Abstract：
:Despite substantial progress in dialysis patients' management, cardiovascular disease remains the major cause of death. Nearly half of deaths on dialysis are secondary to myocardial infarction, cardiac arrest, malignant arrhythmias and other cardiac causes. The high prevalence of diabetes, anemia, hyperparathyroidism and hypertension among chronic dialysis patients fosters structural heart diseases. Moreover, fluid overload and metabolic abnormalities such as metabolic acidosis, dyskalemia and dysmagnesemia lead to an increased risk of clinically significant arrhythmias and sudden cardiac death. End-stage renal disease (ESRD) is often characterized by the presence of sympathetic hyperactivity and activation of the renin-angiotensin-aldosterone system (RAAS). Control of sympathetic outflow, blockade of the RAAS and prevention of electrolyte disorders should be the mainstay of cardiovascular prevention in ESRD patients. This review summarizes the current available literature regarding the epidemiology of arrhythmias in dialysis patients, the underlying mechanism of atrial fibrillation or sudden death and potential interventions to reduce the risk of arrhythmias in dialysis patients, including medical therapy or defibrillators.
journal_name
J Nephroljournal_title
Journal of nephrologyauthors
Voroneanu L,Covic Asubject
Has Abstractpub_date
2009-11-01 00:00:00pages
716-25issue
6eissn
1121-8428issn
1724-6059pii
897AD346-CD07-4ABD-B019-BD6A59322B37journal_volume
22pub_type
杂志文章,评审abstract：:The kidney maintains systemic acid-base homeostasis through proximal tubular reclamation of filtered bicarbonate, and excretion of the daily mineral acid load by collecting duct type A intercalated cells. Impairment of either process produces renal tubular acidosis (RTA). This article will provide an overview of famil...
journal_title：Journal of nephrology
pub_type： 杂志文章,评审
doi：
更新日期：2010-11-01 00:00:00
abstract：:Henoch-Schonlein purpura is a clinical syndrome characterized by the association of skin, joint, and gastrointestinal symptoms. Henoch-Schonlein purpura is characterized by wide-spread vasculitis. Although the clinical symptoms of this disease are characteristic, the diagnosis is not always easy to establish because o...
journal_title：Journal of nephrology
pub_type： 杂志文章
doi：
更新日期：2005-11-01 00:00:00
abstract：:Hyperuricosuric calcium urolithiasis is a condition of mixed calcium oxalate stones characterized by hyperuricosuria either in isolation or in conjunction with other risk factors for calcium oxalate stones such as hypercalciuria, hyperoxaluria, and hypocitraturia. There are three proposed physicochemical models of pat...
journal_title：Journal of nephrology
pub_type： 杂志文章,评审
doi：10.1007/s40620-018-0469-3
更新日期：2018-04-01 00:00:00
abstract：BACKGROUND:Incremental dialysis may preserve residual renal function and improve survival in comparison with full-dose dialysis; however, available evidence is limited. We therefore compared all-cause mortality and residual kidney function (RKF) loss in incremental and full-dose dialysis and time to full-dose dialysis ...
journal_title：Journal of nephrology
pub_type： 杂志文章,meta分析
doi：10.1007/s40620-018-00577-9
更新日期：2019-10-01 00:00:00
abstract：:The proximal tubule reabsorbs approximately 80% of the filtered load of bicarbonate. Defects in the process of bicarbonate reabsorption result in loss of bicarbonate and proximal renal tubular acidosis. Global proximal tubule dysfunction is known as the Fanconi's syndrome. Both isolated proximal renal tubular acidosis...
journal_title：Journal of nephrology
pub_type： 杂志文章,评审
doi：
更新日期：2006-03-01 00:00:00
abstract：:Gitelman syndrome (GS), an inherited disorder due to loss of function in mutations of the gene encoding the distal convoluted tubule Na-Cl cotransporter (NCCT), is characterized by hypokalemia metabolic alkalosis, hypomagnesemia and hypocalciuria. A 18-year-old girl was admitted to our hospital with a history of muscl...
journal_title：Journal of nephrology
pub_type： 杂志文章
doi：
更新日期：2010-09-01 00:00:00
abstract：:The widely differing functions of vitamin D are based both on a wide diffusion of its specific receptor (VDR) and on the ability of many cells, in addition to renal tubular cells, to synthesize calcitriol for autocrine and paracrine functions. In the last few years, many published studies have added new insights into ...
journal_title：Journal of nephrology
pub_type： 杂志文章,评审
doi：10.5301/JN.2011.7767
更新日期：2011-05-01 00:00:00
abstract：BACKGROUND:The regulation of renal hemodynamics is closely related to the L-arginine (L-Arg)/nitric oxide (NO) pathway. NO - metabolized from L-Arg - is capable of improving renal function in ischemic and toxic acute renal failure (ARF), while NO synthase (NOS) inhibition induces deterioration in renal function. The mo...
