The continuous challenge of cardiovascular and bone and bone disease in uremic patients: clinical consequences of hyperphosphatemia and advanced therapeutic approaches.

Abstract:

:This review focuses on a series of risk factors involved in the pathogenesis of cardiovascular complications in patients undergoing Regular Dialysis Treatment (RDT). Many of them are not modifiable by any pharmacological strategies or dialysis therapy, others - such as phosphate overload - can be corrected successfully, thus slowing progression of vascular calcification. Another important reason to control serum phosphate is that its accumulation in the body plays a key role in trigger-ing, directly or indirectly, PTH secretion with important metabolic consequences, mainly in the bone. The need to control serum phosphate levels relies mostly on the use of phosphate binders and in this review the pro-con analysis of several P binders (Calcium Salts, Sevelamer, Lanthanum Carbonate) is presented in terms of safety and efficacy.

journal_name

J Nephrol

journal_title

Journal of nephrology

authors

Brancaccio D,Zoccali C

subject

Has Abstract

pub_date

2006-01-01 00:00:00

pages

12-20

issue

1

eissn

1121-8428

issn

1724-6059

journal_volume

19

pub_type

杂志文章,评审
  • Limitations of Cockcroft-Gault and MDRD formulas in estimating GFR among top-level rugby players.

    abstract:INTRODUCTION:We measured serum creatinine concentrations in 17 male athletes of the Italian national rugby team. METHODS:Blood was obtained before the start of training and during the competitive season. Serum creatinine level was measured by Jaffé reaction at 4 time points during the season, with a formal measure of ...

    journal_title:Journal of nephrology

    pub_type: 杂志文章

    doi:10.5301/jn.5000094

    authors: Banfi G,Sloand J,Shelly M,Del Fabbro M,Barassi A,Melzi d'Eril GV

    更新日期:2012-11-01 00:00:00

  • A primer on survival analysis.

    abstract::Survival analysis is the statistical method for studying the time between entry to a study and a subsequent event. Survival is often the most important outcome in both observational and intervention studies. The analysis of survival, however, is not simple because of a number of factors. The time between entry to a st...

    journal_title:Journal of nephrology

    pub_type: 杂志文章,评审

    doi:

    authors: Khan IH,Prescott GJ

    更新日期:2004-03-01 00:00:00

  • Rubidium deficiency in dialysis patients.

    abstract:BACKGROUND:Since dialysis has brought long-term survival to uremic patients, we can now speculate on more subtle problems derived from imbalance or sub-optimal regulation of some elements such as trace metals. We focused on the rubidium (Rb) status in dialysis patients (HD), as concerns about its possible deficiency ha...

    journal_title:Journal of nephrology

    pub_type: 杂志文章

    doi:

    authors: Canavese C,DeCostanzi E,Branciforte L,Caropreso A,Nonnato A,Pietra R,Fortaner S,Jacono F,Angelini G,Gallieni M,Fop F,Sabbioni E

    更新日期:2001-05-01 00:00:00

  • The association of endothelin-1 levels with renal survival in polycystic kidney disease patients.

    abstract:BACKGROUND:The prominent features of autosomal dominant polycystic kidney disease (ADPKD) are early development of hypertension, chronic kidney disease and cardiovascular problems. Thus, we aimed to investigate the role of endothelin, a vascular biomarker, in the clinical course of ADPKD, including renal and cardiovasc...

    journal_title:Journal of nephrology

    pub_type: 杂志文章

    doi:10.1007/s40620-018-0514-2

    authors: Kocyigit I,Eroglu E,Kaynar AS,Kocer D,Kargi S,Zararsiz G,Bayramov R,Imamoglu H,Sipahioglu MH,Tokgoz B,Dundar M,Oymak O

    更新日期:2019-02-01 00:00:00

  • Italian randomized trial of hemoglobin maintenance to prevent or delay left ventricular hypertrophy in chronic kidney disease.

    abstract:BACKGROUND:This study is part of a 3-country study testing whether normal levels of hemoglobin (Hgb) delay the progression of left ventricular (LV) growth in chronic kidney disease (CKD) patients not on dialysis. METHODS:This was an open-label, randomized, multicenter, controlled trial conducted in 27 tertiary-care ho...

    journal_title:Journal of nephrology

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:

    authors: Cianciaruso B,Ravani P,Barrett BJ,Levin A,ITA-EPO-7 investigators.

