The presence and impact of diastolic dysfunction on physical function and body composition in hemodialysis patients.

Abstract:

BACKGROUND:Cardiovascular (CV) diseases are the main cause of death in maintenance hemodialysis (MHD) patients. Muscle wasting and physical function decline are common in MHD patients, and significantly impair their quality of life. These can result from abnormalities in cardiac function, which can be further worsened by physical deconditioning. Left ventricular diastolic function parameters were recently shown to be a better predictor of exercise capacity than systolic measures in patients with CV complications. But little is known about the relationship between cardiac function and physical function in MHD patients. METHODS:In 82 MHD patients, left ventricular systolic dysfunction (LVSD) was assessed by ejection fraction and fractional shortening with echocardiography, and left ventricular diastolic dysfunction (LVDD) was assessed by pulse wave and tissue Doppler indices. Physical function was assessed by gait speed, performance on a shuttle walk test, and leg muscle strength. Dual-emission X-ray absorptiometry (DXA) was used to measure whole body lean mass (WBLM). RESULTS:The prevalence of LVDD and LVSD was 48.8 and 12.2%, respectively. Gait speed, shuttle walk time, leg strength, and WBLM% were significantly higher in the group without LVDD than with LVDD (p < 0.05 for all). However, there was no significant difference in any measure of physical function or body composition between patients with and without LVSD. CONCLUSION:These data suggest that LVDD is more closely related to physical function and body composition than LVSD in MHD patients, and hence that LVDD may be an important therapeutic target.

journal_name

J Nephrol

journal_title

Journal of nephrology

authors

Jeong JH,Wu PT,Kistler BM,Fitschen PJ,Biruete AG,Phillips SA,Ali MM,Fernhall B,Wilund KR

doi

10.1007/s40620-015-0188-y

subject

Has Abstract

pub_date

2015-12-01 00:00:00

pages

739-47

issue

6

eissn

1121-8428

issn

1724-6059

pii

10.1007/s40620-015-0188-y

journal_volume

28

pub_type

杂志文章
  • New markers of accelerated atherosclerosis in end-stage renal disease.

    abstract::Over the last two decades, several studies have reported a high prevalence of cardiovascular disease in patients with end-stage renal disease (ESRD). This population usually presents both the traditional and non-traditional risk factors for atherosclerosis. Inflammation as well as impaired nitric oxide production are ...

    journal_title:Journal of nephrology

    pub_type: 杂志文章,评审

    doi:

    authors: Rattazzi M,Puato M,Faggin E,Bertipaglia B,Grego F,Pauletto P

    更新日期:2003-01-01 00:00:00

  • Acute kidney injury based on the KDIGO criteria among ST elevation myocardial infarction patients treated by primary percutaneous intervention.

    abstract:BACKGROUND:Acute kidney injury (AKI) following acute ST elevation myocardial infarction (STEMI) is associated with adverse outcomes. The recently proposed KDIGO criteria suggested modifications to the consensus classification system for AKI, namely lowering the threshold of increase in absolute serum creatinine and ext...

    journal_title:Journal of nephrology

    pub_type: 杂志文章

    doi:10.1007/s40620-017-0461-3

    authors: Margolis G,Gal-Oz A,Letourneau-Shesaf S,Khoury S,Keren G,Shacham Y

    更新日期:2018-06-01 00:00:00

  • Role of tubulointerstitial plasmin in the progression of IgA nephropathy.

    abstract:BACKGROUND:Plasmin has recently been reported to be associated with renal fibrosis in experimental models, but its role in human renal diseases is unclear. METHODS:Fifty-seven patients with IgA nephropathy (IgAN) were evaluated retrospectively. Plasmin in their renal biopsy tissues was assessed by in situ zymography u...

    journal_title:Journal of nephrology

    pub_type: 杂志文章

    doi:10.1007/s40620-015-0205-1

    authors: Uchida T,Oda T,Takechi H,Matsubara H,Watanabe A,Yamamoto K,Oshima N,Sakurai Y,Kono T,Shimazaki H,Tamai S,Kumagai H

    更新日期:2016-02-01 00:00:00

  • Normothermic perfusion of ischaemic porcine kidneys: an evaluation of ex vivo function and endothelin receptor antagonism.

