Proximal renal tubular acidosis.

Abstract:

:The proximal tubule reabsorbs approximately 80% of the filtered load of bicarbonate. Defects in the process of bicarbonate reabsorption result in loss of bicarbonate and proximal renal tubular acidosis. Global proximal tubule dysfunction is known as the Fanconi's syndrome. Both isolated proximal renal tubular acidosis and the Fanconi's syndrome can result from inherited defects or can be acquired. This review will discuss the mechanisms that cause defects in proximal tubule bicarbonate transport as well as the common causes of isolated proximal renal tubular acidosis and the Fanconi syndrome.

journal_name

J Nephrol

journal_title

Journal of nephrology

authors

Quigley R

subject

Has Abstract

pub_date

2006-03-01 00:00:00

pages

S41-5

eissn

1121-8428

issn

1724-6059

journal_volume

19 Suppl 9

pub_type

杂志文章,评审
  • Microarray applications in nephrology with special focus on transplantation.

    abstract::The increase in progressive kidney disease, rising numbers of patients with end-stage renal disease, organ shortages for kidney transplants and poor long-term graft survival rates underline the need for better strategies to diagnose, prevent and treat renal disease. Histological analysis, based on renal biopsies and r...

    journal_title:Journal of nephrology

    pub_type: 杂志文章,评审

    doi:10.5301/jn.5000205

    authors: Mueller TF,Mas VR

    更新日期:2012-09-01 00:00:00

  • Nodular glomerulosclerosis in a non-diabetic patient: case report and review of literature.

    abstract::We report a unusual case of idiopathic nodular glomerulosclerosis mimicking changes that develop in diabetic nephropathy. A 66-year-old non-diabetic female developed nephrotic range proteinuria and the work up was unremarkable. Light and electron microscopy showed mesangial expansion with Kimmelsteil-Wilson nodules an...

    journal_title:Journal of nephrology

    pub_type: 杂志文章,评审

    doi:

    authors: Navaneethan SD,Singh S,Choudhry W

    更新日期:2005-09-01 00:00:00

  • Continuous renal replacement therapies: anticoagulation in the critically ill at high risk of bleeding.

    abstract:BACKGROUND:The ongoing necessity for systemic heparinization is a well-known disadvantage of continuous renal replacement therapies (CRRT), and alternative methods of anticoagulation may be required. Our aim was to evaluate, in patients with a high risk of bleeding, the possibility of an acceptable filter life with non...

    journal_title:Journal of nephrology

    pub_type: 杂志文章

    doi:

    authors: Morabito S,Guzzo I,Solazzo A,Muzi L,Luciani R,Pierucci A

    更新日期:2003-07-01 00:00:00

  • Treating anemia at different stages of renal disease.

    abstract::Cardiovascular disease is the leading cause of the poor long-term survival of patients with chronic kidney disease (CKD). Anemia, which is a frequent and early complication of CKD, not only impairs patients' quality of life, but also is an independent risk factor for adverse cardiovascular outcomes. This may be due to...

    journal_title:Journal of nephrology

    pub_type: 杂志文章,评审

    doi:

    authors: Locatelli F,Del Vecchio L,Pozzoni P

    更新日期:2007-11-01 00:00:00

  • Ad vesice dolorem et ad eos qui urinam non faciunt (For bladder pain and when a person cannot urinate): nephrological disorders in Anglo-Saxon medicine.

    abstract::The attitude of 19th century (and even of 20th century) scholars toward medieval and, particularly, Anglo-Saxon medicine has been of severe criticism. According to them it was filled with superstition and stupidities. However, in these last fifty years research has proved that, compared with the Continent, Anglo-Saxon...

    journal_title:Journal of nephrology

    pub_type: 历史文章,杂志文章

    doi:

    authors: D'Aronco MA

    更新日期:2009-11-01 00:00:00

  • A more tubulocentric view of diabetic kidney disease.

