Regulation of sodium transporters in the kidney during cyclosporine treatment.

Abstract:

:Cyclosporine (CsA) is among the most widely used immunosuppressants for preventing graft rejection and autoimmune diseases. However, its clinical use is hampered by its significant nephrotoxicity and effects as a cause of hypertension. The proximal tubular Na+-H+ exchanger (NHE3) is responsible for transcellular reabsorption of 30%-60% of the sodium filtered by the glomerulus. CsA induces a reduction of absolute sodium reabsorption, and this effect is, most probably, correlated with the decrease of NHE3 activity. In Henle's loop, in physiological conditions, the Na+-K+-2Cl- cotransporter (NKCC2) reabsorbs approximately 20% of the filtered Na+ and Cl-. CsA increases the NKCC2 activity in cultured bovine renal NBL-1 cells. In the collecting duct, CsA may cause hypertension by stimulating the epithelial Na+ channel (ENaC) through a pathway associated with inhibition of ABCA1 and consequent elevation of cholesterol in the cells. It is still unclear whether CsA regulates the Na+-Cl- cotransporter in the distal tubule and ENaC in the collecting duct. Aside from this, there is evidence suggesting the possible involvement of free radicals during the development of CsA-induced hypertension. The hypertensive effect is, most probably, correlated with higher levels of superoxide (O2-) that decreases glomerular filtration rate and may affect fluid reabsorption along the nephron.

journal_name

J Nephrol

journal_title

Journal of nephrology

authors

Damiano S,Scanni R,Ciarcia R,Florio S,Capasso G

subject

Has Abstract

pub_date

2010-11-01 00:00:00

pages

S191-8

eissn

1121-8428

issn

1724-6059

pii

A4133E0B-3D5F-4010-97E6-A9D54CB1FAAD

journal_volume

23 Suppl 16

pub_type

杂志文章,评审
  • Three-dimensional contrast-enhanced magnetic resonance angiography (3-D CE-MRA) in the evaluation of hemodialysis access complications, and the condition of central veins in patients who are candidates for hemodialysis access.

    abstract:BACKGROUND:Arteriovenous (AV) fistulas are crucial in patients requiring long-term hemodialysis (HD). Dysfunctions of these fistulas are the most common causes of recurrent hospitalizations. This study aimed to evaluate the feasibility, safety and usefulness of contrast-enhanced magnetic resonance angiography (CE-MRA) ...

    journal_title:Journal of nephrology

    pub_type: 杂志文章

    doi:

    authors: Paksoy Y,Gormus N,Tercan MA

    更新日期:2004-01-01 00:00:00

  • Effects of short daily hemodialysis and extended standard hemodialysis on blood pressure and cardiac hypertrophy: a comparative study.

    abstract:BACKGROUND:Causes of hypertension and cardiac hypertrophy in hemodialysis (HD) patients are multiple, but the role of fluid overload appears to be crucial. Short daily HD (sDHD = 2 hr x 6/week) seems to allow reductions in left ventricular mass (LVM) through the reduction of extracellular water (ECW). Better cardiovasc...

    journal_title:Journal of nephrology

    pub_type: 杂志文章

    doi:

    authors: Fagugli RM,Pasini P,Pasticci F,Ciao G,Cicconi B,Buoncristiani U

    更新日期:2006-01-01 00:00:00

  • Adherence to phosphate binders in hemodialysis patients: prevalence and determinants.

    abstract:BACKGROUND:Phosphate control is a crucial treatment goal in end-stage renal disease, but poor patient adherence to phosphate binder therapy remains a challenge. This study aimed to estimate the extent of phosphate binder adherence in hemodialysis patients and to identify potential determinants. METHODS:Phosphate binde...

    journal_title:Journal of nephrology

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1007/s40620-014-0062-3

    authors: Van Camp YP,Vrijens B,Abraham I,Van Rompaey B,Elseviers MM

    更新日期:2014-12-01 00:00:00

  • Renal structure in type 2 diabetes: facts and misconceptions.

    abstract::The clinical manifestations of diabetic nephropathy are similar in type 1 and type 2 diabetes, while the renal lesions may differ. Indeed, diabetic glomerulopathy is the predominant renal lesion in type 1 diabetes, although also tubular, interstitial and arteriolar lesions are present in the advanced stages of renal d...