    abstract:BACKGROUND:Non-heart-beating donors suffer a period of warm ischaemia (WI) injury, resulting in higher rates of delayed graft function compared with heart-beating donors. Endothelin is believed to play a pathophysiological role in the intense vasospasm associated with WI. This study aimed to investigate renal function ...

    journal_title:Journal of nephrology

    pub_type: 杂志文章

    doi:

    authors: Mann CD,Metcalfe MS,Nicholson ML

    更新日期:2009-01-01 00:00:00

  • Recurrent hemolytic uremic syndrome associated with intestinal lymphangiectasia.

    abstract::A 17-year-old boy was admitted to the hospital twice in a year for 2 episodes of hemolytic uremic syndrome (HUS). During these 2 HUS episodes he had diarrhea, decreased serum complement, decreased total protein and decreased serum albumin concentrations. We suggest that protein-losing enteropathy and hypocomplementemi...

    journal_title:Journal of nephrology

    pub_type: 杂志文章

    doi:

    authors: Kalman S,Bakkaloğlu S,Dalgiç B,Ozkaya O,Söylemezoğlu O,Buyan N

    更新日期:2007-03-01 00:00:00

  • Antiproteinuric effect of olmesartan in patients with IgA nephropathy.

    abstract:BACKGROUND:IgA nephropathy is one of the most common primary glomerulonephritides, and the clinical course of almost 40% of the patients progresses to end-stage renal disease (ESRD) within 20 years. Angiotensin-converting enzyme (ACE) inhibitors and/ or angiotensin II receptor blockers (ARBs) induce a marked renoprotec...

    journal_title:Journal of nephrology

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:

    authors: Tomino Y,Kawamura T,Kimura K,Endoh M,Hosoya T,Horikoshi S,Utsunomiya Y,Yasuda T,Toyoda M,Tsuge T,Kaneko K

    更新日期:2009-03-01 00:00:00

  • Three-dimensional contrast-enhanced magnetic resonance angiography (3-D CE-MRA) in the evaluation of hemodialysis access complications, and the condition of central veins in patients who are candidates for hemodialysis access.

    abstract:BACKGROUND:Arteriovenous (AV) fistulas are crucial in patients requiring long-term hemodialysis (HD). Dysfunctions of these fistulas are the most common causes of recurrent hospitalizations. This study aimed to evaluate the feasibility, safety and usefulness of contrast-enhanced magnetic resonance angiography (CE-MRA) ...

    journal_title:Journal of nephrology

    pub_type: 杂志文章

    doi:

    authors: Paksoy Y,Gormus N,Tercan MA

    更新日期:2004-01-01 00:00:00

  • Aortic intimal sarcoma masquerading as bilateral renal artery stenosis.

    abstract::Aortic intimal sarcoma is a rare tumor with poor prognosis. The most common manifestations are thromboembolic phenomena and vascular obstruction. We present a case of aortic intimal sarcoma causing bilateral renal artery stenosis which manifested as resistant hypertension and acute kidney inury. Multiple attempts to s...

    journal_title:Journal of nephrology

    pub_type: 杂志文章

    doi:10.5301/jn.5000283

    authors: Sethi S,Pothineni NK,Syal G,Ali SM,Krause MW

    更新日期:2013-09-01 00:00:00

  • The vascular endothelium in chronic renal failure.

    abstract::Chronic renal failure (CRF) is associated with a 20-fold increased risk of cardiovascular death, two principal mechanisms being: sudden, arrhythmic death associated with left ventricular hypertrophy, and ischaemic heart disease, associated with accelerated atherosclerosis. In recent years, the vascular endothelium has...

    journal_title:Journal of nephrology

    pub_type: 杂志文章,评审

    doi:

    authors: Morris ST,Jardine AG

    更新日期:2000-03-01 00:00:00

  • Association between malnutrition, integrin expression and impaired granulocyte adhesion in chronically hemodialyzed patients.

    abstract:BACKGROUND:The relationship between malnutrition in hemodialysis (HD) patients with a chronic inflammatory condition and the expression levels of leukocyte integrins and their adhesiveness to fibronectin was investigated. METHODS:Subjective global assessment, albumin and body mass index were used as nutritional marker...

    journal_title:Journal of nephrology

    pub_type: 杂志文章

    doi:

    authors: Corradi-Perini C,Riella MC,Cattaneo RI,Weffort-Santos AM

    更新日期:2010-03-01 00:00:00

  • Peroxynitrite plays a key role in glomerular lesions in diabetic rats.

