Abstract:
BACKGROUND:Mineral and bone parameters are actively managed in end-stage renal disease (ESRD). However, whether these undergo circadian variation is not known. We investigated the circadian variation of mineral and bone parameters in patients on long-term hemodialysis. METHODS:Seventeen ESRD patients on long-term hemodialysis and eight volunteers without kidney disease were enrolled. Subjects had all medications that affect calcium-phosphate-parathyroid hormone balance (phosphate binders, vitamin D analogues, and calcimimetics) discontinued. Thereafter, for a period of 5 days, subjects consumed a diet controlled in calcium (1,200 mg per day) and phosphorus (1,000 mg per day) content. On the sixth day (a non-dialysis day for the ESRD patients), enrollees underwent twelve 2-h blood draws for phosphate, ionized calcium, parathyroid hormone (PTH), total 25-hydroxy vitamin D (25OHD), and fibroblast growth factor-23 (FGF-23). RESULTS:In the ESRD patients plasma phosphate demonstrated significant circadian variation (P < 0.00001). The peak occurred around 3:30 am and nadir occurred around 11:00 am. Ionized calcium (P = 0.0036), PTH (P = 0.0004) and 25OHD (P = 0.009) also varied significantly during the circadian period; for ionized calcium peak and nadir occurred around 12:15 pm and 8:00 pm, parathyroid hormone 5:45 pm and 10:15 am, and 25OHD 9:45 am and 4:00 pm respectively. FGF-23 did not show a significant circadian variation. Only phosphate (P < 0.0001) and PTH (P = 0.00008) demonstrated circadian variation in the control group. CONCLUSIONS:Blood concentrations of phosphate, calcium, PTH and 25-hydroxy vitamin D, exhibit a circadian variation in patients with ESRD. Knowledge of these phenomena is pertinent for the interpretation of clinical testing.
journal_name
J Nephroljournal_title
Journal of nephrologyauthors
Trivedi H,Szabo A,Zhao S,Cantor T,Raff Hdoi
10.1007/s40620-014-0124-6subject
Has Abstractpub_date
2015-06-01 00:00:00pages
351-9issue
3eissn
1121-8428issn
1724-6059journal_volume
28pub_type
杂志文章abstract:BACKGROUND:The aim of this work was to investigate the benefit of basiliximab induction therapy in living-related-donor kidney transplantation. METHODS:One hundred adult recipients of a first kidney allograft were randomized into two treatment groups, one to receive basiliximab and the second as a control. All patient...
journal_title:Journal of nephrology
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2003-05-01 00:00:00
abstract:BACKGROUND:Dialysate calcium (Ca) concentration should be viewed as part of the integrated therapeutic regimen to control renal osteodystrophy and maintain normal mineral metabolism. Thus, a correct ionized calcium mass balance (Ca++MB) during hemodialysis (HD) is crucial in the treatment of renal osteodystrophy. The G...
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pub_type: 杂志文章,随机对照试验
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abstract:BACKGROUND:Renal tubular epithelial cells (TECs) function as antigen-presenting cells because they constitutively express MHC class II molecules and have the ability to present peptide antigen to CD4+T cells. However, the costimulatory signals provided by TECs for optimal T-cell activation have not been fully character...
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journal_title:Journal of nephrology
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journal_title:Journal of nephrology
pub_type: 杂志文章,多中心研究,随机对照试验
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abstract::Despite substantial progress in dialysis patients' management, cardiovascular disease remains the major cause of death. Nearly half of deaths on dialysis are secondary to myocardial infarction, cardiac arrest, malignant arrhythmias and other cardiac causes. The high prevalence of diabetes, anemia, hyperparathyroidism ...
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journal_title:Journal of nephrology
pub_type: 杂志文章
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更新日期:1999-07-01 00:00:00
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journal_title:Journal of nephrology
pub_type: 杂志文章,评审
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journal_title:Journal of nephrology
pub_type: 杂志文章
doi:
更新日期:2005-11-01 00:00:00
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journal_title:Journal of nephrology
pub_type: 杂志文章,评审
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更新日期:2004-11-01 00:00:00
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journal_title:Journal of nephrology
pub_type: 杂志文章,评审
doi:
更新日期:1997-01-01 00:00:00
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journal_title:Journal of nephrology
pub_type: 杂志文章
doi:10.1007/s40620-016-0370-x
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pub_type: 杂志文章,评审
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更新日期:2010-11-01 00:00:00
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pub_type: 杂志文章,meta分析
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更新日期:2019-10-01 00:00:00
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doi:
更新日期:2010-01-01 00:00:00
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journal_title:Journal of nephrology
pub_type: 杂志文章
doi:
更新日期:2006-05-01 00:00:00
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journal_title:Journal of nephrology
pub_type: 杂志文章,评审
doi:
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journal_title:Journal of nephrology
pub_type: 杂志文章,评审
doi:10.1007/s40620-017-0448-0
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pub_type: 杂志文章,多中心研究
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pub_type: 杂志文章
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journal_title:Journal of nephrology
pub_type: 杂志文章
doi:
更新日期:2009-01-01 00:00:00
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journal_title:Journal of nephrology
pub_type: 杂志文章
doi:
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pub_type: 杂志文章
doi:
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journal_title:Journal of nephrology
pub_type: 杂志文章,评审
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pub_type: 杂志文章
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更新日期:2010-03-01 00:00:00
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