Abstract：
BACKGROUND:The G-1082A polymorphism of the interleukin-10 (IL-10) gene has been associated with modified gene expression and the progression of primary IgA nephropathy (IgAN). In the present study, we evaluated its influence on recurrent IgAN after renal transplantation. METHODS:We studied 103 patients who suffered from IgAN and underwent renal transplantation, followed up for 5.8 -/+ 3.4 years. A cohort of 206 matched renal allograft recipients with other primary diseases was analyzed as a control group. IL-10 gene G-1082A polymorphism was determined by PCR amplification. RESULTS:Microscopic hematuria and/or proteinuria of more than 500 mg/24 hours occurred in 22 patients (21%). Histological confirmation of IgAN recurrence was obtained in 16 patients. Young recipient age was associated with biopsy-proven IgAN recurrence in the Kaplan-Meier analysis of recurrence-free survival (p=0.05). The presence of IgAN recurrence had no impact on graft survival (not significant [NS]). Furthermore, graft survival was similar in patients with IgAN and patients with other primary diseases (NS). The IL-10 GG genotype was associated with a higher recurrence rate in the Kaplan-Meier analysis of recurrence-free survival (p<0.05). CONCLUSIONS:IgAN recurrence is a common complication, especially in younger renal transplant recipients. IL-10 gene G-1082A polymorphism was associated with an increased recurrence rate.
journal_name
J Nephroljournal_title
Journal of nephrologyauthors
Bantis C,Heering PJ,Aker S,Schwandt C,Grabensee B,Ivens Ksubject
Has Abstractpub_date
2008-11-01 00:00:00pages
941-6issue
6eissn
1121-8428issn
1724-6059journal_volume
21pub_type
杂志文章abstract：INTRODUCTION:Several studies have suggested an effect of calcineurin inhibitors on arterial compliance in kidney transplant recipients. We aimed to investigate whether the type of calcineurin inhibitor influences large and small artery compliance in these patients independently of other determinants. METHODS:Patients ...
journal_title：Journal of nephrology
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pub_type： 杂志文章,多中心研究,随机对照试验
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journal_title：Journal of nephrology
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journal_title：Journal of nephrology
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更新日期：2005-01-01 00:00:00
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pub_type： 临床试验,杂志文章
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journal_title：Journal of nephrology
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更新日期：2002-09-01 00:00:00
