当前位置： SCI文献检索 > JOURNAL OF NEPHROLOGY期刊下所有文献 > Effect of heparan sulphate on kidney tissue expression of TGF-beta, rhoA, laminin and fibronectin in subtotally nephrectomized rats.

Effect of heparan sulphate on kidney tissue expression of TGF-beta, rhoA, laminin and fibronectin in subtotally nephrectomized rats.

Abstract：

BACKGROUND:Different mitogens are involved in the pathogenesis of kidney damage after subtotal nephrectomy. One of them, TGF-beta, controls mesangial cell proliferation and interstitial fibrosclerosis. The transduction of the TGF-beta signal is controlled by intracellular signalling molecules such as Ras G monomeric proteins. Renal damage after subtotal nephrectomy (5/6 Nx) can be prevented by heparins, but so far no immunohistochemical correlation between TGF-beta, TGF-beta induced matrix molecules and Rho proteins has been investigated. Since the Ras transduction pathway has recently been associated with progression of renal damage, we evaluated the effect of heparan sulphate (HS) on the expression of TGF-beta, laminin, fibronectin and a Ras protein, RhoA, in the rat remnant kidney model. METHODS:The immunoperoxidase technique was employed to reveal the antigens on 18 remnant kidneys from 5/6 nephrectomized rats, nine untreated and nine treated with oral HS, and on seven normal kidneys from sham-operated rats. Data were semiquantitatively analyzed by an image analyzer (Quantimet, Leica). RESULTS:The expression of the antigens was significantly higher in the remnant kidneys than in normals. The high TGF-beta, laminin, fibronectin and RhoA expression observed in subtotally nephrectomized rats suggests a role for these molecules in the pathogenesis of progressive renal damage. However, apart from RhoA, HS-treated rats had significantly lower levels of the antigens than the untreated rats. CONCLUSIONS:HS treatment is associated with significantly lower renal expression of TGF-beta, laminin and fibronectin, but not of RhoA. This suggests that the renal-protective effect of HS may be obtained by modulating the TGF-beta pathway, independently of RhoA-mediated transduction.

journal_name

J Nephrol

journal_title

Journal of nephrology

authors

Bernardini N,Cupisti A,Mattii L,Segnani C,Dolf A,Barsotti M,Barsotti G

subject

Has Abstract

pub_date

2002-09-01 00:00:00

pages

530-8

issue

5

eissn

1121-8428

issn

1724-6059

journal_volume

15

pub_type

杂志文章

相关文献

JOURNAL OF NEPHROLOGY文献大全
  • The effect of anemia and left ventricular geometric patterns on renal disease progression in type 2 diabetic nephropathy.

    abstract：BACKGROUND:Left ventricular (LV) geometric patterns have never been evaluated as independent risk factors for renal disease progression (RDP). We investigated the risk factors for RDP in type 2 diabetic nephropathy patients, especially focusing on the effects of LV geometric patterns. METHODS:This was a single-center ...

    journal_title：Journal of nephrology

    pub_type： 杂志文章

    doi：10.5301/jn.2010.353

    authors： Moon SJ,Bae KS,Park HC,Kim JK,Park JT,Lee JE,Rim SJ,Ha SK

    更新日期：2011-01-01 00:00:00

  • Looking at appearance of urine before performing a renal biopsy in nephrotic syndrome.

    abstract：:Chyluria results from an abnormal connection between lymphatic bed and urinary tract, causing lymph leakage into the urine. The clinical picture often begins with the appearance of cloudy, milky urines accompanied by monolateral flank pain, malnutrition, weight loss and weakness. We report a case of chyluria that occu...

    journal_title：Journal of nephrology

    pub_type： 杂志文章

    doi：10.5301/JN.2011.8355

    authors： Graziani G,Cucchiari D,Verdesca S,Balzarini L,Montanelli A,Ponticelli C

    更新日期：2011-09-01 00:00:00

  • Plasma sulfate concentration and hyperhomocysteinemia in hemodialysis patients.

    abstract：BACKGROUND:Severe hyperhomocysteinemia is common in hemodialysis patients, who also present a dramatic increase in plasma concentrations of sulfate, one of the main products of methionine and cysteine catabolism. The aim of this study was to verify the relationship between high plasma sulfate levels and cysteine or hom...

    journal_title：Journal of nephrology

    pub_type： 杂志文章

    doi：

    authors： Brunetti M,Terracina L,Timio M,Saronio P,Capodicasa E

    更新日期：2001-01-01 00:00:00

  • Haemoglobinuria for the early identification of aHUS relapse: data from the ItalKId-HUS Network.

