The calcium-sensing receptor.

Abstract:

:To maintain divalent ion concentration within the body, a complex sensor has evolved to identify the changes in the extracellular environment and cause the surrounding cells to either secrete or absorb in response to change. An important member of these "sensors" is the calcium-sensing receptor (CaSR), which is constantly monitoring the extracellular environment for changes in salinity, pH, calcium, amino acids and polyamines. The kidney plays a very important role in monitoring both salinity and also water concentration of the presented filtered load. Recent studies have shown that the CaSR is expressed along the nephron and can play an important role in both calcium and salt absorption, and also in the handling of water in the thick ascending limb. This review will outline the basic physiology of the receptor and will then go on to discuss some of the roles that the receptor plays in the various nephron segments. It will conclude with a brief section on future directions and how specific renal receptor-targeted drugs may provide an effective means to regulate both ionic absorption and water balance.

journal_name

J Nephrol

journal_title

Journal of nephrology

authors

Geibel JP

subject

Has Abstract

pub_date

2010-11-01 00:00:00

pages

S130-5

eissn

1121-8428

issn

1724-6059

pii

992EC5A8-6ECD-4F53-87BC-833317FA53A7

journal_volume

23 Suppl 16

pub_type

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