Acute renal failure in the elderly: epidemiology and clinical features.

Abstract:

:Structural and functional alterations affecting the aging kidney predispose to an increased risk of acute renal failure (ARF) in the elderly. This is a common problem becoming more relevant because of an increase in life expectancy. The epidemiology of ARF in the elderly is far from being well assessed, because of the lack of uniform definition criteria, variable etiology, coexistence of several comorbidities, and the various clinical settings and geographic areas where the condition is managed, with a higher incidence in developed regions where elderly patients predominate. In 2004, the Acute Dialysis Quality Initiative group proposed the RIFLE criteria for diagnosis and stratification of ARF. More recently, the Acute Kidney Injury Network proposed several refinements to the RIFLE criteria, and the use of the term acute kidney injury (AKI) has been suggested to mean any abrupt reduction in kidney function, while restricting use of the term ARF to severe dysfunction requiring renal replacement treatment. Although in elderly patients the more frequent forms of AKI are functional or obstructive, parenchymal AKI, such as acute tubular necrosis and contrast-induced nephropathy, still frequently occur. Elderly patients with chronic renal disease (CKD) who develop AKI are at high risk for mortality, and are prone to non-recovery from AKI and progression to more advanced stages of CKD and even to end-stage renal disease. Panels of AKI biomarkers are likely to improve early diagnosis and treatment, thus reducing morbidity and mortality of older patients from this condition in the future.

journal_name

J Nephrol

journal_title

Journal of nephrology

authors

Del Giudice A,Aucella F

doi

10.5301/jn.5000141

subject

Has Abstract

pub_date

2012-01-01 00:00:00

pages

S48-57

eissn

1121-8428

issn

1724-6059

pii

87B63102-DD73-439C-933E-54E24E3C1181

journal_volume

25 Suppl 19

pub_type

杂志文章,评审
  • Silent chronic kidney disease epidemic seen from Europe: designing strategies for clinical management of the early stages.

    abstract::Given the alarming predictions of the potentially devastating future epidemic of end-stage renal disease (ESRD), further knowledge is still urgently needed on this topic. The real dimensions of the problem are still unclear. It is difficult to compare Europe and the USA because different criteria are used in data coll...

    journal_title:Journal of nephrology

    pub_type: 杂志文章

    doi:

    authors: Gambaro G,D'Angelo A,Conte M,Bonfante L,De Biase V,Lupo A

    更新日期:2005-03-01 00:00:00

  • Hypertension in the elderly: new and old evidence that treatment may benefit the old.

    abstract::Hypertension is prevalent and remains an important risk factor in elderly and very elderly. Randomized controlled outcome trials have shown benefit of antihypertensive treatment in patients with systolic diastolic hypertension and in patients with isolated systolic hypertension, aged 60 years and over. More recently b...

    journal_title:Journal of nephrology

    pub_type: 杂志文章

    doi:

    authors: Fagard RH

    更新日期:2009-09-01 00:00:00

  • Stage 5-CKD under nephrology care: to dialyze or not to dialyze, that is the question.

    abstract::Appropriate timing of starting chronic dialysis in patients with advanced chronic kidney disease (CKD) under nephrology care still is undefined. We systematically reviewed the most recent studies that have compared outcomes of stage 5-CKD under conservative versus substitutive treatment. Eleven studies, most in elderl...

    journal_title:Journal of nephrology

    pub_type: 杂志文章,评审

    doi:10.1007/s40620-015-0243-8

    authors: Pacilio M,Minutolo R,Garofalo C,Liberti ME,Conte G,De Nicola L

    更新日期:2016-04-01 00:00:00

  • GBV-C/HGV infection in end-stage renal disease.

    abstract::Recently, two independent teams detected presumed hepatitis agents, which were designated HGV and hepatitis GB virus C; they represent a new genus in the family Flaviviridae. The most accurate way to assess the epidemiology of GBV-C/HGV infection remains the combination of RT-PCR and anti-GBV-C/HGV E2 techniques, to d...

    journal_title:Journal of nephrology

    pub_type: 杂志文章,评审

    doi:

    authors: Fabrizi F,Martin P

    更新日期:1999-05-01 00:00:00

  • Consumption of nitrate-containing vegetables is inversely associated with hypertension in adults: a prospective investigation from the Tehran Lipid and Glucose Study.