    abstract：BACKGROUND:Atypical haemolytic uremic syndrome (aHUS) is at high risk of relapse at any time, therefore patients require lifelong monitoring. The most appropriate way to monitor patients is not yet clear. Patients could be monitored for relapse by urine dipstick testing for haemoglobinuria based on the hypothesis that ...

    journal_title：Journal of nephrology

    pub_type： 杂志文章

    doi：10.1007/s40620-021-00965-8

    authors： Brambilla M,Ardissino G,Paglialonga F,Testa S,Capone V,Montini G

    更新日期：2021-01-18 00:00:00

  • IgA nephropathy in a patient with chronic granulomatous disease.

    abstract：:We report the first documented case of X-linked chronic granulomatous disease (CGD) in association with IgA nephropathy in a 22 year old male with multiple soft tissue abscesses. The case highlights the potential role of staphylococcal infections in the pathogenesis of IgA nephropathy and suggests the hypothesis that ...

    journal_title：Journal of nephrology

    pub_type： 杂志文章

    doi：

    authors： Narsipur SS,Shanley PF

    更新日期：2002-11-01 00:00:00

  • Crystals, Randall's plaques and renal stones: do bone and atherosclerosis teach us something?

    abstract：:The pathogenesis of calcium-oxalate (CaOx) renal stones is still debated and a number of issues needs to be clarified. In particular, it is difficult to combine the intraluminal physical-chemical imbalance and fixed particle theory with the evidence that CaOx stones actually form and grow on Randall's plaque in the re...

    journal_title：Journal of nephrology

    pub_type： 杂志文章,评审

    doi：

    authors： Gambaro G,D'Angelo A,Fabris A,Tosetto E,Anglani F,Lupo A

    更新日期：2004-11-01 00:00:00

  • Adherence to phosphate binders in hemodialysis patients: prevalence and determinants.

    abstract：BACKGROUND:Phosphate control is a crucial treatment goal in end-stage renal disease, but poor patient adherence to phosphate binder therapy remains a challenge. This study aimed to estimate the extent of phosphate binder adherence in hemodialysis patients and to identify potential determinants. METHODS:Phosphate binde...

    journal_title：Journal of nephrology

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1007/s40620-014-0062-3

    authors： Van Camp YP,Vrijens B,Abraham I,Van Rompaey B,Elseviers MM

    更新日期：2014-12-01 00:00:00

  • Peripheral artery disease and blood pressure profile abnormalities in hemodialysis patients.

    abstract：BACKGROUND:Patients undergoing chronic hemodialysis (HD) are at increased risk for peripheral artery disease (PAD). Both ankle-brachial index (ABI) and ambulatory blood pressure monitoring (ABPM) in the interdialytic period have been shown to be strong predictors of all-cause mortality. METHODS:This cross-sectional st...

    journal_title：Journal of nephrology

    pub_type： 杂志文章

    doi：10.1007/s40620-016-0322-5

    authors： Viazzi F,Leoncini G,Ratto E,Storace G,Gonnella A,Garneri D,Bonino B,Cappadona F,Parodi EL,Verzola D,Garibotto G,Pontremoli R

    更新日期：2017-06-01 00:00:00

  • Familial renal tubular acidosis.

    abstract：:The kidney maintains systemic acid-base homeostasis through proximal tubular reclamation of filtered bicarbonate, and excretion of the daily mineral acid load by collecting duct type A intercalated cells. Impairment of either process produces renal tubular acidosis (RTA). This article will provide an overview of famil...

    journal_title：Journal of nephrology

    pub_type： 杂志文章,评审

    doi：

    authors： Alper SL

    更新日期：2010-11-01 00:00:00

  • Consumption of nitrate-containing vegetables is inversely associated with hypertension in adults: a prospective investigation from the Tehran Lipid and Glucose Study.

    abstract：BACKGROUND:There is growing evidence of the potential properties of nitrate-rich foods against development of hypertension (HTN) and vascular disease. In this study, we investigated the association of nitrate-containing vegetables (NCVs) with risk of HTN after 3 years of follow-up. METHODS:This prospective study was c...

    journal_title：Journal of nephrology

    pub_type： 杂志文章

    doi：10.1007/s40620-015-0229-6

    authors： Golzarand M,Bahadoran Z,Mirmiran P,Zadeh-Vakili A,Azizi F

    更新日期：2016-06-01 00:00:00

  • Structural features of IgA molecules which contribute to IgA nephropathy.