    abstract:BACKGROUND:Oxidative stress plays a crucial role in chronic complications of diabetes such as diabetic nephropathy (DN), the main cause of renal failure. In diabetes, whether peroxynitrite (ONOO(-)), generated from inducible nitric oxide synthase (iNOS) induced by tumor necrosis factor alpha (TNF-alpha), plays a primar...

    journal_title:Journal of nephrology

    pub_type: 杂志文章

    doi:

    authors: Xiao H,Li Y,Qi J,Wang H,Liu K

    更新日期:2009-11-01 00:00:00

  • Preeclampsia and cardiovascular risk: general characteristics, counseling and follow-up.

    abstract::The pathophysiological mechanisms underlying preeclampsia, a serious complication of pregnancy, are largely unknown. Since, on the other hand, the various risk factors are known, primary and secondary prevention with pre- and inter-pregnancy counseling should be undertaken, and a follow-up should be conducted to evalu...

    journal_title:Journal of nephrology

    pub_type: 杂志文章,评审

    doi:

    authors: Buemi M,Bolignano D,Barilla A,Nostro L,Crasci E,Campo S,Coppolino G,D'Anna R

    更新日期:2008-09-01 00:00:00

  • Salt intake and hypertension therapy.

    abstract::Hypertension is a risk factor for cardiovascular and renal organ damage. Environmental conditions affect the development of high blood pressure (BP), although genetic influences are also important. Current international guidelines recommend reducing dietary sodium to no more than 100 mmol (about 2.4 g sodium or approx...

    journal_title:Journal of nephrology

    pub_type: 杂志文章,评审

    doi:

    authors: Milan A,Mulatero P,Rabbia F,Veglio F

    更新日期:2002-01-01 00:00:00

  • A primer on survival analysis.

    abstract::Survival analysis is the statistical method for studying the time between entry to a study and a subsequent event. Survival is often the most important outcome in both observational and intervention studies. The analysis of survival, however, is not simple because of a number of factors. The time between entry to a st...

    journal_title:Journal of nephrology

    pub_type: 杂志文章,评审

    doi:

    authors: Khan IH,Prescott GJ

    更新日期:2004-03-01 00:00:00

  • Reversible vascular calcifications associated with hypervitaminosis D.

    abstract::A 64-year-old man was hospitalized in 2002 with symptoms of stupor, weakness, and renal colic. The clinical examination indicated borderline hypertension, small masses in the glutei, and polyuria. Laboratory tests evidenced high serum concentrations of creatinine, calcium, and phosphate. Imaging assessments disclosed ...

    journal_title:Journal of nephrology

    pub_type: 杂志文章

    doi:10.1007/s40620-015-0228-7

    authors: Cirillo M,Bilancio G,Cirillo C

    更新日期:2016-02-01 00:00:00

  • Primary renal lymphoma and xanthogranulomatous pyelonephritis in childhood.

    abstract::Primary renal non-Hodgkin's lymphoma is very rare in childhood. A six-year-old boy presented with bilateral non-obstructive multinodular nephromegaly and renal failure. Percutaneous needle biopsy showed large-cell lymphoma. The patient was started on chemotherapy. A right nephrectomy was done when systemic hypertensio...

    journal_title:Journal of nephrology

    pub_type: 杂志文章,评审

    doi:

    authors: Karadeniz C,Oguz A,Ataoglu O,Citak C,Buyan N,Pinarli G,Ozkaya O,Kapucu O

    更新日期:2002-09-01 00:00:00

  • Clinical and therapeutic aspects of diabetic nephropathy.

    abstract:UNLABELLED:The prognosis of renal survival in both type 1 and type 2 diabetes mellitus is not benign. Several factors characterize the increase in the risk of developing renal damage in diabetic patients, distinguished in diabetes-related factors, genetic factors and other factors. DIAGNOSIS:Diagnosis requires standar...

    journal_title:Journal of nephrology

    pub_type: 杂志文章,评审

    doi:

    authors: Strippoli GF,Di Paolo S,Cincione R,Di Palma AM,Teutonico A,Grandaliano G,Schena FP,Gesualdo L

    更新日期:2003-07-01 00:00:00

  • Increasing relevance of donor-specific antibodies in antibody-mediated rejection.

