Urinary proteome in a snapshot: normal urine and glomerulonephritis.

Abstract:

:The analysis of the urinary proteome is a potential source of information regarding the kidney's physiopathology. A clear knowledge of the protein composition of normal urine is an essential prerequisite to looking at its pathology. Technological evolution in the field of proteomics (2-dimensional [2D] electrophoresis, equalization, mass spectrometry and exosomes) has greatly expanded the power of analysis, allowing the detection of almost 2,000 spots in normal urine, only a minor part of which has been characterized as isoforms of known proteins. The identity of most spots (80%) remains to be determined. The analysis of urine composition in nephrotic syndrome (glomerulosclerosis and membranous nephropathy) and in lupus nephritis is in progress, but has not yet furnished any relevant material. The unique exception is the presence of acidic components that suggests alteration of the charge selectivity properties of the glomerular wall in cases of heavy proteinuria. In lupus nephritis, prostaglandin-H2-isomerase and hepcidin have also been identified as activity biomarkers. Several overexpressed or underexpressed proteins have also been found in urine IgA nephropathy, but their specificity needs validation. Decreased levels of aquaporin 2 and of inter-a-trypsin-inhibitor heavy chain 4 have been associated, respectively, with hypertension and with a different response to angiotensin-converting enzyme inhibition in IgA nephropathy patients. From the present stage, mainly characterized by discovery of new proteins in urine, we should now proceed to their validation as biomarkers of diseases and possibly to clinical trials. Participation by basic scientists and clinicians together in projects launched by worldwide organizations is of vital importance.

journal_name

J Nephrol

journal_title

Journal of nephrology

authors

Santucci L,Candiano G,Bruschi M,Bodria M,Murtas C,Petretto A,Ghiggeri GM

doi

10.5301/jn.5000233

subject

Has Abstract

pub_date

2013-07-01 00:00:00

pages

610-6

issue

4

eissn

1121-8428

issn

1724-6059

pii

BC05DC5F-C1A6-48C0-BAEA-540F9413E329

journal_volume

26

pub_type

杂志文章,评审
  • AT1 receptors and the actin cytoskeleton during angiotensin II treatment.

    abstract:BACKGROUND:The response of proximal convoluted tubules (PCTs) to angiotensin II is mediated by specific type 1 receptors found on both apical and basolateral surface membrane cells. After ligand association with type 1 receptors, different signaling pathways are triggered and determine changes in fluid absorption (Jv)....

    journal_title:Journal of nephrology

    pub_type: 杂志文章

    doi:

    authors: Bertels IM,Gontijo JA,Figueiredo JF

    更新日期:2007-01-01 00:00:00

  • Necrotising, proliferative glomerulonephritis due to monoclonal cryoglobulinaemia.

    abstract::Renal involvement is uncommon in the rare condition of Type I cryoglobulinaemia. On review of the literature most cases featured membranoproliferative glomerulonephritis on renal biopsy. In this case report, we describe a presentation of rapidly progressive glomerulonephritis that histologically demonstrated necrotisi...

    journal_title:Journal of nephrology

    pub_type: 杂志文章

    doi:

    authors: Boudville N,Walton J,House AA

    更新日期:2006-05-01 00:00:00

  • Continuous ambulatory peritoneal dialysis and sclerosing encapsulating peritonitis: tamoxifen as a new therapeutic agent?

    abstract::Sclerosing encapsulating peritonitis (SEP) is a serious complication of long-term continuous ambulatory peritoneal dialysis (CAPD), very likely related to a persisting expression of the transforming growth factor beta1 (TGFbeta1) gene on peritoneal mesothelial cells. We report the case of a 67-year-old uremic woman wh...

    journal_title:Journal of nephrology

    pub_type: 杂志文章

    doi:

    authors: Allaria PM,Giangrande A,Gandini E,Pisoni IB

    更新日期:1999-11-01 00:00:00

  • Thin glomerular basement membrane disease.

    abstract::The term thin glomerular basement membrane disease (TBMD) refers to a condition characterised by thinning of the GBM at electron microscopy examination and, clinically, by isolated hematuria, frequently occurring in other family members, with no extra-renal manifestations. Progression towards chronic renal failure (CR...

