当前位置： SCI文献检索 > JOURNAL OF NEPHROLOGY期刊下所有文献 > Gonadal dysfunction in men with chronic kidney disease: clinical features, prognostic implications and therapeutic options.

Gonadal dysfunction in men with chronic kidney disease: clinical features, prognostic implications and therapeutic options.

Abstract：

:Gonadal dysfunction is a frequent finding in men with chronic kidney disease and with end-stage renal disease. Testosterone deficiency, usually accompanied by elevation of serum gonadotropin concentrations, is present in 26-66% of men with different degrees of renal failure. Uremia-associated hypogonadism is multifactorial in its origin, and rarely improves with initiation of dialysis, although it usually normalizes after renal transplantation. Experimental and clinical evidence suggests that testosterone may have important clinical implications with regards to kidney disease progression, derangements in sexual drive, libido and erectile dysfunction, development of anemia, impairment of muscle mass and strength, and also progression of atherosclerosis and cardiovascular disease. Additionally, low testosterone levels in hemodialysis patients have been associated with increased mortality risk in some studies. Currently, we count with available therapeutic options in the management of uremic hypogonadism, from optimal delivery of dialysis and adequate nutritional intake, to hormone replacement therapy with different testosterone preparations. Other potential options for treatment include the use of antiestrogens, dopamine agonists, erythropoiesis-stimulating factors, vitamins, essential trace elements, chorionic gonadotropin and renal transplantation. Potential adverse effects of androgen replacement therapy in patients with kidney disease comprise, however, erythrocytosis, prostate and breast cancer growth, reduced fertility, gynecomastia, obstructive sleep apnea and fluid retention. Androgen preparations should be used with caution with stringent monitoring in uremic men. Although there are encouraging data suggesting plausible benefits from testosterone replacement therapy, further studies are needed with regards to safety and effectiveness of this therapy.

journal_name

J Nephrol

journal_title

Journal of nephrology

authors

Iglesias P,Carrero JJ,Díez JJ

doi

10.5301/JN.2011.8481

subject

Has Abstract

pub_date

2012-01-01 00:00:00

pages

31-42

issue

1

eissn

1121-8428

issn

1724-6059

pii

87CD67EB-3E45-4B5F-8D0F-C54402218DBF

journal_volume

25

pub_type

杂志文章,评审

相关文献

JOURNAL OF NEPHROLOGY文献大全
  • Associations between calcineurin inhibitors and arterial compliance in kidney transplant recipients.

    abstract：INTRODUCTION:Several studies have suggested an effect of calcineurin inhibitors on arterial compliance in kidney transplant recipients. We aimed to investigate whether the type of calcineurin inhibitor influences large and small artery compliance in these patients independently of other determinants. METHODS:Patients ...

    journal_title：Journal of nephrology

    pub_type： 杂志文章

    doi：

    authors： Wystrychowski G,Chudek J,Zukowska-Szczechowska E,Wiecek A,Grzeszczak W

    更新日期：2008-01-01 00:00:00

  • Osteoporosis, bone mineral density and CKD-MBD: treatment considerations.

    abstract：:Osteoporosis and chronic kidney disease (CKD) have both independently important potential impact on bone health. A significant number of patients with CKD stages 3a-5D have been shown to have low bone mineral density (BMD), leading to a strikingly elevated risk of fractures (mainly hip fractures) and higher associated...

    journal_title：Journal of nephrology

    pub_type： 杂志文章,评审

    doi：10.1007/s40620-017-0404-z

    authors： Bover J,Bailone L,López-Báez V,Benito S,Ciceri P,Galassi A,Cozzolino M

    更新日期：2017-10-01 00:00:00

  • Continuous renal replacement therapies: anticoagulation in the critically ill at high risk of bleeding.

    abstract：BACKGROUND:The ongoing necessity for systemic heparinization is a well-known disadvantage of continuous renal replacement therapies (CRRT), and alternative methods of anticoagulation may be required. Our aim was to evaluate, in patients with a high risk of bleeding, the possibility of an acceptable filter life with non...

    journal_title：Journal of nephrology

    pub_type： 杂志文章

    doi：

    authors： Morabito S,Guzzo I,Solazzo A,Muzi L,Luciani R,Pierucci A

    更新日期：2003-07-01 00:00:00

  • Modeling the effect of 3 missense AGXT mutations on dimerization of the AGT enzyme in primary hyperoxaluria type 1.