    abstract::One of the major concerns in organ transplantation is the early detection of humoral rejection, through improved diagnostic and prognostic biomarkers. Long-term survival of renal allografts is significantly lower in recipients developing donor-specific anti-HLA antibodies (DSAs) either pretransplant or posttransplant....

    journal_title:Journal of nephrology

    pub_type: 杂志文章,评审

    doi:10.5301/jn.5000240

    authors: Zito A,Schena A,Grandaliano G,Gesualdo L,Schena FP

    更新日期:2013-03-01 00:00:00

  • Clinical manifestations of systemic paraphenylene diamine intoxication.

    abstract:BACKGROUND:To report clinical symptoms and outcome of systemic paraphenylene diamine (PPD) intoxication. METHODS:Our study was retrospective. It was conducted over 6 yrs (1994-2000) in the medical intensive care unit (ICU) of a university hospital and it concerned 19 patients hospitalized for systemic PPD intoxication...

    journal_title:Journal of nephrology

    pub_type: 杂志文章

    doi:

    authors: Kallel H,Chelly H,Dammak H,Bahloul M,Ksibi H,Hamida CB,Chaari A,Rekik N,De Broe ME,Bouaziz M

    更新日期:2005-05-01 00:00:00

  • Involvement of TGF-beta signal for peritoneal sclerosing in continuous ambulatory peritoneal dialysis.

    abstract:BACKGROUND:Functional failure of the peritoneal membrane is the most serious problem in long-term continuous ambulatory peritoneal dialysis (CAPD). Transforming growth factor-beta (TGF-ss) is one of the key mediators of fibrosis in some organs, and is thought to be involved in peritoneal alterations. In this study, we ...

    journal_title:Journal of nephrology

    pub_type: 杂志文章

    doi:

    authors: Naiki Y,Maeda Y,Matsuo K,Yonekawa S,Sakaguchi M,Iwamoto I,Hasegawa H,Kanamaru A

    更新日期:2003-01-01 00:00:00

  • Bilateral emphysematous pyelonephritis with perirenal abscess cured by conservative therapy.

    abstract::Emphysematous pyelonephritis is a rare life-threatening infection of the renal parenchyma. It usually affects unilateral kidney and occurs mostly in diabetic patients. It is characterized by the presence of gas within the renal parenchyma and requires prompt diagnosis and early aggressive therapy. Bilateral emphysemat...

    journal_title:Journal of nephrology

    pub_type: 杂志文章

    doi:

    authors: Lim CS,Kim WB,Kim YS,Ahn C,Han JS,Kim S,Lee JS

    更新日期:2000-03-01 00:00:00

  • HBV-related cutaneous periarteritis nodosa in a patient 16 years after renal transplantation: efficacy of lamivudine.

    abstract::Cutaneous periarteritis nodosa (PAN) is a clinical feature characterized by chronic, benign course; its pathogenesis is unknown. In patients submitted to renal transplantation cutaneous PAN is a rare complication. We report a case of cutaneous PAN associated with the reappearance of hepatitis B antigen 16 years after ...

    journal_title:Journal of nephrology

    pub_type: 杂志文章

    doi:

    authors: Bedani PL,Bergami M,Cavazzini PL,Strumia R,Morelli MC,Stabellini G,Gilli P

    更新日期:2001-09-01 00:00:00

  • Correlation of bone mineral density with the histological findings of renal osteodystrophy in patients on hemodialysis.

    abstract:AIMS:To examine the distribution of bone mineral density (BMD) in different histological groups of renal osteodystrophy. PATIENTS:We prospectively studied 62 patients, 41 men and 21 women, aged 57+/-11.5 years, who had been on hemodialysis for 60+/-55 months. The women had been amenorrheic for 13+/-4 years and 7 patie...

    journal_title:Journal of nephrology

    pub_type: 杂志文章

    doi:

    authors: Gerakis A,Hadjidakis D,Kokkinakis E,Apostolou T,Raptis S,Billis A

    更新日期:2000-11-01 00:00:00

  • Nrf2 and Sp family synergistically enhance the expression of ion transporters in potassium-depleted conditions.

    abstract:INTRODUCTION:During potassium (K) depletion, many adaptive responses are likely mediated through a complex network that involves expression of a variety of genes. We identified that the Nrf2 gene was differentially expressed between normal and K-depleted rat kidney. METHODS:To investigate the effect of Nrf2 on colonic...

