Lipid abnormalities in the nephrotic syndrome: the therapeutic role of statins.

abstract：:Synthetic immunosuppressive drugs are largely used in immune-related renal diseases and in kidney transplantation. Most of these drugs have a low therapeutic index (the ratio that compares the blood concentration at which a drug becomes toxic and the concentration at which the drug is effective), which means that the ...

journal_title：Journal of nephrology

authors： Ponticelli C,Glassock RJ

更新日期：2019-12-01 00:00:00

abstract：:Diabetic nephropathy (DN) is a common complication of Diabetes Mellitus (DM) Types 1 and 2, and prevention of end stage renal disease (ESRD) remains a major challenge. Despite its high prevalence, the pathogenesis of DN is still controversial. Initial glomerular disease manifested by hyperfiltration and loss of glomer...

journal_title：Journal of nephrology

authors： Zeni L,Norden AGW,Cancarini G,Unwin RJ

更新日期：2017-12-01 00:00:00

abstract：:The proximal tubule reabsorbs approximately 80% of the filtered load of bicarbonate. Defects in the process of bicarbonate reabsorption result in loss of bicarbonate and proximal renal tubular acidosis. Global proximal tubule dysfunction is known as the Fanconi's syndrome. Both isolated proximal renal tubular acidosis...

journal_title：Journal of nephrology

authors： Quigley R

更新日期：2006-03-01 00:00:00

abstract：BACKGROUND:This study was undertaken to examine whether there is an association between parity and age at first birth and risk of death from chronic renal failure (CRF). STUDY DESIGN:Prospective cohort study. SETTING AND PARTICIPANTS:The study cohort consisted of 1 292 462 women who had a first and singleton childbir...

journal_title：Journal of nephrology

authors： Kuo CC,Lee CT,Chen CC,Tsai SS,Yang CY

更新日期：2013-03-01 00:00:00

abstract：:Sudden cardiac death (SCD) is a major cause of concern in end stage renal disease (ESRD), contributing to 70% of cardiovascular mortality and 27% of all-cause mortality in dialysis patients. Yet its mechanisms and pathogenesis remain largely obscure. This review discusses the potential reasons for an exaggerated risk ...

journal_title：Journal of nephrology

authors： Zachariah D,Kalra PR,Roberts PR

更新日期：2015-04-01 00:00:00

abstract：BACKGROUND:Early initiation of therapy is warranted for patients with idiopathic membranous nephropathy (IMN) who have severe proteinuria. Therapy with tacrolimus (TAC) or intravenous cyclophosphamide (CYC) may be an option in treating such patients. METHODS:This prospective cohort study included patients with IMN who...

journal_title：Journal of nephrology

authors： Li X,Lv R,He Q,Li H,Du X,Lin W,Li Q,He X,Wang S,Chen J

更新日期：2008-07-01 00:00:00

abstract：BACKGROUND:Plasmin has recently been reported to be associated with renal fibrosis in experimental models, but its role in human renal diseases is unclear. METHODS:Fifty-seven patients with IgA nephropathy (IgAN) were evaluated retrospectively. Plasmin in their renal biopsy tissues was assessed by in situ zymography u...

journal_title：Journal of nephrology

authors： Uchida T,Oda T,Takechi H,Matsubara H,Watanabe A,Yamamoto K,Oshima N,Sakurai Y,Kono T,Shimazaki H,Tamai S,Kumagai H

更新日期：2016-02-01 00:00:00

abstract：:In 1998, the Italian Ministry of Health urged the Italian Society of Nephrology (SIN) to draft recommendations for uniform decision-making procedures in the field of dialysis. In accordance with the Ministry's specifications, at the time the Society approved diagnostic protocols regarding clinical questions, but witho...

journal_title：Journal of nephrology

authors： Buzzi F,Cecioni R,Di Paolo M,National Task Force for Bioethics in Nephrology.

更新日期：2001-03-01 00:00:00

abstract：BACKGROUND AND METHODS:Smoking is associated with hyperparathyroidism in the elderly general population and nicotine, the main component of tobacco smoke, stimulates PTH release in experimental models. Although smoking is a persisting problem in patients with end-stage renal disease (ESRD), the association between smok...

journal_title：Journal of nephrology

authors： Tripepi G,Mattace-Raso F,Pizzini P,Cutrupi S,Witteman J,Zoccali C,Mallamaci F

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:The response of proximal convoluted tubules (PCTs) to angiotensin II is mediated by specific type 1 receptors found on both apical and basolateral surface membrane cells. After ligand association with type 1 receptors, different signaling pathways are triggered and determine changes in fluid absorption (Jv)....

