Palliative care in nephrology.

abstract：BACKGROUND:Accumulating experimental and clinical evidence reveals beneficial effects of n-3 polyunsaturated fatty acids (PUFAs) in kidney disease by modulating inflammation and fibrosis mechanisms that lead to renal failure. METHODS:EPA, DHA (n-3 PUFAs) and AA (n-6 PUFA) effects, compared to those of AngII, on renal ...

journal_title：Journal of nephrology

authors： Priante G,Musacchio E,Valvason C,Clari G,Bordin L,Sartori L,Baggio B

更新日期：2013-07-01 00:00:00

abstract：:The proximal tubule reabsorbs approximately 80% of the filtered load of bicarbonate. Defects in the process of bicarbonate reabsorption result in loss of bicarbonate and proximal renal tubular acidosis. Global proximal tubule dysfunction is known as the Fanconi's syndrome. Both isolated proximal renal tubular acidosis...

journal_title：Journal of nephrology

authors： Quigley R

更新日期：2006-03-01 00:00:00

abstract：BACKGROUND:Pericardial effusion in uremic patients (UPE) was first described by R. Bright in 1836. It is generally agreed that patients require emergency pericardial drainage when tamponade signs are present, but in patients with no tamponade the optimal timing for drainage remains unclear. METHODS:To define patients ...

journal_title：Journal of nephrology

authors： Bataille S,Brunet P,Decourt A,Bonnet G,Loundou A,Berland Y,Habib G,Vacher-Coponat H

更新日期：2015-02-01 00:00:00

abstract：BACKGROUND:Plasmin has recently been reported to be associated with renal fibrosis in experimental models, but its role in human renal diseases is unclear. METHODS:Fifty-seven patients with IgA nephropathy (IgAN) were evaluated retrospectively. Plasmin in their renal biopsy tissues was assessed by in situ zymography u...

journal_title：Journal of nephrology

authors： Uchida T,Oda T,Takechi H,Matsubara H,Watanabe A,Yamamoto K,Oshima N,Sakurai Y,Kono T,Shimazaki H,Tamai S,Kumagai H

更新日期：2016-02-01 00:00:00

abstract：BACKGROUND:Gut-derived uremic toxins have been associated with adverse outcomes in chronic kidney disease (CKD). Alterations in bowel habits, including constipation, seem to play an additional role in uremic toxicity. The aim of this study is to investigate the association of bowel habits with gut-derived uremic toxins...

journal_title：Journal of nephrology

authors： Pereira NBF,Ramos CI,de Andrade LS,Teixeira RR,Nakao LS,Rodrigues SD,de Lima JD,Dalboni MA,Cuppari L

更新日期：2020-10-01 00:00:00

abstract：:Patients with type 2 diabetes run a high risk for progressive renal function loss. Many interventions have been tested to reduce the risk, but we are nowadays still confronted with a high unmet need. To improve on this unmet need, we will have to change the current strategies in drug discovery, clinical trials and cli...

journal_title：Journal of nephrology

authors： de Zeeuw D

更新日期：2020-12-01 00:00:00

abstract：:Hemolytic uremic syndrome (HUS) is a rare disease characterized by microangiopathic hemolytic anemia, thrombocytopenia and acute renal failure. It is usually secondary to infections by strains of Escherichia coli (STEC) that produce Shiga-like toxin. In about 10% of patients, no STEC infections are reported. In these ...

journal_title：Journal of nephrology

authors： Valoti E,Alberti M,Noris M

更新日期：2012-11-01 00:00:00

abstract：BACKGROUND:Oxidative stress plays a crucial role in chronic complications of diabetes such as diabetic nephropathy (DN), the main cause of renal failure. In diabetes, whether peroxynitrite (ONOO(-)), generated from inducible nitric oxide synthase (iNOS) induced by tumor necrosis factor alpha (TNF-alpha), plays a primar...

journal_title：Journal of nephrology

authors： Xiao H,Li Y,Qi J,Wang H,Liu K

更新日期：2009-11-01 00:00:00

abstract：BACKGROUND:Dialysate calcium (Ca) concentration should be viewed as part of the integrated therapeutic regimen to control renal osteodystrophy and maintain normal mineral metabolism. Thus, a correct ionized calcium mass balance (Ca++MB) during hemodialysis (HD) is crucial in the treatment of renal osteodystrophy. The G...

journal_title：Journal of nephrology

authors： Basile C,Libutti P,Di Turo AL,Tundo S,Maselli P,Casucci F,Losurdo N,Teutonico A,Vernaglione L,Lomonte C