    journal_title:Journal of nephrology

    pub_type: 杂志文章,评审

    doi:

    authors: Frascá GM,Onetti-Muda A,Renieri A

    更新日期:2000-01-01 00:00:00

  • Gonadal dysfunction in men with chronic kidney disease: clinical features, prognostic implications and therapeutic options.

    abstract::Gonadal dysfunction is a frequent finding in men with chronic kidney disease and with end-stage renal disease. Testosterone deficiency, usually accompanied by elevation of serum gonadotropin concentrations, is present in 26-66% of men with different degrees of renal failure. Uremia-associated hypogonadism is multifact...

    journal_title:Journal of nephrology

    pub_type: 杂志文章,评审

    doi:10.5301/JN.2011.8481

    authors: Iglesias P,Carrero JJ,Díez JJ

    更新日期:2012-01-01 00:00:00

  • Regulation of sodium transporters in the kidney during cyclosporine treatment.

    abstract::Cyclosporine (CsA) is among the most widely used immunosuppressants for preventing graft rejection and autoimmune diseases. However, its clinical use is hampered by its significant nephrotoxicity and effects as a cause of hypertension. The proximal tubular Na+-H+ exchanger (NHE3) is responsible for transcellular reabs...

    journal_title:Journal of nephrology

    pub_type: 杂志文章,评审

    doi:

    authors: Damiano S,Scanni R,Ciarcia R,Florio S,Capasso G

    更新日期:2010-11-01 00:00:00

  • Renal structure in type 2 diabetes: facts and misconceptions.

    abstract::The clinical manifestations of diabetic nephropathy are similar in type 1 and type 2 diabetes, while the renal lesions may differ. Indeed, diabetic glomerulopathy is the predominant renal lesion in type 1 diabetes, although also tubular, interstitial and arteriolar lesions are present in the advanced stages of renal d...

    journal_title:Journal of nephrology

    pub_type: 杂志文章,评审

    doi:10.1007/s40620-020-00797-y

    authors: Di Vincenzo A,Bettini S,Russo L,Mazzocut S,Mauer M,Fioretto P

    更新日期:2020-10-01 00:00:00

  • Epicardial adipose tissue volume increase in hemodialysis patients treated with sevelamer or calcium-based phosphate binders: a substudy of the Renagel in new dialysis trial.

    abstract:BACKGROUND:In the general population and in hemodialysis patients epicardial adipose tissue (EAT) has been associated with increased mortality and cardiovascular events. Weight loss and lipid lowering therapies reduced EAT in the general population. It is unknown whether sevelamer, a phosphate (Pi) binder that lowers c...

    journal_title:Journal of nephrology

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/s40620-016-0310-9

    authors: Ko SM,Zhang C,Chen Z,D'Marco L,Bellasi A,Stillman AE,Block G,Raggi P

    更新日期:2016-10-01 00:00:00

  • Consumption of nitrate-containing vegetables is inversely associated with hypertension in adults: a prospective investigation from the Tehran Lipid and Glucose Study.

    abstract:BACKGROUND:There is growing evidence of the potential properties of nitrate-rich foods against development of hypertension (HTN) and vascular disease. In this study, we investigated the association of nitrate-containing vegetables (NCVs) with risk of HTN after 3 years of follow-up. METHODS:This prospective study was c...

    journal_title:Journal of nephrology

    pub_type: 杂志文章

    doi:10.1007/s40620-015-0229-6

    authors: Golzarand M,Bahadoran Z,Mirmiran P,Zadeh-Vakili A,Azizi F

    更新日期:2016-06-01 00:00:00

  • Nodular glomerulosclerosis in a non-diabetic patient: case report and review of literature.

    abstract::We report a unusual case of idiopathic nodular glomerulosclerosis mimicking changes that develop in diabetic nephropathy. A 66-year-old non-diabetic female developed nephrotic range proteinuria and the work up was unremarkable. Light and electron microscopy showed mesangial expansion with Kimmelsteil-Wilson nodules an...

    journal_title:Journal of nephrology

    pub_type: 杂志文章,评审

    doi:

    authors: Navaneethan SD,Singh S,Choudhry W

    更新日期:2005-09-01 00:00:00

  • Further insights about the beneficial effects of n-3 fatty acids in the early molecular events of renal fibrosis in vitro.