    更新日期:2008-11-01 00:00:00

  • Pregnancy in patients with kidney disease.

    abstract:QUESTIONS:- To what extent can ailing kidneys adapt their functions to the demands of pregnancy? - What risks is the nephropathic patient prone to throughout pregnancy compared with those of the general population, and which specific risks does her kidney disease determine? - What risks is the baby of a nephropathic pr...

    journal_title:Journal of nephrology

    pub_type: 杂志文章,评审

    doi:

    authors: Stratta P,Canavese C,Quaglia M

    更新日期:2006-03-01 00:00:00

  • Left ventricular hypertrophy and progression of chronic kidney disease.

    abstract::Reduced glomerular filtration rate and albuminuria do not account for the total risk of developing end-stage renal disease (ESRD), suggesting that other factors might be involved in progressive renal function worsening. Among these, cardiovascular disease, even subclinical, could play a role. The role of left ventricu...

    journal_title:Journal of nephrology

    pub_type: 社论,评审

    doi:10.5301/jn.5000114

    authors: Paoletti E

    更新日期:2012-11-01 00:00:00

  • Ventricular function and all-cause mortality in chronic kidney disease patients with angiographic coronary artery disease.

    abstract:BACKGROUND:Coronary artery disease (CAD) and chronic kidney disease (CKD) lead to high morbidity and mortality rates. Traditional and nontraditional risk factors, hypertension, fluid overloading and anemia can lead to myocardial ischemia, chamber hypertrophy and dilatation, and low left ventricular ejection fraction (L...

    journal_title:Journal of nephrology

    pub_type: 杂志文章

    doi:

    authors: Wu IW,Hung MJ,Chen YC,Hsu HJ,Cherng WJ,Chang CJ,Wu MS

    更新日期:2010-03-01 00:00:00

  • Association of physical activity with mortality in chronic kidney disease.

    abstract:BACKGROUND:Chronic kidney disease (CKD) is an important risk factor for all-cause mortality. In the general population, physical activity is associated with reduced mortality. We examined the association of level of physical activity with mortality in patients with predominantly nondiabetic CKD stage 3-4. METHODS:We s...

    journal_title:Journal of nephrology

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:

    authors: Chen JL,Lerner D,Ruthazer R,Castaneda-Sceppa C,Levey AS

    更新日期:2008-03-01 00:00:00

  • Byzantine doctrines on uroscopy in the Liber Orinalibus of Hermogenes (codex 69 Montecassino).

    abstract::The Liber medicine orinalibus (codex 69 Montecassino) of Hermogenes is the first known manuscript to have a Latin translation from the original Greek work of Magnus of Emesa (or Nisibis). The particular text here translated, from the so-called Commentatio, mentions direct transliteration of Greek concepts such as chym...

    journal_title:Journal of nephrology

    pub_type: 历史文章,杂志文章

    doi:10.5301/JN.2011.6461

    authors: Iorio L,Lamagna M

    更新日期:2011-05-01 00:00:00

  • Associations between preoperative continuation of renin-angiotensin system inhibitor and cardiac surgery-associated acute kidney injury: a propensity score-matching analysis.

    abstract:BACKGROUND:Cardiac surgery-associated acute kidney injury (CSA-AKI) is associated with high risk for complications and mortality. Whether renin-angiotensin system (RAS) inhibitor should be continued or withdrawn in patients with long-term use before cardiac surgery has been lack of consensus. METHODS:We performed this...

    journal_title:Journal of nephrology

    pub_type: 杂志文章,多中心研究

    doi:10.1007/s40620-019-00657-4

    authors: Chou YH,Huang TM,Wu VC,Chen WS,Wang CH,Chou NK,Chiang WC,Chu TS,Lin SL,National Taiwan University Study Group on Acute Renal Failure (NSARF).