    abstract:BACKGROUND:There is growing evidence of the potential properties of nitrate-rich foods against development of hypertension (HTN) and vascular disease. In this study, we investigated the association of nitrate-containing vegetables (NCVs) with risk of HTN after 3 years of follow-up. METHODS:This prospective study was c...

    journal_title:Journal of nephrology

    pub_type: 杂志文章

    doi:10.1007/s40620-015-0229-6

    authors: Golzarand M,Bahadoran Z,Mirmiran P,Zadeh-Vakili A,Azizi F

    更新日期:2016-06-01 00:00:00

  • Ferumoxytol: a new era of iron deficiency anemia treatment for patients with chronic kidney disease.

    abstract::Ferumoxytol is a new product approved for intravenous use by the US Food and Drug Administration (FDA) in the treatment of iron deficiency anemia in adults with chronic kidney disease. This approval was based on data from 3 open-label, randomized, controlled clinical trials. In all of these trials, ferumoxytol was wel...

    journal_title:Journal of nephrology

    pub_type: 杂志文章,评审

    doi:10.5301/jn.5000025

    authors: Kowalczyk M,Banach M,Rysz J

    更新日期:2011-11-01 00:00:00

  • Effect of n-3 polyunsaturated fatty acids on cyclosporine pharmacokinetics in kidney graft recipients: a randomized placebo-controlled study.

    abstract::Highly concentrated marine polyunsaturated fatty acids (n-3 PUFA), affecting the lipids and lipophilic drugs metabolism, can interfere with cyclosporine (CyA) pharmacokinetics. This prospective, randomized and placebo-controlled, double-blind study involved 42 kidney graft recipients. From day +1, 21 pts (E) received ...

    journal_title:Journal of nephrology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors: Busnach G,Stragliotto E,Minetti E,Perego A,Brando B,Broggi ML,Civati G

    更新日期:1998-03-01 00:00:00

  • Effects of turmeric on uremic pruritus in end stage renal disease patients: a double-blind randomized clinical trial.

    abstract:BACKGROUND:Uremic pruritus as a symptom that affects hemodialysis (HD) patients can decrease the quality of life and increase morbidity in these patients. The aim of this study was to evaluate the effects of turmeric on uremic pruritus in HD patients. SUBJECTS AND METHODS:This was a double-blind placebo-controlled tri...

    journal_title:Journal of nephrology

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/s40620-014-0039-2

    authors: Pakfetrat M,Basiri F,Malekmakan L,Roozbeh J

    更新日期:2014-04-01 00:00:00

  • Rapidly progressive glomerulonephritis.

    abstract::The management of rapidly progressive glomerulonephritis has been transformed over the past thirty years. It has become one of the few forms of glomerulonephritis that can be effectively treated, and today overall renal survival is as high as 70%. Effective management of patients with RPGN requires prompt and accurate...

    journal_title:Journal of nephrology

    pub_type: 杂志文章,评审

    doi:

    authors: Erwig LP,Rees AJ

    更新日期:1999-07-01 00:00:00

  • Further insights about the beneficial effects of n-3 fatty acids in the early molecular events of renal fibrosis in vitro.

    abstract:BACKGROUND:Accumulating experimental and clinical evidence reveals beneficial effects of n-3 polyunsaturated fatty acids (PUFAs) in kidney disease by modulating inflammation and fibrosis mechanisms that lead to renal failure. METHODS:EPA, DHA (n-3 PUFAs) and AA (n-6 PUFA) effects, compared to those of AngII, on renal ...

    journal_title:Journal of nephrology

    pub_type: 杂志文章

    doi:10.5301/jn.5000193

    authors: Priante G,Musacchio E,Valvason C,Clari G,Bordin L,Sartori L,Baggio B

    更新日期:2013-07-01 00:00:00

  • Visfatin is related to lipid dysregulation, endothelial dysfunction and atherosclerosis in patients with chronic kidney disease.

    abstract:BACKGROUND AND AIMS:This study aimed to test the hypothesis that visfatin is associated with atherosclerosis in patients with chronic kidney disease (CKD). METHODS:In the study, we measured serum triglycerides, total cholesterol, high-density lipoprotein (HDL) cholesterol, low-density lipoprotein (LDL) cholesterol lev...

