Abstract：
BACKGROUND:Acute kidney injury (AKI) following acute ST elevation myocardial infarction (STEMI) is associated with adverse outcomes. The recently proposed KDIGO criteria suggested modifications to the consensus classification system for AKI, namely lowering the threshold of increase in absolute serum creatinine and extending the time frame for AKI detection to 7 days. We evaluated the incidence, risk factors, and long-term mortality associated with AKI as classified by the KDIGO definition in a large single center cohort of consecutive STEMI patients. METHODS:We retrospectively studied 2122 consecutive STEMI patients undergoing primary percutaneous coronary intervention (PCI). Recruited patients were admitted between January 2008 and May 2016 to the cardiac intensive care unit with the diagnosis of acute STEMI. We compared the utilization of the KDIGO and consensus criteria for the diagnosis of AKI and its relation to long term mortality. RESULTS:The KDIGO criteria allowed the identification of more patients as having AKI (10.6 vs. 5.6%, p < 0.001) compared to the consensus criteria. Even mild elevation of serum creatinine (≥ 0.3 mg/dL) was associated with a marked increase in all-cause mortality (HR 4.7, 95% CI 3.1-6.43, p < 0.001). Patients with AKI whose renal function resolved prior to hospital discharge still had significantly higher mortality compared to patients with no AKI (23 vs. 8%, HR 3.1, 95% CI 2.09-4.90, p < 0.001). CONCLUSION:KDIGO criteria is more sensitive than the consensus criteria in defining AKI in STEMI patients and identifying populations at risk for long term adverse outcomes.
journal_name
J Nephroljournal_title
Journal of nephrologyauthors
Margolis G,Gal-Oz A,Letourneau-Shesaf S,Khoury S,Keren G,Shacham Ydoi
10.1007/s40620-017-0461-3subject
Has Abstractpub_date
2018-06-01 00:00:00pages
423-428issue
3eissn
1121-8428issn
1724-6059pii
10.1007/s40620-017-0461-3journal_volume
31pub_type
杂志文章abstract：INTRODUCTION:Several studies have suggested an effect of calcineurin inhibitors on arterial compliance in kidney transplant recipients. We aimed to investigate whether the type of calcineurin inhibitor influences large and small artery compliance in these patients independently of other determinants. METHODS:Patients ...
journal_title：Journal of nephrology
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abstract：:Sclerosing encapsulating peritonitis (SEP) is a serious complication of long-term continuous ambulatory peritoneal dialysis (CAPD), very likely related to a persisting expression of the transforming growth factor beta1 (TGFbeta1) gene on peritoneal mesothelial cells. We report the case of a 67-year-old uremic woman wh...
journal_title：Journal of nephrology
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abstract：:We report a unusual case of idiopathic nodular glomerulosclerosis mimicking changes that develop in diabetic nephropathy. A 66-year-old non-diabetic female developed nephrotic range proteinuria and the work up was unremarkable. Light and electron microscopy showed mesangial expansion with Kimmelsteil-Wilson nodules an...
journal_title：Journal of nephrology
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journal_title：Journal of nephrology
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abstract：:Page kidney was first described in animal experiments in 1939. In the 1950s and 1960s the human counterpart became evident. In this review we examine the modest literature on this rare but important renal/urological complication, summarize the clinical features, and discuss the best approach to diagnosis and managemen...
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journal_title：Journal of nephrology
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journal_title：Journal of nephrology
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更新日期：2010-09-01 00:00:00
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journal_title：Journal of nephrology
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doi：10.1007/s40620-014-0068-x
更新日期：2014-10-01 00:00:00
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journal_title：Journal of nephrology
pub_type： 杂志文章
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更新日期：2004-05-01 00:00:00
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journal_title：Journal of nephrology
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更新日期：2018-02-01 00:00:00
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journal_title：Journal of nephrology
pub_type： 杂志文章
doi：
更新日期：2005-07-01 00:00:00
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journal_title：Journal of nephrology
pub_type： 杂志文章
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更新日期：2012-01-01 00:00:00
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journal_title：Journal of nephrology
pub_type： 社论,评审
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更新日期：2012-11-01 00:00:00
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journal_title：Journal of nephrology
pub_type： 杂志文章,评审
doi：
更新日期：1998-03-01 00:00:00
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journal_title：Journal of nephrology
pub_type： 杂志文章,评审
doi：10.1007/s40620-020-00793-2
更新日期：2020-12-01 00:00:00
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更新日期：2005-03-01 00:00:00
abstract：:The origin of the Teutonic Order of Hospitalers St. Mary (Ordo Hospitalis S. Mariae Teutonicorum Hi-erosolymitani) is presented. The St. Mary Hospitaler Teutonic Order arrived in the XIIIth century to Pomezania, then inhabited by pagan Prussian tribes. The Knights of the Order started to Christianize the Prussians, th...
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pub_type： 历史文章,杂志文章
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更新日期：2006-05-01 00:00:00
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journal_title：Journal of nephrology
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journal_title：Journal of nephrology
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更新日期：2004-07-01 00:00:00
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journal_title：Journal of nephrology
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journal_title：Journal of nephrology
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