Abstract:
BACKGROUND AND AIMS:This study aimed to test the hypothesis that visfatin is associated with atherosclerosis in patients with chronic kidney disease (CKD). METHODS:In the study, we measured serum triglycerides, total cholesterol, high-density lipoprotein (HDL) cholesterol, low-density lipoprotein (LDL) cholesterol levels and the following blood markers of endothelial function and inflammation: endothelin-1 (ET-1), nitric oxide (NO), thrombomodulin and high-sensitivity C-reactive protein (hsCRP) in 117 patients with CKD stage 4 or 5 and in 50 normal controls. Flow-mediated dilatation (FMD) was assessed by high-resolution brachial ultrasonography, and carotid intima-media thickness (IMT) was determined by vascular ultrasound. Plasma visfatin concentrations were measured by ELISA. RESULTS:Compared with healthy controls, endothelial dysfunction was observed in all CKD patients. Visfatin levels were strongly correlated with hsCRP levels, serum triglyceride levels and LDL cholesterol levels, and negatively correlated with HDL cholesterol, estimated glomerular filtration rate (eGFR) and FMD levels in the CKD patients (p<0.05, for all). Moreover, carotid IMT was found to be significantly related to visfatin levels (p<0.05). CONCLUSION:Overall, the study showed that in CKD patients, higher visfatin levels are associated with decreased GFR, increased serum triglyceride and LDL cholesterol levels and impaired endothelial function. Moreover, visfatin levels also correlated with hsCRP levels and carotid IMT, suggesting that visfatin may play an important role in uremia-related atherosclerosis.
journal_name
J Nephroljournal_title
Journal of nephrologyauthors
Mu J,Feng B,Ye Z,Yuan F,Zeng W,Luo Z,Qi Wdoi
10.5301/jn.2010.3488subject
Has Abstractpub_date
2011-03-01 00:00:00pages
177-84issue
2eissn
1121-8428issn
1724-6059pii
BB393B24-7CBA-47F3-8A6B-DB281C7DD628journal_volume
24pub_type
杂志文章abstract:BACKGROUND:Cardiac surgery-associated acute kidney injury (CSA-AKI) is associated with high risk for complications and mortality. Whether renin-angiotensin system (RAS) inhibitor should be continued or withdrawn in patients with long-term use before cardiac surgery has been lack of consensus. METHODS:We performed this...
journal_title:Journal of nephrology
pub_type: 杂志文章,多中心研究
doi:10.1007/s40620-019-00657-4
更新日期:2019-12-01 00:00:00
abstract:INTRODUCTION:Several studies have suggested an effect of calcineurin inhibitors on arterial compliance in kidney transplant recipients. We aimed to investigate whether the type of calcineurin inhibitor influences large and small artery compliance in these patients independently of other determinants. METHODS:Patients ...
journal_title:Journal of nephrology
pub_type: 杂志文章
doi:
更新日期:2008-01-01 00:00:00
abstract::Some antihypertensive drugs may have a renoprotective effect, that is partially independent of their ability to reduce blood pressure. ACE-inhibitors are safe and effective agents that are capable of reducing proteinuria and preventing CRF progression. The results of the AIPRI extension study suggest that they may als...
journal_title:Journal of nephrology
pub_type: 杂志文章,评审
doi:
更新日期:1998-11-01 00:00:00
abstract:AIMS:To examine the distribution of bone mineral density (BMD) in different histological groups of renal osteodystrophy. PATIENTS:We prospectively studied 62 patients, 41 men and 21 women, aged 57+/-11.5 years, who had been on hemodialysis for 60+/-55 months. The women had been amenorrheic for 13+/-4 years and 7 patie...
journal_title:Journal of nephrology
pub_type: 杂志文章
doi:
更新日期:2000-11-01 00:00:00
abstract::Ferumoxytol is a new product approved for intravenous use by the US Food and Drug Administration (FDA) in the treatment of iron deficiency anemia in adults with chronic kidney disease. This approval was based on data from 3 open-label, randomized, controlled clinical trials. In all of these trials, ferumoxytol was wel...
journal_title:Journal of nephrology
pub_type: 杂志文章,评审
doi:10.5301/jn.5000025
更新日期:2011-11-01 00:00:00
abstract::One of the major concerns in organ transplantation is the early detection of humoral rejection, through improved diagnostic and prognostic biomarkers. Long-term survival of renal allografts is significantly lower in recipients developing donor-specific anti-HLA antibodies (DSAs) either pretransplant or posttransplant....
journal_title:Journal of nephrology
pub_type: 杂志文章,评审
doi:10.5301/jn.5000240
更新日期:2013-03-01 00:00:00
abstract::The pathogenesis of calcium-oxalate (CaOx) renal stones is still debated and a number of issues needs to be clarified. In particular, it is difficult to combine the intraluminal physical-chemical imbalance and fixed particle theory with the evidence that CaOx stones actually form and grow on Randall's plaque in the re...