    更新日期:2019-12-01 00:00:00

  • Increased placental expression of tissue factor is associated with abnormal uterine and umbilical Doppler waveforms in severe preeclampsia with fetal growth restriction.

    abstract:BACKGROUND:This study investigated whether modifications of placental expression of endothelin-1 (ET-1), nitric oxide synthase (NOS) and tissue factor (TF) are associated with abnormal Doppler waveforms. METHODS:Fourteen pre-term severe preeclamptic (PE) women with fetal growth restriction (FGR) and 14 normal preg nan...

    journal_title:Journal of nephrology

    pub_type: 杂志文章

    doi:

    authors: Di Paolo S,Volpe P,Grandaliano G,Stallone G,Schena A,Greco P,Resta L,Selvaggi L,Cincione R,Schena FP,Gesualdo L

    更新日期:2003-09-01 00:00:00

  • Are chronic dialysis patients at increased risk for cancer?

    abstract::This review summarizes the plausible mechanisms of carcinogenesis, critically analyzes the literature on cancer risk and discusses issues of cancer screening in chronic dialysis patients. Despite conflicting results among various studies, there is sufficient evidence to conclude that there is a heightened incidence of...

    journal_title:Journal of nephrology

    pub_type: 杂志文章,评审

    doi:

    authors: Mandayam S,Shahinian VB

    更新日期:2008-03-01 00:00:00

  • Chronic hypotension in the dialysis patient.

    abstract::Chronic hypotension, defined by a systolic blood pressure < 100 mmHg in the interdialytic period, affects 5-10% of hemodialysis patients, and is more prevalent among patients on long-term hemodialysis. This complication requires a substantial amount of medical and nursing care before and during dialysis to control its...

    journal_title:Journal of nephrology

    pub_type: 杂志文章,评审

    doi:

    authors: Cases A,Coll E

    更新日期:2002-07-01 00:00:00

  • Incremental dialysis in ESRD: systematic review and meta-analysis.

    abstract:BACKGROUND:Incremental dialysis may preserve residual renal function and improve survival in comparison with full-dose dialysis; however, available evidence is limited. We therefore compared all-cause mortality and residual kidney function (RKF) loss in incremental and full-dose dialysis and time to full-dose dialysis ...

    journal_title:Journal of nephrology

    pub_type: 杂志文章,meta分析

    doi:10.1007/s40620-018-00577-9

    authors: Garofalo C,Borrelli S,De Stefano T,Provenzano M,Andreucci M,Cabiddu G,La Milia V,Vizzardi V,Sandrini M,Cancarini G,Cupisti A,Bellizzi V,Russo R,Chiodini P,Minutolo R,Conte G,De Nicola L

    更新日期:2019-10-01 00:00:00

  • Uric acid and nocturnal nondipping in hypertensive patients with normal renal function.

    abstract:BACKGROUND:The effect of uric acid on nocturnal dipping in hypertensive patients is unknown. We analyzed the specific relationship between uric acid and nocturnal dipping status in newly diagnosed essential hypertensive patients with normal renal function. METHODS:Two hundred fifteen patients with newly diagnosed esse...

    journal_title:Journal of nephrology

    pub_type: 杂志文章

    doi:

    authors: Afsar B,Elsurer R,Ozdemir FN,Sezer S

    更新日期:2008-05-01 00:00:00

  • Multifocal bilateral renal cell carcinoma and retinal angiomas in a patient with de novo von Hippel-Lindau disease: identification of a new germline mutation.

    abstract::Von Hippel-Lindau (VHL) disease is a rare autosomal dominant disorder characterized by multifocal and bilateral renal cell carcinoma and cysts, retinal angiomas, hemangioblastoma of the central nervous system, pheochromocytoma, epididymis cystoadenoma, pancreatic cysts and/or islet cell tumors. However, phenotypic man...

    journal_title:Journal of nephrology

    pub_type: 杂志文章

    doi:

    authors: Sessa A,Battini G,Meroni M,Pitingolo F,Righetti M,Ciotti P,Di Maria E,Bellone E,Ajmar F,Mandich P

    更新日期:2005-03-01 00:00:00

  • Renal diseases in John Allen's 'Synopsis Universae Medicinae Practicae...'.

    abstract::John Allen, a British physician of the eighteenth century, deserves being remembered for a series of inventions, but most importantly -- from a 'medical' point of view -- for his highly praised manuscript, the 'Universae Medicinae Practicae,sive Doctissimorum Virorum de Morbis Eorumque Causis ac Remediis Judicia', whi...

