Abstract:
:A 64-year-old man was hospitalized in 2002 with symptoms of stupor, weakness, and renal colic. The clinical examination indicated borderline hypertension, small masses in the glutei, and polyuria. Laboratory tests evidenced high serum concentrations of creatinine, calcium, and phosphate. Imaging assessments disclosed widespread vascular calcifications, gluteal calcifications, and pelvic ectasia. Subsequent lab tests indicated suppressed serum parathyroid hormone, extremely high serum 25-hydroxy vitamin D, and normal serum 1,25-dihydroxy vitamin D. Treatment was started with intravenous infusion of saline and furosemide due to the evidence of hypercalcemia. Prednisone and omeprazole were added given the evidence of hypervitaminosis D. The treatment improved serum calcium, kidney function, and consciousness. The medical history disclosed recent treatment with exceptionally high doses of slow-release intra-muscular cholecalciferol and the recent excretion of urinary stones. The patient was discharged when it was possible to stop the intravenous treatment. The post-discharge treatment included oral hydration, furosemide, prednisone and omeprazole for approximately 6 months up to complete resolution of the hypercalcemia. The patient came back 12 years later because of microhematuria. Lab tests were normal for calcium/phosphorus homeostasis and kidney function. Imaging tests indicated only minor vascular calcifications. This is the first evidence of reversible vascular calcifications secondary to hypervitaminosis D.
journal_name
J Nephroljournal_title
Journal of nephrologyauthors
Cirillo M,Bilancio G,Cirillo Cdoi
10.1007/s40620-015-0228-7subject
Has Abstractpub_date
2016-02-01 00:00:00pages
129-31issue
1eissn
1121-8428issn
1724-6059pii
10.1007/s40620-015-0228-7journal_volume
29pub_type
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journal_title:Journal of nephrology
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pub_type: 杂志文章,评审
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更新日期:1999-05-01 00:00:00
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journal_title:Journal of nephrology
pub_type: 杂志文章,评审
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更新日期:2007-11-01 00:00:00
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更新日期:2010-11-01 00:00:00
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journal_title:Journal of nephrology
pub_type: 杂志文章,评审
doi:10.1007/s40620-017-0448-0
更新日期:2018-02-01 00:00:00
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pub_type: 杂志文章,多中心研究,随机对照试验
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journal_title:Journal of nephrology
pub_type: 杂志文章
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更新日期:1999-01-01 00:00:00
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pub_type: 杂志文章,多中心研究
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