Abstract:
:The newly described endothelium-dependent vasoactive substances, nitric oxide and endothelins, have been the subject of intense investigative interest and have been demonstrated to promote a wide array of autocrine and paracrine functions. Recent data highlight their emerging role as potential important mediators of renal failure in general, thus suggesting that they might also contribute to renal dysfunction in the setting of advanced hepatic disease. Most but not all investigators, have demonstrated that circulating ET-1 levels are elevated in patients with advanced liver disease, and some reports have suggested that the magnitude of the elevation correlates with the degree of renal dysfunction. Concomitantly, several investigators have demonstrated NO overproduction as assessed by elevated levels of NO2- and NO3- in patients with advanced liver disease. It has been suggested that serum nitrite/nitrate levels are highest in patients with functional renal failure (i.e., HRS) and that these levels correlate with the magnitude of endotoxemia. Although large voids in our knowledge remain, the available evidence suggest that a reset balance between vasoconstrictor and vasodilatory stimuli may contribute to the renal hemodynamic abnormalities that characterize the renal functional abnormalities of liver disease.
journal_name
J Nephroljournal_title
Journal of nephrologyauthors
Epstein M,Goligorsky MSsubject
Has Abstractpub_date
1997-05-01 00:00:00pages
120-35issue
3eissn
1121-8428issn
1724-6059journal_volume
10pub_type
杂志文章,评审abstract::Recent molecular cloning experiments have identified the existence of four NBC isoforms (NBC1, 2, 3 and 4) and two NBC-related proteins AE4 and NCBE (Anion Exchanger 4 and Sodium-dependent Chloride-Bicarbonate Exchanger). Except for AE4 which does not transport Na, all are presumed to mediate the cotransport of Na+ an...
journal_title:Journal of nephrology
pub_type: 杂志文章,评审
doi:
更新日期:2002-03-01 00:00:00
abstract:BACKGROUND:Drug-related problems (DRPs) are common in chronic kidney disease (CKD) patients. We developed a 2-step consultation including a clinical pharmacist (CP) session and a nephrologist conventional care consultation to explore the feasibility of a pilot drug-oriented disease management program in controlling iat...
journal_title:Journal of nephrology
pub_type: 杂志文章
doi:10.5301/jn.5000063
更新日期:2012-09-01 00:00:00
abstract:BACKGROUND:Reset osmostat (RO) occurs in 36% of patients with syndrome of inappropriate antidiuretic hormone secretion (SIADH) and is not often considered when evaluating hyponatremic patients. Patients with RO are not usually treated, but recent awareness that symptoms are associated with mild hyponatremia creates a t...
journal_title:Journal of nephrology
pub_type: 杂志文章
doi:10.5301/jn.5000074
更新日期:2012-09-01 00:00:00
abstract::The role of the kidney in controlling and maintaining plasma potassium levels in the normal range requires the presence and activity of renal potassium channels, and their importance has been highlighted in patients with Bartter syndrome harboring mutations in the ROMK (Kir1.1, KCJN1) channel and hyperkalemia. However...
journal_title:Journal of nephrology
pub_type: 杂志文章
doi:
更新日期:2010-01-01 00:00:00
abstract::Marcello Malpighi was born in Crevalcore on March 10, 1628 and died in Rome on July 25, 1694. In Bologna he had among his opponents Giovanni Gerolamo Sbaraglia and Paoli Mini who prevented him being appointed to the chair of anatomy. This paper describes the reasons for this long term debate. ...
journal_title:Journal of nephrology
pub_type: 传,历史文章,杂志文章
doi:
更新日期:2004-07-01 00:00:00
abstract:BACKGROUND AND AIMS:Arterial stiffness is a risk factor for chronic kidney disease progression (CKD). Pulse pressure is a surrogate marker of arterial stiffness. It is unclear if pulse pressure predicts CKD progression in type 2 diabetes mellitus. METHODS:This was prospective study involving 1494 patients with estimat...
journal_title:Journal of nephrology
pub_type: 杂志文章
doi:10.1007/s40620-020-00954-3
更新日期:2021-01-25 00:00:00
abstract::There is little doubt that molecular biological intervention therapy has come of age and its potential is arousing tremendous excitement. A gene transfer technique, the HVJ-liposome method, is now applicable as a tool for the dissection of molecular aspects in the pathophysiology of renal diseases, and for gene therap...
journal_title:Journal of nephrology
pub_type: 杂志文章,评审
doi:
更新日期:1998-01-01 00:00:00
abstract:BACKGROUND:The therapeutic effects of immunosuppressive agents such as cyclosporin A, mycophenolate mofetil, rituximab and sirolimus on primary focal segmental glomerulosclerosis (FSGS) remain controversial. The present study was intended to review and analyze the treatment results of immunosuppressive agents for prima...