    journal_title:Journal of nephrology

    pub_type: 传,历史文章,杂志文章

    doi:

    authors: Mezzogiorno A,Iorio L,Esposito A,Flamourakis M,Esposito V

    更新日期:2006-05-01 00:00:00

  • Calcium mass balances during standard bicarbonate hemodialysis and long-hour slow-flow bicarbonate hemodialysis.

    abstract:BACKGROUND:Dialysate calcium (Ca) concentration should be viewed as part of the integrated therapeutic regimen to control renal osteodystrophy and maintain normal mineral metabolism. Thus, a correct ionized calcium mass balance (Ca++MB) during hemodialysis (HD) is crucial in the treatment of renal osteodystrophy. The G...

    journal_title:Journal of nephrology

    pub_type: 杂志文章,随机对照试验

    doi:10.5301/JN.2011.6385

    authors: Basile C,Libutti P,Di Turo AL,Tundo S,Maselli P,Casucci F,Losurdo N,Teutonico A,Vernaglione L,Lomonte C

    更新日期:2011-11-01 00:00:00

  • Correlation of bone mineral density with the histological findings of renal osteodystrophy in patients on hemodialysis.

    abstract:AIMS:To examine the distribution of bone mineral density (BMD) in different histological groups of renal osteodystrophy. PATIENTS:We prospectively studied 62 patients, 41 men and 21 women, aged 57+/-11.5 years, who had been on hemodialysis for 60+/-55 months. The women had been amenorrheic for 13+/-4 years and 7 patie...

    journal_title:Journal of nephrology

    pub_type: 杂志文章

    doi:

    authors: Gerakis A,Hadjidakis D,Kokkinakis E,Apostolou T,Raptis S,Billis A

    更新日期:2000-11-01 00:00:00

  • IgA nephropathy in a patient with chronic granulomatous disease.

    abstract::We report the first documented case of X-linked chronic granulomatous disease (CGD) in association with IgA nephropathy in a 22 year old male with multiple soft tissue abscesses. The case highlights the potential role of staphylococcal infections in the pathogenesis of IgA nephropathy and suggests the hypothesis that ...

    journal_title:Journal of nephrology

    pub_type: 杂志文章

    doi:

    authors: Narsipur SS,Shanley PF

    更新日期:2002-11-01 00:00:00

  • Endothelin and nitric oxide in hepatorenal syndrome: a balance reset.

    abstract::The newly described endothelium-dependent vasoactive substances, nitric oxide and endothelins, have been the subject of intense investigative interest and have been demonstrated to promote a wide array of autocrine and paracrine functions. Recent data highlight their emerging role as potential important mediators of r...

    journal_title:Journal of nephrology

    pub_type: 杂志文章,评审

    doi:

    authors: Epstein M,Goligorsky MS

    更新日期:1997-05-01 00:00:00

  • Sarcopenia in chronic kidney disease: what have we learned so far?

    abstract::The term sarcopenia was first introduced in 1988 by Irwin Rosenberg to define a condition of muscle loss that occurs in the elderly. Since then, a broader definition comprising not only loss of muscle mass, but also loss of muscle strength and low physical performance due to ageing or other conditions, was developed a...

    journal_title:Journal of nephrology

    pub_type: 杂志文章,评审

    doi:10.1007/s40620-020-00840-y

    authors: Sabatino A,Cuppari L,Stenvinkel P,Lindholm B,Avesani CM

    更新日期:2020-09-02 00:00:00

  • Acute renal failure in the elderly: epidemiology and clinical features.

    abstract::Structural and functional alterations affecting the aging kidney predispose to an increased risk of acute renal failure (ARF) in the elderly. This is a common problem becoming more relevant because of an increase in life expectancy. The epidemiology of ARF in the elderly is far from being well assessed, because of the...

    journal_title:Journal of nephrology

    pub_type: 杂志文章,评审

    doi:10.5301/jn.5000141

    authors: Del Giudice A,Aucella F

    更新日期:2012-01-01 00:00:00

  • Progression of cardiac valve calcification and decline of renal function in CKD patients.

