Na+:HCO3- cotransporters (NBC): expression and regulation in the kidney.

abstract：:Cardiovascular disease is the leading cause of the poor long-term survival of patients with chronic kidney disease (CKD). Anemia, which is a frequent and early complication of CKD, not only impairs patients' quality of life, but also is an independent risk factor for adverse cardiovascular outcomes. This may be due to...

journal_title：Journal of nephrology

authors： Locatelli F,Del Vecchio L,Pozzoni P

更新日期：2007-11-01 00:00:00

abstract：:Given the alarming predictions of the potentially devastating future epidemic of end-stage renal disease (ESRD), further knowledge is still urgently needed on this topic. The real dimensions of the problem are still unclear. It is difficult to compare Europe and the USA because different criteria are used in data coll...

journal_title：Journal of nephrology

authors： Gambaro G,D'Angelo A,Conte M,Bonfante L,De Biase V,Lupo A

更新日期：2005-03-01 00:00:00

abstract：:Appropriate timing of starting chronic dialysis in patients with advanced chronic kidney disease (CKD) under nephrology care still is undefined. We systematically reviewed the most recent studies that have compared outcomes of stage 5-CKD under conservative versus substitutive treatment. Eleven studies, most in elderl...

journal_title：Journal of nephrology

authors： Pacilio M,Minutolo R,Garofalo C,Liberti ME,Conte G,De Nicola L

更新日期：2016-04-01 00:00:00

abstract：BACKGROUND:Uromodulin (Tamm-Horsfall protein) is the most abundant urinary protein in healthy individuals. Despite 60 years of research, its physiological role remains rather elusive. Familial juvenile hyperuricemic nephropathy and medullary cystic kidney disease Type 2 are autosomal dominant tubulointerstitial nephrop...

journal_title：Journal of nephrology

authors： Dinour D,Ganon L,Nomy LI,Ron R,Holtzman EJ

更新日期：2014-06-01 00:00:00

abstract：BACKGROUND:The detailed mechanisms and treatment methods of chronic kidney disease (CKD) in patients with chronic heart failure (CHF) are not fully understood. We conducted a prospective study in CHF patients manifesting CKD to examine if AST-120 (Kremezin) improves cardiac and renal functions. METHODS:Twenty outpatie...

journal_title：Journal of nephrology

authors： Shibahara H,Shibahara N

更新日期：2010-09-01 00:00:00

abstract：:Dynamic progress in the basic sciences such as clinical chemistry exerted a great influence on the development of clinical science in medicine in the 19th century. We should rate Prof. Leon Marchlewski among the group of prominent foreign and Polish scientists working in that period. Marchlewski was born in 1869 in Wl...

journal_title：Journal of nephrology

authors： Ostrowski J,Muszytowski M,Rutkowski B

更新日期：2011-05-01 00:00:00

abstract：BACKGROUND:Accumulating experimental and clinical evidence reveals beneficial effects of n-3 polyunsaturated fatty acids (PUFAs) in kidney disease by modulating inflammation and fibrosis mechanisms that lead to renal failure. METHODS:EPA, DHA (n-3 PUFAs) and AA (n-6 PUFA) effects, compared to those of AngII, on renal ...

journal_title：Journal of nephrology

authors： Priante G,Musacchio E,Valvason C,Clari G,Bordin L,Sartori L,Baggio B

更新日期：2013-07-01 00:00:00

abstract：BACKGROUND:The risks connected with dialysis fluid contamination are well established. Epidemiological studies have demonstrated just how difficult it is to obtain permanently satisfactory quality standards. Therefore, dialysis centers must have effective and regular quality control programs, particularly with the grow...

journal_title：Journal of nephrology

authors： Pizzarelli F,Cerrai T,Biagini M,Malaguti M,Bargagna R

更新日期：2004-07-01 00:00:00

abstract：:Sarcoidosis is a multisystem disorder of unknown etiology, which may occur in all tissues and organs of the body. Clinical presentation may be quite variable and affected by race. The most commonly affected system is the lungs with >95% of patients displaying such involvement. Renal involvement is uncommon (<2%) and m...

journal_title：Journal of nephrology

authors： Carmichael P,O'Donnell JP

更新日期：2003-09-01 00:00:00

abstract：BACKGROUND:Atypical haemolytic uremic syndrome (aHUS) is at high risk of relapse at any time, therefore patients require lifelong monitoring. The most appropriate way to monitor patients is not yet clear. Patients could be monitored for relapse by urine dipstick testing for haemoglobinuria based on the hypothesis that ...