journal_title：Journal of nephrology

authors： Bertels IM,Gontijo JA,Figueiredo JF

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:The risks connected with dialysis fluid contamination are well established. Epidemiological studies have demonstrated just how difficult it is to obtain permanently satisfactory quality standards. Therefore, dialysis centers must have effective and regular quality control programs, particularly with the grow...

journal_title：Journal of nephrology

authors： Pizzarelli F,Cerrai T,Biagini M,Malaguti M,Bargagna R

更新日期：2004-07-01 00:00:00

abstract：BACKGROUND:Until now, the survival of iliac vein tunneled cuffed catheters (TCCs) used in elderly patients has not been fully investigated. Accordingly, we evaluated their use in elderly hemodialysis patients with no other venous access options. METHODS:A total of 70 elderly patients with iliac vein TCCs undergoing ch...

journal_title：Journal of nephrology

authors： Wang L,Wei F,Sun G,Chen H,Yu H,Jiang A

更新日期：2016-02-01 00:00:00

abstract：INTRODUCTION:The literature on the clinical effectiveness of treatments for steroid-resistant nephrotic syndrome (SRNS) is very limited. The available evidence suggests a beneficial effect of cyclosporine on remission rates. Mycophenolate mofetil (MMF) represents a promising therapeutic alternative without nephrotoxici...

journal_title：Journal of nephrology

authors： Gargah TT,Lakhoua MR

更新日期：2011-03-01 00:00:00

abstract：OBJECTIVES:HERMEX is a population-based study which tries to evaluate the relative weight of cardiovascular risk factors in inhabitants of Extremadura, Spain. This report presents the data about chronic kidney disease (CKD) in a Spanish population sample. METHODS:For an observational cross-sectional population-based s...

journal_title：Journal of nephrology

authors： Robles NR,Felix FJ,Fernandez-Berges D,Perez-Castán JF,Zaro MJ,Lozano L,Alvarez-Palacios P,Garcia-Trigo A,Tejero V,Morcillo Y,Hidalgo AB

更新日期：2013-07-01 00:00:00

abstract：:The increase in progressive kidney disease, rising numbers of patients with end-stage renal disease, organ shortages for kidney transplants and poor long-term graft survival rates underline the need for better strategies to diagnose, prevent and treat renal disease. Histological analysis, based on renal biopsies and r...

journal_title：Journal of nephrology

authors： Mueller TF,Mas VR

更新日期：2012-09-01 00:00:00

abstract：:We report 4 cases of sepsis-induced acute renal failure (ARF) with peculiar clinical presentation in which the renal biopsy was the only clue to a correct diagnosis. We observed 66 cases of ARF in a 4-year experience. Seven (11%) were associated with sepsis; in 3 of these (4.5%) a shock was present. Clinical picture o...

journal_title：Journal of nephrology

authors： Feriozzi S,Muda AO,Massimetti C,Costantini S,Ancarani E

更新日期：1998-09-01 00:00:00

abstract：BACKGROUND:Chronic renal failure (CRF) is associated with a tendency to atherosclerosis due to the enhanced oxidative stress and insufficient antioxidant enzyme activities such as superoxide dismutase (SOD), catalase (CAT) and paraoxonase (PON 1), together with abnormalities in lipid parameters. We determined the in vi...

journal_title：Journal of nephrology

authors： Ak G,Ozgönül M,Sözmen EY,Aslan SL,Sözmen B

更新日期：2002-03-01 00:00:00

abstract：OBJECTIVE:Intradialytic exercise (IDE) is not yet a routine practice for hemodialysis patients, the lack of guidelines supporting it being a major reason. This systematic review and meta-analysis of aerobic IDE interventions examined the efficacy of IDE regarding quality of life (QOL), serum phosphorus, dialysis effici...

journal_title：Journal of nephrology

authors： Salhab N,Karavetian M,Kooman J,Fiaccadori E,El Khoury CF

更新日期：2019-08-01 00:00:00

abstract：:Renal transplantation is associated with better survival and improved quality of life compared to maintenance dialysis. Although many sleep disorders improve or even disappear after a successful transplantation, sleep quality remains low, and the prevalence of sleep complaints, although lower than in dialysis patients...

journal_title：Journal of nephrology

authors： Sabbatini M,Pisani A,Crispo A,Nappi R,Gallo R,Cianciaruso B,Federico S

更新日期：2008-03-01 00:00:00

abstract：BACKGROUND:The regulation of renal hemodynamics is closely related to the L-arginine (L-Arg)/nitric oxide (NO) pathway. NO - metabolized from L-Arg - is capable of improving renal function in ischemic and toxic acute renal failure (ARF), while NO synthase (NOS) inhibition induces deterioration in renal function. The mo...

