听力与言语-语言病理学

行为科学

医学伦理学

  • Airway Sensory Nerve Density Is Increased in Chronic Cough.

    abstract::Rationale: Chronic cough is characterized by frequent urges to cough and a heightened sensitivity to inhaled irritants. Airway sensory nerves trigger cough. We hypothesized that sensory nerve density is increased in chronic cough, which may contribute to excessive and persistent coughing.Objectives: To measure airway ...

    journal_title:American journal of respiratory and critical care medicine

    pub_type: 杂志文章

    doi:10.1164/rccm.201912-2347OC

    authors: Shapiro CO,Proskocil BJ,Oppegard LJ,Blum ED,Kappel NL,Chang CH,Fryer AD,Jacoby DB,Costello RW,Drake MG

    更新日期:2021-02-01 00:00:00

  • Bronchial Thermoplasty Induced Airway Smooth Muscle Reduction and Clinical Response in Severe Asthma. The TASMA Randomized Trial.

    abstract::Rationale: Bronchial thermoplasty (BT) is a bronchoscopic treatment for severe asthma targeting airway smooth muscle (ASM). Observational studies have shown ASM mass reduction after BT, but appropriate control groups are lacking. Furthermore, as treatment response is variable, identifying optimal candidates for BT tre...

    journal_title:American journal of respiratory and critical care medicine

    pub_type: 杂志文章

    doi:10.1164/rccm.201911-2298OC

    authors: Goorsenberg AWM,d'Hooghe JNS,Srikanthan K,Ten Hacken NHT,Weersink EJM,Roelofs JJTH,Kemp SV,Bel EH,Shah PL,Annema JT,Bonta PI,TASMA research group.

    更新日期:2021-01-15 00:00:00

  • Plasma Soluble Suppression of Tumorigenicity-2 Associates with Ventilator Liberation in Acute Hypoxemic Respiratory Failure.

    abstract:RATIONALE:Standard physiologic assessments of extubation readiness in patients with acute hypoxemic respiratory failure (AHRF) may not reflect lung injury resolution and could adversely affect clinical decision-making and patient outcomes. OBJECTIVES:We hypothesized that elevations in inflammatory plasma biomarkers so...

    journal_title:American journal of respiratory and critical care medicine

    pub_type: 杂志文章

    doi:10.1164/rccm.202005-1951OC

    authors: Alladina J,Levy SD,Cho JL,Brait KL,Rao SR PhD,Camacho A,Hibbert KA,Harris RS,Medoff BD,Januzzi JL,Thompson BT,Bajwa EK

    更新日期:2021-01-05 00:00:00

  • Informing Healthcare Decisions with Observational Research Assessing Causal Effect. An Official American Thoracic Society Research Statement.

    abstract::Rationale: Decisions in medicine are made on the basis of knowledge and reasoning, often in shared conversations with patients and families in consideration of clinical practice guideline recommendations, individual preferences, and individual goals. Observational studies can provide valuable knowledge to inform guide...

    journal_title:American journal of respiratory and critical care medicine

    pub_type: 杂志文章

    doi:10.1164/rccm.202010-3943ST

    authors: Gershon AS,Lindenauer PK,Wilson KC,Rose L,Walkey AJ,Sadatsafavi M,Anstrom KJ,Au DH,Bender BG,Brookhart MA,Dweik RA,Han MK,Joo MJ,Lavergne V,Mehta AB,Miravitlles M,Mularski RA,Roche N,Oren E,Riekert KA,Schoenberg N

    更新日期:2021-01-01 00:00:00

  • Sepsis and Cancer: An Interplay of Friends and Foes.

    abstract::Sepsis and cancer share a number of pathophysiological features, and both result from the inability of the host's immune system to cope with the initial insult (tissue invasion by pathogens and malignant cell transformation, respectively). The common coexistence of both disorders and the profound related alterations i...

    journal_title:American journal of respiratory and critical care medicine

    pub_type: 杂志文章,评审

    doi:10.1164/rccm.202004-1116TR

    authors: Mirouse A,Vigneron C,Llitjos JF,Chiche JD,Mira JP,Mokart D,Azoulay E,Pène F

    更新日期:2020-12-15 00:00:00

  • Human Lung Resident Macrophages Co-localize with and Provide Co-stimulation to PD1hi Tissue Resident Memory T Cells.

