Nrf2 and Sp family synergistically enhance the expression of ion transporters in potassium-depleted conditions.

Abstract:

INTRODUCTION:During potassium (K) depletion, many adaptive responses are likely mediated through a complex network that involves expression of a variety of genes. We identified that the Nrf2 gene was differentially expressed between normal and K-depleted rat kidney. METHODS:To investigate the effect of Nrf2 on colonic H/K-ATPase and kNBC1, overexpression of Nrf2 was carried out in 293T and CV1 cell lines, and experiments were conducted in low-K media. Sp family was cotransfected with Nrf2 to examine the relationship between the 2 molecules and their effect on ion transporters. RESULTS:Ion transporters were activated by overexpression of Nrf2 and cotransfection of Nrf2 with Sp family genes showed additional enhancement of colonic H/K-ATPase and kNBC1 expression and their promoter activities. Pretreatment with low-K media increased the transcriptional activity of Nrf2, colonic H/K-ATPase and kNBC1. Furthermore, transfection of dominant-negative Nrf2 completely abolished low-K-mediated expression of the ion transporters. CONCLUSION:These results suggest that Nrf2 mediates transcriptional activation of colonic H/K-ATPase and kNBC1 in response to K-depleted stress and augments Sp family-mediated expression of these ion transporters.

journal_name

J Nephrol

journal_title

Journal of nephrology

authors

Lee CB,Lee YS,Lee JY,Lee SE,Ahn KY

doi

10.5301/JN.2011.8448

subject

Has Abstract

pub_date

2012-03-01 00:00:00

pages

225-32

issue

2

eissn

1121-8428

issn

1724-6059

pii

6661CE86-C45E-4E1F-A4CE-4DD2C8C730CE

journal_volume

25

pub_type

杂志文章
  • Circadian variation of mineral and bone parameters in end-stage renal disease.

    abstract:BACKGROUND:Mineral and bone parameters are actively managed in end-stage renal disease (ESRD). However, whether these undergo circadian variation is not known. We investigated the circadian variation of mineral and bone parameters in patients on long-term hemodialysis. METHODS:Seventeen ESRD patients on long-term hemo...

    journal_title:Journal of nephrology

    pub_type: 杂志文章

    doi:10.1007/s40620-014-0124-6

    authors: Trivedi H,Szabo A,Zhao S,Cantor T,Raff H

    更新日期:2015-06-01 00:00:00

  • Normothermic perfusion of ischaemic porcine kidneys: an evaluation of ex vivo function and endothelin receptor antagonism.

    abstract:BACKGROUND:Non-heart-beating donors suffer a period of warm ischaemia (WI) injury, resulting in higher rates of delayed graft function compared with heart-beating donors. Endothelin is believed to play a pathophysiological role in the intense vasospasm associated with WI. This study aimed to investigate renal function ...

    journal_title:Journal of nephrology

    pub_type: 杂志文章

    doi:

    authors: Mann CD,Metcalfe MS,Nicholson ML

    更新日期:2009-01-01 00:00:00

  • The calcium-sensing receptor.

    abstract::To maintain divalent ion concentration within the body, a complex sensor has evolved to identify the changes in the extracellular environment and cause the surrounding cells to either secrete or absorb in response to change. An important member of these "sensors" is the calcium-sensing receptor (CaSR), which is consta...

    journal_title:Journal of nephrology

    pub_type: 杂志文章,评审

    doi:

    authors: Geibel JP

    更新日期:2010-11-01 00:00:00

  • Genomic damage in endothelial progenitor cells from uremic patients in hemodialysis.

    abstract:INTRODUCTION:End stage renal disease (ESRD) is associated with a high incidence of cardiovascular disease and cancer. Patients undergoing hemodialysis show a reduced number and an impaired function of endothelial progenitor cells (EPCs), which in physiological conditions contribute to repair the vascular damage. In pat...

    journal_title:Journal of nephrology

    pub_type: 杂志文章

    doi:

    authors: Buemi M,Costa C,Floccari F,Coppolino G,Campo S,Bolignano D,Sturiale A,Lacquaniti A,Buemi A,Loddo S,Teti D

