Abstract：
:Evidence-based medicine provides tools to evaluate dialysis outcomes by integrating knowledge obtained from interventional and observational studies. This is illustrated in relation to three important topics: dialysis membranes, dialysis dose and anemia. Clinical trials and observational evidence support each other in indicating a decrease in dialysis-related amyloidosis morbidity when high-flux dialysis is used, whereas the impact of dialysis membranes on mortality is still controversial. Two clinical trials are currently investigating this issue: the American Hemodialysis (HEMO) Study and the European Membrane Permeability and ESRD Patient Outcome (MPO) Study. As indicated by the National Cooperative Dialysis Study (NCDS), dialysis dose is an important determinant of patient outcome. Although Gotch's analysis of the NCDS showed no further benefits for Kt/V>0.9, the analysis by Keshaviah showed a progressive benefit as Kt/V increased beyond 0.9. This finding has been confirmed by observational studies, of which the Dialysis Outcome and Practice Patterns Study (DOPPS) is the most recent and interesting. Further information is also expected from the HEMO study. The findings of observational and interventional studies are consistent in indicating anemia as a major determinant of morbidity and mortality in dialysis patients. American and European guidelines advise hemoglobin levels of 11-12 g/dl and hematocrit levels of 33-36%. The real benefit of completely correcting anemia is not so clear. In conclusion, far from being in opposition, clinical trials and observational studies can provide an integrated contribution to the analysis of dialysis outcomes.
journal_name
J Nephroljournal_title
Journal of nephrologyauthors
Locatelli F,Andrulli S,D'Amico Msubject
Has Abstractpub_date
2001-11-01 00:00:00pages
S101-8eissn
1121-8428issn
1724-6059journal_volume
14 Suppl 4pub_type
杂志文章,评审abstract：BACKGROUND:The ongoing necessity for systemic heparinization is a well-known disadvantage of continuous renal replacement therapies (CRRT), and alternative methods of anticoagulation may be required. Our aim was to evaluate, in patients with a high risk of bleeding, the possibility of an acceptable filter life with non...
journal_title：Journal of nephrology
pub_type： 杂志文章
doi：
更新日期：2003-07-01 00:00:00
abstract：BACKGROUND:The endogenous inhibitor of nitric oxide synthase (NOS), asymmetric dimethylarginine (ADMA), is implicated in endothelial dysfunction and is a marker of renal disease progression and cardiovascular (CV) complications. Various cell species exhibit the enzymatic system that generates and degrades this methylar...
journal_title：Journal of nephrology
pub_type： 杂志文章
doi：
更新日期：2007-09-01 00:00:00
abstract：BACKGROUND:Drug-related problems (DRPs) are common in chronic kidney disease (CKD) patients. We developed a 2-step consultation including a clinical pharmacist (CP) session and a nephrologist conventional care consultation to explore the feasibility of a pilot drug-oriented disease management program in controlling iat...
journal_title：Journal of nephrology
pub_type： 杂志文章
doi：10.5301/jn.5000063
更新日期：2012-09-01 00:00:00
abstract：:The relevance of the Salerno Medical School is examined through the contributions of Magister Maurus, Alfano I, Giovanni Plateario, Giovanni Afflacio, Bartolomeo and Urso of Calabria. An unpublished treatise on De Urinis in middlelatin and Italian volgare is introduced here for the first time by discussing the lapis o...
journal_title：Journal of nephrology
pub_type： 历史文章,杂志文章
doi：
更新日期：2004-03-01 00:00:00
abstract：:We report the first documented case of X-linked chronic granulomatous disease (CGD) in association with IgA nephropathy in a 22 year old male with multiple soft tissue abscesses. The case highlights the potential role of staphylococcal infections in the pathogenesis of IgA nephropathy and suggests the hypothesis that ...
journal_title：Journal of nephrology
pub_type： 杂志文章
doi：
更新日期：2002-11-01 00:00:00
abstract：:It has been increasingly apparent that end-stage renal disease (ESRD) patients carry an inflammatory burden, which may play a pivotal role in the evolution of not only wasting but also of the massive increase in the relative risk of cardiovascular disease (CVD). Also increased oxidative stress (an impairment of the pr...
journal_title：Journal of nephrology
pub_type： 杂志文章,评审
doi：
更新日期：2004-11-01 00:00:00
abstract：:Hyperlipidaemia complicating the nephrotic syndrome is characterised by elevated levels of total and LDL cholesterol, often with hypertriglyceridaemia and low HDL cholesterol levels. The underlying mechanisms are complex but involve abnormalities of both lipoprotein synthesis and catabolism. Experience to date suggest...
journal_title：Journal of nephrology
pub_type： 杂志文章,评审
doi：
更新日期：2001-11-01 00:00:00
abstract：BACKGROUND:Numerous data support the possible role of myeloblastin/proteinase 3 (PR3) in growth and differentiation of neutrophil granulocytes and certain monocyte subtypes. However, whether PR3 is expressed in non-myeloid cells remains a matter of debate even though recent studies clearly demonstrated its expression i...