更新日期：2011-11-01 00:00:00

abstract：:During Fabry disease, progressive glycosphingolipid deposition in the kidney causes gradual deterioration of renal function with proteinuria, uremia and hypertension. This results in end-stage renal disease (ESRD) which is one of the leading causes of morbidity and premature mortality in affected patients. Given the e...

journal_title：Journal of nephrology

authors： Cybulla M,Kurschat C,West M,Nicholls K,Torras J,Sunder-Plassmann G,Feriozzi S

更新日期：2013-07-01 00:00:00

abstract：:Recent molecular cloning experiments have identified the existence of four NBC isoforms (NBC1, 2, 3 and 4) and two NBC-related proteins AE4 and NCBE (Anion Exchanger 4 and Sodium-dependent Chloride-Bicarbonate Exchanger). Except for AE4 which does not transport Na, all are presumed to mediate the cotransport of Na+ an...

journal_title：Journal of nephrology

authors： Soleimani M

更新日期：2002-03-01 00:00:00

abstract：:Kidney stone disease is a common condition with a high recurrence rate and elevated costs. Despite the well-known positive effects of high fluid intake, there are little data about the roles of water composition and timing of ingestion during the day. This study examines the effect of two different waters [calcium-bic...

journal_title：Journal of nephrology

authors： Ferraro PM,Baccaro R,Baroni S,D'Alessandri L,Carpenito C,Di Daniele N,Urbani A,Gambaro G

更新日期：2020-06-08 00:00:00

abstract：BACKGROUND:The most frequent cause of death in hemodialysis (HD) patients is cardiovascular disease (CVD), and chronic inflammation has been identified as an epidemiologically important risk factor for CVD. Elevated levels of minor acute phase reactants, such as ceruloplasmin (Cp) and transferrin, have been related to ...

journal_title：Journal of nephrology

authors： Panichi V,Taccola D,Rizza GM,Consani C,Migliori M,Filippi C,Paoletti S,Sidoti A,Borracelli D,Panicucci E,Giovannini L

更新日期：2004-09-01 00:00:00

abstract：:Renal fibrogenesis can be induced by several injury mechanisms in different renal diseases, but ultimately produces identical fibrotic changes in the kidney. Recently, a number of agents that can inhibit extracellular matrix (ECM) accumulation have been studied, suggesting a therapeutic utility in the treatment of fib...

journal_title：Journal of nephrology

authors： Negri AL

更新日期：2004-07-01 00:00:00

abstract：:IgA nephropathy (IgAN) is characterised by the mesangial deposition of polymeric IgA1 (pIgA1). pIgA1 production is reduced in the mucosal immune system in IgAN and increased in the marrow; this switch may be secondary to a defect in gammadeltaT cell control of IgA production. However this does not explain the mechanis...

journal_title：Journal of nephrology

authors： Feehally J,Allen AC

更新日期：1999-03-01 00:00:00

abstract：BACKGROUND:This study was undertaken to examine whether there is an association between parity and age at first birth and risk of death from chronic renal failure (CRF). STUDY DESIGN:Prospective cohort study. SETTING AND PARTICIPANTS:The study cohort consisted of 1 292 462 women who had a first and singleton childbir...

journal_title：Journal of nephrology

authors： Kuo CC,Lee CT,Chen CC,Tsai SS,Yang CY

更新日期：2013-03-01 00:00:00

abstract：BACKGROUND:Uromodulin (Tamm-Horsfall protein) is the most abundant urinary protein in healthy individuals. Despite 60 years of research, its physiological role remains rather elusive. Familial juvenile hyperuricemic nephropathy and medullary cystic kidney disease Type 2 are autosomal dominant tubulointerstitial nephrop...

journal_title：Journal of nephrology

authors： Dinour D,Ganon L,Nomy LI,Ron R,Holtzman EJ

更新日期：2014-06-01 00:00:00

abstract：:Cyclosporine A has been empirically used for more than 12 years in the treatment of idiopathic nephrotic syndrome, in both children and adults. There is consistent evidence, from both experimental and human studies, that the highly lipophilic cyclosporine molecule diminishes or abolishes proteinuria by two differing m...

journal_title：Journal of nephrology

authors： Meyrier A

更新日期：1997-01-01 00:00:00

abstract：:The term sarcopenia was first introduced in 1988 by Irwin Rosenberg to define a condition of muscle loss that occurs in the elderly. Since then, a broader definition comprising not only loss of muscle mass, but also loss of muscle strength and low physical performance due to ageing or other conditions, was developed a...

journal_title：Journal of nephrology

authors： Sabatino A,Cuppari L,Stenvinkel P,Lindholm B,Avesani CM

更新日期：2020-09-02 00:00:00

abstract：:Page kidney was first described in animal experiments in 1939. In the 1950s and 1960s the human counterpart became evident. In this review we examine the modest literature on this rare but important renal/urological complication, summarize the clinical features, and discuss the best approach to diagnosis and managemen...