    更新日期:2010-05-01 00:00:00

  • Dialysis requirement, long-term major adverse cardiovascular events (MACE) and all-cause mortality in hospital acquired acute kidney injury (AKI): a propensity-matched cohort study.

    abstract:BACKGROUND:Dialysis-requiring acute kidney injury (D-AKI) is common in hospitalized patients. Many patients survive the immediate post AKI period, thus at risk of suffering long-term sequelae of AKI. Prior studies examining long term outcomes lack non-dialyzed AKI control groups. Without non-dialyzed AKI control group,...

    journal_title:Journal of nephrology

    pub_type: 杂志文章

    doi:10.1007/s40620-016-0321-6

    authors: Omotoso BA,Abdel-Rahman EM,Xin W,Ma JZ,Scully KW,Arogundade FA,Balogun RA

    更新日期:2016-12-01 00:00:00

  • Testing for the cytosine insertion in the VNTR of the MUC1 gene in a cohort of Italian patients with autosomal dominant tubulointerstitial kidney disease.

    abstract:INTRODUCTION:Medullary cystic kidney disease type 1 (MCKD1; OMIM #174000) is a familial progressive tubule-interstitial nephropathy belonging to the recently defined group of autosomal dominant tubulointerstitial kidney diseases (ADTKD). CASE REPORT:A specific type of cytosine insertion in the extracellular variable n...

    journal_title:Journal of nephrology

    pub_type: 杂志文章

    doi:10.1007/s40620-016-0282-9

    authors: Musetti C,Babu D,Fusco I,Mellone S,Zonta A,Quaglia M,Cantaluppi V,Stratta P,Giordano M

    更新日期:2016-06-01 00:00:00

  • Antineoplastic effect of proliferation signal inhibitors: from biology to clinical application.

    abstract::The authors review the antineoplastic effect of mammalian target of rapamycin (mTOR) inhibitors and their biological basis. mTOR is an intracellular serine/threonine kinase that is a central controller of cell growth and proliferation. mTOR integrates signals from sources such as nutrients and growth factors. mTOR reg...

    journal_title:Journal of nephrology

    pub_type: 杂志文章,评审

    doi:

    authors: Bertoni E,Salvadori M

    更新日期:2009-07-01 00:00:00

  • Ceruloplasmin and acute phase protein levels are associated with cardiovascular disease in chronic dialysis patients.

    abstract:BACKGROUND:The most frequent cause of death in hemodialysis (HD) patients is cardiovascular disease (CVD), and chronic inflammation has been identified as an epidemiologically important risk factor for CVD. Elevated levels of minor acute phase reactants, such as ceruloplasmin (Cp) and transferrin, have been related to ...

    journal_title:Journal of nephrology

    pub_type: 杂志文章

    doi:

    authors: Panichi V,Taccola D,Rizza GM,Consani C,Migliori M,Filippi C,Paoletti S,Sidoti A,Borracelli D,Panicucci E,Giovannini L

    更新日期:2004-09-01 00:00:00

  • Leon Marchlewski: one of the precursors of clinical chemistry.

    abstract::Dynamic progress in the basic sciences such as clinical chemistry exerted a great influence on the development of clinical science in medicine in the 19th century. We should rate Prof. Leon Marchlewski among the group of prominent foreign and Polish scientists working in that period. Marchlewski was born in 1869 in Wl...

    journal_title:Journal of nephrology

    pub_type: 传,历史文章,杂志文章

    doi:10.5301/JN.2011.6454

    authors: Ostrowski J,Muszytowski M,Rutkowski B

    更新日期:2011-05-01 00:00:00

  • A rare post-transplant malignancy, cerebellar hemangioblastoma: a case report.

    abstract:INTRODUCTION:Post-transplant malignancies are among the most important complications in organ transplantation. Hemangioblastoma (HB) is especially prevalent in the cerebellum. CASE REPORT:A 20-year-old male who first started dialysis therapy, and then underwent kidney transplantation from a living-relative donor. Five...

    journal_title:Journal of nephrology

    pub_type: 杂志文章

    doi:

    authors: Oztürk S,Soyluk O,Görçin S,Alişir S,Güven D,Türkmen A,Sever MS

    更新日期:2005-11-01 00:00:00

  • Differential proteomic analysis of renal tissue in mesangial proliferative glomerulonephritis using iTRAQ technology.