journal_title：Journal of nephrology
pub_type： 杂志文章
doi：
更新日期：2005-07-01 00:00:00
abstract：:The newly described endothelium-dependent vasoactive substances, nitric oxide and endothelins, have been the subject of intense investigative interest and have been demonstrated to promote a wide array of autocrine and paracrine functions. Recent data highlight their emerging role as potential important mediators of r...
journal_title：Journal of nephrology
pub_type： 杂志文章,评审
doi：
更新日期：1997-05-01 00:00:00
abstract：BACKGROUND:Hypertension and left ventricular hypertrophy (LVH) are independent predictors of morbidity and mortality in maintenance hemodialysis (MHD) patients. The level of serum asymmetric dimethylarginine (ADMA) is increased in MHD patients, which is a kind of uremic toxin. It can competitively inhibit nitric oxide ...
journal_title：Journal of nephrology
pub_type： 杂志文章,随机对照试验
doi：10.5301/jn.2011.6252
更新日期：2011-03-01 00:00:00
abstract：BACKGROUND AND AIMS:Reduction of intestinal load of phosphorus is important for the prevention and treatment of chronic kidney disease (CKD)-mineral and bone disorder (MBD). However, this strategy is limited by patients' poor adherence to dietary prescription and by the existence of hidden sources of phosphorus. In add...
journal_title：Journal of nephrology
pub_type： 杂志文章
doi：10.1007/s40620-016-0306-5
更新日期：2016-12-01 00:00:00
abstract：:We report 4 cases of sepsis-induced acute renal failure (ARF) with peculiar clinical presentation in which the renal biopsy was the only clue to a correct diagnosis. We observed 66 cases of ARF in a 4-year experience. Seven (11%) were associated with sepsis; in 3 of these (4.5%) a shock was present. Clinical picture o...
journal_title：Journal of nephrology
pub_type： 杂志文章
doi：
更新日期：1998-09-01 00:00:00
abstract：BACKGROUND:Uromodulin (Tamm-Horsfall protein) is the most abundant urinary protein in healthy individuals. Despite 60 years of research, its physiological role remains rather elusive. Familial juvenile hyperuricemic nephropathy and medullary cystic kidney disease Type 2 are autosomal dominant tubulointerstitial nephrop...
journal_title：Journal of nephrology
pub_type： 杂志文章
doi：10.1007/s40620-014-0079-7
更新日期：2014-06-01 00:00:00
abstract：:Diabetic kidney disease (DKD) affects approximately one-third of patients with diabetes and taking into consideration the high cardiovascular risk burden associated to this condition a multifactorial therapeutic approach is traditionally recommended, in which glucose and blood pressure control play a central role. The...
journal_title：Journal of nephrology
pub_type： 杂志文章,评审
doi：10.1007/s40620-020-00803-3
更新日期：2020-10-01 00:00:00
abstract：:Cell-to-cell signal exchange during antigen presentation deeply influences the profile and extent of the immune response. Together with the TCR/MHC-mediated signal, accessory signals are provided to the T cell by the antigen-presenting cell (APC), through specific receptor-ligand interactions that represent indispensa...
journal_title：Journal of nephrology
pub_type： 杂志文章,评审
doi：
更新日期：2002-01-01 00:00:00
abstract：:Gonadal dysfunction is a frequent finding in men with chronic kidney disease and with end-stage renal disease. Testosterone deficiency, usually accompanied by elevation of serum gonadotropin concentrations, is present in 26-66% of men with different degrees of renal failure. Uremia-associated hypogonadism is multifact...
journal_title：Journal of nephrology
pub_type： 杂志文章,评审
doi：10.5301/JN.2011.8481
更新日期：2012-01-01 00:00:00
abstract：BACKGROUND:Accurate assessment of kidney function level is the key to the identification and management of chronic kidney disease (CKD). Glomerular filtration rate (GFR) is the best measure of overall kidney function in health and disease. There is no consensus about the method to be used routinely to measure and/or es...
journal_title：Journal of nephrology
pub_type： 杂志文章
doi：
更新日期：2006-03-01 00:00:00
abstract：BACKGROUND AND AIMS:Arterial stiffness is a risk factor for chronic kidney disease progression (CKD). Pulse pressure is a surrogate marker of arterial stiffness. It is unclear if pulse pressure predicts CKD progression in type 2 diabetes mellitus. METHODS:This was prospective study involving 1494 patients with estimat...
journal_title：Journal of nephrology
pub_type： 杂志文章
doi：10.1007/s40620-020-00954-3
更新日期：2021-01-25 00:00:00
abstract：BACKGROUND:The effect of interleukin-11 (IL-11) on transforming growth factor-ß (TGF-ß) is controversial and has not been examined in renal diseases. In this study, we (i) characterised the up-regulation of TGF-ß1, phospho-p38 MAPK (p-p38 MAPK) and extracellular matrix during pathogenesis of glomerulonephritis and (ii)...