    abstract:RATIONALE:Tissue resident memory T cells play a critical role in the defense against inhaled pathogens. The isolation and study of human lung tissue resident memory T cells and lung resident macrophages is limited by experimental constraints. OBJECTIVES:To characterize the spatial and functional relationship between l...

    journal_title:American journal of respiratory and critical care medicine

    pub_type: 杂志文章

    doi:10.1164/rccm.202006-2403OC

    authors: Snyder ME,Sembrat J,Noda K,Myerburg MM,Craig A,Mitash N,Harano T,Furukawa M,Pilewski J,McDyer J,Rojas M,Sanchez P

    更新日期:2020-12-11 00:00:00

  • Polyclonality, Shared Strains, and Convergent Evolution in Chronic CF S. aureus Airway Infection.

    abstract:RATIONALE:S. aureus is the most common respiratory pathogen isolated from patients with cystic fibrosis (CF) in the US. While modes of acquisition and genetic adaptation have been described for Pseudomonas aeruginosa, resulting in improved diagnosis and treatment, these features remain more poorly defined for S. aureus...

    journal_title:American journal of respiratory and critical care medicine

    pub_type: 杂志文章

    doi:10.1164/rccm.202003-0735OC

    authors: Long DR,Wolter DJ,Lee M,Precit M,McLean K,Holmes E,Penewit K,Waalkes A,Hoffman LR,Salipante SJ

    更新日期:2020-12-09 00:00:00

  • Noninvasive Ventilation Use in Critically Ill Patients with Acute Asthma Exacerbations.

    abstract::Rationale: Noninvasive ventilation decreases the need for invasive mechanical ventilation and mortality among patients with chronic obstructive pulmonary disease but has not been well studied in asthma.Objectives: To assess the association between noninvasive ventilation and subsequent need for invasive mechanical ven...

    journal_title:American journal of respiratory and critical care medicine

    pub_type: 杂志文章

    doi:10.1164/rccm.201910-2021OC

    authors: Althoff MD,Holguin F,Yang F,Grunwald GK,Moss M,Vandivier RW,Ho PM,Kiser TH,Burnham EL

    更新日期:2020-12-01 00:00:00

  • Increased Platelet Aggregation in Children and Adolescents with Sleep-disordered Breathing.

    abstract::Rationale: Sleep-disordered breathing (SDB) is associated with increased vascular resistance in children and adults. Persistent increased vascular resistance damages vascular endothelial cells-a marker of which is increased platelet activation.Objectives: This study compared whole-blood impedance platelet aggregation ...

    journal_title:American journal of respiratory and critical care medicine

    pub_type: 杂志文章

    doi:10.1164/rccm.201911-2229OC

    authors: Kontos A,Willoughby S,Lushington K,Martin J,Wabnitz D,Dorrian J,Kennedy D

    更新日期:2020-12-01 00:00:00

  • From Gold 0 to Pre-COPD.

    abstract::Currently the diagnosis of chronic obstructive pulmonary disease (COPD) requires the demonstration of airflow limitation, defined as a post-bronchodilator FEV1/FVC <0.7, a measurement that remains methodologically robust and widely available. FEV1 is one of the most powerful predictors of clinically relevant outcomes ...

    journal_title:American journal of respiratory and critical care medicine

    pub_type: 杂志文章

    doi:10.1164/rccm.202008-3328PP

    authors: Han MK,Agusti A,Celli BR,Criner GJ,Halpin DMG,Roche N,Papi A,Stockley RA,Wedzicha J,Vogelmeier CF

    更新日期:2020-11-19 00:00:00

  • Chronic Hypersensitivity Pneumonitis, an Interstitial Lung Disease with Distinct Molecular Signatures.

    abstract::Rationale: Chronic hypersensitivity pneumonitis (CHP) is caused by an immune response to antigen inhalation and is characterized by variable histopathological and clinical features. A subset of subjects with CHP have usual interstitial pneumonia and appear to be clinically similar to subjects with idiopathic pulmonary...

