Abstract:
BACKGROUND:Removal of anti-glomerular basement membrane (anti-GBM) antibody by extracorporeal treatment including plasmapheresis or immunoadsorption (IA) has been considered an effective method in the treatment of Goodpasture's syndrome. In this study, we investigated the effect of IA on serum anti-GBM level and evaluated its clinical efficacy in patients with Goodpasture's syndrome. METHODS:Four patients with Goodpasture's syndrome were enrolled in this study. All patients presented with severe renal failure and needed hemodialysis. They were treated with staphylococcal protein A IA, together with intravenous pulse methylprednisolone therapy and mycophenolate mofetil (n=3) or intermittent intravenous cyclophosphamide (n=1). IA was administered for 10 cycles per session and 8-10 sessions as a course; a total of 30-60 L of plasma was regenerated in each course. RESULTS:Serum anti-GBM antibody level decreased to the normal range in 3 patients after 1 course of IA treatment and remained negative in 2 patients who were followed up for 4 months. In the other patient, serum anti-GBM antibody level decreased by 62.8% after the first course of IA treatment and decreased to the normal range after the second course of IA. Rebound of serum anti-GBM was found in all patients during the first 3 to 4 IA sessions. Pulmonary hemorrhage resolved in all patients, including 1 patient who was unresponsive to methylprednisolone pulse therapy. One of the 4 patients who required initial hemodialysis on admission could stop hemodialysis after IA, and the other 3 patients who had 100% glomerular crescents were on maintenance hemodialysis. CONCLUSIONS:IA could remove serum anti-GBM antibody and resolve pulmonary hemorrhage effectively; the efficacy of IA in improving renal function is markedly determined by the severity of renal damage.
journal_name
J Nephroljournal_title
Journal of nephrologyauthors
Hu W,Liu Z,Ji D,Xie H,Gong D,Li Lsubject
Has Abstractpub_date
2006-05-01 00:00:00pages
312-7issue
3eissn
1121-8428issn
1724-6059journal_volume
19pub_type
杂志文章abstract::Ferumoxytol is a new product approved for intravenous use by the US Food and Drug Administration (FDA) in the treatment of iron deficiency anemia in adults with chronic kidney disease. This approval was based on data from 3 open-label, randomized, controlled clinical trials. In all of these trials, ferumoxytol was wel...
journal_title:Journal of nephrology
pub_type: 杂志文章,评审
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更新日期:2011-11-01 00:00:00
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journal_title:Journal of nephrology
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journal_title:Journal of nephrology
pub_type: 临床试验,杂志文章
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journal_title:Journal of nephrology
pub_type: 指南,杂志文章,实务指引
doi:
更新日期:2001-03-01 00:00:00
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journal_title:Journal of nephrology
pub_type: 杂志文章,评审
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journal_title:Journal of nephrology
pub_type: 杂志文章
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journal_title:Journal of nephrology
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:2005-05-01 00:00:00
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journal_title:Journal of nephrology
pub_type: 杂志文章
doi:
更新日期:2000-03-01 00:00:00
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journal_title:Journal of nephrology
pub_type: 杂志文章
doi:
更新日期:2005-03-01 00:00:00
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journal_title:Journal of nephrology
pub_type: 杂志文章,评审
doi:
更新日期:2008-09-01 00:00:00
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journal_title:Journal of nephrology
pub_type: 杂志文章
doi:
更新日期:2001-01-01 00:00:00
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journal_title:Journal of nephrology
pub_type: 杂志文章
doi:
更新日期:2010-05-01 00:00:00
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journal_title:Journal of nephrology
pub_type: 杂志文章,评审
doi:
更新日期:2002-07-01 00:00:00
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journal_title:Journal of nephrology
pub_type: 杂志文章
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journal_title:Journal of nephrology
pub_type: 杂志文章,评审
doi:
更新日期:2000-05-01 00:00:00
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journal_title:Journal of nephrology
pub_type: 杂志文章
doi:
更新日期:2005-05-01 00:00:00
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journal_title:Journal of nephrology
pub_type: 杂志文章,评审
doi:
更新日期:1999-09-01 00:00:00
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journal_title:Journal of nephrology
pub_type: 传,历史文章,杂志文章
doi:
更新日期:2006-05-01 00:00:00
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journal_title:Journal of nephrology
pub_type: 杂志文章
doi:
更新日期:2005-11-01 00:00:00
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journal_title:Journal of nephrology
pub_type: 社论,评审
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journal_title:Journal of nephrology
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doi:
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journal_title:Journal of nephrology
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更新日期:2010-11-01 00:00:00
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journal_title:Journal of nephrology
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更新日期:2010-11-01 00:00:00
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journal_title:Journal of nephrology
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更新日期:2004-03-01 00:00:00
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journal_title:Journal of nephrology
pub_type: 杂志文章,评审
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更新日期:2013-11-01 00:00:00
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pub_type: 杂志文章
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更新日期:2019-04-01 00:00:00
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journal_title:Journal of nephrology
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