    abstract：INTRODUCTION:Mutations of the AGXT gene encoding the alanine:glyoxylate aminotransferase liver enzyme (AGT) cause primary hyperoxaluria type 1 (PH1). Here we report a molecular modeling study of selected missense AGXT mutations: the common Gly170Arg and the recently described Gly47Arg and Ser81Leu variants, predicted t...

    journal_title：Journal of nephrology

    pub_type： 杂志文章

    doi：

    authors： Robbiano A,Frecer V,Miertus J,Zadro C,Ulivi S,Bevilacqua E,Mandrile G,De Marchi M,Miertus S,Amoroso A

    更新日期：2010-11-01 00:00:00

  • Comparing the impact of older age on outcome in chronic kidney disease of different etiologies: a prospective cohort study.

    abstract：BACKGROUND:In older patients with chronic kidney disease (CKD), the risk of progression to end stage renal disease and cardiovascular death both differ compared to younger patients. This likely reflects differences in case mix and co-morbid burdens. We sought to establish the extent to which age itself is an independen...

    journal_title：Journal of nephrology

    pub_type： 杂志文章

    doi：10.1007/s40620-018-0529-8

    authors： Raman M,Green D,Middleton RJ,Kalra PA

    更新日期：2018-12-01 00:00:00

  • Nonsteroidal anti-inflammatory drug use in patients with chronic kidney disease.

    abstract：AIMS:Nonsteroidal anti-inflammatory drugs (NSAIDs) are the cornerstone of pain management. There are no detailed data on NSAIDs use in Poland, especially in patients with chronic kidney disease (CKD). The aim of this study was to evaluate the frequency, circumstances, and causes of NSAIDs use as well as knowledge of th...

    journal_title：Journal of nephrology

    pub_type： 杂志文章

    doi：10.1007/s40620-016-0352-z

    authors： Heleniak Z,Cieplińska M,Szychliński T,Rychter D,Jagodzińska K,Kłos A,Kuźmiuk I,Tylicka MJ,Tylicki L,Rutkowski B,Dębska-Ślizień A

    更新日期：2017-12-01 00:00:00

  • Improvement of hypertension and LVH in maintenance hemodialysis patients treated with sustained-release isosorbide mononitrate.

    abstract：BACKGROUND:Hypertension and left ventricular hypertrophy (LVH) are independent predictors of morbidity and mortality in maintenance hemodialysis (MHD) patients. The level of serum asymmetric dimethylarginine (ADMA) is increased in MHD patients, which is a kind of uremic toxin. It can competitively inhibit nitric oxide ...

    journal_title：Journal of nephrology

    pub_type： 杂志文章,随机对照试验

    doi：10.5301/jn.2011.6252

    authors： Li H,Wang SX

    更新日期：2011-03-01 00:00:00

  • Association of physical activity with mortality in chronic kidney disease.

    abstract：BACKGROUND:Chronic kidney disease (CKD) is an important risk factor for all-cause mortality. In the general population, physical activity is associated with reduced mortality. We examined the association of level of physical activity with mortality in patients with predominantly nondiabetic CKD stage 3-4. METHODS:We s...

    journal_title：Journal of nephrology

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：

    authors： Chen JL,Lerner D,Ruthazer R,Castaneda-Sceppa C,Levey AS

    更新日期：2008-03-01 00:00:00

  • Hypertension in the elderly: new and old evidence that treatment may benefit the old.

    abstract：:Hypertension is prevalent and remains an important risk factor in elderly and very elderly. Randomized controlled outcome trials have shown benefit of antihypertensive treatment in patients with systolic diastolic hypertension and in patients with isolated systolic hypertension, aged 60 years and over. More recently b...

    journal_title：Journal of nephrology

    pub_type： 杂志文章

    doi：

    authors： Fagard RH

    更新日期：2009-09-01 00:00:00

  • The peritoneal sieving of sodium: a simple and powerful test to rule out the onset of encapsulating peritoneal sclerosis in patients undergoing peritoneal dialysis.

    abstract：BACKGROUND AND AIMS:Encapsulating peritoneal sclerosis (EPS) is an uncommon but severe complication of peritoneal dialysis (PD). A reliable screening tool to identify patients at risk of developing or not EPS is currently not available. We aimed to evaluate whether the reduction in dialysate sodium concentration (sodiu...