    journal_title:American journal of respiratory and critical care medicine

    pub_type: 杂志文章

    doi:10.1164/rccm.202001-0134OC

    authors: Furusawa H,Cardwell JH,Okamoto T,Walts AD,Konigsberg IR,Kurche JS,Bang TJ,Schwarz MI,Brown KK,Kropski JA,Rojas M,Cool CD,Lee JS,Wolters PJ,Yang IV,Schwartz DA

    更新日期:2020-11-15 00:00:00

  • Long Noncoding RNA TYKRIL Plays a Role in Pulmonary Hypertension via the p53-mediated Regulation of PDGFRβ.

    abstract::Rationale: Long noncoding RNAs (lncRNAs) are emerging as important regulators of diverse biological functions. Their role in pulmonary arterial hypertension (PAH) remains to be explored.Objectives: To elucidate the role of TYKRIL (tyrosine kinase receptor-inducing lncRNA) as a regulator of p53/ PDGFRβ (platelet-derive...

    journal_title:American journal of respiratory and critical care medicine

    pub_type: 杂志文章

    doi:10.1164/rccm.201910-2041OC

    authors: Zehendner CM,Valasarajan C,Werner A,Boeckel JN,Bischoff FC,John D,Weirick T,Glaser SF,Rossbach O,Jaé N,Demolli S,Khassafi F,Yuan K,de Jesus Perez VA,Michalik KM,Chen W,Seeger W,Guenther A,Wasnick RM,Uchida S,Zeihe

    更新日期:2020-11-15 00:00:00

  • Mucus Plugs and Emphysema in the Pathophysiology of Airflow Obstruction and Hypoxemia in Smokers.

    abstract:BACKGROUND:The relative roles of mucus plugs and emphysema in mechanisms of airflow limitation and hypoxemia in smokers with chronic obstructive pulmonary disease (COPD) are uncertain. METHODS:We analyzed computed tomography (CT) lung images and lung function in participants in the Subpopulations and Intermediate Outc...

    journal_title:American journal of respiratory and critical care medicine

    pub_type: 杂志文章

    doi:10.1164/rccm.202006-2248OC

    authors: Dunican EM,Elicker BM,Henry T,Gierada DS,Schiebler ML,Anderson W,Barjaktarevic I,Barr RG,Bleecker ER,Boucher RC,Bowler RP,Christenson SA,Comellas A,Cooper CB,Couper D,Criner GJ,Dransfield M,Doerschuk CM,Drummond MB,

    更新日期:2020-11-12 00:00:00

  • TWIST1 Drives Smooth Muscle Cell Proliferation in Pulmonary Hypertension via Loss of GATA-6 and BMPR2.

    abstract::Rationale: The bHLH (basic helix-loop-helix) transcription factor TWIST1 (Twist-related protein 1) controls cell proliferation and differentiation in tissue development and disease processes. Recently, endothelial TWIST1 has been linked to pulmonary hypertension (PH) and endothelial-to-mesenchymal transition, yet the ...

    journal_title:American journal of respiratory and critical care medicine

    pub_type: 杂志文章

    doi:10.1164/rccm.201909-1884OC

    authors: Fan Y,Gu X,Zhang J,Sinn K,Klepetko W,Wu N,Foris V,Solymosi P,Kwapiszewska G,Kuebler WM

    更新日期:2020-11-01 00:00:00

  • The Association of Aging Biomarkers, Interstitial Lung Abnormalities, and Mortality.

    abstract:RATIONALE:The association between aging and idiopathic pulmonary fibrosis is established. The associations between aging-related biomarkers and interstitial lung abnormalities (ILA) have not been comprehensively evaluated. OBJECTIVE:Evaluate associations between aging biomarkers, ILA, and all-cause mortality. METHODS...

    journal_title:American journal of respiratory and critical care medicine

    pub_type: 杂志文章

    doi:10.1164/rccm.202007-2993OC

    authors: Sanders JL,Putman RK,Dupuis J,Xu H,Murabito JM,Araki T,Nishino M,Benjamin EJ,Levy DL,Vasan RS,Washko GR,Curtis JL,Freeman CM,Bowler R,Hatabu H,O'Connor GT,Hunninghake GM

    更新日期:2020-10-20 00:00:00

  • WITHDRAWN: Proposal for Initiative of Evidence-based Treatment of COVID-19 Patients with Worsening Hypoxia.

