Management of hepatitis C virus infection in patients with chronic kidney disease: position statement of the joint committee of Italian association for the study of the liver (AISF), Italian society of internal medicine (SIMI), Italian society of infectio

Abstract:

:Hepatitis C virus (HCV) infection is now considered a systemic disease due to the occurrence of extra-hepatic manifestations. Among these, the renal involvement is frequent. HCV infection, in fact, is strongly associated with proteinuria and chronic kidney disease (CKD) and negatively affects the prognosis of renal patients. In the last few years, availability of more specific and effective drugs against HCV has dramatically changed the clinical course of this disease. These drugs may provide further advantages in the CKD population as a whole by reducing progression of renal disease, mortality rate and by increasing the survival of graft in renal transplant recipients. The strict pathogenetic and prognostic link between HCV infection and CKD requires an ongoing relationship among the healthcare professionals involved in the treatment of both HCV infection and CKD. Therefore, Scientific Societies involved in the care of this high-risk population in Italy have organized a joint expert panel. The aim of the panel is to produce a position statement that can be used in daily clinical practice for the management of HCV infected patients across the whole spectrum of renal disease, from the conservative phase to renal replacement treatments (dialysis and transplantation). Sharing specific evidence-based expertise of different professional healthcare is the first step to obtain a common ground of knowledge on which to instate a model for multidisciplinary management of this high-risk population. Statements cover seven areas including epidemiology of CKD, HCV-induced glomerular damage, HCV-related renal risk, staging of liver disease in patients with CKD, prevention of transmission of HCV in hemodialysis units, treatment of HCV infection and management of HCV in kidney transplantation.

journal_name

J Nephrol

journal_title

Journal of nephrology

authors

Minutolo R,Aghemo A,Chirianni A,Fabrizi F,Gesualdo L,Giannini EG,Maggi P,Montinaro V,Paoletti E,Persico M,Perticone F,Petta S,Puoti M,Raimondo G,Rendina M,Zignego AL,Italian Society of Nephrology (SIN).,Italian Associat

doi

10.1007/s40620-018-0523-1

subject

Has Abstract

pub_date

2018-10-01 00:00:00

pages

685-712

issue

5

eissn

1121-8428

issn

1724-6059

pii

10.1007/s40620-018-0523-1

journal_volume

31

pub_type

杂志文章,实务指引
  • Staphylococcal protein A immunoadsorption for Goodpasture's syndrome in four Chinese patients.

    abstract:BACKGROUND:Removal of anti-glomerular basement membrane (anti-GBM) antibody by extracorporeal treatment including plasmapheresis or immunoadsorption (IA) has been considered an effective method in the treatment of Goodpasture's syndrome. In this study, we investigated the effect of IA on serum anti-GBM level and evalua...

    journal_title:Journal of nephrology

    pub_type: 杂志文章

    doi:

    authors: Hu W,Liu Z,Ji D,Xie H,Gong D,Li L

    更新日期:2006-05-01 00:00:00

  • Familial renal tubular acidosis.

    abstract::The kidney maintains systemic acid-base homeostasis through proximal tubular reclamation of filtered bicarbonate, and excretion of the daily mineral acid load by collecting duct type A intercalated cells. Impairment of either process produces renal tubular acidosis (RTA). This article will provide an overview of famil...

    journal_title:Journal of nephrology

    pub_type: 杂志文章,评审

    doi:

    authors: Alper SL

    更新日期:2010-11-01 00:00:00

  • Gadolinium-associated nephrogenic systemic fibrosis: the need for nephrologists' awareness.

    abstract::Nephrogenic systemic fibrosis (NSF) / nephrogenic fibrosing dermopathy (NFD) is a recently described disease, occurring only in patients with variable degrees of renal failure (RF) previously exposed to gadolinium-based contrast agents (GBCAs) for magnetic resonance imaging. Public advisories are consistent on some ke...

    journal_title:Journal of nephrology

    pub_type: 杂志文章,评审

    doi:

    authors: Canavese C,Mereu MC,Aime S,Lazzarich E,Fenoglio R,Quaglia M,Stratta P

    更新日期:2008-05-01 00:00:00

  • Relationship of chronic kidney disease to cardiovascular death and myocardial infarction following coronary stenting.