journal_title:Journal of nephrology
pub_type: 杂志文章,评审
doi:
更新日期:2004-11-01 00:00:00
abstract:BACKGROUND:Because urinary low molecular weight protein (LMWP) measurement shows changes in renal integrity at an early stage, beta2-microglobulin (B2m), retinol-binding protein (RBP) and alpha1-microglobulin (A1m) were evaluated in 24-hour urine collection of 65 patients with pure monoclonal light chain (MLC) proteinu...
journal_title:Journal of nephrology
pub_type: 杂志文章
doi:
更新日期:2007-11-01 00:00:00
abstract:BACKGROUND:Until now, the survival of iliac vein tunneled cuffed catheters (TCCs) used in elderly patients has not been fully investigated. Accordingly, we evaluated their use in elderly hemodialysis patients with no other venous access options. METHODS:A total of 70 elderly patients with iliac vein TCCs undergoing ch...
journal_title:Journal of nephrology
pub_type: 杂志文章
doi:10.1007/s40620-015-0198-9
更新日期:2016-02-01 00:00:00
abstract:BACKGROUND:Gut-derived uremic toxins have been associated with adverse outcomes in chronic kidney disease (CKD). Alterations in bowel habits, including constipation, seem to play an additional role in uremic toxicity. The aim of this study is to investigate the association of bowel habits with gut-derived uremic toxins...
journal_title:Journal of nephrology
pub_type: 杂志文章
doi:10.1007/s40620-020-00819-9
更新日期:2020-10-01 00:00:00
abstract:BACKGROUND:Pericardial effusion in uremic patients (UPE) was first described by R. Bright in 1836. It is generally agreed that patients require emergency pericardial drainage when tamponade signs are present, but in patients with no tamponade the optimal timing for drainage remains unclear. METHODS:To define patients ...
journal_title:Journal of nephrology
pub_type: 杂志文章
doi:10.1007/s40620-014-0107-7
更新日期:2015-02-01 00:00:00
abstract::The kidney maintains systemic acid-base homeostasis through proximal tubular reclamation of filtered bicarbonate, and excretion of the daily mineral acid load by collecting duct type A intercalated cells. Impairment of either process produces renal tubular acidosis (RTA). This article will provide an overview of famil...
journal_title:Journal of nephrology
pub_type: 杂志文章,评审
doi:
更新日期:2010-11-01 00:00:00
abstract::Klaus Hierholzer (1929-2007) dissected various functions influenced by steroids in the distal tubule and showed that aldosterone in low doses reversed the sodium and potassium transport defect in adrenalectomized rats, through a rapid activation of Na+,K+-ATPase. Subsequent studies addressed the role of 11-beta-hydrox...
journal_title:Journal of nephrology
pub_type: 传,历史文章,杂志文章
doi:
更新日期:2009-11-01 00:00:00
abstract::Late-presenting end-stage renal disease is a significant problem worldwide. Up to 70% of patients start dialysis in an unplanned manner without a definitive dialysis access in place. Haemodialysis via a central venous catheter is the default modality for the majority of such patients, and peritoneal dialysis is usuall...
journal_title:Journal of nephrology
pub_type: 杂志文章,评审
doi:10.1007/s40620-018-0485-3
更新日期:2019-02-01 00:00:00
abstract::Renal involvement is uncommon in the rare condition of Type I cryoglobulinaemia. On review of the literature most cases featured membranoproliferative glomerulonephritis on renal biopsy. In this case report, we describe a presentation of rapidly progressive glomerulonephritis that histologically demonstrated necrotisi...
journal_title:Journal of nephrology
pub_type: 杂志文章
doi:
更新日期:2006-05-01 00:00:00
abstract:BACKGROUND:Carotid artery intima-media thickness (CIMT) has been used as a marker of atherosclerosis. An insertion/deletion (I/D) polymorphism of the angiotensin-converting enzyme (ACE) gene is associated with various cardiovascular diseases. This study is aimed at evaluating early atherosclerotic involvement of caroti...
journal_title:Journal of nephrology
pub_type: 杂志文章
doi:
更新日期:1999-07-01 00:00:00
abstract::That systemic hypertension is involved in the progression of human renal disease is mostly suggested by the way anti-hypertensive treatment affects the course of the disease. Clinical evidence has been obtained from observational studies as well as from studies of dietary protein restriction. In addition, several tria...
journal_title:Journal of nephrology
pub_type: 杂志文章,评审
doi:
更新日期:2000-05-01 00:00:00
abstract::A 64-year-old man was hospitalized in 2002 with symptoms of stupor, weakness, and renal colic. The clinical examination indicated borderline hypertension, small masses in the glutei, and polyuria. Laboratory tests evidenced high serum concentrations of creatinine, calcium, and phosphate. Imaging assessments disclosed ...
journal_title:Journal of nephrology
pub_type: 杂志文章
doi:10.1007/s40620-015-0228-7
更新日期:2016-02-01 00:00:00
abstract:BACKGROUND:Previous in vitro experiments of human polycystic kidney disease (PKD) cells reported that caffeine is a risk factor for the promotion of cyst enlargement in patients with autosomal dominant PKD (ADPKD). The relentless progression of ADPKD inclines the majority of physicians to advocate minimization of caffe...