    journal_title:Journal of nephrology

    pub_type: 杂志文章,评审

    doi:10.1007/s40620-020-00797-y

    authors: Di Vincenzo A,Bettini S,Russo L,Mazzocut S,Mauer M,Fioretto P

    更新日期:2020-10-01 00:00:00

  • Angioplasty of the renal artery: antihypertensive and renal effects.

    abstract::Percutaneous transluminal angioplasty of the renal artery (PTRA) has been increasingly used over the past 20 years for treating renovascular hypertension (RVH). From the experience gathered so far it is justified to state that this technique is the first choice for patients with fibromuscular renal artery stenosis (RA...

    journal_title:Journal of nephrology

    pub_type: 杂志文章,评审

    doi:

    authors: Morganti A

    更新日期:2000-11-01 00:00:00

  • Familial renal tubular acidosis.

    abstract::The kidney maintains systemic acid-base homeostasis through proximal tubular reclamation of filtered bicarbonate, and excretion of the daily mineral acid load by collecting duct type A intercalated cells. Impairment of either process produces renal tubular acidosis (RTA). This article will provide an overview of famil...

    journal_title:Journal of nephrology

    pub_type: 杂志文章,评审

    doi:

    authors: Alper SL

    更新日期:2010-11-01 00:00:00

  • The presence and impact of diastolic dysfunction on physical function and body composition in hemodialysis patients.

    abstract:BACKGROUND:Cardiovascular (CV) diseases are the main cause of death in maintenance hemodialysis (MHD) patients. Muscle wasting and physical function decline are common in MHD patients, and significantly impair their quality of life. These can result from abnormalities in cardiac function, which can be further worsened ...

    journal_title:Journal of nephrology

    pub_type: 杂志文章

    doi:10.1007/s40620-015-0188-y

    authors: Jeong JH,Wu PT,Kistler BM,Fitschen PJ,Biruete AG,Phillips SA,Ali MM,Fernhall B,Wilund KR

    更新日期:2015-12-01 00:00:00

  • Preeclampsia and cardiovascular risk: general characteristics, counseling and follow-up.

    abstract::The pathophysiological mechanisms underlying preeclampsia, a serious complication of pregnancy, are largely unknown. Since, on the other hand, the various risk factors are known, primary and secondary prevention with pre- and inter-pregnancy counseling should be undertaken, and a follow-up should be conducted to evalu...

    journal_title:Journal of nephrology

    pub_type: 杂志文章,评审

    doi:

    authors: Buemi M,Bolignano D,Barilla A,Nostro L,Crasci E,Campo S,Coppolino G,D'Anna R

    更新日期:2008-09-01 00:00:00

  • Crescentic glomerulonephritis associated with renal cell carcinoma after cancer immunotherapy.

    abstract::A 59 year-old woman showed rapidly progressive glomerulonephritis during immunotherapy for metastatic renal cell carcinoma. She received unilateral nephrectomy and cytotoxic T lymphocyte (CTL) therapy for the treatment of retroperitoneal lymph node metastasis of renal cell carcinoma. With CTL therapy, her retroperiton...

    journal_title:Journal of nephrology

    pub_type: 杂志文章

    doi:

    authors: Kai H,Yamagata K,Usui J,Shimizu Y,Hirayama A,Yoh K,Mase K,Hirayama K,Nagase S,Nagata M,Kawai K,Akaza H,Koyama A

    更新日期:2005-07-01 00:00:00

  • Proximal renal tubular acidosis.

    abstract::The proximal tubule reabsorbs approximately 80% of the filtered load of bicarbonate. Defects in the process of bicarbonate reabsorption result in loss of bicarbonate and proximal renal tubular acidosis. Global proximal tubule dysfunction is known as the Fanconi's syndrome. Both isolated proximal renal tubular acidosis...

    journal_title:Journal of nephrology

    pub_type: 杂志文章,评审

    doi:

    authors: Quigley R

    更新日期:2006-03-01 00:00:00

  • Continuous ambulatory peritoneal dialysis and sclerosing encapsulating peritonitis: tamoxifen as a new therapeutic agent?

    abstract::Sclerosing encapsulating peritonitis (SEP) is a serious complication of long-term continuous ambulatory peritoneal dialysis (CAPD), very likely related to a persisting expression of the transforming growth factor beta1 (TGFbeta1) gene on peritoneal mesothelial cells. We report the case of a 67-year-old uremic woman wh...