    abstract：:IgA nephropathy (IgAN) is characterised by the mesangial deposition of polymeric IgA1 (pIgA1). pIgA1 production is reduced in the mucosal immune system in IgAN and increased in the marrow; this switch may be secondary to a defect in gammadeltaT cell control of IgA production. However this does not explain the mechanis...

    journal_title：Journal of nephrology

    pub_type： 杂志文章,评审

    doi：

    authors： Feehally J,Allen AC

    更新日期：1999-03-01 00:00:00

  • Metformin-associated lactic acidosis: case reports and literature review.

    abstract：BACKGROUND:Lactic acidosis is a widely recognized, though rare, side effect of metformin. This paper describes five patients admitted to Chang Gung Memorial Hospital from 1 September 1998 to 31 May 2001 suffering severe lactic acidosis caused by metformin, and reviews the literature. PATIENTS:Five cases diagnosed as h...

    journal_title：Journal of nephrology

    pub_type： 杂志文章,评审

    doi：

    authors： Chang CT,Chen YC,Fang JT,Huang CC

    更新日期：2002-07-01 00:00:00

  • The future of Diabetic Kidney Disease management: reducing the unmet need.

    abstract：:Patients with type 2 diabetes run a high risk for progressive renal function loss. Many interventions have been tested to reduce the risk, but we are nowadays still confronted with a high unmet need. To improve on this unmet need, we will have to change the current strategies in drug discovery, clinical trials and cli...

    journal_title：Journal of nephrology

    pub_type： 杂志文章,评审

    doi：10.1007/s40620-020-00820-2

    authors： de Zeeuw D

    更新日期：2020-12-01 00:00:00

  • Associations between calcineurin inhibitors and arterial compliance in kidney transplant recipients.

    abstract：INTRODUCTION:Several studies have suggested an effect of calcineurin inhibitors on arterial compliance in kidney transplant recipients. We aimed to investigate whether the type of calcineurin inhibitor influences large and small artery compliance in these patients independently of other determinants. METHODS:Patients ...

    journal_title：Journal of nephrology

    pub_type： 杂志文章

    doi：

    authors： Wystrychowski G,Chudek J,Zukowska-Szczechowska E,Wiecek A,Grzeszczak W

    更新日期：2008-01-01 00:00:00

  • The protean face of renal sarcoid.

    abstract：:Sarcoidosis is a multisystem disorder of unknown etiology, which may occur in all tissues and organs of the body. Clinical presentation may be quite variable and affected by race. The most commonly affected system is the lungs with >95% of patients displaying such involvement. Renal involvement is uncommon (<2%) and m...

    journal_title：Journal of nephrology

    pub_type： 杂志文章

    doi：

    authors： Carmichael P,O'Donnell JP

    更新日期：2003-09-01 00:00:00

  • Clinical significance of IgM and C1q deposition in the mesangium in pediatric idiopathic nephrotic syndrome.

    abstract：BACKGROUND:In biopsy-proven idiopathic nephrotic syndrome (INS), immunoglobulin M (IgM) and C1q are occasionally deposited in the mesangium. In pediatric nephrology, the significance of mesangial IgM or C1q deposits is controversial, based on previous reports. The aim of this study was to explore the clinical significa...

    journal_title：Journal of nephrology

    pub_type： 杂志文章

    doi：10.5301/jn.5000133

    authors： Kanemoto K,Ito H,Anzai M,Matsumura C,Kurayama H

    更新日期：2013-03-01 00:00:00

  • Preemptive liver transplantation in primary hyperoxaluria type 1: timing and preliminary results.

    abstract：:Preemptive isolated liver transplantation (PLTX) can cure the metabolic defect in primary hyperoxaluria type 1 (PH1) but there are no uniformally accepted recommendations concerning the timing of this transplantation procedure. We have performed PLTX successfully in 4 children (age 3-9 years) with PH1 with no mortalit...

    journal_title：Journal of nephrology

    pub_type： 杂志文章,评审

    doi：

    authors： Kemper MJ,Nolkemper D,Rogiers X,Timmermann K,Sturm E,Malago M,Broelsch CE,Burdelski M,Müller-Wiefel DE

    更新日期：1998-03-01 00:00:00

  • Wild-type uromodulin prevents NFkB activation in kidney cells, while mutant uromodulin, causing FJHU nephropathy, does not.