    abstract:BACKGROUND:Mesangial proliferative glomerulonephritis (MePGN) is characterized by excessive mesangial cell proliferation and mesangial matrix expansion, which lead to glomerular sclerosis and obliteration and, in turn, to deteriorating renal function. To identify and quantify the total proteins in renal tissues of MePG...

    journal_title:Journal of nephrology

    pub_type: 杂志文章

    doi:10.5301/jn.5000124

    authors: Sui W,Tang D,Zou T,Zou G,Chen J,Li H,Li L,Hou Y,Li H,Dai Y

    更新日期:2013-01-01 00:00:00

  • News from the cyst: insights into polycystic kidney disease.

    abstract::Autosomal recessive and autosomal dominant polycystic kidney disease (ADPKD and ARPKD) are 2 major variants of inherited diseases leading to the cystic degeneration of the kidney and other organs. Primary cilia have moved into the focus of research as it is becoming increasingly clear that dysfunction of this special ...

    journal_title:Journal of nephrology

    pub_type: 杂志文章

    doi:

    authors: Wagner CA

    更新日期:2008-01-01 00:00:00

  • Nonsteroidal anti-inflammatory drug use in patients with chronic kidney disease.

    abstract:AIMS:Nonsteroidal anti-inflammatory drugs (NSAIDs) are the cornerstone of pain management. There are no detailed data on NSAIDs use in Poland, especially in patients with chronic kidney disease (CKD). The aim of this study was to evaluate the frequency, circumstances, and causes of NSAIDs use as well as knowledge of th...

    journal_title:Journal of nephrology

    pub_type: 杂志文章

    doi:10.1007/s40620-016-0352-z

    authors: Heleniak Z,Cieplińska M,Szychliński T,Rychter D,Jagodzińska K,Kłos A,Kuźmiuk I,Tylicka MJ,Tylicki L,Rutkowski B,Dębska-Ślizień A

    更新日期:2017-12-01 00:00:00

  • Association of plasma adiponectin and cardiovascular risk profiles in nondiabetic uremic patients on peritoneal dialysis.

    abstract:BACKGROUND:Adiponectin, a novel adipocytokine with antiinflammatory and antiatherosclerosis properties, has been found to be an inverse predictor of cardiovascular outcomes among uremic patients on hemodialysis. However, its role in uremic patients on continuous ambulatory peritoneal dialysis (CAPD) remains unclear. Th...

    journal_title:Journal of nephrology

    pub_type: 杂志文章

    doi:

    authors: Tsao YT,Hsu YJ,Chu NF,Lai CH,Chiu JS,Lin SH

    更新日期:2008-09-01 00:00:00

  • Transplant tolerance: progress and challenges.

    abstract::Organ transplantation has proven to be an effective therapeutic for a wide variety of disease states, but the chronic immunosuppression required for allograft survival increases the risk for infection and neoplasia. In the past 50 years, a wealth of experimental data has been accumulated relating to strategies to pres...

    journal_title:Journal of nephrology

    pub_type: 杂志文章,评审

    doi:

    authors: Casiraghi F,Aiello S,Remuzzi G

    更新日期:2010-05-01 00:00:00

  • Improvement of hypertension and LVH in maintenance hemodialysis patients treated with sustained-release isosorbide mononitrate.

    abstract:BACKGROUND:Hypertension and left ventricular hypertrophy (LVH) are independent predictors of morbidity and mortality in maintenance hemodialysis (MHD) patients. The level of serum asymmetric dimethylarginine (ADMA) is increased in MHD patients, which is a kind of uremic toxin. It can competitively inhibit nitric oxide ...

    journal_title:Journal of nephrology

    pub_type: 杂志文章,随机对照试验

    doi:10.5301/jn.2011.6252

    authors: Li H,Wang SX

    更新日期:2011-03-01 00:00:00

  • Reversible vascular calcifications associated with hypervitaminosis D.

    abstract::A 64-year-old man was hospitalized in 2002 with symptoms of stupor, weakness, and renal colic. The clinical examination indicated borderline hypertension, small masses in the glutei, and polyuria. Laboratory tests evidenced high serum concentrations of creatinine, calcium, and phosphate. Imaging assessments disclosed ...