    abstract::Diabetic nephropathy (DN) is a common complication of Diabetes Mellitus (DM) Types 1 and 2, and prevention of end stage renal disease (ESRD) remains a major challenge. Despite its high prevalence, the pathogenesis of DN is still controversial. Initial glomerular disease manifested by hyperfiltration and loss of glomer...

    journal_title:Journal of nephrology

    pub_type: 杂志文章,评审

    doi:10.1007/s40620-017-0423-9

    authors: Zeni L,Norden AGW,Cancarini G,Unwin RJ

    更新日期:2017-12-01 00:00:00

  • Mycophenolate mofetil in treatment of childhood steroid-resistant nephrotic syndrome.

    abstract:INTRODUCTION:The literature on the clinical effectiveness of treatments for steroid-resistant nephrotic syndrome (SRNS) is very limited. The available evidence suggests a beneficial effect of cyclosporine on remission rates. Mycophenolate mofetil (MMF) represents a promising therapeutic alternative without nephrotoxici...

    journal_title:Journal of nephrology

    pub_type: 杂志文章

    doi:10.5301/jn.2011.6327

    authors: Gargah TT,Lakhoua MR

    更新日期:2011-03-01 00:00:00

  • Osteoporosis, bone mineral density and CKD-MBD: treatment considerations.

    abstract::Osteoporosis and chronic kidney disease (CKD) have both independently important potential impact on bone health. A significant number of patients with CKD stages 3a-5D have been shown to have low bone mineral density (BMD), leading to a strikingly elevated risk of fractures (mainly hip fractures) and higher associated...

    journal_title:Journal of nephrology

    pub_type: 杂志文章,评审

    doi:10.1007/s40620-017-0404-z

    authors: Bover J,Bailone L,López-Báez V,Benito S,Ciceri P,Galassi A,Cozzolino M

    更新日期:2017-10-01 00:00:00

  • The effect of polymorphism of uric acid transporters on uric acid transport.

    abstract::The abnormal metabolism of uric acid results in many disease such as chronic kidney disease, hyperuricemia, nephrolithiasis, gout, hypertension, vascular disease and so on. Serum uric acid levels are maintained by the balance between production and elimination. There are many factors that maintain the balance of serum...

    journal_title:Journal of nephrology

    pub_type: 杂志文章,评审

    doi:10.1007/s40620-018-0546-7

    authors: Wang Z,Cui T,Ci X,Zhao F,Sun Y,Li Y,Liu R,Wu W,Yi X,Liu C

    更新日期:2019-04-01 00:00:00

  • Three-dimensional contrast-enhanced magnetic resonance angiography (3-D CE-MRA) in the evaluation of hemodialysis access complications, and the condition of central veins in patients who are candidates for hemodialysis access.

    abstract:BACKGROUND:Arteriovenous (AV) fistulas are crucial in patients requiring long-term hemodialysis (HD). Dysfunctions of these fistulas are the most common causes of recurrent hospitalizations. This study aimed to evaluate the feasibility, safety and usefulness of contrast-enhanced magnetic resonance angiography (CE-MRA) ...

    journal_title:Journal of nephrology

    pub_type: 杂志文章

    doi:

    authors: Paksoy Y,Gormus N,Tercan MA

    更新日期:2004-01-01 00:00:00

  • Effects of turmeric on uremic pruritus in end stage renal disease patients: a double-blind randomized clinical trial.

    abstract:BACKGROUND:Uremic pruritus as a symptom that affects hemodialysis (HD) patients can decrease the quality of life and increase morbidity in these patients. The aim of this study was to evaluate the effects of turmeric on uremic pruritus in HD patients. SUBJECTS AND METHODS:This was a double-blind placebo-controlled tri...

    journal_title:Journal of nephrology

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/s40620-014-0039-2

    authors: Pakfetrat M,Basiri F,Malekmakan L,Roozbeh J

    更新日期:2014-04-01 00:00:00

  • Hypertension and progression of renal disease.

    abstract::That systemic hypertension is involved in the progression of human renal disease is mostly suggested by the way anti-hypertensive treatment affects the course of the disease. Clinical evidence has been obtained from observational studies as well as from studies of dietary protein restriction. In addition, several tria...