journal_title：Journal of nephrology

authors： Schramm L,Weierich T,Heldbreder E,Zimmermann J,Netzer KO,Wanner C

更新日期：2005-07-01 00:00:00

abstract：:The abnormal metabolism of uric acid results in many disease such as chronic kidney disease, hyperuricemia, nephrolithiasis, gout, hypertension, vascular disease and so on. Serum uric acid levels are maintained by the balance between production and elimination. There are many factors that maintain the balance of serum...

journal_title：Journal of nephrology

authors： Wang Z,Cui T,Ci X,Zhao F,Sun Y,Li Y,Liu R,Wu W,Yi X,Liu C

更新日期：2019-04-01 00:00:00

abstract：:Given the alarming predictions of the potentially devastating future epidemic of end-stage renal disease (ESRD), further knowledge is still urgently needed on this topic. The real dimensions of the problem are still unclear. It is difficult to compare Europe and the USA because different criteria are used in data coll...

journal_title：Journal of nephrology

authors： Gambaro G,D'Angelo A,Conte M,Bonfante L,De Biase V,Lupo A

更新日期：2005-03-01 00:00:00

abstract：BACKGROUND:Pericardial effusion in uremic patients (UPE) was first described by R. Bright in 1836. It is generally agreed that patients require emergency pericardial drainage when tamponade signs are present, but in patients with no tamponade the optimal timing for drainage remains unclear. METHODS:To define patients ...

journal_title：Journal of nephrology

authors： Bataille S,Brunet P,Decourt A,Bonnet G,Loundou A,Berland Y,Habib G,Vacher-Coponat H

更新日期：2015-02-01 00:00:00

abstract：BACKGROUND:This study aimed to evaluate the health-related quality of life (HRQOL) and burden on family caregivers of chronic dialysis patients and to analyze which factors were associated with it. METHODS:A cross-sectional multicentric study was carried out with 221 patient/caregiver pairs. General population Short F...

journal_title：Journal of nephrology

authors： Alvarez-Ude F,Valdés C,Estébanez C,Rebollo P,FAMIDIAL Study Group.

更新日期：2004-11-01 00:00:00

abstract：BACKGROUND:Oxidative stress plays a crucial role in chronic complications of diabetes such as diabetic nephropathy (DN), the main cause of renal failure. In diabetes, whether peroxynitrite (ONOO(-)), generated from inducible nitric oxide synthase (iNOS) induced by tumor necrosis factor alpha (TNF-alpha), plays a primar...

journal_title：Journal of nephrology

authors： Xiao H,Li Y,Qi J,Wang H,Liu K

更新日期：2009-11-01 00:00:00

abstract：:The expansion of genomic medicine is furthering our understanding of many human diseases. This is well illustrated in the field of nephrology, through the characterization, discovery, and growing insight into various renal diseases through use of Next Generation Sequencing (NGS) technologies. This review will provide ...

journal_title：Journal of nephrology

authors： Nestor JG,Groopman EE,Gharavi AG

更新日期：2018-02-01 00:00:00

abstract：BACKGROUND:Mesangial proliferative glomerulonephritis (MePGN) is characterized by excessive mesangial cell proliferation and mesangial matrix expansion, which lead to glomerular sclerosis and obliteration and, in turn, to deteriorating renal function. To identify and quantify the total proteins in renal tissues of MePG...

journal_title：Journal of nephrology

authors： Sui W,Tang D,Zou T,Zou G,Chen J,Li H,Li L,Hou Y,Li H,Dai Y

更新日期：2013-01-01 00:00:00

abstract：:Dynamic progress in the basic sciences such as clinical chemistry exerted a great influence on the development of clinical science in medicine in the 19th century. We should rate Prof. Leon Marchlewski among the group of prominent foreign and Polish scientists working in that period. Marchlewski was born in 1869 in Wl...

journal_title：Journal of nephrology

authors： Ostrowski J,Muszytowski M,Rutkowski B

更新日期：2011-05-01 00:00:00

abstract：BACKGROUND:With improvements in technology, renal biopsies have become safer and could potentially be effectively carried out in the outpatient setting. The purpose of our study is to compare the safety and cost of performing outpatient versus inpatient renal biopsies at a single Northern California pediatric hospital....

journal_title：Journal of nephrology

authors： Lau KK,Berg GL,Butani L

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:The recent multicenter, randomized, open-label INDEPENDENT study demonstrated that sevelamer improves survival in new to hemodialysis (HD) patients compared with calcium carbonate. The objective of this study was to determine the cost-effectiveness of sevelamer versus calcium carbonate for patients new to HD...

journal_title：Journal of nephrology

authors： Ruggeri M,Bellasi A,Cipriani F,Molony D,Bell C,Russo D,Di Iorio B

更新日期：2015-10-01 00:00:00