    journal_title:Journal of nephrology

    pub_type: 杂志文章

    doi:10.5301/JN.2011.8448

    authors: Lee CB,Lee YS,Lee JY,Lee SE,Ahn KY

    更新日期:2012-03-01 00:00:00

  • Serum adiponectin and cardiovascular risk in chronic kidney disease and kidney transplantation.

    abstract:BACKGROUND:Serum adiponectin is inversely linked to obesity, impaired glucose homeostasis, dyslipidemia and hypertension and has been suggested as a possible marker of cardiovascular (CV) disease in the general population. However, its role in chronic kidney disease and following renal transplantation is not well estab...

    journal_title:Journal of nephrology

    pub_type: 杂志文章

    doi:

    authors: Chitalia N,Raja RB,Bhandara T,Agrawal P,Kaski JC,Jha V,Banerjee D

    更新日期:2010-01-01 00:00:00

  • Modeling the effect of 3 missense AGXT mutations on dimerization of the AGT enzyme in primary hyperoxaluria type 1.

    abstract:INTRODUCTION:Mutations of the AGXT gene encoding the alanine:glyoxylate aminotransferase liver enzyme (AGT) cause primary hyperoxaluria type 1 (PH1). Here we report a molecular modeling study of selected missense AGXT mutations: the common Gly170Arg and the recently described Gly47Arg and Ser81Leu variants, predicted t...

    journal_title:Journal of nephrology

    pub_type: 杂志文章

    doi:

    authors: Robbiano A,Frecer V,Miertus J,Zadro C,Ulivi S,Bevilacqua E,Mandrile G,De Marchi M,Miertus S,Amoroso A

    更新日期:2010-11-01 00:00:00

  • Clinical significance of IgM and C1q deposition in the mesangium in pediatric idiopathic nephrotic syndrome.

    abstract:BACKGROUND:In biopsy-proven idiopathic nephrotic syndrome (INS), immunoglobulin M (IgM) and C1q are occasionally deposited in the mesangium. In pediatric nephrology, the significance of mesangial IgM or C1q deposits is controversial, based on previous reports. The aim of this study was to explore the clinical significa...

    journal_title:Journal of nephrology

    pub_type: 杂志文章

    doi:10.5301/jn.5000133

    authors: Kanemoto K,Ito H,Anzai M,Matsumura C,Kurayama H

    更新日期:2013-03-01 00:00:00

  • Identification of drug-related problems in ambulatory chronic kidney disease patients: a 6-month prospective study.

    abstract:BACKGROUND:Drug-related problems (DRPs) are common in chronic kidney disease (CKD) patients. We developed a 2-step consultation including a clinical pharmacist (CP) session and a nephrologist conventional care consultation to explore the feasibility of a pilot drug-oriented disease management program in controlling iat...

    journal_title:Journal of nephrology

    pub_type: 杂志文章

    doi:10.5301/jn.5000063

    authors: Belaiche S,Romanet T,Allenet B,Calop J,Zaoui P

    更新日期:2012-09-01 00:00:00

  • Acute colchicine intoxication during clarithromycin administration in patients with chronic renal failure.

    abstract::Colchicine is an effective antiinflammatory medication. It should be used with great caution, however, in patients requiring dialysis. Coadministration of colchicine and macrolides may impair colchicine elimination, resulting in excess drug exposure and toxicity. We report 2 renal failure cases of colchicine intoxicat...

    journal_title:Journal of nephrology

    pub_type: 杂志文章

    doi:

    authors: Akdag I,Ersoy A,Kahvecioglu S,Gullulu M,Dilek K

    更新日期:2006-07-01 00:00:00

  • Contrast-induced nephropathy and its prevention: What do we really know from evidence-based findings?

    abstract:INTRODUCTION:Contrast-induced acute kidney injury, also referred to as contrast-induced nephropathy (CIN), is a potentially serious renal complication associated with the use of iodinated contrast media (CM) in patients at risk. With the dramatic growth in contrast-enhanced imaging services worldwide, including procedu...

    journal_title:Journal of nephrology

    pub_type: 杂志文章,评审

    doi:

    authors: Reddan D,Laville M,Garovic VD

    更新日期:2009-05-01 00:00:00