    journal_title：Journal of nephrology

    pub_type： 杂志文章

    doi：10.1007/s40620-016-0371-9

    authors： La Milia V,Longhi S,Sironi E,Pontoriero G

    更新日期：2018-02-01 00:00:00

  • Cardiorenal protective effect of the oral uremic toxin absorbent AST-120 in chronic heart disease patients with moderate CKD.

    abstract：BACKGROUND:The detailed mechanisms and treatment methods of chronic kidney disease (CKD) in patients with chronic heart failure (CHF) are not fully understood. We conducted a prospective study in CHF patients manifesting CKD to examine if AST-120 (Kremezin) improves cardiac and renal functions. METHODS:Twenty outpatie...

    journal_title：Journal of nephrology

    pub_type： 杂志文章

    doi：

    authors： Shibahara H,Shibahara N

    更新日期：2010-09-01 00:00:00

  • Effects of phosphorus-restricted diet and phosphate-binding therapy on outcomes in patients with chronic kidney disease.

    abstract：BACKGROUND:Phosphorus is associated with mortality in patients with chronic kidney disease (CKD) not on dialysis, possibly through phosphorus-dependent vascular calcification. Although a phosphorus-restricted diet reduces serum phosphorus, it is unlikely that it reduces vascular calcification progression in CKD. This s...

    journal_title：Journal of nephrology

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1007/s40620-014-0071-2

    authors： Russo D,Bellasi A,Pota A,Russo L,Di Iorio B

    更新日期：2015-02-01 00:00:00

  • Epicardial adipose tissue volume increase in hemodialysis patients treated with sevelamer or calcium-based phosphate binders: a substudy of the Renagel in new dialysis trial.

    abstract：BACKGROUND:In the general population and in hemodialysis patients epicardial adipose tissue (EAT) has been associated with increased mortality and cardiovascular events. Weight loss and lipid lowering therapies reduced EAT in the general population. It is unknown whether sevelamer, a phosphate (Pi) binder that lowers c...

    journal_title：Journal of nephrology

    pub_type： 杂志文章,随机对照试验

    doi：10.1007/s40620-016-0310-9

    authors： Ko SM,Zhang C,Chen Z,D'Marco L,Bellasi A,Stillman AE,Block G,Raggi P

    更新日期：2016-10-01 00:00:00

  • Pathogenetic concepts of membranous glomerulopathy (MGN).

    abstract：:Membranous glomerulopathy (MGN) is a frequent cause for nephrotic syndrome in adults. In this overview, the basic pathogenic features of Heymann nephritis, a "classical" model of MGN in rats, are compared with those of human MGN. While the pathogenic antigen(s) of rat Heymann nephritis (the polyspecific receptor prote...

    journal_title：Journal of nephrology

    pub_type： 杂志文章,评审

    doi：

    authors： Kerjaschki D

    更新日期：2000-11-01 00:00:00

  • Active compounds extracted from extra virgin olive oil counteract mesothelial-to-mesenchymal transition of peritoneal mesothelium cells exposed to conventional peritoneal dialysate: in vitro and in vivo evidences.

    abstract：:During peritoneal dialysis (PD), peritoneal mesothelial cells undergo a transition from an epithelial phenotype to a mesenchymal phenotype that, together with the inflammatory process, promotes tissue fibrosis and a failure of peritoneal membrane function. To date, there is no definitive treatment for the progressive ...

    journal_title：Journal of nephrology

    pub_type： 杂志文章

    doi：10.1007/s40620-016-0368-4

    authors： Lupinacci S,Toteda G,Vizza D,Perri A,Benincasa C,Mollica A,La Russa A,Gigliotti P,Leone F,Lofaro D,Bonofiglio M,Perri E,Bonofiglio R

    更新日期：2017-12-01 00:00:00

  • Long-term effect of coffee consumption on autosomal dominant polycystic kidneys disease progression: results from the Suisse ADPKD, a Prospective Longitudinal Cohort Study.

    abstract：BACKGROUND:Previous in vitro experiments of human polycystic kidney disease (PKD) cells reported that caffeine is a risk factor for the promotion of cyst enlargement in patients with autosomal dominant PKD (ADPKD). The relentless progression of ADPKD inclines the majority of physicians to advocate minimization of caffe...

