Abstract：
BACKGROUND AND AIMS:It has been well documented that gene and DNA alterations occur frequently in benign primary parathyroid adenomas as well as in parathyroid glands with secondary hyperplasia. However, it has not been shown whether a correlation exists between somatic DNA aberrations and clinical data. METHODS:We analyzed the frequency of chromosomal aberrations in adenomas obtained from 25 patients with primary hyperparathyroidism (pHPT) and 60 parathyroid nodules from 20 uremic patients with secondary hyperparathyroidism (sHPT). The relation of chromosomal aberrations to parathyroid hormone, as well as calcium and phosphate serum concentrations, was assessed. Allelic changes were evaluated by microsatellite allelotyping using 105 polymorphic markers. RESULTS:Somatic chromosomal aberrations were found in 23 out of 25 adenomas, in hyperplastic lesions from 16 out of 20 patients. In pHPT as well as in sHPT a positive correlation was found between the number of chromosomal alterations and serum phosphate concentration (tau=0.270, p=0.05; and tau=0.362, p=0.03, respectively). Only in pHPT was a negative correlation of borderline significance between serum parathormone (PTH) and number of aberrated chromosomes noticed (tau=-0.258, p=0.07). There was no correlation between the number of DNA changes and serum concentration of calcium or tumor volume. CONCLUSION:Hyperphosphatemia may increase the risk of specific and random chromosomal aberrations due to increasing proliferation rate of parathyroid cells in patients with sHPT.
journal_name
J Nephroljournal_title
Journal of nephrologyauthors
Chudek J,Nagy A,Kokot F,Podwinski A,Wiecek A,Ritz E,Kovacs Gsubject
Has Abstractpub_date
2007-03-01 00:00:00pages
164-72issue
2eissn
1121-8428issn
1724-6059journal_volume
20pub_type
杂志文章abstract：BACKGROUND:Atypical haemolytic uremic syndrome (aHUS) is at high risk of relapse at any time, therefore patients require lifelong monitoring. The most appropriate way to monitor patients is not yet clear. Patients could be monitored for relapse by urine dipstick testing for haemoglobinuria based on the hypothesis that ...
journal_title：Journal of nephrology
pub_type： 杂志文章
doi：10.1007/s40620-021-00965-8
更新日期：2021-01-18 00:00:00
abstract：:Survival analysis is the statistical method for studying the time between entry to a study and a subsequent event. Survival is often the most important outcome in both observational and intervention studies. The analysis of survival, however, is not simple because of a number of factors. The time between entry to a st...
journal_title：Journal of nephrology
pub_type： 杂志文章,评审
doi：
更新日期：2004-03-01 00:00:00
abstract：:Diabetic nephropathy (DN) is a common complication of Diabetes Mellitus (DM) Types 1 and 2, and prevention of end stage renal disease (ESRD) remains a major challenge. Despite its high prevalence, the pathogenesis of DN is still controversial. Initial glomerular disease manifested by hyperfiltration and loss of glomer...
journal_title：Journal of nephrology
pub_type： 杂志文章,评审
doi：10.1007/s40620-017-0423-9
更新日期：2017-12-01 00:00:00
abstract：:The goal of palliative care is to achieve good quality of life for patients with chronic life-limiting illnesses, and their families, through assessment and management of physical, psychosocial and spiritual problems and needs. Patients with kidney diseases present a particular target of such care from the time of dia...
journal_title：Journal of nephrology
pub_type： 杂志文章
doi：
更新日期：2008-03-01 00:00:00
abstract：BACKGROUND:We tested the hypothesis that the universal application of myocardial scanning with single-photon emission computed tomography (SPECT) would result in better risk stratification in renal transplant candidates (RTC) compared with SPECT being restricted to patients who, in addition to renal disease, had other ...
journal_title：Journal of nephrology
pub_type： 杂志文章
doi：
更新日期：2010-05-01 00:00:00
abstract：BACKGROUND AND AIMS:This study aimed to test the hypothesis that visfatin is associated with atherosclerosis in patients with chronic kidney disease (CKD). METHODS:In the study, we measured serum triglycerides, total cholesterol, high-density lipoprotein (HDL) cholesterol, low-density lipoprotein (LDL) cholesterol lev...
journal_title：Journal of nephrology
pub_type： 杂志文章
doi：10.5301/jn.2010.3488
更新日期：2011-03-01 00:00:00
abstract：:A definite epidemiological association exists between kidney stone disease and arterial hypertension, but the pathophysiological mechanisms are still not fully understood. Hypercalciuria or inflammation and oxidative stress have been proposed as possible links. However, there is more convincing evidence that the assoc...
journal_title：Journal of nephrology
pub_type： 杂志文章,评审
doi：10.1007/s40620-014-0068-x
更新日期：2014-10-01 00:00:00
abstract：BACKGROUND:This study was undertaken to examine whether there is an association between parity and age at first birth and risk of death from chronic renal failure (CRF). STUDY DESIGN:Prospective cohort study. SETTING AND PARTICIPANTS:The study cohort consisted of 1 292 462 women who had a first and singleton childbir...