    abstract:BACKGROUND:Chronic kidney disease is a risk factor for death in the year following myocardial infarction or coronary angioplasty. Whether the risk is similar after coronary stenting, whether impaired renal function is associated with an increased risk of cardiovascular death or myocardial infarction (MI) after coronary...

    journal_title:Journal of nephrology

    pub_type: 杂志文章,随机对照试验

    doi:

    authors: Charytan DM,Kuntz RE,Chhabra A,Cutlip DE

    更新日期:2006-11-01 00:00:00

  • The protean face of renal sarcoid.

    abstract::Sarcoidosis is a multisystem disorder of unknown etiology, which may occur in all tissues and organs of the body. Clinical presentation may be quite variable and affected by race. The most commonly affected system is the lungs with >95% of patients displaying such involvement. Renal involvement is uncommon (<2%) and m...

    journal_title:Journal of nephrology

    pub_type: 杂志文章

    doi:

    authors: Carmichael P,O'Donnell JP

    更新日期:2003-09-01 00:00:00

  • Left ventricular hypertrophy and progression of chronic kidney disease.

    abstract::Reduced glomerular filtration rate and albuminuria do not account for the total risk of developing end-stage renal disease (ESRD), suggesting that other factors might be involved in progressive renal function worsening. Among these, cardiovascular disease, even subclinical, could play a role. The role of left ventricu...

    journal_title:Journal of nephrology

    pub_type: 社论,评审

    doi:10.5301/jn.5000114

    authors: Paoletti E

    更新日期:2012-11-01 00:00:00

  • Silent chronic kidney disease epidemic seen from Europe: designing strategies for clinical management of the early stages.

    abstract::Given the alarming predictions of the potentially devastating future epidemic of end-stage renal disease (ESRD), further knowledge is still urgently needed on this topic. The real dimensions of the problem are still unclear. It is difficult to compare Europe and the USA because different criteria are used in data coll...

    journal_title:Journal of nephrology

    pub_type: 杂志文章

    doi:

    authors: Gambaro G,D'Angelo A,Conte M,Bonfante L,De Biase V,Lupo A

    更新日期:2005-03-01 00:00:00

  • Correlation of bone mineral density with the histological findings of renal osteodystrophy in patients on hemodialysis.

    abstract:AIMS:To examine the distribution of bone mineral density (BMD) in different histological groups of renal osteodystrophy. PATIENTS:We prospectively studied 62 patients, 41 men and 21 women, aged 57+/-11.5 years, who had been on hemodialysis for 60+/-55 months. The women had been amenorrheic for 13+/-4 years and 7 patie...

    journal_title:Journal of nephrology

    pub_type: 杂志文章

    doi:

    authors: Gerakis A,Hadjidakis D,Kokkinakis E,Apostolou T,Raptis S,Billis A

    更新日期:2000-11-01 00:00:00

  • Further insights about the beneficial effects of n-3 fatty acids in the early molecular events of renal fibrosis in vitro.

    abstract:BACKGROUND:Accumulating experimental and clinical evidence reveals beneficial effects of n-3 polyunsaturated fatty acids (PUFAs) in kidney disease by modulating inflammation and fibrosis mechanisms that lead to renal failure. METHODS:EPA, DHA (n-3 PUFAs) and AA (n-6 PUFA) effects, compared to those of AngII, on renal ...

    journal_title:Journal of nephrology

    pub_type: 杂志文章

    doi:10.5301/jn.5000193

    authors: Priante G,Musacchio E,Valvason C,Clari G,Bordin L,Sartori L,Baggio B

    更新日期:2013-07-01 00:00:00

  • The vascular endothelium in chronic renal failure.

    abstract::Chronic renal failure (CRF) is associated with a 20-fold increased risk of cardiovascular death, two principal mechanisms being: sudden, arrhythmic death associated with left ventricular hypertrophy, and ischaemic heart disease, associated with accelerated atherosclerosis. In recent years, the vascular endothelium has...

    journal_title:Journal of nephrology

    pub_type: 杂志文章,评审

    doi:

    authors: Morris ST,Jardine AG

    更新日期:2000-03-01 00:00:00

  • Clinical and therapeutic aspects of diabetic nephropathy.