journal_title：Journal of nephrology

authors： Brambilla M,Ardissino G,Paglialonga F,Testa S,Capone V,Montini G

更新日期：2021-01-18 00:00:00

abstract：AIM:The objective of this study was to determine whether the baseline estimated glomerular filtration rate (eGFR) level was independently associated with in-hospital mortality in generalized patients with hospital-acquired acute kidney injury (HA-AKI) in China. METHODS:All of the patients admitted to a tertiary medica...

journal_title：Journal of nephrology

authors： Han YC,Tu Y,Liu H,Pan MM,Tang RN,Liu BC

更新日期：2016-06-01 00:00:00

abstract：BACKGROUND:Gut-derived uremic toxins have been associated with adverse outcomes in chronic kidney disease (CKD). Alterations in bowel habits, including constipation, seem to play an additional role in uremic toxicity. The aim of this study is to investigate the association of bowel habits with gut-derived uremic toxins...

journal_title：Journal of nephrology

authors： Pereira NBF,Ramos CI,de Andrade LS,Teixeira RR,Nakao LS,Rodrigues SD,de Lima JD,Dalboni MA,Cuppari L

更新日期：2020-10-01 00:00:00

abstract：:Marcello Malpighi was born in Crevalcore on March 10, 1628 and died in Rome on July 25, 1694. In Bologna he had among his opponents Giovanni Gerolamo Sbaraglia and Paoli Mini who prevented him being appointed to the chair of anatomy. This paper describes the reasons for this long term debate. ...

journal_title：Journal of nephrology

authors： Campieri C,Persici E,Stefoni S

更新日期：2004-07-01 00:00:00

abstract：:Autosomal recessive and autosomal dominant polycystic kidney disease (ADPKD and ARPKD) are 2 major variants of inherited diseases leading to the cystic degeneration of the kidney and other organs. Primary cilia have moved into the focus of research as it is becoming increasingly clear that dysfunction of this special ...

journal_title：Journal of nephrology

authors： Wagner CA

更新日期：2008-01-01 00:00:00

abstract：INTRODUCTION:Mutations of the AGXT gene encoding the alanine:glyoxylate aminotransferase liver enzyme (AGT) cause primary hyperoxaluria type 1 (PH1). Here we report a molecular modeling study of selected missense AGXT mutations: the common Gly170Arg and the recently described Gly47Arg and Ser81Leu variants, predicted t...

journal_title：Journal of nephrology

authors： Robbiano A,Frecer V,Miertus J,Zadro C,Ulivi S,Bevilacqua E,Mandrile G,De Marchi M,Miertus S,Amoroso A

更新日期：2010-11-01 00:00:00

abstract：BACKGROUND AND AIMS:It has been well documented that gene and DNA alterations occur frequently in benign primary parathyroid adenomas as well as in parathyroid glands with secondary hyperplasia. However, it has not been shown whether a correlation exists between somatic DNA aberrations and clinical data. METHODS:We an...

journal_title：Journal of nephrology

authors： Chudek J,Nagy A,Kokot F,Podwinski A,Wiecek A,Ritz E,Kovacs G

更新日期：2007-03-01 00:00:00

abstract：BACKGROUND:Targeted screening interventions for chronic kidney disease (CKD) are increasingly being implemented in various community settings. However, the overall success of these programs is uncertain. Therefore, the aim of this review is to determine whether targeted screening is effective in detecting people with u...

journal_title：Journal of nephrology

authors： Gheewala PA,Zaidi STR,Jose MD,Bereznicki L,Peterson GM,Castelino RL

更新日期：2018-02-01 00:00:00

abstract：:Survival analysis is the statistical method for studying the time between entry to a study and a subsequent event. Survival is often the most important outcome in both observational and intervention studies. The analysis of survival, however, is not simple because of a number of factors. The time between entry to a st...

journal_title：Journal of nephrology

authors： Khan IH,Prescott GJ

更新日期：2004-03-01 00:00:00

abstract：:The widely differing functions of vitamin D are based both on a wide diffusion of its specific receptor (VDR) and on the ability of many cells, in addition to renal tubular cells, to synthesize calcitriol for autocrine and paracrine functions. In the last few years, many published studies have added new insights into ...

journal_title：Journal of nephrology

authors： Messa P,Alfieri C,Rastaldi MP

更新日期：2011-05-01 00:00:00

abstract：BACKGROUND:Since dialysis has brought long-term survival to uremic patients, we can now speculate on more subtle problems derived from imbalance or sub-optimal regulation of some elements such as trace metals. We focused on the rubidium (Rb) status in dialysis patients (HD), as concerns about its possible deficiency ha...

journal_title：Journal of nephrology

authors： Canavese C,DeCostanzi E,Branciforte L,Caropreso A,Nonnato A,Pietra R,Fortaner S,Jacono F,Angelini G,Gallieni M,Fop F,Sabbioni E