    abstract::Ahead of Print article withdrawn by publisher. ...

    journal_title:American journal of respiratory and critical care medicine

    pub_type: 杂志文章

    doi:10.1164/rccm.202009-3684CP

    authors: Kanwar BA

    更新日期:2020-10-07 00:00:00

  • Assessing the Accuracy of a Deep Learning Method to Risk Stratify Indeterminate Pulmonary Nodules.

    abstract::Rationale: The management of indeterminate pulmonary nodules (IPNs) remains challenging, resulting in invasive procedures and delays in diagnosis and treatment. Strategies to decrease the rate of unnecessary invasive procedures and optimize surveillance regimens are needed.Objectives: To develop and validate a deep le...

    journal_title:American journal of respiratory and critical care medicine

    pub_type: 杂志文章

    doi:10.1164/rccm.201903-0505OC

    authors: Massion PP,Antic S,Ather S,Arteta C,Brabec J,Chen H,Declerck J,Dufek D,Hickes W,Kadir T,Kunst J,Landman BA,Munden RF,Novotny P,Peschl H,Pickup LC,Santos C,Smith GT,Talwar A,Gleeson F

    更新日期:2020-07-15 00:00:00

  • Natural History of Cognitive Impairment in Critical Illness Survivors. A Systematic Review.

    abstract::Long-term cognitive impairment is common among ICU survivors, but its natural history remains unclear. In this systematic review, we report the frequency of cognitive impairment in ICU survivors across various time points after ICU discharge that were extracted from 46 of the 3,350 screened records. Prior studies used...

    journal_title:American journal of respiratory and critical care medicine

    pub_type: 杂志文章

    doi:10.1164/rccm.201904-0816CI

    authors: Honarmand K,Lalli RS,Priestap F,Chen JL,McIntyre CW,Owen AM,Slessarev M

    更新日期:2020-07-15 00:00:00

  • Association of Premorbid Blood Pressure with Vasopressor Infusion Duration in Patients with Shock.

    abstract::Rationale: Guidelines for vasopressor titration suggest a universal target-mean arterial pressure (MAP) >65 mm Hg. The implications for patients with premorbid low/high blood pressure are unknown.Objectives: To investigate the relationship between premorbid blood pressure and vasopressor duration for patients with sho...

    journal_title:American journal of respiratory and critical care medicine

    pub_type: 杂志文章

    doi:10.1164/rccm.201908-1681OC

    authors: Gershengorn HB,Stelfox HT,Niven DJ,Wunsch H

    更新日期:2020-07-01 00:00:00

  • Reduction in All-Cause Mortality with Fluticasone Furoate/Umeclidinium/Vilanterol in Patients with Chronic Obstructive Pulmonary Disease.

    abstract::Rationale: The IMPACT (Informing the Pathway of Chronic Obstructive Pulmonary Disease Treatment) trial demonstrated a significant reduction in all-cause mortality (ACM) risk with fluticasone furoate/umeclidinium/vilanterol (FF/UMEC/VI) versus UMEC/VI in patients with chronic obstructive pulmonary disease (COPD) at ris...

    journal_title:American journal of respiratory and critical care medicine

    pub_type: 杂志文章,随机对照试验

    doi:10.1164/rccm.201911-2207OC

    authors: Lipson DA,Crim C,Criner GJ,Day NC,Dransfield MT,Halpin DMG,Han MK,Jones CE,Kilbride S,Lange P,Lomas DA,Lettis S,Manchester P,Martin N,Midwinter D,Morris A,Pascoe SJ,Singh D,Wise RA,Martinez FJ

    更新日期:2020-06-15 00:00:00

  • Genetic Admixture and Survival in Diverse Populations with Pulmonary Arterial Hypertension.

    abstract::Rationale: Limited information is available on racial/ethnic differences in pulmonary arterial hypertension (PAH).Objectives: Determine effects of race/ethnicity and ancestry on mortality and disease outcomes in diverse patients with PAH.Methods: Patients with Group 1 PAH were included from two national registries wit...