    journal_title:Journal of nephrology

    pub_type: 杂志文章

    doi:

    authors: Allaria PM,Giangrande A,Gandini E,Pisoni IB

    更新日期:1999-11-01 00:00:00

  • Haemoglobinuria for the early identification of aHUS relapse: data from the ItalKId-HUS Network.

    abstract:BACKGROUND:Atypical haemolytic uremic syndrome (aHUS) is at high risk of relapse at any time, therefore patients require lifelong monitoring. The most appropriate way to monitor patients is not yet clear. Patients could be monitored for relapse by urine dipstick testing for haemoglobinuria based on the hypothesis that ...

    journal_title:Journal of nephrology

    pub_type: 杂志文章

    doi:10.1007/s40620-021-00965-8

    authors: Brambilla M,Ardissino G,Paglialonga F,Testa S,Capone V,Montini G

    更新日期:2021-01-18 00:00:00

  • Effects of prednisone on biomarkers of tubular damage induced by radiocontrast in interventional cardiology.

    abstract:BACKGROUND:Contrast-induced nephropathy (CI-AKI) is a complication of diagnostic/therapeutic hemodynamic procedures in cardiology, which may also cause renal cholesterolinic atheroembolism. Despite the 
severe clinical impact of these complications, there is no optimal therapy for preventing and treating them. We sugge...

    journal_title:Journal of nephrology

    pub_type: 杂志文章

    doi:10.5301/jn.5000266

    authors: Ribichini F,Gambaro A,Pighi M,Pesarini G,Ferraro PM,Zuppi C,Baroni S,Penitente R,Ferrero V,Vassanelli C

    更新日期:2013-05-01 00:00:00

  • Evaluation of dialysis outcomes: experimental versus observational evidence.

    abstract::Evidence-based medicine provides tools to evaluate dialysis outcomes by integrating knowledge obtained from interventional and observational studies. This is illustrated in relation to three important topics: dialysis membranes, dialysis dose and anemia. Clinical trials and observational evidence support each other in...

    journal_title:Journal of nephrology

    pub_type: 杂志文章,评审

    doi:

    authors: Locatelli F,Andrulli S,D'Amico M

    更新日期:2001-11-01 00:00:00

  • Microarray applications in nephrology with special focus on transplantation.

    abstract::The increase in progressive kidney disease, rising numbers of patients with end-stage renal disease, organ shortages for kidney transplants and poor long-term graft survival rates underline the need for better strategies to diagnose, prevent and treat renal disease. Histological analysis, based on renal biopsies and r...

    journal_title:Journal of nephrology

    pub_type: 杂志文章,评审

    doi:10.5301/jn.5000205

    authors: Mueller TF,Mas VR

    更新日期:2012-09-01 00:00:00

  • Chronic hypotension in the dialysis patient.

    abstract::Chronic hypotension, defined by a systolic blood pressure < 100 mmHg in the interdialytic period, affects 5-10% of hemodialysis patients, and is more prevalent among patients on long-term hemodialysis. This complication requires a substantial amount of medical and nursing care before and during dialysis to control its...

    journal_title:Journal of nephrology

    pub_type: 杂志文章,评审

    doi:

    authors: Cases A,Coll E

    更新日期:2002-07-01 00:00:00

  • Immunosuppressive treatment in primary focal segmental glomerulosclerosis.

    abstract:BACKGROUND:The therapeutic effects of immunosuppressive agents such as cyclosporin A, mycophenolate mofetil, rituximab and sirolimus on primary focal segmental glomerulosclerosis (FSGS) remain controversial. The present study was intended to review and analyze the treatment results of immunosuppressive agents for prima...

    journal_title:Journal of nephrology

    pub_type: 杂志文章,评审

    doi:10.5301/jn.5000092

    authors: Xu S,Xu G,Zeng L

    更新日期:2012-09-01 00:00:00

  • Active compounds extracted from extra virgin olive oil counteract mesothelial-to-mesenchymal transition of peritoneal mesothelium cells exposed to conventional peritoneal dialysate: in vitro and in vivo evidences.

    abstract::During peritoneal dialysis (PD), peritoneal mesothelial cells undergo a transition from an epithelial phenotype to a mesenchymal phenotype that, together with the inflammatory process, promotes tissue fibrosis and a failure of peritoneal membrane function. To date, there is no definitive treatment for the progressive ...