更新日期：2001-05-01 00:00:00

abstract：BACKGROUND:Oxidative stress plays a crucial role in chronic complications of diabetes such as diabetic nephropathy (DN), the main cause of renal failure. In diabetes, whether peroxynitrite (ONOO(-)), generated from inducible nitric oxide synthase (iNOS) induced by tumor necrosis factor alpha (TNF-alpha), plays a primar...

journal_title：Journal of nephrology

authors： Xiao H,Li Y,Qi J,Wang H,Liu K

更新日期：2009-11-01 00:00:00

abstract：BACKGROUND:This study is part of a 3-country study testing whether normal levels of hemoglobin (Hgb) delay the progression of left ventricular (LV) growth in chronic kidney disease (CKD) patients not on dialysis. METHODS:This was an open-label, randomized, multicenter, controlled trial conducted in 27 tertiary-care ho...

journal_title：Journal of nephrology

authors： Cianciaruso B,Ravani P,Barrett BJ,Levin A,ITA-EPO-7 investigators.

更新日期：2008-11-01 00:00:00

abstract：:Acute kidney injury (AKI) is an increasing health burden with high morbidity and mortality rates worldwide. AKI is a risk factor for chronic kidney disease (CKD) development and progression to end stage renal disease (ESRD). Rapid action is required to find treatment options for AKI, plus to anticipate the development...

journal_title：Journal of nephrology

authors： Kurzhagen JT,Dellepiane S,Cantaluppi V,Rabb H

更新日期：2020-12-01 00:00:00

abstract：:The partial correction of anemia and the normalization of phosphate and blood pressure are the mainstay of treatment of patients with chronic kidney disease (CKD). Available anti-hypertensive drugs, erythropoiesis stimulating agents (ESAs) and iron supplements have resolved quite satisfactorily the goal of controlling...

journal_title：Journal of nephrology

authors： Locatelli F,Del Vecchio L

更新日期：2017-12-01 00:00:00

abstract：OBJECTIVE:To investigate the pregnancy outcomes for patients with stage 3-4 chronic kidney disease (CKD) and the effects of pregnancy on kidney function. METHODS:Clinical data of pregnant women with CKD in the Peking University First Hospital between January 1st 2005 and October 1st 2016 were retrospectively analysed....

journal_title：Journal of nephrology

authors： He Y,Liu J,Cai Q,Lv J,Yu F,Chen Q,Zhao M

更新日期：2018-12-01 00:00:00

abstract：:Kidney remodeling is a response to intrinsic or extrinsic triggers of kidney injury. Injury initiates a set of universal response programs that were positively selected through evolution to control potentially life-threatening dangers and to regain homeostasis, including tissue repair. These danger control programs ar...

journal_title：Journal of nephrology

authors： Migliorini A,Ebid R,Scherbaum CR,Anders HJ

更新日期：2013-05-01 00:00:00

abstract：BACKGROUND:Patients undergoing chronic hemodialysis (HD) are at increased risk for peripheral artery disease (PAD). Both ankle-brachial index (ABI) and ambulatory blood pressure monitoring (ABPM) in the interdialytic period have been shown to be strong predictors of all-cause mortality. METHODS:This cross-sectional st...

journal_title：Journal of nephrology

authors： Viazzi F,Leoncini G,Ratto E,Storace G,Gonnella A,Garneri D,Bonino B,Cappadona F,Parodi EL,Verzola D,Garibotto G,Pontremoli R

更新日期：2017-06-01 00:00:00

abstract：:Structural and functional alterations affecting the aging kidney predispose to an increased risk of acute renal failure (ARF) in the elderly. This is a common problem becoming more relevant because of an increase in life expectancy. The epidemiology of ARF in the elderly is far from being well assessed, because of the...

journal_title：Journal of nephrology

authors： Del Giudice A,Aucella F

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:Chronic renal failure (CRF) is associated with a tendency to atherosclerosis due to the enhanced oxidative stress and insufficient antioxidant enzyme activities such as superoxide dismutase (SOD), catalase (CAT) and paraoxonase (PON 1), together with abnormalities in lipid parameters. We determined the in vi...

journal_title：Journal of nephrology

authors： Ak G,Ozgönül M,Sözmen EY,Aslan SL,Sözmen B

更新日期：2002-03-01 00:00:00

abstract：:Patients with type 2 diabetes run a high risk for progressive renal function loss. Many interventions have been tested to reduce the risk, but we are nowadays still confronted with a high unmet need. To improve on this unmet need, we will have to change the current strategies in drug discovery, clinical trials and cli...

journal_title：Journal of nephrology

authors： de Zeeuw D

更新日期：2020-12-01 00:00:00