    journal_title:American journal of respiratory and critical care medicine

    pub_type: 杂志文章

    doi:10.1164/rccm.201907-1447OC

    authors: Karnes JH,Wiener HW,Schwantes-An TH,Natarajan B,Sweatt AJ,Chaturvedi A,Arora A,Batai K,Nair V,Steiner HE,Giles JB,Yu J,Hosseini M,Pauciulo MW,Lutz KA,Coleman AW,Feldman J,Vanderpool R,Tang H,Garcia JGN,Yuan JX,K

    更新日期:2020-06-01 00:00:00

  • Localization of Macrophages in the Human Lung via Design-based Stereology.

    abstract::Rationale: Interstitial macrophages (IMs) and airspace macrophages (AMs) play critical roles in lung homeostasis and host defense, and are central to the pathogenesis of a number of lung diseases. However, the absolute numbers of macrophages and the precise anatomic locations they occupy in the healthy human lung have...

    journal_title:American journal of respiratory and critical care medicine

    pub_type: 杂志文章

    doi:10.1164/rccm.201911-2105OC

    authors: Hume PS,Gibbings SL,Jakubzick CV,Tuder RM,Curran-Everett D,Henson PM,Smith BJ,Janssen WJ

    更新日期:2020-05-15 00:00:00

  • Expiratory Resistances Prevent Expiratory Diaphragm Contraction, Flow Limitation, and Lung Collapse.

    abstract::Rationale: Tidal expiratory flow limitation (tidal-EFL) is not completely avoidable by applying positive end-expiratory pressure and may cause respiratory and hemodynamic complications in ventilated patients with lungs prone to collapse. During spontaneous breathing, expiratory diaphragmatic contraction counteracts ti...

    journal_title:American journal of respiratory and critical care medicine

    pub_type: 杂志文章

    doi:10.1164/rccm.201909-1690OC

    authors: Pellegrini M,Gudmundsson M,Bencze R,Segelsjö M,Freden F,Rylander C,Hedenstierna G,Larsson AS,Perchiazzi G

    更新日期:2020-05-15 00:00:00

  • Pharmacologic Management of Chronic Obstructive Pulmonary Disease. An Official American Thoracic Society Clinical Practice Guideline.

    abstract::Background: This document provides clinical recommendations for the pharmacologic treatment of chronic obstructive pulmonary disease (COPD). It represents a collaborative effort on the part of a panel of expert COPD clinicians and researchers along with a team of methodologists under the guidance of the American Thora...

    journal_title:American journal of respiratory and critical care medicine

    pub_type: 杂志文章

    doi:10.1164/rccm.202003-0625ST

    authors: Nici L,Mammen MJ,Charbek E,Alexander PE,Au DH,Boyd CM,Criner GJ,Donaldson GC,Dreher M,Fan VS,Gershon AS,Han MK,Krishnan JA,Martinez FJ,Meek PM,Morgan M,Polkey MI,Puhan MA,Sadatsafavi M,Sin DD,Washko GR,Wedzicha

    更新日期:2020-05-01 00:00:00

  • Identifying Clinical Research Priorities in Adult Pulmonary and Critical Care: NHLBI Working Group Report.

    abstract::Preventing, treating, and promoting recovery from critical illness due to pulmonary disease are foundational goals of the critical care community and the National Heart, Lung, and Blood Institute. Decades of clinical research in acute respiratory distress syndrome, acute respiratory failure, pneumonia, and sepsis have...

    journal_title:American journal of respiratory and critical care medicine

    pub_type: 杂志文章

    doi:10.1164/rccm.201908-1595WS

    authors: Semler MW,Bernard GR,Aaron SD,Angus DC,Biros MH,Brower RG,Calfee CS,Colantuoni EA,Ferguson ND,Gong MN,Hopkins RO,Hough CL,Iwashyna TJ,Levy BD,Martin TR,Matthay MA,Mizgerd JP,Moss M,Needham DM,Self WH,Seymour CW,

    更新日期:2020-03-09 00:00:00

  • Identification of Cardiac Magnetic Resonance Imaging Thresholds for Risk Stratification in Pulmonary Arterial Hypertension.

    abstract::Rationale: Pulmonary arterial hypertension (PAH) is a life-shortening condition. The European Society of Cardiology and European Respiratory Society and the REVEAL (North American Registry to Evaluate Early and Long-Term PAH Disease Management) risk score calculator (REVEAL 2.0) identify thresholds to predict 1-year m...