    abstract:UNLABELLED:The prognosis of renal survival in both type 1 and type 2 diabetes mellitus is not benign. Several factors characterize the increase in the risk of developing renal damage in diabetic patients, distinguished in diabetes-related factors, genetic factors and other factors. DIAGNOSIS:Diagnosis requires standar...

    journal_title:Journal of nephrology

    pub_type: 杂志文章,评审

    doi:

    authors: Strippoli GF,Di Paolo S,Cincione R,Di Palma AM,Teutonico A,Grandaliano G,Schena FP,Gesualdo L

    更新日期:2003-07-01 00:00:00

  • Renal structure in type 2 diabetes: facts and misconceptions.

    abstract::The clinical manifestations of diabetic nephropathy are similar in type 1 and type 2 diabetes, while the renal lesions may differ. Indeed, diabetic glomerulopathy is the predominant renal lesion in type 1 diabetes, although also tubular, interstitial and arteriolar lesions are present in the advanced stages of renal d...

    journal_title:Journal of nephrology

    pub_type: 杂志文章,评审

    doi:10.1007/s40620-020-00797-y

    authors: Di Vincenzo A,Bettini S,Russo L,Mazzocut S,Mauer M,Fioretto P

    更新日期:2020-10-01 00:00:00

  • Immunosuppressive treatment in primary focal segmental glomerulosclerosis.

    abstract:BACKGROUND:The therapeutic effects of immunosuppressive agents such as cyclosporin A, mycophenolate mofetil, rituximab and sirolimus on primary focal segmental glomerulosclerosis (FSGS) remain controversial. The present study was intended to review and analyze the treatment results of immunosuppressive agents for prima...

    journal_title:Journal of nephrology

    pub_type: 杂志文章,评审

    doi:10.5301/jn.5000092

    authors: Xu S,Xu G,Zeng L

    更新日期:2012-09-01 00:00:00

  • Phosphatemia is related to chromosomal aberrations of parathyroid glands in patients with hyperparathyroidism.

    abstract:BACKGROUND AND AIMS:It has been well documented that gene and DNA alterations occur frequently in benign primary parathyroid adenomas as well as in parathyroid glands with secondary hyperplasia. However, it has not been shown whether a correlation exists between somatic DNA aberrations and clinical data. METHODS:We an...

    journal_title:Journal of nephrology

    pub_type: 杂志文章

    doi:

    authors: Chudek J,Nagy A,Kokot F,Podwinski A,Wiecek A,Ritz E,Kovacs G

    更新日期:2007-03-01 00:00:00

  • Clinical significance of IgM and C1q deposition in the mesangium in pediatric idiopathic nephrotic syndrome.

    abstract:BACKGROUND:In biopsy-proven idiopathic nephrotic syndrome (INS), immunoglobulin M (IgM) and C1q are occasionally deposited in the mesangium. In pediatric nephrology, the significance of mesangial IgM or C1q deposits is controversial, based on previous reports. The aim of this study was to explore the clinical significa...

    journal_title:Journal of nephrology

    pub_type: 杂志文章

    doi:10.5301/jn.5000133

    authors: Kanemoto K,Ito H,Anzai M,Matsumura C,Kurayama H

    更新日期:2013-03-01 00:00:00

  • Peroxynitrite plays a key role in glomerular lesions in diabetic rats.

    abstract:BACKGROUND:Oxidative stress plays a crucial role in chronic complications of diabetes such as diabetic nephropathy (DN), the main cause of renal failure. In diabetes, whether peroxynitrite (ONOO(-)), generated from inducible nitric oxide synthase (iNOS) induced by tumor necrosis factor alpha (TNF-alpha), plays a primar...

    journal_title:Journal of nephrology

    pub_type: 杂志文章

    doi:

    authors: Xiao H,Li Y,Qi J,Wang H,Liu K

    更新日期:2009-11-01 00:00:00

  • Endotoxin-induced acute renal failure in rats: effects of L-arginine and nitric oxide synthase inhibition on renal function.

    abstract:BACKGROUND:The regulation of renal hemodynamics is closely related to the L-arginine (L-Arg)/nitric oxide (NO) pathway. NO - metabolized from L-Arg - is capable of improving renal function in ischemic and toxic acute renal failure (ARF), while NO synthase (NOS) inhibition induces deterioration in renal function. The mo...

