Abstract:
BACKGROUND:Accumulating experimental and clinical evidence reveals beneficial effects of n-3 polyunsaturated fatty acids (PUFAs) in kidney disease by modulating inflammation and fibrosis mechanisms that lead to renal failure. METHODS:EPA, DHA (n-3 PUFAs) and AA (n-6 PUFA) effects, compared to those of AngII, on renal fibrotic processes at the extracellular matrix (ECM) level were verified in human mesangial cells in vitro, by means of RT-PCR, mitogenic assay and Western-blot analysis. RESULTS:Unlike AngII, EPA and DHA enhanced the expression of MMP2 and DN, a TGFbeta inhibitor, while decreasing mitogenic factors such as PDGF and bFGF, and cell proliferation. Moreover, n-3 PUFAs elicited Bax expression in AngII-treated cells and downregulated COX-2--an enzyme involved in the inflammatory cascade. The mechanism of action could implicate PPARgamma activation, as this transcription factor was shown to translocate to the nucleus upon n-3 PUFA treatment. CONCLUSIONS:These results complement our previous reports demonstrating that EPA and DHA prevent ECM accumulation and inflammation that typify the fibrotic process, providing new insights into the cellular and molecular mechanisms underlying their beneficial effects. We confirm that n-3 PUFAs could effectively counteract kidney fibrosis development providing a rationale for their use in clinical settings.
journal_name
J Nephroljournal_title
Journal of nephrologyauthors
Priante G,Musacchio E,Valvason C,Clari G,Bordin L,Sartori L,Baggio Bdoi
10.5301/jn.5000193subject
Has Abstractpub_date
2013-07-01 00:00:00pages
652-9issue
4eissn
1121-8428issn
1724-6059pii
01D2D4AC-F966-4514-95C9-B96085C64334journal_volume
26pub_type
杂志文章abstract::Patients with chronic kidney disease (CKD) have a greatly enhanced risk of cardiovascular morbidity and mortality. Over the past decade it has come clear that a disturbed calcium-phosphate metabolism, with Fibroblast Growth Factor-23 as a key hormone, is partly accountable for this enhanced risk. Numerous studies have...
journal_title:Journal of nephrology
pub_type: 杂志文章,评审
doi:10.1007/s40620-020-00715-2
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journal_title:Journal of nephrology
pub_type: 杂志文章,随机对照试验
doi:
更新日期:2006-11-01 00:00:00
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journal_title:Journal of nephrology
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abstract::Aim of the study was the definition of a predictive model for the initial diagnosis of thrombotic microangiopathies (TMA). We retrospectively collected data on all adult patients admitted to the Gemelli Hospital from 2010 to 2014. ICD-9 codes from primary diagnoses were used for TMA diagnosis. Demographic and laborato...
journal_title:Journal of nephrology
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doi:10.1007/s40620-018-0468-4
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abstract::Modern nephrology developed in Poland mostly from the internal medicine department chaired in Warsaw by the great internist prof. Witold Orłowski (1874-1966). Three of his pupils Tadeusz Orłowski, Jan Roguski and Jakub Penson independently established the foundations of clinical nephrology and renal replacement therap...
journal_title:Journal of nephrology
pub_type: 历史文章,杂志文章
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更新日期:2006-05-01 00:00:00
abstract:BACKGROUND:Recently, some studies have emphasized the role of plasma 25-(OH)vitamin D (25OHD) levels in mineral metabolism dysregulation in chronic kidney diseases (CKDs). However, to date little attention has been paid to 25OHD metabolism abnormalities after renal transplantation (Tx). This cross-sectional study aimed...
journal_title:Journal of nephrology
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doi:
更新日期:2005-01-01 00:00:00
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journal_title:Journal of nephrology
pub_type: 杂志文章,评审
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abstract:BACKGROUND:There have been many studies in recent years concerning the role of nitric oxide (NO) in acute renal failure (ARF). In this study, the effects of the inhibition or the induction of NO synthase (NOS) on gentamicin-induced ARF was investigated in isolated perfused rat kidneys. METHODS:Kidneys from male Spragu...
journal_title:Journal of nephrology
pub_type: 杂志文章
doi:
更新日期:2005-09-01 00:00:00
abstract::Calciphylaxis, or calcific uremic arteriolopathy, is a vascular ossification-calcification disease involving cutaneous or visceral arterioles, with ischemic damage of the surrounding tissues, usually in the setting of chronic kidney disease. Pathogenesis is still unclear and probably comprises the participation of vas...
journal_title:Journal of nephrology
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journal_title:Journal of nephrology
pub_type: 杂志文章,多中心研究,随机对照试验
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journal_title:Journal of nephrology
pub_type: 杂志文章
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abstract:OBJECTIVE:Chronic kidney disease (CKD) pregnancies are at high risk of developing adverse outcomes. In non-pregnant subjects with CKD, higher urinary IgM levels are associated with poor renal survival and higher rates of cardiovascular deaths. In this study, we assessed whether urinary IgM levels are associated with an...
journal_title:Journal of nephrology
pub_type: 杂志文章
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journal_title:Journal of nephrology
pub_type: 杂志文章
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journal_title:Journal of nephrology
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更新日期:2016-02-01 00:00:00
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doi:
更新日期:2004-11-01 00:00:00
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journal_title:Journal of nephrology
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更新日期:2000-11-01 00:00:00
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journal_title:Journal of nephrology
pub_type: 杂志文章,评审
doi:10.5301/jn.5000092
更新日期:2012-09-01 00:00:00
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journal_title:Journal of nephrology
pub_type: 杂志文章,评审
doi:
更新日期:2009-07-01 00:00:00
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journal_title:Journal of nephrology
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pub_type: 临床试验,杂志文章
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journal_title:Journal of nephrology
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doi:
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更新日期:2008-03-01 00:00:00
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更新日期:2021-01-18 00:00:00
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journal_title:Journal of nephrology
pub_type: 杂志文章,实务指引,评审
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更新日期:2017-06-01 00:00:00
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journal_title:Journal of nephrology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:
更新日期:2009-03-01 00:00:00
abstract::The widely differing functions of vitamin D are based both on a wide diffusion of its specific receptor (VDR) and on the ability of many cells, in addition to renal tubular cells, to synthesize calcitriol for autocrine and paracrine functions. In the last few years, many published studies have added new insights into ...
journal_title:Journal of nephrology
pub_type: 杂志文章,评审
doi:10.5301/JN.2011.7767
更新日期:2011-05-01 00:00:00
abstract::A 17-year-old boy was admitted to the hospital twice in a year for 2 episodes of hemolytic uremic syndrome (HUS). During these 2 HUS episodes he had diarrhea, decreased serum complement, decreased total protein and decreased serum albumin concentrations. We suggest that protein-losing enteropathy and hypocomplementemi...
journal_title:Journal of nephrology
pub_type: 杂志文章
doi:
更新日期:2007-03-01 00:00:00
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journal_title:Journal of nephrology
pub_type: 杂志文章,评审
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更新日期:2000-05-01 00:00:00
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journal_title:Journal of nephrology
pub_type: 杂志文章
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