    abstract:BACKGROUND:Accumulating experimental and clinical evidence reveals beneficial effects of n-3 polyunsaturated fatty acids (PUFAs) in kidney disease by modulating inflammation and fibrosis mechanisms that lead to renal failure. METHODS:EPA, DHA (n-3 PUFAs) and AA (n-6 PUFA) effects, compared to those of AngII, on renal ...

    journal_title:Journal of nephrology

    pub_type: 杂志文章

    doi:10.5301/jn.5000193

    authors: Priante G,Musacchio E,Valvason C,Clari G,Bordin L,Sartori L,Baggio B

    更新日期:2013-07-01 00:00:00

  • Microarray applications in nephrology with special focus on transplantation.

    abstract::The increase in progressive kidney disease, rising numbers of patients with end-stage renal disease, organ shortages for kidney transplants and poor long-term graft survival rates underline the need for better strategies to diagnose, prevent and treat renal disease. Histological analysis, based on renal biopsies and r...

    journal_title:Journal of nephrology

    pub_type: 杂志文章,评审

    doi:10.5301/jn.5000205

    authors: Mueller TF,Mas VR

    更新日期:2012-09-01 00:00:00

  • Bioethics in nephrology: guidelines for decision-making in Italy.

    abstract::In 1998, the Italian Ministry of Health urged the Italian Society of Nephrology (SIN) to draft recommendations for uniform decision-making procedures in the field of dialysis. In accordance with the Ministry's specifications, at the time the Society approved diagnostic protocols regarding clinical questions, but witho...

    journal_title:Journal of nephrology

    pub_type: 指南,杂志文章,实务指引

    doi:

    authors: Buzzi F,Cecioni R,Di Paolo M,National Task Force for Bioethics in Nephrology.

    更新日期:2001-03-01 00:00:00

  • Many clinically silent access stenoses can be identified by ultrasonography.

    abstract:BACKGROUND:Stenoses of vascular accesses are leading factors limiting access survival. Besides physical examination, screening of access stenoses is based mainly on the "dysfunction hypothesis", which states that progressive stenosis causes graft dysfunction, such as decreased flow. We tested whether Doppler ultrasonog...

    journal_title:Journal of nephrology

    pub_type: 杂志文章

    doi:

    authors: Malik J,Slavikova M,Malikova H,Maskova J

    更新日期:2002-11-01 00:00:00

  • Posttransplant recurrence of atypical hemolytic uremic syndrome.

    abstract::Hemolytic uremic syndrome (HUS) is a rare disease characterized by microangiopathic hemolytic anemia, thrombocytopenia and acute renal failure. It is usually secondary to infections by strains of Escherichia coli (STEC) that produce Shiga-like toxin. In about 10% of patients, no STEC infections are reported. In these ...

    journal_title:Journal of nephrology

    pub_type: 杂志文章,评审

    doi:10.5301/jn.5000146

    authors: Valoti E,Alberti M,Noris M

    更新日期:2012-11-01 00:00:00

  • Renal transplantation and sleep: a new life is not enough.

    abstract::Renal transplantation is associated with better survival and improved quality of life compared to maintenance dialysis. Although many sleep disorders improve or even disappear after a successful transplantation, sleep quality remains low, and the prevalence of sleep complaints, although lower than in dialysis patients...

    journal_title:Journal of nephrology

    pub_type: 杂志文章

    doi:

    authors: Sabbatini M,Pisani A,Crispo A,Nappi R,Gallo R,Cianciaruso B,Federico S

    更新日期:2008-03-01 00:00:00

  • Peroxynitrite plays a key role in glomerular lesions in diabetic rats.

    abstract:BACKGROUND:Oxidative stress plays a crucial role in chronic complications of diabetes such as diabetic nephropathy (DN), the main cause of renal failure. In diabetes, whether peroxynitrite (ONOO(-)), generated from inducible nitric oxide synthase (iNOS) induced by tumor necrosis factor alpha (TNF-alpha), plays a primar...

    journal_title:Journal of nephrology

    pub_type: 杂志文章

    doi:

    authors: Xiao H,Li Y,Qi J,Wang H,Liu K

    更新日期:2009-11-01 00:00:00

  • Proteinase 3/myeloblastin as a growth factor in human kidney cells.

