The continuous challenge of cardiovascular and bone and bone disease in uremic patients: clinical consequences of hyperphosphatemia and advanced therapeutic approaches.

abstract：:Cyclosporine A has been empirically used for more than 12 years in the treatment of idiopathic nephrotic syndrome, in both children and adults. There is consistent evidence, from both experimental and human studies, that the highly lipophilic cyclosporine molecule diminishes or abolishes proteinuria by two differing m...

journal_title：Journal of nephrology

authors： Meyrier A

更新日期：1997-01-01 00:00:00

abstract：:Although several in vitro studies and clinical observations suggest that ACE-inhibitors (ACE-I) are a promising treatment for IgA nephropathy (IgAN), meta-analysis of published data is not yet conclusive. Therefore, a European double-blinded, prospective, randomized therapeutic trial was designed to evaluate ACE-I tre...

journal_title：Journal of nephrology

authors： Coppo R,Chiesa M,Peruzzi L,Amore A

更新日期：2001-11-01 00:00:00

abstract：:The combination of hypomagnesemia and hypocalciuria is the phenotypic signature of two distinct genetic renal tubular transport disorders: Gitelman's syndrome and autosomal dominant isolated renal magnesium wasting. In the past 5 years the genetic defects underlying these disorders have been elucidated through positio...

journal_title：Journal of nephrology

authors： Knoers NV,de Jong JC,Meij IC,Van Den Heuvel LP,Bindels RJ

更新日期：2003-03-01 00:00:00

abstract：AIMS:This joint document of the Italian Diabetes Society and the Italian Society of Nephrology reviews the natural history of diabetic kidney disease (DKD) in the light of the recent epidemiological literature and provides updated recommendations on anti-hyperglycemic treatment with non-insulin agents. DATA SYNTHESIS:...

journal_title：Journal of nephrology

authors： Pugliese G,Penno G,Natali A,Barutta F,Di Paolo S,Reboldi G,Gesualdo L,De Nicola L,Italian Diabetes Society and the Italian Society of Nephrology.

更新日期：2020-02-01 00:00:00

abstract：:Urine samples can be readily obtained from patients in everyday clinical practice. Therefore, the availability of urine allows physicians to obtain relevant clinical information in a timely manner. Since the measurement of urinary protein levels is essential in diagnosing and treating a host of diseases, the potential...

journal_title：Journal of nephrology

authors： Résimont G,Piéroni L,Bigot-Corbel E,Cavalier E,Delanaye P

更新日期：2020-04-23 00:00:00

abstract：:Von Hippel-Lindau (VHL) disease is a rare autosomal dominant disorder characterized by multifocal and bilateral renal cell carcinoma and cysts, retinal angiomas, hemangioblastoma of the central nervous system, pheochromocytoma, epididymis cystoadenoma, pancreatic cysts and/or islet cell tumors. However, phenotypic man...

journal_title：Journal of nephrology

authors： Sessa A,Battini G,Meroni M,Pitingolo F,Righetti M,Ciotti P,Di Maria E,Bellone E,Ajmar F,Mandich P

更新日期：2005-03-01 00:00:00

abstract：BACKGROUND:Different mitogens are involved in the pathogenesis of kidney damage after subtotal nephrectomy. One of them, TGF-beta, controls mesangial cell proliferation and interstitial fibrosclerosis. The transduction of the TGF-beta signal is controlled by intracellular signalling molecules such as Ras G monomeric pr...

journal_title：Journal of nephrology

authors： Bernardini N,Cupisti A,Mattii L,Segnani C,Dolf A,Barsotti M,Barsotti G

更新日期：2002-09-01 00:00:00

abstract：:A definite epidemiological association exists between kidney stone disease and arterial hypertension, but the pathophysiological mechanisms are still not fully understood. Hypercalciuria or inflammation and oxidative stress have been proposed as possible links. However, there is more convincing evidence that the assoc...

journal_title：Journal of nephrology

authors： Cupisti A,D'Alessandro C,Samoni S,Meola M,Egidi MF

更新日期：2014-10-01 00:00:00

abstract：BACKGROUND:There is growing evidence of the potential properties of nitrate-rich foods against development of hypertension (HTN) and vascular disease. In this study, we investigated the association of nitrate-containing vegetables (NCVs) with risk of HTN after 3 years of follow-up. METHODS:This prospective study was c...

journal_title：Journal of nephrology

authors： Golzarand M,Bahadoran Z,Mirmiran P,Zadeh-Vakili A,Azizi F

更新日期：2016-06-01 00:00:00

abstract：BACKGROUND:No study has evaluated the efficacy of non-calcium-containing phosphate binders in slowing progression of cardiac valve calcification or deterioration of kidney function in patients with chronic kidney disease not on dialysis. This study addressed these issues. METHODS:Outpatients (n = 170) with stage 3-4 c...