journal_title：Journal of nephrology
pub_type： 杂志文章
doi：
更新日期：2003-11-01 00:00:00
abstract：:Synthetic immunosuppressive drugs are largely used in immune-related renal diseases and in kidney transplantation. Most of these drugs have a low therapeutic index (the ratio that compares the blood concentration at which a drug becomes toxic and the concentration at which the drug is effective), which means that the ...
journal_title：Journal of nephrology
pub_type： 杂志文章,评审
doi：10.1007/s40620-019-00602-5
更新日期：2019-12-01 00:00:00
abstract：BACKGROUND:The recent multicenter, randomized, open-label INDEPENDENT study demonstrated that sevelamer improves survival in new to hemodialysis (HD) patients compared with calcium carbonate. The objective of this study was to determine the cost-effectiveness of sevelamer versus calcium carbonate for patients new to HD...
journal_title：Journal of nephrology
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1007/s40620-014-0122-8
更新日期：2015-10-01 00:00:00
abstract：:A 59 year-old woman showed rapidly progressive glomerulonephritis during immunotherapy for metastatic renal cell carcinoma. She received unilateral nephrectomy and cytotoxic T lymphocyte (CTL) therapy for the treatment of retroperitoneal lymph node metastasis of renal cell carcinoma. With CTL therapy, her retroperiton...
journal_title：Journal of nephrology
pub_type： 杂志文章
doi：
更新日期：2005-07-01 00:00:00
abstract：:To maintain divalent ion concentration within the body, a complex sensor has evolved to identify the changes in the extracellular environment and cause the surrounding cells to either secrete or absorb in response to change. An important member of these "sensors" is the calcium-sensing receptor (CaSR), which is consta...
journal_title：Journal of nephrology
pub_type： 杂志文章,评审
doi：
更新日期：2010-11-01 00:00:00
abstract：OBJECTIVE:It is uncertain whether increasing 25-hydroxyvitamin D (25-D) levels in chronic kidney disease (CKD) patients above those recommended by current guidelines result in progressive amelioration of secondary hyperparathyroidism. Our objective was to identify a potential therapeutic 25-D target which optimally low...
journal_title：Journal of nephrology
pub_type： 杂志文章,多中心研究
doi：10.1007/s40620-015-0186-0
更新日期：2016-02-01 00:00:00
abstract：BACKGROUND:Chronic renal failure (CRF) is associated with a tendency to atherosclerosis due to the enhanced oxidative stress and insufficient antioxidant enzyme activities such as superoxide dismutase (SOD), catalase (CAT) and paraoxonase (PON 1), together with abnormalities in lipid parameters. We determined the in vi...
journal_title：Journal of nephrology
pub_type： 杂志文章
doi：
更新日期：2002-03-01 00:00:00
abstract：:End-stage renal disease (ESRD) is a significant global health problem that places a considerable burden on health care resources. The leading cause of death in ESRD patients is cardiovascular disease, which is often preceded by changes in cardiac geometry, including left ventricular hypertrophy (LVH). Treatments that ...
journal_title：Journal of nephrology
pub_type： 杂志文章,评审
doi：10.5301/JN.2011.8422
更新日期：2011-07-01 00:00:00
abstract：:There is little doubt that molecular biological intervention therapy has come of age and its potential is arousing tremendous excitement. A gene transfer technique, the HVJ-liposome method, is now applicable as a tool for the dissection of molecular aspects in the pathophysiology of renal diseases, and for gene therap...
journal_title：Journal of nephrology
pub_type： 杂志文章,评审
doi：
更新日期：1998-01-01 00:00:00
abstract：:During peritoneal dialysis (PD), peritoneal mesothelial cells undergo a transition from an epithelial phenotype to a mesenchymal phenotype that, together with the inflammatory process, promotes tissue fibrosis and a failure of peritoneal membrane function. To date, there is no definitive treatment for the progressive ...
journal_title：Journal of nephrology
pub_type： 杂志文章
doi：10.1007/s40620-016-0368-4
更新日期：2017-12-01 00:00:00
abstract：:A symposium on kidney stones and mineral metabolism held on December 2017 in Brussels, Belgium was the first international multidisciplinary conference of the International Collaborative Network on Kidney Stones and Mineral Metabolism. This meeting addressed epidemiology, underlying pathophysiological mechanisms, gene...
journal_title：Journal of nephrology
pub_type：
doi：10.1007/s40620-019-00587-1
更新日期：2019-10-01 00:00:00
abstract：BACKGROUND:Previous in vitro experiments of human polycystic kidney disease (PKD) cells reported that caffeine is a risk factor for the promotion of cyst enlargement in patients with autosomal dominant PKD (ADPKD). The relentless progression of ADPKD inclines the majority of physicians to advocate minimization of caffe...