    abstract:BACKGROUND:Numerous data support the possible role of myeloblastin/proteinase 3 (PR3) in growth and differentiation of neutrophil granulocytes and certain monocyte subtypes. However, whether PR3 is expressed in non-myeloid cells remains a matter of debate even though recent studies clearly demonstrated its expression i...

    journal_title:Journal of nephrology

    pub_type: 杂志文章

    doi:

    authors: Relle M,Mayet WJ,Strand D,Brenner W,Galle PR,Schwarting A

    更新日期:2003-11-01 00:00:00

  • Urinary excretion of low molecular weight proteins in patients with pure monoclonal light chain proteinuria.

    abstract:BACKGROUND:Because urinary low molecular weight protein (LMWP) measurement shows changes in renal integrity at an early stage, beta2-microglobulin (B2m), retinol-binding protein (RBP) and alpha1-microglobulin (A1m) were evaluated in 24-hour urine collection of 65 patients with pure monoclonal light chain (MLC) proteinu...

    journal_title:Journal of nephrology

    pub_type: 杂志文章

    doi:

    authors: Madalena L,Facio ML,Angerosa M,Pandolfo M,Bresciani P,Alejandre M,Pizzolato M,Toblli JE

    更新日期:2007-11-01 00:00:00

  • Cardiorenal protective effect of the oral uremic toxin absorbent AST-120 in chronic heart disease patients with moderate CKD.

    abstract:BACKGROUND:The detailed mechanisms and treatment methods of chronic kidney disease (CKD) in patients with chronic heart failure (CHF) are not fully understood. We conducted a prospective study in CHF patients manifesting CKD to examine if AST-120 (Kremezin) improves cardiac and renal functions. METHODS:Twenty outpatie...

    journal_title:Journal of nephrology

    pub_type: 杂志文章

    doi:

    authors: Shibahara H,Shibahara N

    更新日期:2010-09-01 00:00:00

  • CKD complications in kidney-transplanted patients going back to dialysis: impact on patients outcomes.

    abstract:AIMS:The management of chronic kidney disease (CKD) complications is not always adequate in patients with a failed kidney transplant. We aimed to evaluate the frequency of CKD complications and assess whether they may lead to worse outcomes in this patient population. METHOD:We analyzed 49 kidney transplant recipients...

    journal_title:Journal of nephrology

    pub_type: 杂志文章,多中心研究

    doi:10.1007/s40620-017-0449-z

    authors: Aniort J,Kaysi S,Garrouste C,Abdelkader MH,Isnard M,Aguilera D,Ali Y,Bouiller M,Mulliez A,Heng AE

    更新日期:2018-02-01 00:00:00

  • Comparing the impact of older age on outcome in chronic kidney disease of different etiologies: a prospective cohort study.

    abstract:BACKGROUND:In older patients with chronic kidney disease (CKD), the risk of progression to end stage renal disease and cardiovascular death both differ compared to younger patients. This likely reflects differences in case mix and co-morbid burdens. We sought to establish the extent to which age itself is an independen...

    journal_title:Journal of nephrology

    pub_type: 杂志文章

    doi:10.1007/s40620-018-0529-8

    authors: Raman M,Green D,Middleton RJ,Kalra PA

    更新日期:2018-12-01 00:00:00

  • Looking at appearance of urine before performing a renal biopsy in nephrotic syndrome.

    abstract::Chyluria results from an abnormal connection between lymphatic bed and urinary tract, causing lymph leakage into the urine. The clinical picture often begins with the appearance of cloudy, milky urines accompanied by monolateral flank pain, malnutrition, weight loss and weakness. We report a case of chyluria that occu...

    journal_title:Journal of nephrology

    pub_type: 杂志文章

    doi:10.5301/JN.2011.8355

    authors: Graziani G,Cucchiari D,Verdesca S,Balzarini L,Montanelli A,Ponticelli C

    更新日期:2011-09-01 00:00:00

  • Health related quality of life (HRQOL) in the elderly on renal replacement therapy.

    abstract::Various opinions have been presented about the influence of age on the health-related quality of life (HRQOL) of patients on renal replacement therapy (RRT). Some authors sustain that age worsens HRQOL, while others show the opposite. It has been seen that a psychological adjustment occurs with aging, even when chroni...