    journal_title:Journal of nephrology

    pub_type: 杂志文章,评审

    doi:

    authors: Maschio G,Oldrizzi L,Marcantoni C,Rugiu C

    更新日期:2000-05-01 00:00:00

  • Stage 5-CKD under nephrology care: to dialyze or not to dialyze, that is the question.

    abstract::Appropriate timing of starting chronic dialysis in patients with advanced chronic kidney disease (CKD) under nephrology care still is undefined. We systematically reviewed the most recent studies that have compared outcomes of stage 5-CKD under conservative versus substitutive treatment. Eleven studies, most in elderl...

    journal_title:Journal of nephrology

    pub_type: 杂志文章,评审

    doi:10.1007/s40620-015-0243-8

    authors: Pacilio M,Minutolo R,Garofalo C,Liberti ME,Conte G,De Nicola L

    更新日期:2016-04-01 00:00:00

  • Gene transfer and kidney disease.

    abstract::There is little doubt that molecular biological intervention therapy has come of age and its potential is arousing tremendous excitement. A gene transfer technique, the HVJ-liposome method, is now applicable as a tool for the dissection of molecular aspects in the pathophysiology of renal diseases, and for gene therap...

    journal_title:Journal of nephrology

    pub_type: 杂志文章,评审

    doi:

    authors: Imai E,Isaka Y,Akagi Y,Kaneda Y,Hori M

    更新日期:1998-01-01 00:00:00

  • Effects of prednisone on biomarkers of tubular damage induced by radiocontrast in interventional cardiology.

    abstract:BACKGROUND:Contrast-induced nephropathy (CI-AKI) is a complication of diagnostic/therapeutic hemodynamic procedures in cardiology, which may also cause renal cholesterolinic atheroembolism. Despite the 
severe clinical impact of these complications, there is no optimal therapy for preventing and treating them. We sugge...

    journal_title:Journal of nephrology

    pub_type: 杂志文章

    doi:10.5301/jn.5000266

    authors: Ribichini F,Gambaro A,Pighi M,Pesarini G,Ferraro PM,Zuppi C,Baroni S,Penitente R,Ferrero V,Vassanelli C

    更新日期:2013-05-01 00:00:00

  • The peritoneal sieving of sodium: a simple and powerful test to rule out the onset of encapsulating peritoneal sclerosis in patients undergoing peritoneal dialysis.

    abstract:BACKGROUND AND AIMS:Encapsulating peritoneal sclerosis (EPS) is an uncommon but severe complication of peritoneal dialysis (PD). A reliable screening tool to identify patients at risk of developing or not EPS is currently not available. We aimed to evaluate whether the reduction in dialysate sodium concentration (sodiu...

    journal_title:Journal of nephrology

    pub_type: 杂志文章

    doi:10.1007/s40620-016-0371-9

    authors: La Milia V,Longhi S,Sironi E,Pontoriero G

    更新日期:2018-02-01 00:00:00

  • Hypertension in the elderly: new and old evidence that treatment may benefit the old.

    abstract::Hypertension is prevalent and remains an important risk factor in elderly and very elderly. Randomized controlled outcome trials have shown benefit of antihypertensive treatment in patients with systolic diastolic hypertension and in patients with isolated systolic hypertension, aged 60 years and over. More recently b...

    journal_title:Journal of nephrology

    pub_type: 杂志文章

    doi:

    authors: Fagard RH

    更新日期:2009-09-01 00:00:00

  • Dialysis requirement, long-term major adverse cardiovascular events (MACE) and all-cause mortality in hospital acquired acute kidney injury (AKI): a propensity-matched cohort study.

    abstract:BACKGROUND:Dialysis-requiring acute kidney injury (D-AKI) is common in hospitalized patients. Many patients survive the immediate post AKI period, thus at risk of suffering long-term sequelae of AKI. Prior studies examining long term outcomes lack non-dialyzed AKI control groups. Without non-dialyzed AKI control group,...