    journal_title:Journal of nephrology

    pub_type: 杂志文章

    doi:10.5301/jn.2010.3488

    authors: Mu J,Feng B,Ye Z,Yuan F,Zeng W,Luo Z,Qi W

    更新日期:2011-03-01 00:00:00

  • AT1 receptors and the actin cytoskeleton during angiotensin II treatment.

    abstract:BACKGROUND:The response of proximal convoluted tubules (PCTs) to angiotensin II is mediated by specific type 1 receptors found on both apical and basolateral surface membrane cells. After ligand association with type 1 receptors, different signaling pathways are triggered and determine changes in fluid absorption (Jv)....

    journal_title:Journal of nephrology

    pub_type: 杂志文章

    doi:

    authors: Bertels IM,Gontijo JA,Figueiredo JF

    更新日期:2007-01-01 00:00:00

  • Podocyte Wnt/ß-catenin pathway is activated by integrin-linked kinase in clinical and experimental focal segmental glomerulosclerosis.

    abstract:BACKGROUND:Changes in podocyte phenotype and function are characteristic of proteinuric glomerular diseases. Integrin-linked kinase (ILK) functions as a common downstream effector in proteinuric diseases. In addition, ILK was shown to interact with the Wnt signaling pathway. Here, we investigated ILK expression as well...

    journal_title:Journal of nephrology

    pub_type: 杂志文章

    doi:10.5301/jn.5000017

    authors: Naves MA,Requião-Moura LR,Soares MF,Silva-Júnior JA,Mastroianni-Kirsztajn G,Teixeira VP

    更新日期:2012-05-01 00:00:00

  • Haemoglobinuria for the early identification of aHUS relapse: data from the ItalKId-HUS Network.

    abstract:BACKGROUND:Atypical haemolytic uremic syndrome (aHUS) is at high risk of relapse at any time, therefore patients require lifelong monitoring. The most appropriate way to monitor patients is not yet clear. Patients could be monitored for relapse by urine dipstick testing for haemoglobinuria based on the hypothesis that ...

    journal_title:Journal of nephrology

    pub_type: 杂志文章

    doi:10.1007/s40620-021-00965-8

    authors: Brambilla M,Ardissino G,Paglialonga F,Testa S,Capone V,Montini G

    更新日期:2021-01-18 00:00:00

  • Obliteration Index: a simple non-invasive tool for the assessment of peripheral vascular disease in chronic kidney disease.

    abstract:BACKGROUND:Peripheral artery disease (PAD) represents a major complication in chronic kidney disease (CKD) patients, but its early diagnosis is still problematic. Traditionally, ankle-arm blood pressure index (API) determined by means of a simple hand-held unidimensional Doppler device has been used for noninvasive dia...

    journal_title:Journal of nephrology

    pub_type: 杂志文章

    doi:

    authors: Saková R,Dusilová-Sulková S,Lopot F,Polakovic V

    更新日期:2009-07-01 00:00:00

  • Transplant tolerance: progress and challenges.

    abstract::Organ transplantation has proven to be an effective therapeutic for a wide variety of disease states, but the chronic immunosuppression required for allograft survival increases the risk for infection and neoplasia. In the past 50 years, a wealth of experimental data has been accumulated relating to strategies to pres...

    journal_title:Journal of nephrology

    pub_type: 杂志文章,评审

    doi:

    authors: Casiraghi F,Aiello S,Remuzzi G

    更新日期:2010-05-01 00:00:00

  • Posttransplant recurrence of atypical hemolytic uremic syndrome.

    abstract::Hemolytic uremic syndrome (HUS) is a rare disease characterized by microangiopathic hemolytic anemia, thrombocytopenia and acute renal failure. It is usually secondary to infections by strains of Escherichia coli (STEC) that produce Shiga-like toxin. In about 10% of patients, no STEC infections are reported. In these ...

    journal_title:Journal of nephrology

    pub_type: 杂志文章,评审

    doi:10.5301/jn.5000146

    authors: Valoti E,Alberti M,Noris M

    更新日期:2012-11-01 00:00:00

  • Extracellular fluid management and hypertension in urban dwelling versus rural dwelling hemodialysis patients.

    abstract:BACKGROUND:Rural-dwelling hemodialysis patients have less frequent contact with nephrologists than urban-dwelling patients, and are known to have higher mortality. We hypothesized that rural-dwelling hemodialysis patients would have more evidence of poorly controlled extracellular fluid volume (ECVF) than otherwise sim...