    journal_title:American journal of respiratory and critical care medicine

    pub_type: 杂志文章

    doi:10.1164/rccm.201909-1771OC

    authors: Lewis RA,Johns CS,Cogliano M,Capener D,Tubman E,Elliot CA,Charalampopoulos A,Sabroe I,Thompson AAR,Billings CG,Hamilton N,Baster K,Laud PJ,Hickey PM,Middleton J,Armstrong IJ,Hurdman JA,Lawrie A,Rothman AMK,Wild JM,

    更新日期:2020-02-15 00:00:00

  • Comparative Modeling of Tuberculosis Epidemiology and Policy Outcomes in California.

    abstract::Rationale: Mathematical modeling is used to understand disease dynamics, forecast trends, and inform public health prioritization. We conducted a comparative analysis of tuberculosis (TB) epidemiology and potential intervention effects in California, using three previously developed epidemiologic models of TB.Objectiv...

    journal_title:American journal of respiratory and critical care medicine

    pub_type: 杂志文章

    doi:10.1164/rccm.201907-1289OC

    authors: Menzies NA,Parriott A,Shrestha S,Dowdy DW,Cohen T,Salomon JA,Marks SM,Hill AN,Winston CA,Asay GR,Barry P,Readhead A,Flood J,Kahn JG,Shete PB

    更新日期:2020-02-01 00:00:00

  • Early Bactericidal Activity of Different Isoniazid Doses for Drug Resistant TB (INHindsight): A Randomized Open-label Clinical Trial.

    abstract:RATIONALE:High-dose isoniazid is recommended in short-course regimens for multidrug-resistant TB (MDR-TB). The optimal dose of isoniazid and its individual contribution to efficacy against TB strains with inhA or katG mutations are unknown. OBJECTIVE:Define the optimal dose of isoniazid for patients with isoniazid-res...

    journal_title:American journal of respiratory and critical care medicine

    pub_type: 杂志文章

    doi:10.1164/rccm.201910-1960OC

    authors: Dooley KE,Miyahara S,von Groote-Bidlingmaier F,Sun X,Hafner R,Rosenkranz SL,Ignatius EH,Nuermberger EL,Moran L,Donahue K,Swindells S,Vanker N,Diacon AH,A5312 Study Team.

    更新日期:2020-01-16 00:00:00

  • Real-Life Safety and Effectiveness of Lumacaftor-Ivacaftor in Patients with Cystic Fibrosis.

    abstract::Rationale: Lumacaftor-ivacaftor is a CFTR (cystic fibrosis transmembrane conductance regulator) modulator combination recently approved for patients with cystic fibrosis (CF) homozygous for the Phe508del mutation.Objectives: To evaluate the safety and effectiveness of lumacaftor-ivacaftor in adolescents (≥12 yr) and a...

    journal_title:American journal of respiratory and critical care medicine

    pub_type: 杂志文章

    doi:10.1164/rccm.201906-1227OC

    authors: Burgel PR,Munck A,Durieu I,Chiron R,Mely L,Prevotat A,Murris-Espin M,Porzio M,Abely M,Reix P,Marguet C,Macey J,Sermet-Gaudelus I,Corvol H,Bui S,Lemonnier L,Dehillotte C,Da Silva J,Paillasseur JL,Hubert D,French Cy

    更新日期:2020-01-15 00:00:00

  • Assessment of Inflammation in Pulmonary Artery Hypertension by 68Ga-Mannosylated Human Serum Albumin.

    abstract::Rationale: Diagnosis and monitoring of patients with pulmonary artery hypertension (PAH) is currently difficult.Objectives: We aimed to develop a noninvasive imaging modality for PAH that tracks the infiltration of macrophages into the pulmonary vasculature, using a positron emission tomography (PET) agent, 68Ga-2-(p-...

    journal_title:American journal of respiratory and critical care medicine

    pub_type: 杂志文章

    doi:10.1164/rccm.201903-0639OC

    authors: Park JB,Suh M,Park JY,Park JK,Kim YI,Kim H,Cho YS,Kang H,Kim K,Choi JH,Nam JW,Kim HK,Lee YS,Jeong JM,Kim YJ,Paeng JC,Lee SP

    更新日期:2020-01-01 00:00:00

  • Dynamics of IFN-β Responses during Respiratory Viral Infection. Insights for Therapeutic Strategies.

