Abstract：
BACKGROUND:Patients undergoing chronic hemodialysis (HD) are at increased risk for peripheral artery disease (PAD). Both ankle-brachial index (ABI) and ambulatory blood pressure monitoring (ABPM) in the interdialytic period have been shown to be strong predictors of all-cause mortality. METHODS:This cross-sectional study investigated the relationship between ABPM profile and ABI in 81 HD patients. ABPM was measured throughout a 44-h midweek interdialytic period. Pre-dialysis ABI was evaluated with a BOSO ABI device. An ABI value <0.9 or ≥1.3 was defined as abnormal. RESULTS:In the whole study group (72 % males, mean age 67 ± 14 years), there was an increase in BP (p < 0.05) and in systolic BP night/day ratio (n/dSR, p = 0.01) during the interdialytic period. Patients with abnormal ABI (n = 29) more frequently had a positive history for cerebrovascular accident and PAD and higher proBNP values than those with normal ABI (n = 52). No difference was detected among ABPM-derived components except for the n/dSR (p = 0.02). Patients with abnormal ABI showed a significantly increased n/dSR (p = 0.02) and ambulatory arterial stiffness index (AASI) (p = 0.006) on the second day compared to the first. Patients with n/dSR >1 during day 2 (n = 34) were older, showed significantly higher proBNP and AASI and were more likely to reveal abnormal ABI compared to those with a lower n/dSR (p = 0.006). CONCLUSIONS:Abnormal ABI in HD patients is associated to changes in interdialytic ABPM pattern, namely higher n/dSR on day 2. These data may indicate the pathophysiological mechanisms underlying the worse outcome observed in HD patients.
journal_name
J Nephroljournal_title
Journal of nephrologyauthors
Viazzi F,Leoncini G,Ratto E,Storace G,Gonnella A,Garneri D,Bonino B,Cappadona F,Parodi EL,Verzola D,Garibotto G,Pontremoli Rdoi
10.1007/s40620-016-0322-5subject
Has Abstractpub_date
2017-06-01 00:00:00pages
427-433issue
3eissn
1121-8428issn
1724-6059pii
10.1007/s40620-016-0322-5journal_volume
30pub_type
杂志文章abstract：:IgA nephropathy (IgAN) is characterised by the mesangial deposition of polymeric IgA1 (pIgA1). pIgA1 production is reduced in the mucosal immune system in IgAN and increased in the marrow; this switch may be secondary to a defect in gammadeltaT cell control of IgA production. However this does not explain the mechanis...
journal_title：Journal of nephrology
pub_type： 杂志文章,评审
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journal_title：Journal of nephrology
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journal_title：Journal of nephrology
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journal_title：Journal of nephrology
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abstract：AIM:The objective of this study was to determine whether the baseline estimated glomerular filtration rate (eGFR) level was independently associated with in-hospital mortality in generalized patients with hospital-acquired acute kidney injury (HA-AKI) in China. METHODS:All of the patients admitted to a tertiary medica...
journal_title：Journal of nephrology
pub_type： 杂志文章
doi：10.1007/s40620-015-0238-5
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journal_title：Journal of nephrology
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journal_title：Journal of nephrology
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更新日期：1999-05-01 00:00:00
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journal_title：Journal of nephrology
pub_type： 杂志文章,评审
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journal_title：Journal of nephrology
pub_type： 杂志文章
doi：10.5301/jn.5000133
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journal_title：Journal of nephrology
pub_type： 杂志文章
doi：
更新日期：2007-03-01 00:00:00
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journal_title：Journal of nephrology
pub_type： 杂志文章
doi：10.5301/jn.2010.3488
更新日期：2011-03-01 00:00:00
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journal_title：Journal of nephrology
pub_type： 杂志文章,评审
doi：10.1007/s40620-017-0448-0
更新日期：2018-02-01 00:00:00
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journal_title：Journal of nephrology
pub_type： 杂志文章,评审
doi：
更新日期：2002-09-01 00:00:00
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journal_title：Journal of nephrology
pub_type： 杂志文章
doi：10.1007/s40620-017-0396-8
更新日期：2018-02-01 00:00:00
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journal_title：Journal of nephrology
pub_type： 杂志文章
doi：
更新日期：2006-09-01 00:00:00
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journal_title：Journal of nephrology
pub_type： 杂志文章,评审
doi：
更新日期：2010-09-01 00:00:00
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journal_title：Journal of nephrology
pub_type： 杂志文章
doi：
更新日期：2004-11-01 00:00:00
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journal_title：Journal of nephrology
pub_type： 杂志文章,评审
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journal_title：Journal of nephrology
pub_type： 杂志文章,评审
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journal_title：Journal of nephrology
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更新日期：1999-07-01 00:00:00
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journal_title：Journal of nephrology
pub_type： 杂志文章
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journal_title：Journal of nephrology
pub_type： 杂志文章
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journal_title：Journal of nephrology
pub_type： 杂志文章,评审
doi：
更新日期：2009-05-01 00:00:00
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journal_title：Journal of nephrology
pub_type： 杂志文章
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journal_title：Journal of nephrology
pub_type： 杂志文章
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journal_title：Journal of nephrology
pub_type： 杂志文章,评审
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