Abstract：
BACKGROUND:Reduced bone mineral density (BMD) is common in end-stage renal disease (ESRD) patients and predicts outcomes. The chronic kidney disease-mineral bone disorder contributes to low BMD in ESRD; however, the impact of classical risk factors for osteoporosis in the general population, such as body weight and fat mass, remains less well defined in ESRD subjects. METHODS:BMD, body composition (dual-energy X-ray absorptiometry), nutritional status (subjective global assessment), hand grip strength and multiple biomarkers were investigated in 361 patients (218 males; 60.4%) starting on dialysis. The relations between BMD, body composition and biomarkers were analyzed at baseline, and the impact of BMD on mortality was analyzed prospectively. RESULTS:In univariate analysis, T-score correlated with fat mass (r = 0.308, p<0.001), lean body mass (r = 0.278, p<0.001), leptin (r = 0.124, p = 0.028) as well as the anabolic marker insulin-like growth factor-1 (IGF-1; r = 0.301, p<0.001), and its binding proteins IGFBP-1 (r = -0.342, p<0.001) and IGFBP-3 (0.231, p<0.001). BMD T-score was independently associated with age, total fat mass, intact parathyroid hormone and presence of wasting. During 5 years of follow-up, 87 deaths were recorded. Each unit of increase of T-score was associated with decreased all-cause mortality, which persisted after multivariate adjustment (hazard ratio = 0.824, 95% confidence interval, 0.681-0.996). CONCLUSIONS:BMD is associated with body composition, especially total fat mass, nutritional status and mortality risk in ESRD patients.
journal_name
J Nephroljournal_title
Journal of nephrologyauthors
Park SH,Jia T,Qureshi AR,Bárány P,Heimbürger O,Larsson TE,Axelsson J,Stenvinkel P,Lindholm Bdoi
10.5301/jn.5000185subject
Has Abstractpub_date
2013-05-01 00:00:00pages
485-94issue
3eissn
1121-8428issn
1724-6059pii
841160AD-84CF-40B9-BD0F-2DC545B25524journal_volume
26pub_type
杂志文章abstract：:Autosomal dominant polycystic kidney disease (ADPKD) may present with a variety of extrarenal manifestations. Only 1 case of spontaneous coronary artery dissection has been reported so far in ADPKD. Here we report a case of coronary artery dissection occurring in a 38-year-old woman with ADPKD and an unremarkable medi...
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journal_title：Journal of nephrology
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