journal_title:Journal of nephrology
pub_type: 杂志文章
doi:10.1007/s40620-017-0396-8
更新日期:2018-02-01 00:00:00
abstract::Recently, two independent teams detected presumed hepatitis agents, which were designated HGV and hepatitis GB virus C; they represent a new genus in the family Flaviviridae. The most accurate way to assess the epidemiology of GBV-C/HGV infection remains the combination of RT-PCR and anti-GBV-C/HGV E2 techniques, to d...
journal_title:Journal of nephrology
pub_type: 杂志文章,评审
doi:
更新日期:1999-05-01 00:00:00
abstract::The term thin glomerular basement membrane disease (TBMD) refers to a condition characterised by thinning of the GBM at electron microscopy examination and, clinically, by isolated hematuria, frequently occurring in other family members, with no extra-renal manifestations. Progression towards chronic renal failure (CR...
journal_title:Journal of nephrology
pub_type: 杂志文章,评审
doi:
更新日期:2000-01-01 00:00:00
abstract::Percutaneous transluminal angioplasty of the renal artery (PTRA) has been increasingly used over the past 20 years for treating renovascular hypertension (RVH). From the experience gathered so far it is justified to state that this technique is the first choice for patients with fibromuscular renal artery stenosis (RA...
journal_title:Journal of nephrology
pub_type: 杂志文章,评审
doi:
更新日期:2000-11-01 00:00:00
abstract::Glomerulonephritis rarely appears associated with Hodgkin's disease or non-Hodgkin's lymphoma (NHL). We present a patient with a relapse of a non-Hodgkin's lymphoma which first presented as nephrotic syndrome due to focal segmental glomerulosclerosis (FSGS). This case report discusses the unusual association of non-Ho...
journal_title:Journal of nephrology
pub_type: 杂志文章
doi:
更新日期:2007-09-01 00:00:00
abstract:BACKGROUND:Cell-free DNA (cfDNA) is present in the peritoneal effluent of stable peritoneal dialysis (PD) patients, but there are no data on cfDNA in PD patients with peritonitis. We investigated the variation of peritoneal cfDNA levels subsequent to peritonitis in PD patients. METHODS:We enrolled 53 PD patients: 30 w...
journal_title:Journal of nephrology
pub_type: 杂志文章
doi:10.1007/s40620-015-0212-2
更新日期:2016-02-01 00:00:00
abstract:BACKGROUND:Reduced bone mineral density (BMD) is common in end-stage renal disease (ESRD) patients and predicts outcomes. The chronic kidney disease-mineral bone disorder contributes to low BMD in ESRD; however, the impact of classical risk factors for osteoporosis in the general population, such as body weight and fat...
journal_title:Journal of nephrology
pub_type: 杂志文章
doi:10.5301/jn.5000185
更新日期:2013-05-01 00:00:00
abstract:BACKGROUND:Mineral and bone parameters are actively managed in end-stage renal disease (ESRD). However, whether these undergo circadian variation is not known. We investigated the circadian variation of mineral and bone parameters in patients on long-term hemodialysis. METHODS:Seventeen ESRD patients on long-term hemo...
journal_title:Journal of nephrology
pub_type: 杂志文章
doi:10.1007/s40620-014-0124-6
更新日期:2015-06-01 00:00:00
abstract:UNLABELLED:The prognosis of renal survival in both type 1 and type 2 diabetes mellitus is not benign. Several factors characterize the increase in the risk of developing renal damage in diabetic patients, distinguished in diabetes-related factors, genetic factors and other factors. DIAGNOSIS:Diagnosis requires standar...
journal_title:Journal of nephrology
pub_type: 杂志文章,评审
doi:
更新日期:2003-07-01 00:00:00
abstract:BACKGROUND:Chronic renal failure (CRF) is associated with a tendency to atherosclerosis due to the enhanced oxidative stress and insufficient antioxidant enzyme activities such as superoxide dismutase (SOD), catalase (CAT) and paraoxonase (PON 1), together with abnormalities in lipid parameters. We determined the in vi...
journal_title:Journal of nephrology
pub_type: 杂志文章
doi:
更新日期:2002-03-01 00:00:00
abstract::Sclerosing encapsulating peritonitis (SEP) is a serious complication of long-term continuous ambulatory peritoneal dialysis (CAPD), very likely related to a persisting expression of the transforming growth factor beta1 (TGFbeta1) gene on peritoneal mesothelial cells. We report the case of a 67-year-old uremic woman wh...
journal_title:Journal of nephrology
pub_type: 杂志文章
doi:
更新日期:1999-11-01 00:00:00
abstract::Von Hippel-Lindau (VHL) disease is a rare autosomal dominant disorder characterized by multifocal and bilateral renal cell carcinoma and cysts, retinal angiomas, hemangioblastoma of the central nervous system, pheochromocytoma, epididymis cystoadenoma, pancreatic cysts and/or islet cell tumors. However, phenotypic man...
journal_title:Journal of nephrology
pub_type: 杂志文章
doi:
更新日期:2005-03-01 00:00:00