    journal_title:Journal of nephrology

    pub_type: 杂志文章

    doi:

    authors: Schramm L,Weierich T,Heldbreder E,Zimmermann J,Netzer KO,Wanner C

    更新日期:2005-07-01 00:00:00

  • Nodular glomerulosclerosis in a non-diabetic patient: case report and review of literature.

    abstract::We report a unusual case of idiopathic nodular glomerulosclerosis mimicking changes that develop in diabetic nephropathy. A 66-year-old non-diabetic female developed nephrotic range proteinuria and the work up was unremarkable. Light and electron microscopy showed mesangial expansion with Kimmelsteil-Wilson nodules an...

    journal_title:Journal of nephrology

    pub_type: 杂志文章,评审

    doi:

    authors: Navaneethan SD,Singh S,Choudhry W

    更新日期:2005-09-01 00:00:00

  • The association of endothelin-1 levels with renal survival in polycystic kidney disease patients.

    abstract:BACKGROUND:The prominent features of autosomal dominant polycystic kidney disease (ADPKD) are early development of hypertension, chronic kidney disease and cardiovascular problems. Thus, we aimed to investigate the role of endothelin, a vascular biomarker, in the clinical course of ADPKD, including renal and cardiovasc...

    journal_title:Journal of nephrology

    pub_type: 杂志文章

    doi:10.1007/s40620-018-0514-2

    authors: Kocyigit I,Eroglu E,Kaynar AS,Kocer D,Kargi S,Zararsiz G,Bayramov R,Imamoglu H,Sipahioglu MH,Tokgoz B,Dundar M,Oymak O

    更新日期:2019-02-01 00:00:00

  • New markers of accelerated atherosclerosis in end-stage renal disease.

    abstract::Over the last two decades, several studies have reported a high prevalence of cardiovascular disease in patients with end-stage renal disease (ESRD). This population usually presents both the traditional and non-traditional risk factors for atherosclerosis. Inflammation as well as impaired nitric oxide production are ...

    journal_title:Journal of nephrology

    pub_type: 杂志文章,评审

    doi:

    authors: Rattazzi M,Puato M,Faggin E,Bertipaglia B,Grego F,Pauletto P

    更新日期:2003-01-01 00:00:00

  • The impact of bleeding times on major complication rates after percutaneous real-time ultrasound-guided renal biopsies.

    abstract:BACKGROUND:Previous studies have shown that bleeding times have positive predictive values of only 5% for perioperative bleeding in unselected populations. Nevertheless, performing bleeding times prior to all renal biopsies is common in nephrology practice. METHODS:We report complications of 112 renal biopsies done at...

    journal_title:Journal of nephrology

    pub_type: 杂志文章

    doi:

    authors: Stiles KP,Hill C,LeBrun CJ,Reinmuth B,Yuan CM,Abbott KC

    更新日期:2001-07-01 00:00:00

  • Many clinically silent access stenoses can be identified by ultrasonography.

    abstract:BACKGROUND:Stenoses of vascular accesses are leading factors limiting access survival. Besides physical examination, screening of access stenoses is based mainly on the "dysfunction hypothesis", which states that progressive stenosis causes graft dysfunction, such as decreased flow. We tested whether Doppler ultrasonog...

    journal_title:Journal of nephrology

    pub_type: 杂志文章

    doi:

    authors: Malik J,Slavikova M,Malikova H,Maskova J

    更新日期:2002-11-01 00:00:00

  • Peritoneal Cell-free DNA: an innovative method for determining acute cell damage in peritoneal membrane and for monitoring the recovery process after peritonitis.

    abstract:BACKGROUND:Cell-free DNA (cfDNA) is present in the peritoneal effluent of stable peritoneal dialysis (PD) patients, but there are no data on cfDNA in PD patients with peritonitis. We investigated the variation of peritoneal cfDNA levels subsequent to peritonitis in PD patients. METHODS:We enrolled 53 PD patients: 30 w...

    journal_title:Journal of nephrology

    pub_type: 杂志文章

    doi:10.1007/s40620-015-0212-2

    authors: Virzì GM,Milan Manani S,Brocca A,Cantaluppi V,de Cal M,Pastori S,Tantillo I,Zambon R,Crepaldi C,Ronco C

    更新日期:2016-02-01 00:00:00

  • Italian randomized trial of hemoglobin maintenance to prevent or delay left ventricular hypertrophy in chronic kidney disease.

    abstract:BACKGROUND:This study is part of a 3-country study testing whether normal levels of hemoglobin (Hgb) delay the progression of left ventricular (LV) growth in chronic kidney disease (CKD) patients not on dialysis. METHODS:This was an open-label, randomized, multicenter, controlled trial conducted in 27 tertiary-care ho...

    journal_title:Journal of nephrology

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:

    authors: Cianciaruso B,Ravani P,Barrett BJ,Levin A,ITA-EPO-7 investigators.