journal_title:Journal of nephrology
pub_type: 杂志文章,评审
doi:10.5301/jn.5000092
更新日期:2012-09-01 00:00:00
abstract:BACKGROUND AND AIMS:This study aimed to test the hypothesis that visfatin is associated with atherosclerosis in patients with chronic kidney disease (CKD). METHODS:In the study, we measured serum triglycerides, total cholesterol, high-density lipoprotein (HDL) cholesterol, low-density lipoprotein (LDL) cholesterol lev...
journal_title:Journal of nephrology
pub_type: 杂志文章
doi:10.5301/jn.2010.3488
更新日期:2011-03-01 00:00:00
abstract:BACKGROUND:Severe hyperhomocysteinemia is common in hemodialysis patients, who also present a dramatic increase in plasma concentrations of sulfate, one of the main products of methionine and cysteine catabolism. The aim of this study was to verify the relationship between high plasma sulfate levels and cysteine or hom...
journal_title:Journal of nephrology
pub_type: 杂志文章
doi:
更新日期:2001-01-01 00:00:00
abstract:BACKGROUND:The risks connected with dialysis fluid contamination are well established. Epidemiological studies have demonstrated just how difficult it is to obtain permanently satisfactory quality standards. Therefore, dialysis centers must have effective and regular quality control programs, particularly with the grow...
journal_title:Journal of nephrology
pub_type: 杂志文章
doi:
更新日期:2004-07-01 00:00:00
abstract:BACKGROUND:Lactic acidosis is a widely recognized, though rare, side effect of metformin. This paper describes five patients admitted to Chang Gung Memorial Hospital from 1 September 1998 to 31 May 2001 suffering severe lactic acidosis caused by metformin, and reviews the literature. PATIENTS:Five cases diagnosed as h...
journal_title:Journal of nephrology
pub_type: 杂志文章,评审
doi:
更新日期:2002-07-01 00:00:00
abstract::Over the last two decades, several studies have reported a high prevalence of cardiovascular disease in patients with end-stage renal disease (ESRD). This population usually presents both the traditional and non-traditional risk factors for atherosclerosis. Inflammation as well as impaired nitric oxide production are ...
journal_title:Journal of nephrology
pub_type: 杂志文章,评审
doi:
更新日期:2003-01-01 00:00:00
abstract::End-stage renal disease (ESRD) is a significant global health problem that places a considerable burden on health care resources. The leading cause of death in ESRD patients is cardiovascular disease, which is often preceded by changes in cardiac geometry, including left ventricular hypertrophy (LVH). Treatments that ...
journal_title:Journal of nephrology
pub_type: 杂志文章,评审
doi:10.5301/JN.2011.8422
更新日期:2011-07-01 00:00:00
abstract::Renal fibrogenesis can be induced by several injury mechanisms in different renal diseases, but ultimately produces identical fibrotic changes in the kidney. Recently, a number of agents that can inhibit extracellular matrix (ECM) accumulation have been studied, suggesting a therapeutic utility in the treatment of fib...
journal_title:Journal of nephrology
pub_type: 杂志文章,评审
doi:
更新日期:2004-07-01 00:00:00
abstract::IgM secreting myelomas or lymphomas, including Waldenström macroglobulinemia, are associated with a varied spectrum of renal pathology, including intracapillary hyaline deposits, cryoglobulin, membranoproliferative glomerulonephritis, amyloid, monoclonal immunoglobulin deposition disease, cast nephropathy, and lymphom...
journal_title:Journal of nephrology
pub_type: 杂志文章
doi:10.1007/s40620-018-0544-9
更新日期:2018-12-01 00:00:00
abstract:BACKGROUND:Patients with IgA nephropathy and histological vasculitic/crescentic lesions have a poor prognosis. We performed a retrospective study to assess whether treatment with steroids and immunosuppressants would preserve renal function by healing these lesions and thereby prevent progression to glomerular sclerosi...
journal_title:Journal of nephrology
pub_type: 临床试验,杂志文章
doi:
更新日期:2000-09-01 00:00:00
abstract::The partial correction of anemia and the normalization of phosphate and blood pressure are the mainstay of treatment of patients with chronic kidney disease (CKD). Available anti-hypertensive drugs, erythropoiesis stimulating agents (ESAs) and iron supplements have resolved quite satisfactorily the goal of controlling...
journal_title:Journal of nephrology
pub_type: 杂志文章,评审
doi:10.1007/s40620-017-0421-y
更新日期:2017-12-01 00:00:00
abstract:BACKGROUND:Cardiac surgery-associated acute kidney injury (CSA-AKI) is associated with high risk for complications and mortality. Whether renin-angiotensin system (RAS) inhibitor should be continued or withdrawn in patients with long-term use before cardiac surgery has been lack of consensus. METHODS:We performed this...