    journal_title:Journal of nephrology

    pub_type: 杂志文章

    doi:10.1007/s40620-016-0337-y

    authors: Tonelli M,Lloyd A,Pannu N,Klarenbach S,Ravani P,Jindal K,MacRae J,Unsworth L,Manns B,Hemmelgarn B

    更新日期:2018-02-01 00:00:00

  • Medicine in Pomerania and Pomezania during their conquest by the Teutonic Knights.

    abstract::The origin of the Teutonic Order of Hospitalers St. Mary (Ordo Hospitalis S. Mariae Teutonicorum Hi-erosolymitani) is presented. The St. Mary Hospitaler Teutonic Order arrived in the XIIIth century to Pomezania, then inhabited by pagan Prussian tribes. The Knights of the Order started to Christianize the Prussians, th...

    journal_title:Journal of nephrology

    pub_type: 历史文章,杂志文章

    doi:

    authors: Zydowo MM

    更新日期:2006-05-01 00:00:00

  • Management of secondary hyperparathyroidism in Italy: results of the Italian FARO survey.

    abstract:AIMS:In recent years, treatment options for secondary hyperparathyroidism (SHPT) have increased (e.g., paricalcitol, calcimimetics). To determine the impact these new treatments have on achieving K/DOQI targets, an observational, prospective survey was undertaken. METHODS:Four 6-month time-spaced surveys of 2,637 pati...

    journal_title:Journal of nephrology

    pub_type: 杂志文章,多中心研究

    doi:10.5301/jn.2010.6193

    authors: Mazzaferro S,Brancaccio D,Messa P,Andreucci VE,Bellinghieri G,Bigazzi R,Bolasco P,Costanzo AM,di Luzio Paparatti U,Cannella G,FARO Study Group.

    更新日期:2011-03-01 00:00:00

  • A comparison of methods for the measurement of hemodialysis access recirculation.

    abstract:BACKGROUND:NKF K-DOQI clinical practice guidelines recommend a regular monitoring of vascular access (VA) through several methods, such as VA recirculation (AR). Assessment of AR is crucial to avoid inefficiency of hemodialysis (HD). A non-urea based method has been developed (ultrasound dilution Transonics Hemodialysi...

    journal_title:Journal of nephrology

    pub_type: 杂志文章

    doi:

    authors: Basile C,Ruggieri G,Vernaglione L,Montanaro A,Giordano R

    更新日期:2003-11-01 00:00:00

  • Gitelman syndrome with mental retardation: a case report.

    abstract::Gitelman syndrome (GS), an inherited disorder due to loss of function in mutations of the gene encoding the distal convoluted tubule Na-Cl cotransporter (NCCT), is characterized by hypokalemia metabolic alkalosis, hypomagnesemia and hypocalciuria. A 18-year-old girl was admitted to our hospital with a history of muscl...

    journal_title:Journal of nephrology

    pub_type: 杂志文章

    doi:

    authors: Tuhta GA,Tuhta A,Erdogan M

    更新日期:2010-09-01 00:00:00

  • Microalbuminuria in essential hypertension.

    abstract::Some patients with essential hypertension manifest increased urinary albumin excretion (UAE). Hypertensive patients with microalbuminuria manifest abnormal circadian variation of blood pressure, increased serum levels of LDL-cholesterol and lipoprotein(a), a greater rise of serum insulin in response to an oral glucose...

    journal_title:Journal of nephrology

    pub_type: 杂志文章,评审

    doi:

    authors: Bianchi S,Bigazzi R,Campese VM

    更新日期:1997-07-01 00:00:00

  • Treatment of IgA nephropathy with angiotensin converting enzyme inhibitors: design of a prospective randomized multicenter trial.

    abstract::Although several in vitro studies and clinical observations suggest that ACE-inhibitors (ACE-I) are a promising treatment for IgA nephropathy (IgAN), meta-analysis of published data is not yet conclusive. Therefore, a European double-blinded, prospective, randomized therapeutic trial was designed to evaluate ACE-I tre...

    journal_title:Journal of nephrology

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:

    authors: Coppo R,Chiesa M,Peruzzi L,Amore A

    更新日期:2001-11-01 00:00:00

  • Mixed hemodiafiltration reduces erythropoiesis stimulating agents requirement in dialysis patients: a prospective randomized study.