    abstract:BACKGROUND:No study has evaluated the efficacy of non-calcium-containing phosphate binders in slowing progression of cardiac valve calcification or deterioration of kidney function in patients with chronic kidney disease not on dialysis. This study addressed these issues. METHODS:Outpatients (n = 170) with stage 3-4 c...

    journal_title:Journal of nephrology

    pub_type: 杂志文章

    doi:10.5301/jn.5000290

    authors: Di Lullo L,Floccari F,Santoboni A,Barbera V,Rivera RF,Granata A,Morrone L,Russo D

    更新日期:2013-07-01 00:00:00

  • Clinical and therapeutic aspects of diabetic nephropathy.

    abstract:UNLABELLED:The prognosis of renal survival in both type 1 and type 2 diabetes mellitus is not benign. Several factors characterize the increase in the risk of developing renal damage in diabetic patients, distinguished in diabetes-related factors, genetic factors and other factors. DIAGNOSIS:Diagnosis requires standar...

    journal_title:Journal of nephrology

    pub_type: 杂志文章,评审

    doi:

    authors: Strippoli GF,Di Paolo S,Cincione R,Di Palma AM,Teutonico A,Grandaliano G,Schena FP,Gesualdo L

    更新日期:2003-07-01 00:00:00

  • Three-dimensional contrast-enhanced magnetic resonance angiography (3-D CE-MRA) in the evaluation of hemodialysis access complications, and the condition of central veins in patients who are candidates for hemodialysis access.

    abstract:BACKGROUND:Arteriovenous (AV) fistulas are crucial in patients requiring long-term hemodialysis (HD). Dysfunctions of these fistulas are the most common causes of recurrent hospitalizations. This study aimed to evaluate the feasibility, safety and usefulness of contrast-enhanced magnetic resonance angiography (CE-MRA) ...

    journal_title:Journal of nephrology

    pub_type: 杂志文章

    doi:

    authors: Paksoy Y,Gormus N,Tercan MA

    更新日期:2004-01-01 00:00:00

  • Active compounds extracted from extra virgin olive oil counteract mesothelial-to-mesenchymal transition of peritoneal mesothelium cells exposed to conventional peritoneal dialysate: in vitro and in vivo evidences.

    abstract::During peritoneal dialysis (PD), peritoneal mesothelial cells undergo a transition from an epithelial phenotype to a mesenchymal phenotype that, together with the inflammatory process, promotes tissue fibrosis and a failure of peritoneal membrane function. To date, there is no definitive treatment for the progressive ...

    journal_title:Journal of nephrology

    pub_type: 杂志文章

    doi:10.1007/s40620-016-0368-4

    authors: Lupinacci S,Toteda G,Vizza D,Perri A,Benincasa C,Mollica A,La Russa A,Gigliotti P,Leone F,Lofaro D,Bonofiglio M,Perri E,Bonofiglio R

    更新日期:2017-12-01 00:00:00

  • The role of pulse pressure in navigating the paradigm of chronic kidney disease progression in type 2 diabetes mellitus.

    abstract:BACKGROUND AND AIMS:Arterial stiffness is a risk factor for chronic kidney disease progression (CKD). Pulse pressure is a surrogate marker of arterial stiffness. It is unclear if pulse pressure predicts CKD progression in type 2 diabetes mellitus. METHODS:This was prospective study involving 1494 patients with estimat...

    journal_title:Journal of nephrology

    pub_type: 杂志文章

    doi:10.1007/s40620-020-00954-3

    authors: Low S,Moh A,Ang SF,Lim CL,Liu YL,Wang J,Ang K,Tang WE,Kwan PY,Lim Z,Subramaniam T,Sum CF,Lim SC

    更新日期:2021-01-25 00:00:00

  • Nodular glomerulosclerosis in a non-diabetic patient: case report and review of literature.

    abstract::We report a unusual case of idiopathic nodular glomerulosclerosis mimicking changes that develop in diabetic nephropathy. A 66-year-old non-diabetic female developed nephrotic range proteinuria and the work up was unremarkable. Light and electron microscopy showed mesangial expansion with Kimmelsteil-Wilson nodules an...

    journal_title:Journal of nephrology

    pub_type: 杂志文章,评审

    doi:

    authors: Navaneethan SD,Singh S,Choudhry W

    更新日期:2005-09-01 00:00:00