journal_title:Journal of nephrology
pub_type: 杂志文章,多中心研究
doi:10.1007/s40620-019-00657-4
更新日期:2019-12-01 00:00:00
abstract:INTRODUCTION:We measured serum creatinine concentrations in 17 male athletes of the Italian national rugby team. METHODS:Blood was obtained before the start of training and during the competitive season. Serum creatinine level was measured by Jaffé reaction at 4 time points during the season, with a formal measure of ...
journal_title:Journal of nephrology
pub_type: 杂志文章
doi:10.5301/jn.5000094
更新日期:2012-11-01 00:00:00
abstract:BACKGROUND:Changes in podocyte phenotype and function are characteristic of proteinuric glomerular diseases. Integrin-linked kinase (ILK) functions as a common downstream effector in proteinuric diseases. In addition, ILK was shown to interact with the Wnt signaling pathway. Here, we investigated ILK expression as well...
journal_title:Journal of nephrology
pub_type: 杂志文章
doi:10.5301/jn.5000017
更新日期:2012-05-01 00:00:00
abstract::The aging process results in remarkable changes in the kidney. These changes are both anatomical and functional and have been considered the cause of the increased propensity of the elderly to acute or chronic renal failure. However, the majority of the early studies on aging enrolled institutionalized elderly patient...
journal_title:Journal of nephrology
pub_type: 杂志文章,评审
doi:
更新日期:2010-09-01 00:00:00
abstract::Influenza is a commonly encountered and serious pathogen. Patients with end-stage renal disease are more susceptible to serious morbidity and mortality associated with influenza infection. Proper management of patients includes: vaccination, monitoring for symptoms and isolation of potentially infected patients as wel...
journal_title:Journal of nephrology
pub_type: 杂志文章,评审
doi:10.1007/s40620-017-0407-9
更新日期:2018-04-01 00:00:00
abstract::Cell-to-cell signal exchange during antigen presentation deeply influences the profile and extent of the immune response. Together with the TCR/MHC-mediated signal, accessory signals are provided to the T cell by the antigen-presenting cell (APC), through specific receptor-ligand interactions that represent indispensa...
journal_title:Journal of nephrology
pub_type: 杂志文章,评审
doi:
更新日期:2002-01-01 00:00:00
abstract::Jaundice and pancreatitis are serious complications in post renal transplantations; hepatotropic viruses and drugs are commonly implicated. We describe ascaris infestation causing pancreatitis and obstructive jaundice in a renal transplant patient. ...
journal_title:Journal of nephrology
pub_type: 杂志文章
doi:
更新日期:2004-05-01 00:00:00
abstract:BACKGROUND:Uromodulin (Tamm-Horsfall protein) is the most abundant urinary protein in healthy individuals. Despite 60 years of research, its physiological role remains rather elusive. Familial juvenile hyperuricemic nephropathy and medullary cystic kidney disease Type 2 are autosomal dominant tubulointerstitial nephrop...
journal_title:Journal of nephrology
pub_type: 杂志文章
doi:10.1007/s40620-014-0079-7
更新日期:2014-06-01 00:00:00
abstract::Synthetic immunosuppressive drugs are largely used in immune-related renal diseases and in kidney transplantation. Most of these drugs have a low therapeutic index (the ratio that compares the blood concentration at which a drug becomes toxic and the concentration at which the drug is effective), which means that the ...
journal_title:Journal of nephrology
pub_type: 杂志文章,评审
doi:10.1007/s40620-019-00602-5
更新日期:2019-12-01 00:00:00
abstract:BACKGROUND:We tested the hypothesis that the universal application of myocardial scanning with single-photon emission computed tomography (SPECT) would result in better risk stratification in renal transplant candidates (RTC) compared with SPECT being restricted to patients who, in addition to renal disease, had other ...
journal_title:Journal of nephrology
pub_type: 杂志文章
doi:
更新日期:2010-05-01 00:00:00
abstract:BACKGROUND:Phosphorus is associated with mortality in patients with chronic kidney disease (CKD) not on dialysis, possibly through phosphorus-dependent vascular calcification. Although a phosphorus-restricted diet reduces serum phosphorus, it is unlikely that it reduces vascular calcification progression in CKD. This s...
journal_title:Journal of nephrology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1007/s40620-014-0071-2
更新日期:2015-02-01 00:00:00
abstract::Primary renal non-Hodgkin's lymphoma is very rare in childhood. A six-year-old boy presented with bilateral non-obstructive multinodular nephromegaly and renal failure. Percutaneous needle biopsy showed large-cell lymphoma. The patient was started on chemotherapy. A right nephrectomy was done when systemic hypertensio...
journal_title:Journal of nephrology
pub_type: 杂志文章,评审
doi:
更新日期:2002-09-01 00:00:00