    abstract：BACKGROUND:Uromodulin (Tamm-Horsfall protein) is the most abundant urinary protein in healthy individuals. Despite 60 years of research, its physiological role remains rather elusive. Familial juvenile hyperuricemic nephropathy and medullary cystic kidney disease Type 2 are autosomal dominant tubulointerstitial nephrop...

    journal_title：Journal of nephrology

    pub_type： 杂志文章

    doi：10.1007/s40620-014-0079-7

    authors： Dinour D,Ganon L,Nomy LI,Ron R,Holtzman EJ

    更新日期：2014-06-01 00:00:00

  • The use of laboratory tests in diagnosis and monitoring of systemic lupus erythematosus.

    abstract：:Clinical immunology laboratories play an essential role in diagnosis and monitoring of systemic lupus erythematosus (SLE). To obtain the best results in terms of diagnostic performance and clinical usefulness, the following recommendations should be fulfilled: Indirect immunofluorescence on Hep-2 cells remains the met...

    journal_title：Journal of nephrology

    pub_type： 杂志文章,评审

    doi：

    authors： Sinico RA,Bollini B,Sabadini E,Di Toma L,Radice A

    更新日期：2002-11-01 00:00:00

  • Crescentic glomerulonephritis associated with renal cell carcinoma after cancer immunotherapy.

    abstract：:A 59 year-old woman showed rapidly progressive glomerulonephritis during immunotherapy for metastatic renal cell carcinoma. She received unilateral nephrectomy and cytotoxic T lymphocyte (CTL) therapy for the treatment of retroperitoneal lymph node metastasis of renal cell carcinoma. With CTL therapy, her retroperiton...

    journal_title：Journal of nephrology

    pub_type： 杂志文章

    doi：

    authors： Kai H,Yamagata K,Usui J,Shimizu Y,Hirayama A,Yoh K,Mase K,Hirayama K,Nagase S,Nagata M,Kawai K,Akaza H,Koyama A

    更新日期：2005-07-01 00:00:00

  • Management of hepatitis C virus infection in patients with chronic kidney disease: position statement of the joint committee of Italian association for the study of the liver (AISF), Italian society of internal medicine (SIMI), Italian society of infectio

    abstract：:Hepatitis C virus (HCV) infection is now considered a systemic disease due to the occurrence of extra-hepatic manifestations. Among these, the renal involvement is frequent. HCV infection, in fact, is strongly associated with proteinuria and chronic kidney disease (CKD) and negatively affects the prognosis of renal pa...

    journal_title：Journal of nephrology

    pub_type： 杂志文章,实务指引

    doi：10.1007/s40620-018-0523-1

    authors： Minutolo R,Aghemo A,Chirianni A,Fabrizi F,Gesualdo L,Giannini EG,Maggi P,Montinaro V,Paoletti E,Persico M,Perticone F,Petta S,Puoti M,Raimondo G,Rendina M,Zignego AL,Italian Society of Nephrology (SIN).,Italian Associat

    更新日期：2018-10-01 00:00:00

  • Efficacy of low or standard rituximab-based protocols and comparison to Ponticelli's regimen in membranous nephropathy.

    abstract：BACKGROUND:Patients (pts) with primary Membranous nephropathy (MN) have an autoimmune disease caused by autoantibodies against podocyte antigens and 60-80% of them have antibodies directed against the M-type phospholipase A2 receptor (PLA2R). Immunosuppressive treatment is recommended in high-medium risk pts. Recently ...

    journal_title：Journal of nephrology

    pub_type： 杂志文章

    doi：10.1007/s40620-020-00781-6

    authors： Fenoglio R,Baldovino S,Sciascia S,De Simone E,Del Vecchio G,Ferro M,Quattrocchio G,Naretto C,Roccatello D

    更新日期：2020-06-27 00:00:00

  • Klaus Hierholzer (1929-2007) and his impact on our understanding of the renal effects of steroid hormones.

    abstract：:Klaus Hierholzer (1929-2007) dissected various functions influenced by steroids in the distal tubule and showed that aldosterone in low doses reversed the sodium and potassium transport defect in adrenalectomized rats, through a rapid activation of Na+,K+-ATPase. Subsequent studies addressed the role of 11-beta-hydrox...