journal_title：Journal of nephrology

authors： Haydar A,Bakri RS,Prime M,Goldsmith DJ

更新日期：2003-05-01 00:00:00

abstract：INTRODUCTION:Contrast-induced acute kidney injury, also referred to as contrast-induced nephropathy (CIN), is a potentially serious renal complication associated with the use of iodinated contrast media (CM) in patients at risk. With the dramatic growth in contrast-enhanced imaging services worldwide, including procedu...

journal_title：Journal of nephrology

authors： Reddan D,Laville M,Garovic VD

更新日期：2009-05-01 00:00:00

abstract：:End-stage renal disease (ESRD) is a significant global health problem that places a considerable burden on health care resources. The leading cause of death in ESRD patients is cardiovascular disease, which is often preceded by changes in cardiac geometry, including left ventricular hypertrophy (LVH). Treatments that ...

journal_title：Journal of nephrology

authors： Culleton BF,Asola MR

更新日期：2011-07-01 00:00:00

abstract：:Influenza is a commonly encountered and serious pathogen. Patients with end-stage renal disease are more susceptible to serious morbidity and mortality associated with influenza infection. Proper management of patients includes: vaccination, monitoring for symptoms and isolation of potentially infected patients as wel...

journal_title：Journal of nephrology

authors： Bowman BT,Rosner MH

更新日期：2018-04-01 00:00:00

abstract：:Bisphosphonates inhibit bone resorption and are widely used to treat osteolytic metastases and osteoporosis. Renal osteodystrophy patients have continuous bone loss due to chronically elevated parathyroid hormone (PTH). In this open-label study, ibandronate was evaluated for the treatment of reduced bone density in re...

journal_title：Journal of nephrology

authors： Bergner R,Henrich D,Hoffmann M,Schmidt-Gayk H,Lenz T,Upperkamp M

更新日期：2008-07-01 00:00:00

abstract：:Sclerosing encapsulating peritonitis (SEP) is a serious complication of long-term continuous ambulatory peritoneal dialysis (CAPD), very likely related to a persisting expression of the transforming growth factor beta1 (TGFbeta1) gene on peritoneal mesothelial cells. We report the case of a 67-year-old uremic woman wh...

journal_title：Journal of nephrology

authors： Allaria PM,Giangrande A,Gandini E,Pisoni IB

更新日期：1999-11-01 00:00:00

abstract：:Inherited distal renal tubular acidosis (dRTA) is caused by impaired urinary acid excretion resulting in hyperchloremic metabolic acidosis. Although the glomerular filtration rate (GFR) is usually preserved, and hypertension and overt proteinuria are absent, it has to be considered that patients with dRTA also suffer ...

journal_title：Journal of nephrology

authors： Seeger H,Salfeld P,Eisel R,Wagner CA,Mohebbi N

更新日期：2017-06-01 00:00:00

abstract：BACKGROUND:Targeted screening interventions for chronic kidney disease (CKD) are increasingly being implemented in various community settings. However, the overall success of these programs is uncertain. Therefore, the aim of this review is to determine whether targeted screening is effective in detecting people with u...

journal_title：Journal of nephrology

authors： Gheewala PA,Zaidi STR,Jose MD,Bereznicki L,Peterson GM,Castelino RL

更新日期：2018-02-01 00:00:00

abstract：:The authors review the antineoplastic effect of mammalian target of rapamycin (mTOR) inhibitors and their biological basis. mTOR is an intracellular serine/threonine kinase that is a central controller of cell growth and proliferation. mTOR integrates signals from sources such as nutrients and growth factors. mTOR reg...

journal_title：Journal of nephrology

authors： Bertoni E,Salvadori M

更新日期：2009-07-01 00:00:00

abstract：:Clinical immunology laboratories play an essential role in diagnosis and monitoring of systemic lupus erythematosus (SLE). To obtain the best results in terms of diagnostic performance and clinical usefulness, the following recommendations should be fulfilled: Indirect immunofluorescence on Hep-2 cells remains the met...

journal_title：Journal of nephrology

authors： Sinico RA,Bollini B,Sabadini E,Di Toma L,Radice A

更新日期：2002-11-01 00:00:00

abstract：:The attitude of 19th century (and even of 20th century) scholars toward medieval and, particularly, Anglo-Saxon medicine has been of severe criticism. According to them it was filled with superstition and stupidities. However, in these last fifty years research has proved that, compared with the Continent, Anglo-Saxon...

journal_title：Journal of nephrology

authors： D'Aronco MA

更新日期：2009-11-01 00:00:00