    abstract::Rationale: Viral infections are major drivers of exacerbations and clinical burden in patients with asthma and chronic obstructive pulmonary disease (COPD). IFN-β is a key component of the innate immune response to viral infection. To date, studies of inhaled IFN-β treatment have not demonstrated a significant effect ...

    journal_title:American journal of respiratory and critical care medicine

    pub_type: 杂志文章

    doi:10.1164/rccm.201901-0214OC

    authors: Watson A,Spalluto CM,McCrae C,Cellura D,Burke H,Cunoosamy D,Freeman A,Hicks A,Hühn M,Ostridge K,Staples KJ,Vaarala O,Wilkinson T

    更新日期:2020-01-01 00:00:00

  • Therapeutic Effects of Hyaluronic Acid in Bacterial Pneumonia in Ex Vivo Perfused Human Lungs.

    abstract::Rationale: Recent studies have demonstrated that extracellular vesicles (EVs) released during acute lung injury (ALI) were inflammatory.Objectives: The current study was undertaken to test the role of EVs induced and released from severe Escherichia coli pneumonia (E. coli EVs) in the pathogenesis of ALI and to determ...

    journal_title:American journal of respiratory and critical care medicine

    pub_type: 杂志文章

    doi:10.1164/rccm.201812-2296OC

    authors: Liu A,Park JH,Zhang X,Sugita S,Naito Y,Lee JH,Kato H,Hao Q,Matthay MA,Lee JW

    更新日期:2019-11-15 00:00:00

  • Diagnosis and Treatment of Adults with Community-acquired Pneumonia. An Official Clinical Practice Guideline of the American Thoracic Society and Infectious Diseases Society of America.

    abstract::Background: This document provides evidence-based clinical practice guidelines on the management of adult patients with community-acquired pneumonia.Methods: A multidisciplinary panel conducted pragmatic systematic reviews of the relevant research and applied Grading of Recommendations, Assessment, Development, and Ev...

    journal_title:American journal of respiratory and critical care medicine

    pub_type: 杂志文章,实务指引

    doi:10.1164/rccm.201908-1581ST

    authors: Metlay JP,Waterer GW,Long AC,Anzueto A,Brozek J,Crothers K,Cooley LA,Dean NC,Fine MJ,Flanders SA,Griffin MR,Metersky ML,Musher DM,Restrepo MI,Whitney CG

    更新日期:2019-10-01 00:00:00

  • Genetic Advances in Chronic Obstructive Pulmonary Disease. Insights from COPDGene.

    abstract::Chronic obstructive pulmonary disease (COPD) is a common and progressive disease that is influenced by both genetic and environmental factors. For many years, knowledge of the genetic basis of COPD was limited to Mendelian syndromes, such as alpha-1 antitrypsin deficiency and cutis laxa, caused by rare genetic variant...

    journal_title:American journal of respiratory and critical care medicine

    pub_type: 杂志文章,评审

    doi:10.1164/rccm.201808-1455SO

    authors: Ragland MF,Benway CJ,Lutz SM,Bowler RP,Hecker J,Hokanson JE,Crapo JD,Castaldi PJ,DeMeo DL,Hersh CP,Hobbs BD,Lange C,Beaty TH,Cho MH,Silverman EK

    更新日期:2019-09-15 00:00:00

  • A Genetic Risk Score Associated with Chronic Obstructive Pulmonary Disease Susceptibility and Lung Structure on Computed Tomography.

    abstract::Rationale: Chronic obstructive pulmonary disease (COPD) has been associated with numerous genetic variants, yet the extent to which its genetic risk is mediated by variation in lung structure remains unknown.Objectives: To characterize associations between a genetic risk score (GRS) associated with COPD susceptibility...

    journal_title:American journal of respiratory and critical care medicine

    pub_type: 杂志文章

    doi:10.1164/rccm.201812-2355OC

    authors: Oelsner EC,Ortega VE,Smith BM,Nguyen JN,Manichaikul AW,Hoffman EA,Guo X,Taylor KD,Woodruff PG,Couper DJ,Hansel NN,Martinez FJ,Paine R 3rd,Han MK,Cooper C,Dransfield MT,Criner G,Krishnan JA,Bowler R,Bleecker ER,Pet