journal_title：Journal of nephrology

authors： Di Lullo L,Floccari F,Santoboni A,Barbera V,Rivera RF,Granata A,Morrone L,Russo D

更新日期：2013-07-01 00:00:00

abstract：BACKGROUND AND AIMS:It has been well documented that gene and DNA alterations occur frequently in benign primary parathyroid adenomas as well as in parathyroid glands with secondary hyperplasia. However, it has not been shown whether a correlation exists between somatic DNA aberrations and clinical data. METHODS:We an...

journal_title：Journal of nephrology

authors： Chudek J,Nagy A,Kokot F,Podwinski A,Wiecek A,Ritz E,Kovacs G

更新日期：2007-03-01 00:00:00

abstract：BACKGROUND:Renal tubular epithelial cells (TECs) function as antigen-presenting cells because they constitutively express MHC class II molecules and have the ability to present peptide antigen to CD4+T cells. However, the costimulatory signals provided by TECs for optimal T-cell activation have not been fully character...

journal_title：Journal of nephrology

authors： Zhang J,Chen Y,Li J,Zhang R,Wu Y,Zou L,Zhao T,Zhang X,Han J,Chen A,Wu Y

更新日期：2006-07-01 00:00:00

abstract：BACKGROUND AND AIMS:Encapsulating peritoneal sclerosis (EPS) is an uncommon but severe complication of peritoneal dialysis (PD). A reliable screening tool to identify patients at risk of developing or not EPS is currently not available. We aimed to evaluate whether the reduction in dialysate sodium concentration (sodiu...

journal_title：Journal of nephrology

authors： La Milia V,Longhi S,Sironi E,Pontoriero G

更新日期：2018-02-01 00:00:00

abstract：BACKGROUND:Cardiac surgery-associated acute kidney injury (CSA-AKI) is associated with high risk for complications and mortality. Whether renin-angiotensin system (RAS) inhibitor should be continued or withdrawn in patients with long-term use before cardiac surgery has been lack of consensus. METHODS:We performed this...

journal_title：Journal of nephrology

authors： Chou YH,Huang TM,Wu VC,Chen WS,Wang CH,Chou NK,Chiang WC,Chu TS,Lin SL,National Taiwan University Study Group on Acute Renal Failure (NSARF).

更新日期：2019-12-01 00:00:00

abstract：:A 64-year-old man was hospitalized in 2002 with symptoms of stupor, weakness, and renal colic. The clinical examination indicated borderline hypertension, small masses in the glutei, and polyuria. Laboratory tests evidenced high serum concentrations of creatinine, calcium, and phosphate. Imaging assessments disclosed ...

journal_title：Journal of nephrology

authors： Cirillo M,Bilancio G,Cirillo C

更新日期：2016-02-01 00:00:00

abstract：INTRODUCTION:Lack of adherence may influence the efficiency of phosphate binders. Our clinical hypothesis was that if lanthanum carbonate (LC) might offer some advantage over sevelamer (S), that that would be in those patients in whom serum phosphate (P) levels were not controlled by S or in those requiring high doses ...

journal_title：Journal of nephrology

authors： Arenas MD,Rebollo P,Malek T,Moledous A,Gil MT,Alvarez-Ude F,Morales A,Cotilla E

更新日期：2010-11-01 00:00:00

abstract：BACKGROUND:Phosphorus is associated with mortality in patients with chronic kidney disease (CKD) not on dialysis, possibly through phosphorus-dependent vascular calcification. Although a phosphorus-restricted diet reduces serum phosphorus, it is unlikely that it reduces vascular calcification progression in CKD. This s...

journal_title：Journal of nephrology

authors： Russo D,Bellasi A,Pota A,Russo L,Di Iorio B

更新日期：2015-02-01 00:00:00

abstract：:Patients with chronic kidney disease (CKD) have a greatly enhanced risk of cardiovascular morbidity and mortality. Over the past decade it has come clear that a disturbed calcium-phosphate metabolism, with Fibroblast Growth Factor-23 as a key hormone, is partly accountable for this enhanced risk. Numerous studies have...

journal_title：Journal of nephrology

authors： Bouma-de Krijger A,Vervloet MG

更新日期：2020-06-01 00:00:00

abstract：:We report the first documented case of X-linked chronic granulomatous disease (CGD) in association with IgA nephropathy in a 22 year old male with multiple soft tissue abscesses. The case highlights the potential role of staphylococcal infections in the pathogenesis of IgA nephropathy and suggests the hypothesis that ...

journal_title：Journal of nephrology

authors： Narsipur SS,Shanley PF

更新日期：2002-11-01 00:00:00

abstract：BACKGROUND AND AIMS:Reduction of intestinal load of phosphorus is important for the prevention and treatment of chronic kidney disease (CKD)-mineral and bone disorder (MBD). However, this strategy is limited by patients' poor adherence to dietary prescription and by the existence of hidden sources of phosphorus. In add...