    journal_title：Journal of nephrology

    pub_type： 杂志文章

    doi：10.1007/s40620-017-0396-8

    authors： Girardat-Rotar L,Puhan MA,Braun J,Serra AL

    更新日期：2018-02-01 00:00:00

  • Metabolic syndrome and nephrolithiasis: a systematic review and meta-analysis of the scientific evidence.

    abstract：:The metabolic syndrome is a cluster of cardiometabolic alterations at least partly dependent on reduced insulin sensitivity and hyperinsulinemia that can have several renal implications. A systematic review and meta-analysis of studies available in the international literature in English language demonstrates that the...

    journal_title：Journal of nephrology

    pub_type： 杂志文章,meta分析,评审

    doi：10.1007/s40620-014-0085-9

    authors： Rendina D,De Filippo G,D'Elia L,Strazzullo P

    更新日期：2014-08-01 00:00:00

  • Adherence to phosphate binders in hemodialysis patients: prevalence and determinants.

    abstract：BACKGROUND:Phosphate control is a crucial treatment goal in end-stage renal disease, but poor patient adherence to phosphate binder therapy remains a challenge. This study aimed to estimate the extent of phosphate binder adherence in hemodialysis patients and to identify potential determinants. METHODS:Phosphate binde...

    journal_title：Journal of nephrology

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1007/s40620-014-0062-3

    authors： Van Camp YP,Vrijens B,Abraham I,Van Rompaey B,Elseviers MM

    更新日期：2014-12-01 00:00:00

  • Marcello Malpighi and his academic opponents in Bologna.

    abstract：:Marcello Malpighi was born in Crevalcore on March 10, 1628 and died in Rome on July 25, 1694. In Bologna he had among his opponents Giovanni Gerolamo Sbaraglia and Paoli Mini who prevented him being appointed to the chair of anatomy. This paper describes the reasons for this long term debate. ...

    journal_title：Journal of nephrology

    pub_type： 传,历史文章,杂志文章

    doi：

    authors： Campieri C,Persici E,Stefoni S

    更新日期：2004-07-01 00:00:00

  • Left ventricular hypertrophy and progression of chronic kidney disease.

    abstract：:Reduced glomerular filtration rate and albuminuria do not account for the total risk of developing end-stage renal disease (ESRD), suggesting that other factors might be involved in progressive renal function worsening. Among these, cardiovascular disease, even subclinical, could play a role. The role of left ventricu...

    journal_title：Journal of nephrology

    pub_type： 社论,评审

    doi：10.5301/jn.5000114

    authors： Paoletti E

    更新日期：2012-11-01 00:00:00

  • Geriatric nutrition risk index is associated with renal progression, cardiovascular events and all-cause mortality in chronic kidney disease.

    abstract：BACKGROUND:Malnutrition is common and associated with poor outcomes in patients with chronic kidney disease (CKD) and end-stage renal disease (ESRD). Recently, the geriatric nutritional risk index (GNRI) was reported as a novel tool for evaluating nutritional status. However, the association between GNRI and renal outc...

    journal_title：Journal of nephrology

    pub_type： 杂志文章

    doi：10.1007/s40620-019-00676-1

    authors： Xiong J,Wang M,Wang J,Yang K,Shi Y,Zhang J,Zhang B,Zhang L,Zhao J,Chinese Cohort Study of Chronic Kidney Disease (C-STRIDE).

    更新日期：2020-08-01 00:00:00

  • The impact of bleeding times on major complication rates after percutaneous real-time ultrasound-guided renal biopsies.

    abstract：BACKGROUND:Previous studies have shown that bleeding times have positive predictive values of only 5% for perioperative bleeding in unselected populations. Nevertheless, performing bleeding times prior to all renal biopsies is common in nephrology practice. METHODS:We report complications of 112 renal biopsies done at...

    journal_title：Journal of nephrology

    pub_type： 杂志文章

    doi：

    authors： Stiles KP,Hill C,LeBrun CJ,Reinmuth B,Yuan CM,Abbott KC

    更新日期：2001-07-01 00:00:00

  • Lipid abnormalities in the nephrotic syndrome: the therapeutic role of statins.

    abstract：:Hyperlipidaemia complicating the nephrotic syndrome is characterised by elevated levels of total and LDL cholesterol, often with hypertriglyceridaemia and low HDL cholesterol levels. The underlying mechanisms are complex but involve abnormalities of both lipoprotein synthesis and catabolism. Experience to date suggest...