    journal_title:Journal of nephrology

    pub_type: 杂志文章

    doi:10.1007/s40620-015-0228-7

    authors: Cirillo M,Bilancio G,Cirillo C

    更新日期:2016-02-01 00:00:00

  • Human immunodeficiency virus/acquired immunodeficiency syndrome-associated nephropathy at end-stage renal disease in the United States: patient characteristics and survival in the pre highly active antiretroviral therapy era.

    abstract:BACKGROUND:The patient characteristics and course of HlV/AIDS-associated nephropathy (HIVAN) are presented for a national sample of end-stage renal disease (ESRD). METHODS:375,152 patients in the United States Renal Data System were initiated on ESRD therapy between 1 January 1992 and 30 June 1997 and analyzed in an h...

    journal_title:Journal of nephrology

    pub_type: 杂志文章

    doi:

    authors: Abbott KC,Hypolite I,Welch PG,Agodoa LY

    更新日期:2001-09-01 00:00:00

  • Prevention of complications from use of conventional immunosuppressants: a critical review.

    abstract::Synthetic immunosuppressive drugs are largely used in immune-related renal diseases and in kidney transplantation. Most of these drugs have a low therapeutic index (the ratio that compares the blood concentration at which a drug becomes toxic and the concentration at which the drug is effective), which means that the ...

    journal_title:Journal of nephrology

    pub_type: 杂志文章,评审

    doi:10.1007/s40620-019-00602-5

    authors: Ponticelli C,Glassock RJ

    更新日期:2019-12-01 00:00:00

  • Epicardial adipose tissue: new parameter for cardiovascular risk assessment in high risk populations.

    abstract::Epicardial adipose tissue (EAT) is localized between the myocardial surface and visceral layer of the pericardium. It is a metabolically active organ that secretes several cytokines which modulate cardiovascular morphology and function. EAT may interact locally with coronary arteries through paracrine secretion mechan...

    journal_title:Journal of nephrology

    pub_type: 杂志文章,评审

    doi:10.1007/s40620-018-0491-5

    authors: Russo R,Di Iorio B,Di Lullo L,Russo D

    更新日期:2018-12-01 00:00:00

  • Plasma sulfate concentration and hyperhomocysteinemia in hemodialysis patients.

    abstract:BACKGROUND:Severe hyperhomocysteinemia is common in hemodialysis patients, who also present a dramatic increase in plasma concentrations of sulfate, one of the main products of methionine and cysteine catabolism. The aim of this study was to verify the relationship between high plasma sulfate levels and cysteine or hom...

    journal_title:Journal of nephrology

    pub_type: 杂志文章

    doi:

    authors: Brunetti M,Terracina L,Timio M,Saronio P,Capodicasa E

    更新日期:2001-01-01 00:00:00

  • Prevention of progressive fibrosis in chronic renal diseases: antifibrotic agents.

    abstract::Renal fibrogenesis can be induced by several injury mechanisms in different renal diseases, but ultimately produces identical fibrotic changes in the kidney. Recently, a number of agents that can inhibit extracellular matrix (ECM) accumulation have been studied, suggesting a therapeutic utility in the treatment of fib...

    journal_title:Journal of nephrology

    pub_type: 杂志文章,评审

    doi:

    authors: Negri AL

    更新日期:2004-07-01 00:00:00

  • Lupus nephritis: an historical perspective 1968-1998.

    abstract::Lupus is now regarded as a syndrome which results from several related auto-immune processes, although the exact mechanisms of how the disease arises in susceptible individuals remain obscure. When the San Carlo meetings began in 1968, much less was known about the pathogenesis of autoimmunity, but the presence of aut...

    journal_title:Journal of nephrology

    pub_type: 杂志文章,评审

    doi:

    authors: Cameron JS

    更新日期:1999-07-01 00:00:00

  • Staphylococcal protein A immunoadsorption for Goodpasture's syndrome in four Chinese patients.