    journal_title：Journal of nephrology

    pub_type： 传,历史文章,杂志文章

    doi：

    authors： De Santo NG,Fromm M,Russo F,Wiederholt M

    更新日期：2009-11-01 00:00:00

  • Healthcare costs of the progression of chronic kidney disease and different dialysis techniques estimated through administrative database analysis.

    abstract：BACKGROUND:Chronic kidney disease (CKD) progression is associated with significant comorbidities and costs. In Italy, limited evidence of healthcare resource consumption and costs is available. We therefore aimed to investigate the direct healthcare costs in charge to the Lombardy Regional Health Service (RHS) for the ...

    journal_title：Journal of nephrology

    pub_type： 杂志文章

    doi：10.1007/s40620-016-0291-8

    authors： Roggeri A,Roggeri DP,Zocchetti C,Bersani M,Conte F,ReNe (Renal Lombardy Network).,Additional contributors from ReNe Network.

    更新日期：2017-04-01 00:00:00

  • Clinical and therapeutic aspects of diabetic nephropathy.

    abstract：UNLABELLED:The prognosis of renal survival in both type 1 and type 2 diabetes mellitus is not benign. Several factors characterize the increase in the risk of developing renal damage in diabetic patients, distinguished in diabetes-related factors, genetic factors and other factors. DIAGNOSIS:Diagnosis requires standar...

    journal_title：Journal of nephrology

    pub_type： 杂志文章,评审

    doi：

    authors： Strippoli GF,Di Paolo S,Cincione R,Di Palma AM,Teutonico A,Grandaliano G,Schena FP,Gesualdo L

    更新日期：2003-07-01 00:00:00

  • The renoprotective effect of antihypertensive drugs.

    abstract：:Some antihypertensive drugs may have a renoprotective effect, that is partially independent of their ability to reduce blood pressure. ACE-inhibitors are safe and effective agents that are capable of reducing proteinuria and preventing CRF progression. The results of the AIPRI extension study suggest that they may als...

    journal_title：Journal of nephrology

    pub_type： 杂志文章,评审

    doi：

    authors： Locatelli F,Del Vecchio L,Marai P,Colzani S

    更新日期：1998-11-01 00:00:00

  • The calcium-sensing receptor.

    abstract：:To maintain divalent ion concentration within the body, a complex sensor has evolved to identify the changes in the extracellular environment and cause the surrounding cells to either secrete or absorb in response to change. An important member of these "sensors" is the calcium-sensing receptor (CaSR), which is consta...

    journal_title：Journal of nephrology

    pub_type： 杂志文章,评审

    doi：

    authors： Geibel JP

    更新日期：2010-11-01 00:00:00

  • Chronic hypotension in the dialysis patient.

    abstract：:Chronic hypotension, defined by a systolic blood pressure < 100 mmHg in the interdialytic period, affects 5-10% of hemodialysis patients, and is more prevalent among patients on long-term hemodialysis. This complication requires a substantial amount of medical and nursing care before and during dialysis to control its...

    journal_title：Journal of nephrology

    pub_type： 杂志文章,评审

    doi：

    authors： Cases A,Coll E

    更新日期：2002-07-01 00:00:00

  • Contrast-induced nephropathy and its prevention: What do we really know from evidence-based findings?

    abstract：INTRODUCTION:Contrast-induced acute kidney injury, also referred to as contrast-induced nephropathy (CIN), is a potentially serious renal complication associated with the use of iodinated contrast media (CM) in patients at risk. With the dramatic growth in contrast-enhanced imaging services worldwide, including procedu...

    journal_title：Journal of nephrology

    pub_type： 杂志文章,评审

    doi：

    authors： Reddan D,Laville M,Garovic VD

    更新日期：2009-05-01 00:00:00

  • Cross-sectional survey of the prevalence of reduced estimated glomerular filtration rate, albuminuria and cardiovascular risk in a native Spanish population.

    abstract：OBJECTIVES:HERMEX is a population-based study which tries to evaluate the relative weight of cardiovascular risk factors in inhabitants of Extremadura, Spain. This report presents the data about chronic kidney disease (CKD) in a Spanish population sample. METHODS:For an observational cross-sectional population-based s...

    journal_title：Journal of nephrology

    pub_type： 杂志文章

    doi：10.5301/jn.5000221

    authors： Robles NR,Felix FJ,Fernandez-Berges D,Perez-Castán JF,Zaro MJ,Lozano L,Alvarez-Palacios P,Garcia-Trigo A,Tejero V,Morcillo Y,Hidalgo AB

    更新日期：2013-07-01 00:00:00