journal_title：Journal of nephrology

authors： Cupisti A,Moriconi D,D'Alessandro C,Verde F,Marchini M,Saba A,Egidi MF

更新日期：2016-12-01 00:00:00

abstract：BACKGROUND:In the general population and in hemodialysis patients epicardial adipose tissue (EAT) has been associated with increased mortality and cardiovascular events. Weight loss and lipid lowering therapies reduced EAT in the general population. It is unknown whether sevelamer, a phosphate (Pi) binder that lowers c...

journal_title：Journal of nephrology

authors： Ko SM,Zhang C,Chen Z,D'Marco L,Bellasi A,Stillman AE,Block G,Raggi P

更新日期：2016-10-01 00:00:00

abstract：:The pathogenetic role of adiponectin (ADPN) in kidney failure is not yet elucidated, since in vitro and in vivo studies have demonstrated that ADPN exerts both anti-inflammatory and pro-inflammatory effects. Starting from our previous findings demonstrating that HK-2 cells express and secrete ADPN, in this study we in...

journal_title：Journal of nephrology

authors： Perri A,Vizza D,Lupinacci S,Toteda G,De Amicis F,Leone F,Gigliotti P,Lofaro D,La Russa A,Bonofiglio R

更新日期：2016-04-01 00:00:00

abstract：BACKGROUND AND METHODS:Smoking is associated with hyperparathyroidism in the elderly general population and nicotine, the main component of tobacco smoke, stimulates PTH release in experimental models. Although smoking is a persisting problem in patients with end-stage renal disease (ESRD), the association between smok...

journal_title：Journal of nephrology

authors： Tripepi G,Mattace-Raso F,Pizzini P,Cutrupi S,Witteman J,Zoccali C,Mallamaci F

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:With improvements in technology, renal biopsies have become safer and could potentially be effectively carried out in the outpatient setting. The purpose of our study is to compare the safety and cost of performing outpatient versus inpatient renal biopsies at a single Northern California pediatric hospital....

journal_title：Journal of nephrology

authors： Lau KK,Berg GL,Butani L

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:Patients (pts) with primary Membranous nephropathy (MN) have an autoimmune disease caused by autoantibodies against podocyte antigens and 60-80% of them have antibodies directed against the M-type phospholipase A2 receptor (PLA2R). Immunosuppressive treatment is recommended in high-medium risk pts. Recently ...

journal_title：Journal of nephrology

authors： Fenoglio R,Baldovino S,Sciascia S,De Simone E,Del Vecchio G,Ferro M,Quattrocchio G,Naretto C,Roccatello D

更新日期：2020-06-27 00:00:00

abstract：:The aging process results in remarkable changes in the kidney. These changes are both anatomical and functional and have been considered the cause of the increased propensity of the elderly to acute or chronic renal failure. However, the majority of the early studies on aging enrolled institutionalized elderly patient...

journal_title：Journal of nephrology

authors： Esposito C,Dal Canton A

更新日期：2010-09-01 00:00:00

abstract：:Kidney stone disease is a common condition with a high recurrence rate and elevated costs. Despite the well-known positive effects of high fluid intake, there are little data about the roles of water composition and timing of ingestion during the day. This study examines the effect of two different waters [calcium-bic...

journal_title：Journal of nephrology

authors： Ferraro PM,Baccaro R,Baroni S,D'Alessandri L,Carpenito C,Di Daniele N,Urbani A,Gambaro G

更新日期：2020-06-08 00:00:00

abstract：BACKGROUND:Inadvertent sodium (Na(+)) flux may occur during renal replacement therapy (RRT) in ICU. The objective of this study was to estimate sodium flux during RRT. METHODS:Between September 2011 to December 2012 we studied 60 ICU patients receiving extended daily dialysis (EDD, Fresenius 4008S) or continuous renal...

journal_title：Journal of nephrology

authors： Bihari S,Taylor S,Bersten AD

更新日期：2014-08-01 00:00:00

abstract：:John Allen, a British physician of the eighteenth century, deserves being remembered for a series of inventions, but most importantly -- from a 'medical' point of view -- for his highly praised manuscript, the 'Universae Medicinae Practicae,sive Doctissimorum Virorum de Morbis Eorumque Causis ac Remediis Judicia', whi...

journal_title：Journal of nephrology

authors： Mezzogiorno A,Iorio L,Esposito A,Flamourakis M,Esposito V

更新日期：2006-05-01 00:00:00

abstract：:Chronic hypotension, defined by a systolic blood pressure < 100 mmHg in the interdialytic period, affects 5-10% of hemodialysis patients, and is more prevalent among patients on long-term hemodialysis. This complication requires a substantial amount of medical and nursing care before and during dialysis to control its...

journal_title：Journal of nephrology

authors： Cases A,Coll E

更新日期：2002-07-01 00:00:00