    abstract:BACKGROUND:Improved responsiveness to erythropoiesis stimulating agents (ESAs) in patients on on-line post-dilution hemodiafiltration (Post-HDF) compared with conventional hemodialysis (HD) was reported by some authors but challenged by others. This prospective, cross-over randomized study tested the hypothesis that an...

    journal_title:Journal of nephrology

    pub_type: 杂志文章

    doi:10.1007/s40620-020-00709-0

    authors: Pedrini LA,Comelli M,Ruggiero P,Feliciani A,Manfrini V,Cozzi G,Castellano A,Pezzotta M,Gatti G,Arazzi M,Auriemma L,di Benedetto A,Stuard S

    更新日期:2020-10-01 00:00:00

  • Ventricular function and all-cause mortality in chronic kidney disease patients with angiographic coronary artery disease.

    abstract:BACKGROUND:Coronary artery disease (CAD) and chronic kidney disease (CKD) lead to high morbidity and mortality rates. Traditional and nontraditional risk factors, hypertension, fluid overloading and anemia can lead to myocardial ischemia, chamber hypertrophy and dilatation, and low left ventricular ejection fraction (L...

    journal_title:Journal of nephrology

    pub_type: 杂志文章

    doi:

    authors: Wu IW,Hung MJ,Chen YC,Hsu HJ,Cherng WJ,Chang CJ,Wu MS

    更新日期:2010-03-01 00:00:00

  • The association of endothelin-1 levels with renal survival in polycystic kidney disease patients.

    abstract:BACKGROUND:The prominent features of autosomal dominant polycystic kidney disease (ADPKD) are early development of hypertension, chronic kidney disease and cardiovascular problems. Thus, we aimed to investigate the role of endothelin, a vascular biomarker, in the clinical course of ADPKD, including renal and cardiovasc...

    journal_title:Journal of nephrology

    pub_type: 杂志文章

    doi:10.1007/s40620-018-0514-2

    authors: Kocyigit I,Eroglu E,Kaynar AS,Kocer D,Kargi S,Zararsiz G,Bayramov R,Imamoglu H,Sipahioglu MH,Tokgoz B,Dundar M,Oymak O

    更新日期:2019-02-01 00:00:00

  • Renal tubular epithelial expression of the coinhibitory molecule B7-DC (programmed death-1 ligand).

    abstract:BACKGROUND:Renal tubular epithelial cells (TECs) function as antigen-presenting cells because they constitutively express MHC class II molecules and have the ability to present peptide antigen to CD4+T cells. However, the costimulatory signals provided by TECs for optimal T-cell activation have not been fully character...

    journal_title:Journal of nephrology

    pub_type: 杂志文章

    doi:

    authors: Zhang J,Chen Y,Li J,Zhang R,Wu Y,Zou L,Zhao T,Zhang X,Han J,Chen A,Wu Y

    更新日期:2006-07-01 00:00:00

  • Effects of nitric oxide on gentamicin toxicity in isolated perfused rat kidneys.

    abstract:BACKGROUND:There have been many studies in recent years concerning the role of nitric oxide (NO) in acute renal failure (ARF). In this study, the effects of the inhibition or the induction of NO synthase (NOS) on gentamicin-induced ARF was investigated in isolated perfused rat kidneys. METHODS:Kidneys from male Spragu...

    journal_title:Journal of nephrology

    pub_type: 杂志文章

    doi:

    authors: Ghaznavi R,Faghihi M,Kadkhodaee M,Shams S,Khastar H

    更新日期:2005-09-01 00:00:00

  • Limitations of Cockcroft-Gault and MDRD formulas in estimating GFR among top-level rugby players.

    abstract:INTRODUCTION:We measured serum creatinine concentrations in 17 male athletes of the Italian national rugby team. METHODS:Blood was obtained before the start of training and during the competitive season. Serum creatinine level was measured by Jaffé reaction at 4 time points during the season, with a formal measure of ...

    journal_title:Journal of nephrology

    pub_type: 杂志文章

    doi:10.5301/jn.5000094

    authors: Banfi G,Sloand J,Shelly M,Del Fabbro M,Barassi A,Melzi d'Eril GV

    更新日期:2012-11-01 00:00:00