    abstract:BACKGROUND:Removal of anti-glomerular basement membrane (anti-GBM) antibody by extracorporeal treatment including plasmapheresis or immunoadsorption (IA) has been considered an effective method in the treatment of Goodpasture's syndrome. In this study, we investigated the effect of IA on serum anti-GBM level and evalua...

    journal_title:Journal of nephrology

    pub_type: 杂志文章

    doi:

    authors: Hu W,Liu Z,Ji D,Xie H,Gong D,Li L

    更新日期:2006-05-01 00:00:00

  • IgA nephropathy in a patient with chronic granulomatous disease.

    abstract::We report the first documented case of X-linked chronic granulomatous disease (CGD) in association with IgA nephropathy in a 22 year old male with multiple soft tissue abscesses. The case highlights the potential role of staphylococcal infections in the pathogenesis of IgA nephropathy and suggests the hypothesis that ...

    journal_title:Journal of nephrology

    pub_type: 杂志文章

    doi:

    authors: Narsipur SS,Shanley PF

    更新日期:2002-11-01 00:00:00

  • Treatment of vasculitic IgA nephropathy.

    abstract:BACKGROUND:Patients with IgA nephropathy and histological vasculitic/crescentic lesions have a poor prognosis. We performed a retrospective study to assess whether treatment with steroids and immunosuppressants would preserve renal function by healing these lesions and thereby prevent progression to glomerular sclerosi...

    journal_title:Journal of nephrology

    pub_type: 临床试验,杂志文章

    doi:

    authors: Harper L,Ferreira MA,Howie AJ,Savage CO,Richards NT,Michael J,Adu D

    更新日期:2000-09-01 00:00:00

  • Role of tubulointerstitial plasmin in the progression of IgA nephropathy.

    abstract:BACKGROUND:Plasmin has recently been reported to be associated with renal fibrosis in experimental models, but its role in human renal diseases is unclear. METHODS:Fifty-seven patients with IgA nephropathy (IgAN) were evaluated retrospectively. Plasmin in their renal biopsy tissues was assessed by in situ zymography u...

    journal_title:Journal of nephrology

    pub_type: 杂志文章

    doi:10.1007/s40620-015-0205-1

    authors: Uchida T,Oda T,Takechi H,Matsubara H,Watanabe A,Yamamoto K,Oshima N,Sakurai Y,Kono T,Shimazaki H,Tamai S,Kumagai H

    更新日期:2016-02-01 00:00:00

  • Association between malnutrition, integrin expression and impaired granulocyte adhesion in chronically hemodialyzed patients.

    abstract:BACKGROUND:The relationship between malnutrition in hemodialysis (HD) patients with a chronic inflammatory condition and the expression levels of leukocyte integrins and their adhesiveness to fibronectin was investigated. METHODS:Subjective global assessment, albumin and body mass index were used as nutritional marker...

    journal_title:Journal of nephrology

    pub_type: 杂志文章

    doi:

    authors: Corradi-Perini C,Riella MC,Cattaneo RI,Weffort-Santos AM

    更新日期:2010-03-01 00:00:00

  • Ferumoxytol: a new era of iron deficiency anemia treatment for patients with chronic kidney disease.

    abstract::Ferumoxytol is a new product approved for intravenous use by the US Food and Drug Administration (FDA) in the treatment of iron deficiency anemia in adults with chronic kidney disease. This approval was based on data from 3 open-label, randomized, controlled clinical trials. In all of these trials, ferumoxytol was wel...

    journal_title:Journal of nephrology

    pub_type: 杂志文章,评审

    doi:10.5301/jn.5000025

    authors: Kowalczyk M,Banach M,Rysz J

    更新日期:2011-11-01 00:00:00

  • Iron-based phosphate binders: a paradigm shift in the treatment of hyperphosphatemic anemic CKD patients?

    abstract::The partial correction of anemia and the normalization of phosphate and blood pressure are the mainstay of treatment of patients with chronic kidney disease (CKD). Available anti-hypertensive drugs, erythropoiesis stimulating agents (ESAs) and iron supplements have resolved quite satisfactorily the goal of controlling...

    journal_title:Journal of nephrology

    pub_type: 杂志文章,评审

    doi:10.1007/s40620-017-0421-y

    authors: Locatelli F,Del Vecchio L

    更新日期:2017-12-01 00:00:00