    journal_title:Journal of nephrology

    pub_type: 杂志文章

    doi:10.1007/s40620-016-0321-6

    authors: Omotoso BA,Abdel-Rahman EM,Xin W,Ma JZ,Scully KW,Arogundade FA,Balogun RA

    更新日期:2016-12-01 00:00:00

  • A comparison of methods for the measurement of hemodialysis access recirculation.

    abstract:BACKGROUND:NKF K-DOQI clinical practice guidelines recommend a regular monitoring of vascular access (VA) through several methods, such as VA recirculation (AR). Assessment of AR is crucial to avoid inefficiency of hemodialysis (HD). A non-urea based method has been developed (ultrasound dilution Transonics Hemodialysi...

    journal_title:Journal of nephrology

    pub_type: 杂志文章

    doi:

    authors: Basile C,Ruggieri G,Vernaglione L,Montanaro A,Giordano R

    更新日期:2003-11-01 00:00:00

  • Ceruloplasmin and acute phase protein levels are associated with cardiovascular disease in chronic dialysis patients.

    abstract:BACKGROUND:The most frequent cause of death in hemodialysis (HD) patients is cardiovascular disease (CVD), and chronic inflammation has been identified as an epidemiologically important risk factor for CVD. Elevated levels of minor acute phase reactants, such as ceruloplasmin (Cp) and transferrin, have been related to ...

    journal_title:Journal of nephrology

    pub_type: 杂志文章

    doi:

    authors: Panichi V,Taccola D,Rizza GM,Consani C,Migliori M,Filippi C,Paoletti S,Sidoti A,Borracelli D,Panicucci E,Giovannini L

    更新日期:2004-09-01 00:00:00

  • Neoral dose adjustment after conversion from C0 to C2 monitoring in stable renal transplant recipients: a prospective single center study.

    abstract::To determine the clinical impact of conversion from C0 to C2 Neoral monitoring, we conducted a 6-month prospective study in 62 stable renal transplant recipients. Neoral was given alone (19%), with steroids (31%), combined with azathioprine (Aza) or mycophenolate mofetil (MMF) (50%). C0 and C2 target ranges were, resp...

    journal_title:Journal of nephrology

    pub_type: 杂志文章

    doi:

    authors: Sandrini S,Bossini N,Setti G,Mazzucchelli C,Maiorca P,Cancarini G

    更新日期:2004-03-01 00:00:00

  • Italian randomized trial of hemoglobin maintenance to prevent or delay left ventricular hypertrophy in chronic kidney disease.

    abstract:BACKGROUND:This study is part of a 3-country study testing whether normal levels of hemoglobin (Hgb) delay the progression of left ventricular (LV) growth in chronic kidney disease (CKD) patients not on dialysis. METHODS:This was an open-label, randomized, multicenter, controlled trial conducted in 27 tertiary-care ho...

    journal_title:Journal of nephrology

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:

    authors: Cianciaruso B,Ravani P,Barrett BJ,Levin A,ITA-EPO-7 investigators.

    更新日期:2008-11-01 00:00:00

  • Many clinically silent access stenoses can be identified by ultrasonography.

    abstract:BACKGROUND:Stenoses of vascular accesses are leading factors limiting access survival. Besides physical examination, screening of access stenoses is based mainly on the "dysfunction hypothesis", which states that progressive stenosis causes graft dysfunction, such as decreased flow. We tested whether Doppler ultrasonog...

    journal_title:Journal of nephrology

    pub_type: 杂志文章

    doi:

    authors: Malik J,Slavikova M,Malikova H,Maskova J

    更新日期:2002-11-01 00:00:00

  • Bioethics in nephrology: guidelines for decision-making in Italy.

    abstract::In 1998, the Italian Ministry of Health urged the Italian Society of Nephrology (SIN) to draft recommendations for uniform decision-making procedures in the field of dialysis. In accordance with the Ministry's specifications, at the time the Society approved diagnostic protocols regarding clinical questions, but witho...

    journal_title:Journal of nephrology

    pub_type: 指南,杂志文章,实务指引

    doi:

    authors: Buzzi F,Cecioni R,Di Paolo M,National Task Force for Bioethics in Nephrology.