    journal_title：Journal of nephrology

    pub_type： 杂志文章,评审

    doi：

    authors： Wheeler DC

    更新日期：2001-11-01 00:00:00

  • Effects of nitric oxide on gentamicin toxicity in isolated perfused rat kidneys.

    abstract：BACKGROUND:There have been many studies in recent years concerning the role of nitric oxide (NO) in acute renal failure (ARF). In this study, the effects of the inhibition or the induction of NO synthase (NOS) on gentamicin-induced ARF was investigated in isolated perfused rat kidneys. METHODS:Kidneys from male Spragu...

    journal_title：Journal of nephrology

    pub_type： 杂志文章

    doi：

    authors： Ghaznavi R,Faghihi M,Kadkhodaee M,Shams S,Khastar H

    更新日期：2005-09-01 00:00:00

  • Identification of drug-related problems in ambulatory chronic kidney disease patients: a 6-month prospective study.

    abstract：BACKGROUND:Drug-related problems (DRPs) are common in chronic kidney disease (CKD) patients. We developed a 2-step consultation including a clinical pharmacist (CP) session and a nephrologist conventional care consultation to explore the feasibility of a pilot drug-oriented disease management program in controlling iat...

    journal_title：Journal of nephrology

    pub_type： 杂志文章

    doi：10.5301/jn.5000063

    authors： Belaiche S,Romanet T,Allenet B,Calop J,Zaoui P

    更新日期：2012-09-01 00:00:00

  • Prevention of complications from use of conventional immunosuppressants: a critical review.

    abstract：:Synthetic immunosuppressive drugs are largely used in immune-related renal diseases and in kidney transplantation. Most of these drugs have a low therapeutic index (the ratio that compares the blood concentration at which a drug becomes toxic and the concentration at which the drug is effective), which means that the ...

    journal_title：Journal of nephrology

    pub_type： 杂志文章,评审

    doi：10.1007/s40620-019-00602-5

    authors： Ponticelli C,Glassock RJ

    更新日期：2019-12-01 00:00:00

  • Chronic hypotension in the dialysis patient.

    abstract：:Chronic hypotension, defined by a systolic blood pressure < 100 mmHg in the interdialytic period, affects 5-10% of hemodialysis patients, and is more prevalent among patients on long-term hemodialysis. This complication requires a substantial amount of medical and nursing care before and during dialysis to control its...

    journal_title：Journal of nephrology

    pub_type： 杂志文章,评审

    doi：

    authors： Cases A,Coll E

    更新日期：2002-07-01 00:00:00

  • Measurement of reabsorption by single segments of the human nephron.

    abstract：:A widely diffused method to measure the reabsorption by single segments of the nephron in humans is based on water diuresis (WD), assuming that the peak urine flow rate approximates proximal delivery (PD). However, back-diffusion of an unknown volume of solute-free water (CH2O-BD) from lumen to the interstitium even i...

    journal_title：Journal of nephrology

    pub_type： 杂志文章,评审

    doi：

    authors： Bartoli E,Romano G

    更新日期：1999-09-01 00:00:00

  • Current recommended 25-hydroxyvitamin D targets for chronic kidney disease management may be too low.

    abstract：OBJECTIVE:It is uncertain whether increasing 25-hydroxyvitamin D (25-D) levels in chronic kidney disease (CKD) patients above those recommended by current guidelines result in progressive amelioration of secondary hyperparathyroidism. Our objective was to identify a potential therapeutic 25-D target which optimally low...

    journal_title：Journal of nephrology

    pub_type： 杂志文章,多中心研究

    doi：10.1007/s40620-015-0186-0

    authors： Ennis JL,Worcester EM,Coe FL,Sprague SM

    更新日期：2016-02-01 00:00:00

  • Antineoplastic effect of proliferation signal inhibitors: from biology to clinical application.

    abstract：:The authors review the antineoplastic effect of mammalian target of rapamycin (mTOR) inhibitors and their biological basis. mTOR is an intracellular serine/threonine kinase that is a central controller of cell growth and proliferation. mTOR integrates signals from sources such as nutrients and growth factors. mTOR reg...

    journal_title：Journal of nephrology

    pub_type： 杂志文章,评审

    doi：

    authors： Bertoni E,Salvadori M

    更新日期：2009-07-01 00:00:00