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Nonsteroidal anti-inflammatory drug use in patients with chronic kidney disease.

Abstract：

AIMS:Nonsteroidal anti-inflammatory drugs (NSAIDs) are the cornerstone of pain management. There are no detailed data on NSAIDs use in Poland, especially in patients with chronic kidney disease (CKD). The aim of this study was to evaluate the frequency, circumstances, and causes of NSAIDs use as well as knowledge of their side-effects in patients with CKD. METHOD:This cross-sectional study was conducted in 972 individuals with CKD, enrolled in a written survey originally developed by the authors. There were 574 patients with CKD stage I-IV, 414 patients after renal transplantation stage II-IV (CKDT) and 84 dialyzed patients (44 peritoneal, 40 hemodialysis). RESULTS:Among the entire study group, 16.9 % of patients used NSAIDs every day, or several times a week. The average number of tablets taken within a month was 21.8. Subgroup analysis revealed that NSAIDs were taken most often by patients on hemodialysis: 35 % of them used NSAIDs every day or several times a week (43.15 pills per month). The most common reason for using NSAIDs were bone-joint pain (29.3 %) and headache (26.2 %). Side effects of painkillers such as renal function deterioration and the possible promotion of stomach ulcers were experienced by 43.6 and 37.6 % of respondents, respectively. CONCLUSION:Patients with CKD often take NSAIDs. This applies especially to the group of people undergoing hemodialysis, which is mainly associated with chronic osteo-articular pain. The results also show a low awareness of painkillers' adverse effects.

journal_name

J Nephrol

journal_title

Journal of nephrology

authors

Heleniak Z,Cieplińska M,Szychliński T,Rychter D,Jagodzińska K,Kłos A,Kuźmiuk I,Tylicka MJ,Tylicki L,Rutkowski B,Dębska-Ślizień A

doi

10.1007/s40620-016-0352-z

subject

Has Abstract

pub_date

2017-12-01 00:00:00

pages

781-786

issue

6

eissn

1121-8428

issn

1724-6059

pii

10.1007/s40620-016-0352-z

journal_volume

30

pub_type

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