    更新日期:2008-11-01 00:00:00

  • The history of nephrology in Poland.

    abstract::Modern nephrology developed in Poland mostly from the internal medicine department chaired in Warsaw by the great internist prof. Witold Orłowski (1874-1966). Three of his pupils Tadeusz Orłowski, Jan Roguski and Jakub Penson independently established the foundations of clinical nephrology and renal replacement therap...

    journal_title:Journal of nephrology

    pub_type: 历史文章,杂志文章

    doi:

    authors: Czekalski S,Rutkowski B

    更新日期:2006-05-01 00:00:00

  • Proximal renal tubular acidosis.

    abstract::The proximal tubule reabsorbs approximately 80% of the filtered load of bicarbonate. Defects in the process of bicarbonate reabsorption result in loss of bicarbonate and proximal renal tubular acidosis. Global proximal tubule dysfunction is known as the Fanconi's syndrome. Both isolated proximal renal tubular acidosis...

    journal_title:Journal of nephrology

    pub_type: 杂志文章,评审

    doi:

    authors: Quigley R

    更新日期:2006-03-01 00:00:00

  • Carotid intima-media thickness and ACE-gene polymorphism in hemodialysis patients.

    abstract:BACKGROUND:Carotid artery intima-media thickness (CIMT) has been used as a marker of atherosclerosis. An insertion/deletion (I/D) polymorphism of the angiotensin-converting enzyme (ACE) gene is associated with various cardiovascular diseases. This study is aimed at evaluating early atherosclerotic involvement of caroti...

    journal_title:Journal of nephrology

    pub_type: 杂志文章

    doi:

    authors: Nergizoğlu G,Keven K,Gürses MA,Aras O,Ertürk S,Duman N,Ateş K,Akar H,Akar N,Karatan O,Erbay B,Ertuğ AE

    更新日期:1999-07-01 00:00:00

  • News from the cyst: insights into polycystic kidney disease.

    abstract::Autosomal recessive and autosomal dominant polycystic kidney disease (ADPKD and ARPKD) are 2 major variants of inherited diseases leading to the cystic degeneration of the kidney and other organs. Primary cilia have moved into the focus of research as it is becoming increasingly clear that dysfunction of this special ...

    journal_title:Journal of nephrology

    pub_type: 杂志文章

    doi:

    authors: Wagner CA

    更新日期:2008-01-01 00:00:00

  • Uric acid and nocturnal nondipping in hypertensive patients with normal renal function.

    abstract:BACKGROUND:The effect of uric acid on nocturnal dipping in hypertensive patients is unknown. We analyzed the specific relationship between uric acid and nocturnal dipping status in newly diagnosed essential hypertensive patients with normal renal function. METHODS:Two hundred fifteen patients with newly diagnosed esse...

    journal_title:Journal of nephrology

    pub_type: 杂志文章

    doi:

    authors: Afsar B,Elsurer R,Ozdemir FN,Sezer S

    更新日期:2008-05-01 00:00:00

  • Toll-like receptor-4 signaling mediates inflammation and tissue injury in diabetic nephropathy.

    abstract::Toll-like receptors (TLRs) are a class of receptors of the innate immune system which detect pathogen-associated and danger-associated molecular patterns in order to initiate an inflammatory response. TLR2 and TLR4 downward signaling causes the production of proinflammatory cytokines that can induce insulin resistance...

    journal_title:Journal of nephrology

    pub_type: 杂志文章,评审

    doi:10.1007/s40620-017-0432-8

    authors: Garibotto G,Carta A,Picciotto D,Viazzi F,Verzola D

    更新日期:2017-12-01 00:00:00