    journal_title:Journal of nephrology

    pub_type: 杂志文章

    doi:10.1007/s40620-016-0368-4

    authors: Lupinacci S,Toteda G,Vizza D,Perri A,Benincasa C,Mollica A,La Russa A,Gigliotti P,Leone F,Lofaro D,Bonofiglio M,Perri E,Bonofiglio R

    更新日期:2017-12-01 00:00:00

  • Further insights about the beneficial effects of n-3 fatty acids in the early molecular events of renal fibrosis in vitro.

    abstract:BACKGROUND:Accumulating experimental and clinical evidence reveals beneficial effects of n-3 polyunsaturated fatty acids (PUFAs) in kidney disease by modulating inflammation and fibrosis mechanisms that lead to renal failure. METHODS:EPA, DHA (n-3 PUFAs) and AA (n-6 PUFA) effects, compared to those of AngII, on renal ...

    journal_title:Journal of nephrology

    pub_type: 杂志文章

    doi:10.5301/jn.5000193

    authors: Priante G,Musacchio E,Valvason C,Clari G,Bordin L,Sartori L,Baggio B

    更新日期:2013-07-01 00:00:00

  • The effect of polymorphism of uric acid transporters on uric acid transport.

    abstract::The abnormal metabolism of uric acid results in many disease such as chronic kidney disease, hyperuricemia, nephrolithiasis, gout, hypertension, vascular disease and so on. Serum uric acid levels are maintained by the balance between production and elimination. There are many factors that maintain the balance of serum...

    journal_title:Journal of nephrology

    pub_type: 杂志文章,评审

    doi:10.1007/s40620-018-0546-7

    authors: Wang Z,Cui T,Ci X,Zhao F,Sun Y,Li Y,Liu R,Wu W,Yi X,Liu C

    更新日期:2019-04-01 00:00:00

  • Genomic damage in endothelial progenitor cells from uremic patients in hemodialysis.

    abstract:INTRODUCTION:End stage renal disease (ESRD) is associated with a high incidence of cardiovascular disease and cancer. Patients undergoing hemodialysis show a reduced number and an impaired function of endothelial progenitor cells (EPCs), which in physiological conditions contribute to repair the vascular damage. In pat...

    journal_title:Journal of nephrology

    pub_type: 杂志文章

    doi:

    authors: Buemi M,Costa C,Floccari F,Coppolino G,Campo S,Bolignano D,Sturiale A,Lacquaniti A,Buemi A,Loddo S,Teti D

    更新日期:2010-05-01 00:00:00

  • Effect of heparan sulphate on kidney tissue expression of TGF-beta, rhoA, laminin and fibronectin in subtotally nephrectomized rats.

    abstract:BACKGROUND:Different mitogens are involved in the pathogenesis of kidney damage after subtotal nephrectomy. One of them, TGF-beta, controls mesangial cell proliferation and interstitial fibrosclerosis. The transduction of the TGF-beta signal is controlled by intracellular signalling molecules such as Ras G monomeric pr...

    journal_title:Journal of nephrology

    pub_type: 杂志文章

    doi:

    authors: Bernardini N,Cupisti A,Mattii L,Segnani C,Dolf A,Barsotti M,Barsotti G

    更新日期:2002-09-01 00:00:00

  • The peritoneal sieving of sodium: a simple and powerful test to rule out the onset of encapsulating peritoneal sclerosis in patients undergoing peritoneal dialysis.

    abstract:BACKGROUND AND AIMS:Encapsulating peritoneal sclerosis (EPS) is an uncommon but severe complication of peritoneal dialysis (PD). A reliable screening tool to identify patients at risk of developing or not EPS is currently not available. We aimed to evaluate whether the reduction in dialysate sodium concentration (sodiu...

    journal_title:Journal of nephrology

    pub_type: 杂志文章

    doi:10.1007/s40620-016-0371-9

    authors: La Milia V,Longhi S,Sironi E,Pontoriero G

    更新日期:2018-02-01 00:00:00

  • Determinants and survival implications of low bone mineral density in end-stage renal disease patients.

    abstract:BACKGROUND:Reduced bone mineral density (BMD) is common in end-stage renal disease (ESRD) patients and predicts outcomes. The chronic kidney disease-mineral bone disorder contributes to low BMD in ESRD; however, the impact of classical risk factors for osteoporosis in the general population, such as body weight and fat...

    journal_title:Journal of nephrology

    pub_type: 杂志文章

    doi:10.5301/jn.5000185

    authors: Park SH,Jia T,Qureshi AR,Bárány P,Heimbürger O,Larsson TE,Axelsson J,Stenvinkel P,Lindholm B