journal_title：Journal of nephrology
pub_type： 杂志文章
doi：10.5301/jn.5000171
更新日期：2013-03-01 00:00:00
abstract：BACKGROUND:Congenital nephrotic syndrome is an uncommon disorder that may be caused by several diseases. These may be inherited, sporadic, acquired or part of a general malformation syndrome. METHODS:We reviewed the clinical characteristics, pathologic findings, and results of medical management in 30 infants who pres...
journal_title：Journal of nephrology
pub_type： 杂志文章
doi：
更新日期：2001-03-01 00:00:00
abstract：:The term sarcopenia was first introduced in 1988 by Irwin Rosenberg to define a condition of muscle loss that occurs in the elderly. Since then, a broader definition comprising not only loss of muscle mass, but also loss of muscle strength and low physical performance due to ageing or other conditions, was developed a...
journal_title：Journal of nephrology
pub_type： 杂志文章,评审
doi：10.1007/s40620-020-00840-y
更新日期：2020-09-02 00:00:00
abstract：:Patients with chronic kidney disease (CKD) have a greatly enhanced risk of cardiovascular morbidity and mortality. Over the past decade it has come clear that a disturbed calcium-phosphate metabolism, with Fibroblast Growth Factor-23 as a key hormone, is partly accountable for this enhanced risk. Numerous studies have...
journal_title：Journal of nephrology
pub_type： 杂志文章,评审
doi：10.1007/s40620-020-00715-2
更新日期：2020-06-01 00:00:00
abstract：:Cardiovascular disease is the leading cause of the poor long-term survival of patients with chronic kidney disease (CKD). Anemia, which is a frequent and early complication of CKD, not only impairs patients' quality of life, but also is an independent risk factor for adverse cardiovascular outcomes. This may be due to...
journal_title：Journal of nephrology
pub_type： 杂志文章,评审
doi：
更新日期：2007-11-01 00:00:00
abstract：:Influenza is a commonly encountered and serious pathogen. Patients with end-stage renal disease are more susceptible to serious morbidity and mortality associated with influenza infection. Proper management of patients includes: vaccination, monitoring for symptoms and isolation of potentially infected patients as wel...
journal_title：Journal of nephrology
pub_type： 杂志文章,评审
doi：10.1007/s40620-017-0407-9
更新日期：2018-04-01 00:00:00
abstract：:Some patients with essential hypertension manifest increased urinary albumin excretion (UAE). Hypertensive patients with microalbuminuria manifest abnormal circadian variation of blood pressure, increased serum levels of LDL-cholesterol and lipoprotein(a), a greater rise of serum insulin in response to an oral glucose...
journal_title：Journal of nephrology
pub_type： 杂志文章,评审
doi：
更新日期：1997-07-01 00:00:00
abstract：:Kidney remodeling is a response to intrinsic or extrinsic triggers of kidney injury. Injury initiates a set of universal response programs that were positively selected through evolution to control potentially life-threatening dangers and to regain homeostasis, including tissue repair. These danger control programs ar...
journal_title：Journal of nephrology
pub_type： 杂志文章,评审
doi：10.5301/jn.5000247
更新日期：2013-05-01 00:00:00
abstract：AIMS:Nonsteroidal anti-inflammatory drugs (NSAIDs) are the cornerstone of pain management. There are no detailed data on NSAIDs use in Poland, especially in patients with chronic kidney disease (CKD). The aim of this study was to evaluate the frequency, circumstances, and causes of NSAIDs use as well as knowledge of th...
journal_title：Journal of nephrology
pub_type： 杂志文章
doi：10.1007/s40620-016-0352-z
更新日期：2017-12-01 00:00:00
abstract：:Lupus is now regarded as a syndrome which results from several related auto-immune processes, although the exact mechanisms of how the disease arises in susceptible individuals remain obscure. When the San Carlo meetings began in 1968, much less was known about the pathogenesis of autoimmunity, but the presence of aut...
journal_title：Journal of nephrology
pub_type： 杂志文章,评审
doi：
更新日期：1999-07-01 00:00:00
abstract：BACKGROUND:Adiponectin, a novel adipocytokine with antiinflammatory and antiatherosclerosis properties, has been found to be an inverse predictor of cardiovascular outcomes among uremic patients on hemodialysis. However, its role in uremic patients on continuous ambulatory peritoneal dialysis (CAPD) remains unclear. Th...
journal_title：Journal of nephrology
pub_type： 杂志文章
doi：
更新日期：2008-09-01 00:00:00
abstract：BACKGROUND:Renal tubular epithelial cells (TECs) function as antigen-presenting cells because they constitutively express MHC class II molecules and have the ability to present peptide antigen to CD4+T cells. However, the costimulatory signals provided by TECs for optimal T-cell activation have not been fully character...