    journal_title:Journal of nephrology

    pub_type: 杂志文章,评审

    doi:

    authors: Ortega F,Rebollo P

    更新日期:2002-05-01 00:00:00

  • Lipid abnormalities in the nephrotic syndrome: the therapeutic role of statins.

    abstract::Hyperlipidaemia complicating the nephrotic syndrome is characterised by elevated levels of total and LDL cholesterol, often with hypertriglyceridaemia and low HDL cholesterol levels. The underlying mechanisms are complex but involve abnormalities of both lipoprotein synthesis and catabolism. Experience to date suggest...

    journal_title:Journal of nephrology

    pub_type: 杂志文章,评审

    doi:

    authors: Wheeler DC

    更新日期:2001-11-01 00:00:00

  • Recurrent hemolytic uremic syndrome associated with intestinal lymphangiectasia.

    abstract::A 17-year-old boy was admitted to the hospital twice in a year for 2 episodes of hemolytic uremic syndrome (HUS). During these 2 HUS episodes he had diarrhea, decreased serum complement, decreased total protein and decreased serum albumin concentrations. We suggest that protein-losing enteropathy and hypocomplementemi...

    journal_title:Journal of nephrology

    pub_type: 杂志文章

    doi:

    authors: Kalman S,Bakkaloğlu S,Dalgiç B,Ozkaya O,Söylemezoğlu O,Buyan N

    更新日期:2007-03-01 00:00:00

  • Clinical manifestations of systemic paraphenylene diamine intoxication.

    abstract:BACKGROUND:To report clinical symptoms and outcome of systemic paraphenylene diamine (PPD) intoxication. METHODS:Our study was retrospective. It was conducted over 6 yrs (1994-2000) in the medical intensive care unit (ICU) of a university hospital and it concerned 19 patients hospitalized for systemic PPD intoxication...

    journal_title:Journal of nephrology

    pub_type: 杂志文章

    doi:

    authors: Kallel H,Chelly H,Dammak H,Bahloul M,Ksibi H,Hamida CB,Chaari A,Rekik N,De Broe ME,Bouaziz M

    更新日期:2005-05-01 00:00:00

  • Myocardial scintigraphy and clinical stratification as predictors of events in renal transplant candidates.

    abstract:BACKGROUND:We tested the hypothesis that the universal application of myocardial scanning with single-photon emission computed tomography (SPECT) would result in better risk stratification in renal transplant candidates (RTC) compared with SPECT being restricted to patients who, in addition to renal disease, had other ...

    journal_title:Journal of nephrology

    pub_type: 杂志文章

    doi:

    authors: Arantes RL,Gowdak LH,Paula FJ,Ianhez LE,Ramires JA,Krieger EM,De Lima JJ

    更新日期:2010-05-01 00:00:00

  • Wild-type uromodulin prevents NFkB activation in kidney cells, while mutant uromodulin, causing FJHU nephropathy, does not.

    abstract:BACKGROUND:Uromodulin (Tamm-Horsfall protein) is the most abundant urinary protein in healthy individuals. Despite 60 years of research, its physiological role remains rather elusive. Familial juvenile hyperuricemic nephropathy and medullary cystic kidney disease Type 2 are autosomal dominant tubulointerstitial nephrop...

    journal_title:Journal of nephrology

    pub_type: 杂志文章

    doi:10.1007/s40620-014-0079-7

    authors: Dinour D,Ganon L,Nomy LI,Ron R,Holtzman EJ

    更新日期:2014-06-01 00:00:00

  • Determinants and survival implications of low bone mineral density in end-stage renal disease patients.

    abstract:BACKGROUND:Reduced bone mineral density (BMD) is common in end-stage renal disease (ESRD) patients and predicts outcomes. The chronic kidney disease-mineral bone disorder contributes to low BMD in ESRD; however, the impact of classical risk factors for osteoporosis in the general population, such as body weight and fat...

    journal_title:Journal of nephrology

    pub_type: 杂志文章

    doi:10.5301/jn.5000185

    authors: Park SH,Jia T,Qureshi AR,Bárány P,Heimbürger O,Larsson TE,Axelsson J,Stenvinkel P,Lindholm B

    更新日期:2013-05-01 00:00:00