journal_title：Journal of nephrology
pub_type： 杂志文章
doi：10.5301/jn.2010.5094
更新日期：2011-01-01 00:00:00
abstract：:Recently, two independent teams detected presumed hepatitis agents, which were designated HGV and hepatitis GB virus C; they represent a new genus in the family Flaviviridae. The most accurate way to assess the epidemiology of GBV-C/HGV infection remains the combination of RT-PCR and anti-GBV-C/HGV E2 techniques, to d...
journal_title：Journal of nephrology
pub_type： 杂志文章,评审
doi：
更新日期：1999-05-01 00:00:00
abstract：:During peritoneal dialysis (PD), peritoneal mesothelial cells undergo a transition from an epithelial phenotype to a mesenchymal phenotype that, together with the inflammatory process, promotes tissue fibrosis and a failure of peritoneal membrane function. To date, there is no definitive treatment for the progressive ...
journal_title：Journal of nephrology
pub_type： 杂志文章
doi：10.1007/s40620-016-0368-4
更新日期：2017-12-01 00:00:00
abstract：:Although several in vitro studies and clinical observations suggest that ACE-inhibitors (ACE-I) are a promising treatment for IgA nephropathy (IgAN), meta-analysis of published data is not yet conclusive. Therefore, a European double-blinded, prospective, randomized therapeutic trial was designed to evaluate ACE-I tre...
journal_title：Journal of nephrology
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：
更新日期：2001-11-01 00:00:00
abstract：BACKGROUND:Acute kidney injury (AKI) following acute ST elevation myocardial infarction (STEMI) is associated with adverse outcomes. The recently proposed KDIGO criteria suggested modifications to the consensus classification system for AKI, namely lowering the threshold of increase in absolute serum creatinine and ext...
journal_title：Journal of nephrology
pub_type： 杂志文章
doi：10.1007/s40620-017-0461-3
更新日期：2018-06-01 00:00:00
abstract：BACKGROUND:Peripheral artery disease (PAD) represents a major complication in chronic kidney disease (CKD) patients, but its early diagnosis is still problematic. Traditionally, ankle-arm blood pressure index (API) determined by means of a simple hand-held unidimensional Doppler device has been used for noninvasive dia...
journal_title：Journal of nephrology
pub_type： 杂志文章
doi：
更新日期：2009-07-01 00:00:00
abstract：:It has been increasingly apparent that end-stage renal disease (ESRD) patients carry an inflammatory burden, which may play a pivotal role in the evolution of not only wasting but also of the massive increase in the relative risk of cardiovascular disease (CVD). Also increased oxidative stress (an impairment of the pr...
journal_title：Journal of nephrology
pub_type： 杂志文章,评审
doi：
更新日期：2004-11-01 00:00:00
abstract：:During Fabry disease, progressive glycosphingolipid deposition in the kidney causes gradual deterioration of renal function with proteinuria, uremia and hypertension. This results in end-stage renal disease (ESRD) which is one of the leading causes of morbidity and premature mortality in affected patients. Given the e...
journal_title：Journal of nephrology
pub_type： 杂志文章,评审
doi：10.5301/jn.5000214
更新日期：2013-07-01 00:00:00
abstract：:Marcello Malpighi was born in Crevalcore on March 10, 1628 and died in Rome on July 25, 1694. In Bologna he had among his opponents Giovanni Gerolamo Sbaraglia and Paoli Mini who prevented him being appointed to the chair of anatomy. This paper describes the reasons for this long term debate. ...
journal_title：Journal of nephrology
pub_type： 传,历史文章,杂志文章
doi：
更新日期：2004-07-01 00:00:00
abstract：:Renal fibrogenesis can be induced by several injury mechanisms in different renal diseases, but ultimately produces identical fibrotic changes in the kidney. Recently, a number of agents that can inhibit extracellular matrix (ECM) accumulation have been studied, suggesting a therapeutic utility in the treatment of fib...
journal_title：Journal of nephrology
pub_type： 杂志文章,评审
doi：
更新日期：2004-07-01 00:00:00
abstract：QUESTIONS:- To what extent can ailing kidneys adapt their functions to the demands of pregnancy? - What risks is the nephropathic patient prone to throughout pregnancy compared with those of the general population, and which specific risks does her kidney disease determine? - What risks is the baby of a nephropathic pr...
journal_title：Journal of nephrology
pub_type： 杂志文章,评审
doi：
更新日期：2006-03-01 00:00:00
abstract：:Late-presenting end-stage renal disease is a significant problem worldwide. Up to 70% of patients start dialysis in an unplanned manner without a definitive dialysis access in place. Haemodialysis via a central venous catheter is the default modality for the majority of such patients, and peritoneal dialysis is usuall...
journal_title：Journal of nephrology
pub_type： 杂志文章,评审
doi：10.1007/s40620-018-0485-3
更新日期：2019-02-01 00:00:00