    更新日期:2013-05-01 00:00:00

  • Thrombotic microangiopathy with intraglomerular IgM pseudothrombi in Waldenström macroglobulinemia and IgM monoclonal gammopathy.

    abstract::IgM secreting myelomas or lymphomas, including Waldenström macroglobulinemia, are associated with a varied spectrum of renal pathology, including intracapillary hyaline deposits, cryoglobulin, membranoproliferative glomerulonephritis, amyloid, monoclonal immunoglobulin deposition disease, cast nephropathy, and lymphom...

    journal_title:Journal of nephrology

    pub_type: 杂志文章

    doi:10.1007/s40620-018-0544-9

    authors: Tan SYS,Sibley RK,Belani S,Iwasaki S,Yankulin L,Jonelis T,Higgins JPT,Kambham N,Troxell ML

    更新日期:2018-12-01 00:00:00

  • The impact of bleeding times on major complication rates after percutaneous real-time ultrasound-guided renal biopsies.

    abstract:BACKGROUND:Previous studies have shown that bleeding times have positive predictive values of only 5% for perioperative bleeding in unselected populations. Nevertheless, performing bleeding times prior to all renal biopsies is common in nephrology practice. METHODS:We report complications of 112 renal biopsies done at...

    journal_title:Journal of nephrology

    pub_type: 杂志文章

    doi:

    authors: Stiles KP,Hill C,LeBrun CJ,Reinmuth B,Yuan CM,Abbott KC

    更新日期:2001-07-01 00:00:00

  • Are low plasma levels of 25-(OH)vitamin D a major risk factor for hyperparathyroidism independent of calcitriol in renal transplant patients?

    abstract:BACKGROUND:Recently, some studies have emphasized the role of plasma 25-(OH)vitamin D (25OHD) levels in mineral metabolism dysregulation in chronic kidney diseases (CKDs). However, to date little attention has been paid to 25OHD metabolism abnormalities after renal transplantation (Tx). This cross-sectional study aimed...

    journal_title:Journal of nephrology

    pub_type: 杂志文章

    doi:

    authors: Lomonte C,Antonelli M,Vernaglione L,Cazzato F,Casucci F,Chimienti D,Bruno A,Cocola S,Verrelli EA,Basile C

    更新日期:2005-01-01 00:00:00

  • Abdominal aortic calcification and renal resistive index in patients with chronic kidney disease: is there a connection?

    abstract:BACKGROUND:We aimed to evaluate the relationship between abdominal aortic calcification (AAC) and renal resistive index (RRI), parameters associated with cardiovascular outcome, in non-dialysis chronic kidney disease (CKD) patients. METHODS:Seventy-seven stable patients mainly in CKD stages 3B and 4 (44 and 28%), medi...

    journal_title:Journal of nephrology

    pub_type: 杂志文章

    doi:10.1007/s40620-013-0021-4

    authors: Stefan G,Capusa C,Stancu S,Petrescu L,Nedelcu ED,Andreiana I,Mircescu G

    更新日期:2014-04-01 00:00:00

  • Dietary fat modification in patients with chronic kidney disease: n-3 fatty acids and beyond.

    abstract::Replacement of dietary saturated fat with unsaturated fat has been recommended for prevention of cardiovascular disease (CVD) in the general population. Less is known of the health risks in individuals with chronic kidney disease (CKD), of a diet with an unhealthy fat profile, in general characterized by insufficient ...

    journal_title:Journal of nephrology

    pub_type: 杂志文章,评审

    doi:10.5301/jn.5000284

    authors: Huang X,Lindholm B,Stenvinkel P,Carrero JJ

    更新日期:2013-11-01 00:00:00

  • A comparison of methods for the measurement of hemodialysis access recirculation.

    abstract:BACKGROUND:NKF K-DOQI clinical practice guidelines recommend a regular monitoring of vascular access (VA) through several methods, such as VA recirculation (AR). Assessment of AR is crucial to avoid inefficiency of hemodialysis (HD). A non-urea based method has been developed (ultrasound dilution Transonics Hemodialysi...

    journal_title:Journal of nephrology

    pub_type: 杂志文章

    doi:

    authors: Basile C,Ruggieri G,Vernaglione L,Montanaro A,Giordano R

    更新日期:2003-11-01 00:00:00