    更新日期:2001-03-01 00:00:00

  • The extra-phosphate intestinal load from medications: is it a real concern?

    abstract:BACKGROUND AND AIMS:Reduction of intestinal load of phosphorus is important for the prevention and treatment of chronic kidney disease (CKD)-mineral and bone disorder (MBD). However, this strategy is limited by patients' poor adherence to dietary prescription and by the existence of hidden sources of phosphorus. In add...

    journal_title:Journal of nephrology

    pub_type: 杂志文章

    doi:10.1007/s40620-016-0306-5

    authors: Cupisti A,Moriconi D,D'Alessandro C,Verde F,Marchini M,Saba A,Egidi MF

    更新日期:2016-12-01 00:00:00

  • Rapidly progressive glomerulonephritis: current and evolving treatment strategies.

    abstract::Rapidly progressive glomerulonephritis (RPGN) must be diagnosed and treated quickly to prevent irreversible organ injury. The commonest cause of RPGN is anti-neutrophil cytoplasm antibody (ANCA) associated small vessel vasculitis, and the most severe is anti-glomerular basement membrane (GBM) antibody disease. In this...

    journal_title:Journal of nephrology

    pub_type: 杂志文章,评审

    doi:

    authors: Little MA,Pusey CD

    更新日期:2004-11-01 00:00:00

  • The effect of anemia and left ventricular geometric patterns on renal disease progression in type 2 diabetic nephropathy.

    abstract:BACKGROUND:Left ventricular (LV) geometric patterns have never been evaluated as independent risk factors for renal disease progression (RDP). We investigated the risk factors for RDP in type 2 diabetic nephropathy patients, especially focusing on the effects of LV geometric patterns. METHODS:This was a single-center ...

    journal_title:Journal of nephrology

    pub_type: 杂志文章

    doi:10.5301/jn.2010.353

    authors: Moon SJ,Bae KS,Park HC,Kim JK,Park JT,Lee JE,Rim SJ,Ha SK

    更新日期:2011-01-01 00:00:00

  • Correlation of bone mineral density with the histological findings of renal osteodystrophy in patients on hemodialysis.

    abstract:AIMS:To examine the distribution of bone mineral density (BMD) in different histological groups of renal osteodystrophy. PATIENTS:We prospectively studied 62 patients, 41 men and 21 women, aged 57+/-11.5 years, who had been on hemodialysis for 60+/-55 months. The women had been amenorrheic for 13+/-4 years and 7 patie...

    journal_title:Journal of nephrology

    pub_type: 杂志文章

    doi:

    authors: Gerakis A,Hadjidakis D,Kokkinakis E,Apostolou T,Raptis S,Billis A

    更新日期:2000-11-01 00:00:00

  • Congenital nephrotic syndrome: a clinico-pathologic study of thirty children.

    abstract:BACKGROUND:Congenital nephrotic syndrome is an uncommon disorder that may be caused by several diseases. These may be inherited, sporadic, acquired or part of a general malformation syndrome. METHODS:We reviewed the clinical characteristics, pathologic findings, and results of medical management in 30 infants who pres...

    journal_title:Journal of nephrology

    pub_type: 杂志文章

    doi:

    authors: Hamed RM,Shomaf M

    更新日期:2001-03-01 00:00:00

  • Acute colchicine intoxication during clarithromycin administration in patients with chronic renal failure.

    abstract::Colchicine is an effective antiinflammatory medication. It should be used with great caution, however, in patients requiring dialysis. Coadministration of colchicine and macrolides may impair colchicine elimination, resulting in excess drug exposure and toxicity. We report 2 renal failure cases of colchicine intoxicat...

    journal_title:Journal of nephrology

    pub_type: 杂志文章

    doi:

    authors: Akdag I,Ersoy A,Kahvecioglu S,Gullulu M,Dilek K

    更新日期:2006-07-01 00:00:00