journal_title：Journal of nephrology
pub_type： 杂志文章
doi：
更新日期：2006-07-01 00:00:00
abstract：BACKGROUND:The clinical benefits of on-line hemodiafiltration (HDF) versus high-flux membranes hemodialysis (hf-HD) are still debated. In fact, although a superiority of one treatment over the other, especially in terms of mortality, did not emerge from the analysis of clinical trials, improved intradialytic vascular s...
journal_title：Journal of nephrology
pub_type： 杂志文章
doi：10.1007/s40620-018-00581-z
更新日期：2019-06-01 00:00:00
abstract：:Various opinions have been presented about the influence of age on the health-related quality of life (HRQOL) of patients on renal replacement therapy (RRT). Some authors sustain that age worsens HRQOL, while others show the opposite. It has been seen that a psychological adjustment occurs with aging, even when chroni...
journal_title：Journal of nephrology
pub_type： 杂志文章,评审
doi：
更新日期：2002-05-01 00:00:00
abstract：:The analysis of the urinary proteome is a potential source of information regarding the kidney's physiopathology. A clear knowledge of the protein composition of normal urine is an essential prerequisite to looking at its pathology. Technological evolution in the field of proteomics (2-dimensional [2D] electrophoresis...
journal_title：Journal of nephrology
pub_type： 杂志文章,评审
doi：10.5301/jn.5000233
更新日期：2013-07-01 00:00:00
abstract：BACKGROUND:This study aimed to evaluate the health-related quality of life (HRQOL) and burden on family caregivers of chronic dialysis patients and to analyze which factors were associated with it. METHODS:A cross-sectional multicentric study was carried out with 221 patient/caregiver pairs. General population Short F...
journal_title：Journal of nephrology
pub_type： 杂志文章
doi：
更新日期：2004-11-01 00:00:00
abstract：:Rapidly progressive glomerulonephritis (RPGN) must be diagnosed and treated quickly to prevent irreversible organ injury. The commonest cause of RPGN is anti-neutrophil cytoplasm antibody (ANCA) associated small vessel vasculitis, and the most severe is anti-glomerular basement membrane (GBM) antibody disease. In this...
journal_title：Journal of nephrology
pub_type： 杂志文章,评审
doi：
更新日期：2004-11-01 00:00:00
abstract：INTRODUCTION:Mutations of the AGXT gene encoding the alanine:glyoxylate aminotransferase liver enzyme (AGT) cause primary hyperoxaluria type 1 (PH1). Here we report a molecular modeling study of selected missense AGXT mutations: the common Gly170Arg and the recently described Gly47Arg and Ser81Leu variants, predicted t...
journal_title：Journal of nephrology
pub_type： 杂志文章
doi：
更新日期：2010-11-01 00:00:00
abstract：:Kidney stone disease is a common condition with a high recurrence rate and elevated costs. Despite the well-known positive effects of high fluid intake, there are little data about the roles of water composition and timing of ingestion during the day. This study examines the effect of two different waters [calcium-bic...
journal_title：Journal of nephrology
pub_type： 杂志文章
doi：10.1007/s40620-020-00769-2
更新日期：2020-06-08 00:00:00
abstract：:There have been dramatic increases in the understanding of the molecular mechanisms involved in membranous nephropathy (MN) over the past 2 decades. Most of these have come directly from studies carried out in the Heymann nephritis models of MN in rats, which closely simulate the clinical and pathologic features of th...
journal_title：Journal of nephrology
pub_type： 杂志文章,评审
doi：
更新日期：2006-11-01 00:00:00
abstract：BACKGROUND:Chronic kidney disease (CKD) is an important risk factor for all-cause mortality. In the general population, physical activity is associated with reduced mortality. We examined the association of level of physical activity with mortality in patients with predominantly nondiabetic CKD stage 3-4. METHODS:We s...
journal_title：Journal of nephrology
pub_type： 杂志文章,多中心研究,随机对照试验
doi：
更新日期：2008-03-01 00:00:00
abstract：BACKGROUND:Patients undergoing chronic hemodialysis (HD) are at increased risk for peripheral artery disease (PAD). Both ankle-brachial index (ABI) and ambulatory blood pressure monitoring (ABPM) in the interdialytic period have been shown to be strong predictors of all-cause mortality. METHODS:This cross-sectional st...
journal_title：Journal of nephrology
pub_type： 杂志文章
doi：10.1007/s40620-016-0322-5
更新日期：2017-06-01 00:00:00
abstract：BACKGROUND:The detailed mechanisms and treatment methods of chronic kidney disease (CKD) in patients with chronic heart failure (CHF) are not fully understood. We conducted a prospective study in CHF patients manifesting CKD to examine if AST-120 (Kremezin) improves cardiac and renal functions. METHODS:Twenty outpatie...
journal_title：Journal of nephrology
pub_type： 杂志文章
doi：
更新日期：2010-09-01 00:00:00
