non-myeloid cells remains a matter of debate even though recent studies clearly demonstrated its expression i...
journal_title:Journal of nephrology
pub_type: 杂志文章
doi:
更新日期:2003-11-01 00:00:00
abstract:BACKGROUND:Malnutrition is common and associated with poor outcomes in patients with chronic kidney disease (CKD) and end-stage renal disease (ESRD). Recently, the geriatric nutritional risk index (GNRI) was reported as a novel tool for evaluating nutritional status. However, the association between GNRI and renal outc...
journal_title:Journal of nephrology
pub_type: 杂志文章
doi:10.1007/s40620-019-00676-1
更新日期:2020-08-01 00:00:00
abstract:BACKGROUND:Uromodulin (Tamm-Horsfall protein) is the most abundant urinary protein in healthy individuals. Despite 60 years of research, its physiological role remains rather elusive. Familial juvenile hyperuricemic nephropathy and medullary cystic kidney disease Type 2 are autosomal dominant tubulointerstitial nephrop...
journal_title:Journal of nephrology
pub_type: 杂志文章
doi:10.1007/s40620-014-0079-7
更新日期:2014-06-01 00:00:00
abstract:BACKGROUND:Rural-dwelling hemodialysis patients have less frequent contact with nephrologists than urban-dwelling patients, and are known to have higher mortality. We hypothesized that rural-dwelling hemodialysis patients would have more evidence of poorly controlled extracellular fluid volume (ECVF) than otherwise sim...
journal_title:Journal of nephrology
pub_type: 杂志文章
doi:10.1007/s40620-016-0337-y
更新日期:2018-02-01 00:00:00
abstract:UNLABELLED:The prognosis of renal survival in both type 1 and type 2 diabetes mellitus is not benign. Several factors characterize the increase in the risk of developing renal damage in diabetic patients, distinguished in diabetes-related factors, genetic factors and other factors. DIAGNOSIS:Diagnosis requires standar...
journal_title:Journal of nephrology
pub_type: 杂志文章,评审
doi:
更新日期:2003-07-01 00:00:00