journal_title：Journal of nephrology
pub_type： 杂志文章
doi：10.1007/s40620-017-0396-8
更新日期：2018-02-01 00:00:00
abstract：AIMS:This joint document of the Italian Diabetes Society and the Italian Society of Nephrology reviews the natural history of diabetic kidney disease (DKD) in the light of the recent epidemiological literature and provides updated recommendations on anti-hyperglycemic treatment with non-insulin agents. DATA SYNTHESIS:...
journal_title：Journal of nephrology
pub_type： 杂志文章,评审
doi：10.1007/s40620-019-00650-x
更新日期：2020-02-01 00:00:00
abstract：:Cell-to-cell signal exchange during antigen presentation deeply influences the profile and extent of the immune response. Together with the TCR/MHC-mediated signal, accessory signals are provided to the T cell by the antigen-presenting cell (APC), through specific receptor-ligand interactions that represent indispensa...
journal_title：Journal of nephrology
pub_type： 杂志文章,评审
doi：
更新日期：2002-01-01 00:00:00
abstract：INTRODUCTION:Mutations of the AGXT gene encoding the alanine:glyoxylate aminotransferase liver enzyme (AGT) cause primary hyperoxaluria type 1 (PH1). Here we report a molecular modeling study of selected missense AGXT mutations: the common Gly170Arg and the recently described Gly47Arg and Ser81Leu variants, predicted t...
journal_title：Journal of nephrology
pub_type： 杂志文章
doi：
更新日期：2010-11-01 00:00:00
abstract：:The collecting duct is responsible for the final secretion or reabsorption of protons and bicarbonate, respectively. Approximately 2% of the total filtered bicarbonate is reabsorbed in this segment. At least two different types of cells are involved in the transport of protons and bicarbonate, namely, type A and B int...
journal_title：Journal of nephrology
pub_type： 杂志文章,评审
doi：
更新日期：2002-03-01 00:00:00
abstract：:The origin of the Teutonic Order of Hospitalers St. Mary (Ordo Hospitalis S. Mariae Teutonicorum Hi-erosolymitani) is presented. The St. Mary Hospitaler Teutonic Order arrived in the XIIIth century to Pomezania, then inhabited by pagan Prussian tribes. The Knights of the Order started to Christianize the Prussians, th...
journal_title：Journal of nephrology
pub_type： 历史文章,杂志文章
doi：
更新日期：2006-05-01 00:00:00
abstract：:Various opinions have been presented about the influence of age on the health-related quality of life (HRQOL) of patients on renal replacement therapy (RRT). Some authors sustain that age worsens HRQOL, while others show the opposite. It has been seen that a psychological adjustment occurs with aging, even when chroni...
journal_title：Journal of nephrology
pub_type： 杂志文章,评审
doi：
更新日期：2002-05-01 00:00:00
abstract：:The term thin glomerular basement membrane disease (TBMD) refers to a condition characterised by thinning of the GBM at electron microscopy examination and, clinically, by isolated hematuria, frequently occurring in other family members, with no extra-renal manifestations. Progression towards chronic renal failure (CR...
journal_title：Journal of nephrology
pub_type： 杂志文章,评审
doi：
更新日期：2000-01-01 00:00:00
abstract：BACKGROUND:In the general population and in hemodialysis patients epicardial adipose tissue (EAT) has been associated with increased mortality and cardiovascular events. Weight loss and lipid lowering therapies reduced EAT in the general population. It is unknown whether sevelamer, a phosphate (Pi) binder that lowers c...
journal_title：Journal of nephrology
pub_type： 杂志文章,随机对照试验
doi：10.1007/s40620-016-0310-9
更新日期：2016-10-01 00:00:00
abstract：BACKGROUND:Causes of hypertension and cardiac hypertrophy in hemodialysis (HD) patients are multiple, but the role of fluid overload appears to be crucial. Short daily HD (sDHD = 2 hr x 6/week) seems to allow reductions in left ventricular mass (LVM) through the reduction of extracellular water (ECW). Better cardiovasc...
journal_title：Journal of nephrology
pub_type： 杂志文章
doi：
更新日期：2006-01-01 00:00:00
abstract：:Epicardial adipose tissue (EAT) is localized between the myocardial surface and visceral layer of the pericardium. It is a metabolically active organ that secretes several cytokines which modulate cardiovascular morphology and function. EAT may interact locally with coronary arteries through paracrine secretion mechan...
journal_title：Journal of nephrology
pub_type： 杂志文章,评审
doi：10.1007/s40620-018-0491-5
更新日期：2018-12-01 00:00:00
abstract：:The kidney maintains systemic acid-base homeostasis through proximal tubular reclamation of filtered bicarbonate, and excretion of the daily mineral acid load by collecting duct type A intercalated cells. Impairment of either process produces renal tubular acidosis (RTA). This article will provide an overview of famil...
journal_title：Journal of nephrology
pub_type： 杂志文章,评审
doi：
更新日期：2010-11-01 00:00:00