    更新日期:2019-09-15 00:00:00

  • Understanding Lactatemia in Human Sepsis. Potential Impact for Early Management.

    abstract::Rationale: Hyperlactatemia in sepsis may derive from a prevalent impairment of oxygen supply/demand and/or oxygen use. Discriminating between these two mechanisms may be relevant for the early fluid resuscitation strategy.Objectives: To understand the relationship among central venous oxygen saturation (ScvO2), lactat...

    journal_title:American journal of respiratory and critical care medicine

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1164/rccm.201812-2342OC

    authors: Gattinoni L,Vasques F,Camporota L,Meessen J,Romitti F,Pasticci I,Duscio E,Vassalli F,Forni LG,Payen D,Cressoni M,Zanella A,Latini R,Quintel M,Marini JJ

    更新日期:2019-09-01 00:00:00

  • Single-Cell Transcriptomic Analysis of Human Lung Provides Insights into the Pathobiology of Pulmonary Fibrosis.

    abstract::Rationale: The contributions of diverse cell populations in the human lung to pulmonary fibrosis pathogenesis are poorly understood. Single-cell RNA sequencing can reveal changes within individual cell populations during pulmonary fibrosis that are important for disease pathogenesis. Objectives: To determine whether s...

    journal_title:American journal of respiratory and critical care medicine

    pub_type: 杂志文章

    doi:10.1164/rccm.201712-2410OC

    authors: Reyfman PA,Walter JM,Joshi N,Anekalla KR,McQuattie-Pimentel AC,Chiu S,Fernandez R,Akbarpour M,Chen CI,Ren Z,Verma R,Abdala-Valencia H,Nam K,Chi M,Han S,Gonzalez-Gonzalez FJ,Soberanes S,Watanabe S,Williams KJN,Flozak

    更新日期:2019-06-15 00:00:00

  • Impaired Lung Function, Lung Disease, and Risk of Incident Dementia.

    abstract::Rationale: Growing evidence suggests that compromised lung health may be linked to dementia and worsening cognitive ability. Objectives: To test the hypothesis that impaired lung function or lung disease in midlife is associated with greater risk of incident dementia and mild cognitive impairment (MCI) later in life. ...

    journal_title:American journal of respiratory and critical care medicine

    pub_type: 杂志文章

    doi:10.1164/rccm.201807-1220OC

    authors: Lutsey PL,Chen N,Mirabelli MC,Lakshminarayan K,Knopman DS,Vossel KA,Gottesman RF,Mosley TH,Alonso A

    更新日期:2019-06-01 00:00:00

  • Detection of Pediatric Pulmonary Arterial Hypertension by School Electrocardiography Mass Screening.

    abstract::Rationale: To detect pulmonary arterial hypertension (PAH) at any early stage is a promising approach to optimize the outcome. Objectives: To investigate the impact of school ECG-based screening on detecting idiopathic or heritable (I/H)-PAH in the general pediatric population. Methods: This was a nationwide survey of...

    journal_title:American journal of respiratory and critical care medicine

    pub_type: 杂志文章

    doi:10.1164/rccm.201802-0375OC

    authors: Sawada H,Mitani Y,Nakayama T,Fukushima H,Kogaki S,Igarashi T,Ichida F,Ono Y,Nakanishi T,Doi S,Ishikawa S,Matsushima M,Yamada O,Saji T

    更新日期:2019-06-01 00:00:00

  • Early Use of Norepinephrine in Septic Shock Resuscitation (CENSER). A Randomized Trial.

    abstract::Rationale: Recent retrospective evidence suggests the efficacy of early norepinephrine administration during resuscitation; however, prospective data to support this assertion are scarce. Objectives: To conduct a phase II trial evaluating the hypothesis that early low-dose norepinephrine in adults with sepsis with hyp...

    journal_title:American journal of respiratory and critical care medicine

    pub_type: 杂志文章,随机对照试验

    doi:10.1164/rccm.201806-1034OC

    authors: Permpikul C,Tongyoo S,Viarasilpa T,Trainarongsakul T,Chakorn T,Udompanturak S

    更新日期:2019-05-01 00:00:00

971 条记录 1/25 页 « 12345678...2425 »