Abstract:
BACKGROUND:Lipid peroxidation (LPO) plays a role in glomerulonephritis pathogenesis. The role of LPO in IgA nephropathy (IgAN) and the effect of prostaglandin E1 on it, is not determined. METHODS:Levels of malondialdehyde (MDA), superoxide dismutase (SOD) and vitamin E (vitE) were measured in 42 patients with IgAN and in 31 healthy controls. Clinical nephropathy parameters such as daily proteinuria (DP), serum creatinine (Cr) and Cr clearance were obtained. Forty-two IgAN patients were divided into two subgroups according to renal pathology severity. Twenty-one patients with IgAN received lipo-prostaglandin E1 (PGE1) treatment and the other 21 patients received saline as a control. RESULTS:The serum activity of SOD and vitE in IgAN patients was significantly lower than in healthy controls, while the MDA level was higher in the patient groups. DP-related positively to MDA, while it related negatively to SOD and vitE. Cr clearance related negatively to MDA, while it related positively to SOD and vitE. In the moderate pathological group, the MDA level was significantly higher and the SOD activity was lower than in the mild pathological group. The MDA level in the PGE1 treated group was lower than in the control group, but the activity of SOD and vitE did not differ significantly from the control group. DP declined and Cr clearance increased in the PGE1 treated group, while no significant change in serum Cr was noted. CONCLUSIONS:LPO in IgAN was evident and was at least attributed to the decline in antioxidant ability. LPO could play a role in IgAN pathogenesis, and PGE1 is able to ameliorate the LPO in IgAN patients.
journal_name
J Nephroljournal_title
Journal of nephrologyauthors
Tian J,Chen JH,Li Q,He Q,Lin WQsubject
Has Abstractpub_date
2005-05-01 00:00:00pages
243-8issue
3eissn
1121-8428issn
1724-6059journal_volume
18pub_type
临床试验,杂志文章,随机对照试验abstract::In the general population, moderate exercise is associated with several health benefits including a decreased risk of obesity, coronary heart disease, stroke, certain types of cancer and all-cause mortality. In chronic kidney disease (CKD), physical inability is an independent risk of death. Health benefits of regular...
journal_title:Journal of nephrology
pub_type: 杂志文章,评审
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journal_title:Journal of nephrology
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abstract:BACKGROUND:Early initiation of therapy is warranted for patients with idiopathic membranous nephropathy (IMN) who have severe proteinuria. Therapy with tacrolimus (TAC) or intravenous cyclophosphamide (CYC) may be an option in treating such patients. METHODS:This prospective cohort study included patients with IMN who...
journal_title:Journal of nephrology
pub_type: 临床试验,杂志文章
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更新日期:2008-07-01 00:00:00
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journal_title:Journal of nephrology
pub_type: 杂志文章,多中心研究,随机对照试验
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journal_title:Journal of nephrology
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journal_title:Journal of nephrology
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journal_title:Journal of nephrology
pub_type: 杂志文章,评审
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journal_title:Journal of nephrology
pub_type: 杂志文章
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journal_title:Journal of nephrology
pub_type: 杂志文章
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更新日期:2015-06-01 00:00:00
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journal_title:Journal of nephrology
pub_type: 杂志文章
doi:
更新日期:2010-03-01 00:00:00
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journal_title:Journal of nephrology
pub_type: 杂志文章,评审
doi:
更新日期:2003-07-01 00:00:00
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journal_title:Journal of nephrology
pub_type: 杂志文章
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更新日期:2013-09-01 00:00:00
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journal_title:Journal of nephrology
pub_type: 杂志文章
doi:
更新日期:2005-01-01 00:00:00
abstract::End-stage renal disease (ESRD) is a significant global health problem that places a considerable burden on health care resources. The leading cause of death in ESRD patients is cardiovascular disease, which is often preceded by changes in cardiac geometry, including left ventricular hypertrophy (LVH). Treatments that ...
journal_title:Journal of nephrology
pub_type: 杂志文章,评审
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更新日期:2011-07-01 00:00:00
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pub_type: 杂志文章
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journal_title:Journal of nephrology
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pub_type: 杂志文章,评审
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journal_title:Journal of nephrology
pub_type: 杂志文章
doi:
更新日期:2004-07-01 00:00:00
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journal_title:Journal of nephrology
pub_type: 杂志文章
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更新日期:2013-03-01 00:00:00
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journal_title:Journal of nephrology
pub_type: 杂志文章
doi:
更新日期:2008-11-01 00:00:00
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journal_title:Journal of nephrology
pub_type: 杂志文章,评审
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journal_title:Journal of nephrology
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更新日期:2007-09-01 00:00:00
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