Abstract：
BACKGROUND:The detailed mechanisms and treatment methods of chronic kidney disease (CKD) in patients with chronic heart failure (CHF) are not fully understood. We conducted a prospective study in CHF patients manifesting CKD to examine if AST-120 (Kremezin) improves cardiac and renal functions. METHODS:Twenty outpatients with CHF manifesting moderate CKD (serum creatinine 1.3-2.0 mg/dL) were studied. The patients had received AST-120 at a dosage of 6 g/day in combination with existing medications for 24 months. Some parameters of kidney and heart function were monitored. Also the cumulative length of hospital stay and number of admissions for the 2-year periods before and after initiation of AST-120 treatment were calculated. RESULTS:Results of renal function tests, atrial natriuretic peptide, edema, cardiothoracic ratio and hospital stay indicated significant improvements in patients treated with AST-120. The length of hospital stay and number of admissions both decreased significantly during the 2 years of AST-120 treatment compared with the 2 years before treatment, from 39.7 ± 12.9 days to 4.14 ± 2.5 days, and from 0.79 ± 0.21 admissions to 0.21 ± 0.11 admissions, respectively. CONCLUSIONS:AST-120 contributes to the improvement of cardiac and renal functions, and consequently improves the quality of life of patients.
journal_name
J Nephroljournal_title
Journal of nephrologyauthors
Shibahara H,Shibahara Nsubject
Has Abstractpub_date
2010-09-01 00:00:00pages
535-40issue
5eissn
1121-8428issn
1724-6059pii
D4839912-820E-4874-9BD4-8F780F94E9A9journal_volume
23pub_type
杂志文章abstract：:Organ transplantation has proven to be an effective therapeutic for a wide variety of disease states, but the chronic immunosuppression required for allograft survival increases the risk for infection and neoplasia. In the past 50 years, a wealth of experimental data has been accumulated relating to strategies to pres...
journal_title：Journal of nephrology
pub_type： 杂志文章,评审
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更新日期：2010-05-01 00:00:00
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pub_type： 社论,评审
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abstract：BACKGROUND:In end-stage renal disease (ESRD) patients on hemodialysis (HD) there may be a link between oxidative stress, genomic damage and the tendency of peripheral lymphocytes to die by apoptosis. Our aim was to verify this hypothesis, and to ascertain whether the link, if present, could explain lymphopenia in uremi...
journal_title：Journal of nephrology
pub_type： 杂志文章
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更新日期：2006-09-01 00:00:00
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journal_title：Journal of nephrology
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journal_title：Journal of nephrology
pub_type： 杂志文章,评审
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journal_title：Journal of nephrology
pub_type： 杂志文章,多中心研究
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journal_title：Journal of nephrology
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更新日期：2008-05-01 00:00:00
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journal_title：Journal of nephrology
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更新日期：2003-01-01 00:00:00
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journal_title：Journal of nephrology
pub_type： 杂志文章,随机对照试验
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journal_title：Journal of nephrology
pub_type： 杂志文章,评审
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journal_title：Journal of nephrology
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doi：10.1007/s40620-017-0461-3
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journal_title：Journal of nephrology
pub_type： 杂志文章,评审
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journal_title：Journal of nephrology
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更新日期：1998-11-01 00:00:00
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journal_title：Journal of nephrology
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journal_title：Journal of nephrology
pub_type： 杂志文章,评审
doi：
更新日期：2002-07-01 00:00:00
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doi：
更新日期：2002-05-01 00:00:00
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journal_title：Journal of nephrology
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更新日期：2000-03-01 00:00:00
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journal_title：Journal of nephrology
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更新日期：2009-03-01 00:00:00
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journal_title：Journal of nephrology
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